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Cheap flights from Panama City to Santo Domingo from C$ 389

PTY — SDQ
10 Oct — 17 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama City to Santo Domingo

Enter your travel dates to find the best prices.

Cheapest flights from Panama City to Santo Domingo

Fri 25/97:26 p.m. -
Nonstop2h 30m
Mon 28/912:42 p.m. -
Nonstop2h 33m
Deal found 6/9C$ 678
Sat 7/117:39 a.m. -
Nonstop2h 27m
Thu 7/17:05 p.m. -
Nonstop2h 35m
Deal found 7/9C$ 732
Mon 14/910:10 a.m. -
1 stop6h 45m
Thu 24/912:45 p.m. -
1 stop21h 30m
Deal found 9/9C$ 749
Sat 19/1210:41 p.m. -
Nonstop2h 27m
Sat 23/112:06 p.m. -
Nonstop2h 39m
Deal found 6/9C$ 787
Sun 20/98:11 a.m. -
Nonstop2h 31m
Wed 6/112:06 p.m. -
Nonstop2h 39m
Deal found 7/9C$ 791
Mon 14/98:11 a.m. -
Nonstop2h 31m
Sun 4/78:40 a.m. -
Nonstop2h 42m
Deal found 7/9C$ 983
Sun 13/912:44 p.m. -
Nonstop2h 31m
Sun 20/912:42 p.m. -
Nonstop2h 33m
Deal found 7/9C$ 994
Thu 24/94:25 a.m. -
1 stop6h 25m
Mon 28/912:45 p.m. -
1 stop12h 50m
Deal found 8/9C$ 1,071
Tue 8/912:44 p.m. -
Nonstop2h 31m
Thu 10/96:06 a.m. -
Nonstop2h 33m
Deal found 7/9C$ 1,155
Sat 5/97:26 p.m. -
Nonstop2h 30m
Sun 6/92:16 p.m. -
Nonstop2h 33m
Deal found 5/9C$ 1,289
Thu 10/98:11 a.m. -
Nonstop2h 31m
Sat 12/912:42 p.m. -
Nonstop2h 33m
Deal found 6/9C$ 1,355
Sat 14/1110:00 a.m. -
1 stop12h 46m
Sat 21/114:18 p.m. -
2 stops28h 20m
Deal found 9/9C$ 1,397

Find flight deals from Panama City to Santo Domingo

Round-trip from

C$ 678

One-way from

C$ 389

Popular in

July

Cheapest in

January

Average price

C$ 678
Copa Airlines
  • Copa Airlines
  • 25/9-28/9
  • Nonstop
  • 5h 03m total
  • Panama City to Santo Domingo
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Copa Airlines
  • Copa Airlines
  • 11/11-31/12
  • Nonstop
  • 2h 28m total
  • Panama City to Santo Domingo
Search Deals
Highest demand for flights based on searches. 4% potential increase in price (C$ 49 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (C$ 10 potential savings vs. average RT price).
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Average for round-trip flights in September 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Panama City to Santo Domingo that are best for you.

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Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Wed 11/11

7:39 a.m.-11:06 a.m.

Nonstop2h 27m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-11:30 p.m.

Nonstop0h 00m

C$ 389

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Fri 25/9

8:11 a.m.-11:42 a.m.

Nonstop2h 31m

Santo Domingo Las Americas

Tue 29/9

12:42 p.m.-2:15 p.m.

Nonstop2h 33m

C$ 678

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Fri 25/9

7:26 p.m.-10:56 p.m.

Nonstop2h 30m

Santo Domingo Las Americas

Mon 28/9

12:42 p.m.-2:15 p.m.

Nonstop2h 33m

C$ 678

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Thu 15/10

8:11 a.m.-11:41 a.m.

Nonstop2h 30m

Santo Domingo Las Americas

Fri 23/10

6:41 p.m.-8:14 p.m.

Nonstop2h 33m

C$ 678

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Sun 1/11

8:15 a.m.-11:45 a.m.

Nonstop2h 30m

Santo Domingo Las Americas

Sat 7/11

8:55 a.m.-10:30 a.m.

Nonstop2h 35m

C$ 678

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Wed 7/10

7:26 p.m.-10:56 p.m.

Nonstop2h 30m

Santo Domingo Las Americas

Sat 10/10

12:12 p.m.-1:45 p.m.

Nonstop2h 33m

C$ 678

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Sun 1/11

9:42 a.m.-1:10 p.m.

Nonstop2h 28m

Santo Domingo Las Americas

Thu 5/11

5:55 a.m.-7:28 a.m.

Nonstop2h 33m

C$ 678

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Fri 25/9

9:42 a.m.-1:13 p.m.

Nonstop2h 31m

Santo Domingo Las Americas

Wed 30/9

2:16 p.m.-3:49 p.m.

Nonstop2h 33m

C$ 678

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Wed 18/11

8:15 a.m.-11:45 a.m.

Nonstop2h 30m

Santo Domingo Las Americas

Wed 25/11

2:24 p.m.-3:58 p.m.

Nonstop2h 34m

C$ 678

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Tue 3/11

7:26 p.m.-10:58 p.m.

Nonstop2h 32m

Santo Domingo Las Americas

Thu 12/11

12:45 p.m.-2:21 p.m.

Nonstop2h 36m

C$ 678

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Showing 1-10 of 18 resultsSorted by cheapest first
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Best time to book a flight from Panama City to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Panama City with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santo Domingo

How far ahead should I book a flight from Panama City to Santo Domingo?

The price you pay for your flight from Panama City to Santo Domingo may vary depending on when you book. For the best chance of a lower fare, look to book 69 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Panama City to Santo Domingo (average of C$ 623). Flying from Panama City to Santo Domingo in July is currently the most expensive (average of C$ 757). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SDQ?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Santo Domingo as you normally would.

How much does it cost to fly round-trip from Panama City to Santo Domingo?

Airfare is typical for this route at the moment.

Panama City to Santo Domingo flights typically cost between C$ 625 and C$ 757 in September.
The cheapest round-trip price found within the last 5 days was C$ 678 on Copa Airlines (25 Sep-29 Sep).

Reviews of airlines servicing Santo Domingo

Check out reviews from past customers who have flown with Copa Airlines and Avianca from Panama City to Santo Domingo to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,546 reviews
Check prices

Overall

7.6

Comfort

7.4

Boarding

7.8

Food

6.9

Crew

8.1

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Copa Airlines
7.6
Good
1,546 reviews
Copa Airlines
7.6
Good
1,546 reviews
Check prices

Overall

7.6

Comfort

7.4

Boarding

7.8

Food

6.9

Crew

8.1

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Avianca
6.5
Okay
2,553 reviews
Copa Airlines
7.6
Good
1,546 reviews
Check prices

Overall

7.6

Comfort

7.4

Boarding

7.8

Food

6.9

Crew

8.1

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Related info for your journey

  • How long is the flight from Panama City to Santo Domingo?

    Airlines like Copa Airlines fly from Panama City to Santo Domingo in about 2h 31m. The time it takes to get you to your destination is usually consistent. Airlines will cover a distance of 1476 km. Generally, flights for this route are direct.

  • What are the cheapest airlines flying from Panama City to Santo Domingo round-trip?

    Our cheapest airline available from Panama City to Santo Domingo is Avianca. Our recent data shows that you can find tickets from as low as C$ 564 on this airline. An additional option worth looking into is Copa Airlines, starting at C$ 579. Users have found that Avianca is 17% cheaper than the other options available to this destination.

  • What are the most reliable airlines from Panama City to Santo Domingo?

    The top 3 most reliable airlines when flying from Panama City to Santo Domingo are KLM (88%), Air France (88%) and Turkish Airlines (88%).

  • Can I find deals for flights from Panama City to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Panama City to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santo Domingo.

  • Can I find deals for business class flights from Panama City to Santo Domingo?

    Yes. Cheapflights offers flight deals from Panama City to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from Panama City to Santo Domingo (average of C$ 623). Flying from Panama City to Santo Domingo in July is currently the most expensive (average of C$ 757). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 2 airlines flying from Panama City to Santo Domingo

AirlineCheapestAverageFlexibilityOn-time
AviancaCheapestC$ 564AverageC$ 623FlexibilityNo cancel feeOn-time71%
Search Avianca flights
Copa AirlinesCheapestC$ 579AverageC$ 653FlexibilityNo cancel feeOn-time70%
Search Copa Airlines flights

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When you search for this flight from Panama City to Santo Domingo, Cheapflights searches on 900+ travel sites to save you time finding great flight deals online. Additionally, we offer filter features so you can choose a preferred cabin class or airline, see different price ranges, and much more so you can book the flight for you.

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It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama City to Santo Domingo.

Can Cheapflights find flights from Panama City to Santo Domingo with no change fees?

Certainly. Search results for flights to Santo Domingo from Panama City shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

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