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Cheap flights from Santo Domingo to Panama City from C$ 476

SDQ — PTY
26 Nov — 3 Dec1
1 adult
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Santo Domingo Las Americas to Panama City Tocumen Intl are usually found in January or February, booked 90 days in advance, depart on a Saturday or Monday and return on a Monday

Cheap flight deals from Santo Domingo to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Santo Domingo to Panama City

Sat 7/1112:45 p.m. -
1 stop5h 30m
Sat 7/112:30 a.m. -
1 stop8h 20m
Deal found 24/10C$ 675
Sat 5/126:45 p.m. -
1 stop7h 35m
Mon 7/1210:05 a.m. -
1 stop6h 45m
Deal found 25/10C$ 676
Sat 14/1112:10 p.m. -
Nonstop2h 35m
Tue 17/1112:44 p.m. -
Nonstop2h 28m
Deal found 27/10C$ 692
Fri 27/112:20 p.m. -
Nonstop2h 34m
Tue 1/127:40 a.m. -
Nonstop2h 23m
Deal found 27/10C$ 708
Mon 30/1112:45 p.m. -
Nonstop2h 36m
Thu 10/128:15 a.m. -
Nonstop2h 27m
Deal found 27/10C$ 805
Fri 20/112:20 p.m. -
Nonstop2h 34m
Wed 25/118:15 a.m. -
Nonstop2h 30m
Deal found 27/10C$ 821
Sun 1/116:45 p.m. -
1 stop7h 35m
Tue 3/112:30 a.m. -
1 stop14h 20m
Deal found 26/10C$ 825
Sat 21/118:55 a.m. -
Nonstop2h 35m
Thu 3/1212:44 p.m. -
Nonstop2h 29m
Deal found 26/10C$ 850
Thu 24/127:03 p.m. -
Nonstop2h 37m
Mon 28/1210:41 p.m. -
Nonstop2h 27m
Deal found 26/10C$ 860
Thu 24/1212:45 p.m. -
1 stop13h 35m
Sun 27/122:30 a.m. -
1 stop14h 20m
Deal found 24/10C$ 866
Wed 23/122:14 p.m. -
Nonstop2h 44m
Sun 27/1212:44 p.m. -
Nonstop2h 29m
Deal found 24/10C$ 884
Mon 2/117:06 p.m. -
Nonstop2h 34m
Mon 9/118:15 a.m. -
Nonstop2h 30m
Deal found 26/10C$ 899

Find flight deals from Santo Domingo to Panama City

Round-trip from

C$ 675

One-way from

C$ 476

Popular in

August

Cheapest in

January

Average price

C$ 798

Good round-trip deal

C$ 707 or less
Avianca
  • Avianca
  • 17/1-25/1
  • 2 total stops
  • 19h 50m total
  • Santo Domingo to Panama City
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Avianca
  • Avianca
  • 11/11-31/12
  • 1 total stop
  • 5h 30m total
  • Santo Domingo to Panama City
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Highest demand for flights based on searches. 4% potential increase in price (C$ 52 potential increase over avg. RT price).
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Cheapest flight prices on average. 0% potential price decrease (C$ 9 potential savings vs. average RT price).
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Average for round-trip flights in October 2026
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Price to beat on a round-trip flight from Santo Domingo Las Americas to Panama City Tocumen Intl.
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

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Route

Depart

Return

Price

Cheapest round-trip

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Wed 11/11

12:45 p.m.-1:20 a.m.

1 stop13h 35m

Panama City Tocumen Intl

Wed 31/12

12:00 a.m.-12:30 a.m.

Nonstop0h 00m

C$ 476

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Tue 26/1

5:50 a.m.-7:28 a.m.

Nonstop2h 38m

Panama City Tocumen Intl

Sun 31/1

9:42 a.m.-1:08 p.m.

Nonstop2h 26m

C$ 692

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Thu 17/12

5:53 a.m.-7:28 a.m.

Nonstop2h 35m

Panama City Tocumen Intl

Wed 23/12

12:44 p.m.-4:13 p.m.

Nonstop2h 29m

C$ 692

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Wed 25/11

7:06 p.m.-8:40 p.m.

Nonstop2h 34m

Panama City Tocumen Intl

Wed 2/12

12:44 p.m.-4:13 p.m.

Nonstop2h 29m

C$ 692

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Fri 13/11

7:06 p.m.-8:40 p.m.

Nonstop2h 34m

Panama City Tocumen Intl

Fri 20/11

9:42 a.m.-1:10 p.m.

Nonstop2h 28m

C$ 692

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Fri 13/11

7:06 p.m.-8:40 p.m.

Nonstop2h 34m

Panama City Tocumen Intl

Tue 17/11

8:15 a.m.-11:45 a.m.

Nonstop2h 30m

C$ 692

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Thu 28/1

12:06 p.m.-1:45 p.m.

Nonstop2h 39m

Panama City Tocumen Intl

Sun 31/1

12:44 p.m.-4:08 p.m.

Nonstop2h 24m

C$ 692

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Sat 16/1

12:42 p.m.-2:21 p.m.

Nonstop2h 39m

Panama City Tocumen Intl

Sat 23/1

9:42 a.m.-1:08 p.m.

Nonstop2h 26m

C$ 692

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Thu 21/1

8:52 a.m.-10:30 a.m.

Nonstop2h 38m

Panama City Tocumen Intl

Mon 25/1

9:42 a.m.-1:08 p.m.

Nonstop2h 26m

C$ 692

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Tue 22/12

12:09 p.m.-1:45 p.m.

Nonstop2h 36m

Panama City Tocumen Intl

Fri 15/1

12:44 p.m.-4:08 p.m.

Nonstop2h 24m

C$ 692

Flights are sorted by cheapest round-trip flights first.

Deals found on 25/10

Showing 1-10 of 20 resultsSorted by cheapest first
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Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

The best time to book flights from Santo Domingo to Panama City is 89 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of C$ 739). Flying from Santo Domingo to Panama City in August is currently the most expensive (average of C$ 867). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to PTY?

It’s typically best to fly out from Santo Domingo to Panama City in the evening. Doing so could potentially save you 77% on the flight price compared to flying at noon, which is usually more expensive.

How much does it cost to fly round-trip from Santo Domingo to Panama City?

Airfare is below average for this route at the moment.

Santo Domingo to Panama City flights typically cost between C$ 692 and C$ 884 in January.
The cheapest round-trip price found within the last 5 days was C$ 675 on Avianca (17 Jan-25 Jan).

Related info for your journey

  • How popular is this Santo Domingo to Panama City flight route?

    Flights from Santo Domingo Las Americas to Panama City Tocumen Intl have been viewed 58 times in the past calendar month.

  • How long is the flight from Santo Domingo to Panama City?

    Airlines like Copa Airlines fly from Santo Domingo to Panama City in about 2h 38m. The time it takes to get you to your destination is usually consistent. The distance from Santo Domingo to Panama City is about 1476 km. All flights are typically direct.

  • What are the most reliable airlines from Santo Domingo to Panama City?

    No one likes to see their flight delayed. When booking a flight from Santo Domingo to Panama City consider choosing Air France (85%), Copa Airlines (84%) or KLM (80%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Santo Domingo to Panama City?

    The cheapest flight price from Santo Domingo to Panama City is C$ 357. On average you can expect to pay C$ 707. The most popular route, (Santo Domingo Las Americas - Panama City Tocumen Intl), can usually be booked for C$ 692.

  • Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.

  • Can I find deals for business class flights from Santo Domingo to Panama City?

    Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Panama City?

    Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of C$ 739). Flying from Santo Domingo to Panama City in August is currently the most expensive (average of C$ 867). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Certainly. Search results for flights to Panama City from Santo Domingo shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

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Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Panama City from Santo Domingo today and book when prices fit your budget.

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