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Cheap flights from Santo Domingo to Panama City from C$ 381

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/9. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — PTY
28 Aug — 4 Sep1
1 adult
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Santo Domingo Las Americas to Panama City Tocumen Intl are usually found in January or February, booked 78 days in advance, depart on a Friday or Thursday and return on a Monday

Cheap flight deals from Santo Domingo to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Santo Domingo to Panama City
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 29 July 2026.

Thu 6/812:45 p.m.
SDQ
-
PTY
1 stop12h 50m
Avianca
Mon 28/94:25 a.m.
PTY
-
SDQ
1 stop6h 25m
Avianca
Deal found 27/7C$ 804
Sun 16/812:45 p.m.
SDQ
-
PTY
1 stop12h 50m
Avianca
Sun 23/85:55 p.m.
PTY
-
SDQ
1 stop16h 55m
Avianca
Deal found 24/7C$ 807
Sat 15/86:42 p.m.
SDQ
-
PTY
Nonstop2h 32m
Copa Airlines
Sat 22/89:42 a.m.
PTY
-
SDQ
Nonstop2h 31m
Copa Airlines
Deal found 29/7C$ 889
Thu 10/127:03 p.m.
SDQ
-
PTY
Nonstop2h 37m
Copa Airlines
Sun 13/1212:44 p.m.
PTY
-
SDQ
Nonstop2h 29m
Copa Airlines
Deal found 24/7C$ 917
Tue 11/88:48 a.m.
SDQ
-
PTY
Nonstop2h 32m
Copa Airlines
Thu 24/98:11 a.m.
PTY
-
SDQ
Nonstop2h 31m
Copa Airlines
Deal found 28/7C$ 944
Thu 6/82:17 p.m.
SDQ
-
PTY
Nonstop2h 32m
Copa Airlines
Mon 28/97:24 a.m.
PTY
-
SDQ
Nonstop2h 31m
Copa Airlines
Deal found 29/7C$ 1,079
Mon 10/812:43 p.m.
SDQ
-
PTY
Nonstop2h 32m
Copa Airlines
Thu 20/812:44 p.m.
PTY
-
SDQ
Nonstop2h 31m
Copa Airlines
Deal found 24/7C$ 1,120
Tue 4/82:17 p.m.
SDQ
-
PTY
Nonstop2h 32m
Copa Airlines
Tue 11/87:26 p.m.
PTY
-
SDQ
Nonstop2h 30m
Copa Airlines
Deal found 27/7C$ 1,137
Sun 20/96:06 a.m.
SDQ
-
PTY
Nonstop2h 33m
Copa Airlines
Tue 22/99:42 a.m.
PTY
-
SDQ
Nonstop2h 31m
Copa Airlines
Deal found 28/7C$ 1,195

Find flight deals from Santo Domingo to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 29 July 2026.

Round-trip from

C$ 804

One-way from

C$ 381

Popular in

May

Cheapest in

January

Average price

C$ 823
Avianca
  • Avianca
  • 24/8-31/8
  • 2 total stops
  • 13h 30m total
  • Santo Domingo to Panama City
Search Deals
Avianca
  • Avianca
  • 7/9
  • 1 total stop
  • 12h 50m total
  • Santo Domingo to Panama City
Search Deals
Highest demand for flights based on searches. 4% potential increase in price (C$ 50 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease (C$ 10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 29 July 2026.
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 21/8

6:42 p.m.-8:14 p.m.

Nonstop2h 32m

Panama City Tocumen Intl

Fri 28/8

7:26 p.m.-10:56 p.m.

Nonstop2h 30m

C$ 889

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 3/9

12:12 p.m.-1:45 p.m.

Nonstop2h 33m

Panama City Tocumen Intl

Mon 7/9

9:42 a.m.-1:13 p.m.

Nonstop2h 31m

C$ 889

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sat 15/8

6:42 p.m.-8:14 p.m.

Nonstop2h 32m

Panama City Tocumen Intl

Sat 22/8

9:42 a.m.-1:13 p.m.

Nonstop2h 31m

C$ 889

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 25/9

2:16 p.m.-3:49 p.m.

Nonstop2h 33m

Panama City Tocumen Intl

Wed 30/9

12:44 p.m.-4:15 p.m.

Nonstop2h 31m

C$ 889

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 11/11

12:10 p.m.-1:45 p.m.

Nonstop2h 35m

Panama City Tocumen Intl

Sat 14/11

7:26 p.m.-10:58 p.m.

Nonstop2h 32m

C$ 889

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 21/10

8:47 a.m.-10:20 a.m.

Nonstop2h 33m

Panama City Tocumen Intl

Wed 28/10

12:44 p.m.-4:14 p.m.

Nonstop2h 30m

C$ 889

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 6/11

12:45 p.m.-2:21 p.m.

Nonstop2h 36m

Panama City Tocumen Intl

Fri 13/11

12:44 p.m.-4:12 p.m.

Nonstop2h 28m

C$ 889
Quickest round-trip

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sun 1/11

7:06 p.m.-8:40 p.m.

Nonstop2h 34m

Panama City Tocumen Intl

Wed 11/11

7:39 a.m.-11:06 a.m.

Nonstop2h 27m

C$ 889

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 17/9

2:16 p.m.-3:49 p.m.

Nonstop2h 33m

Panama City Tocumen Intl

Fri 23/10

7:26 p.m.-10:56 p.m.

Nonstop2h 30m

C$ 889
Cheapest one-way

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Mon 11/1

2:19 p.m.-3:58 p.m.

Nonstop2h 39m

C$ 856

Flights are sorted by cheapest round-trip flights first.

Deals found on 24/7

Showing 1-10 of 18 resultsSorted by cheapest first
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Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

The best time to book flights from Santo Domingo to Panama City is 77 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of C$ 739). Flying from Santo Domingo to Panama City in May is currently the most expensive (average of C$ 858). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to PTY?

Find hourly flight availability from Santo Domingo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 29 July 2026.

It’s typically best to fly out from Santo Domingo to Panama City in the evening. Doing so could potentially save you 77% on the flight price compared to flying in the morning, which is usually more expensive.

How much does it cost to fly round-trip from Santo Domingo to Panama City?

Airfare is typical for this route at the moment.

Santo Domingo to Panama City flights typically cost between C$ 708 and C$ 889 in August.
The cheapest round-trip price found within the last 5 days was C$ 804 on Avianca (24 Aug-31 Aug).

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Santo Domingo to Panama City flight route?

    Flights from Santo Domingo Las Americas to Panama City Tocumen Intl have been viewed 64 times in the past calendar month.

  • How long is the flight from Santo Domingo to Panama City?

    Airlines like Copa Airlines fly from Santo Domingo to Panama City in about 2h 32m. The time it takes to get you to your destination is usually consistent. The distance from Santo Domingo to Panama City is about 1476 km. All flights are typically direct.

  • What are the most reliable airlines from Santo Domingo to Panama City?

    No one likes to see their flight delayed. When booking a flight from Santo Domingo to Panama City consider choosing Air France (97%), KLM (96%) or Turkish Airlines (95%) as they are the most reliable in getting you off to your destination on time.

  • Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.

  • Can I find deals for business class flights from Santo Domingo to Panama City?

    Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Panama City?

    Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of C$ 739). Flying from Santo Domingo to Panama City in May is currently the most expensive (average of C$ 858). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Deals for Santo Domingo to Panama City flights are sourced from 900+ travel sites when you use Cheapflights. When all flight results come back, Cheapflights lets you sort and filter flights using different criteria to choose better, like price, airport, cabin class, and plenty of other options.

Why should you use Cheapflights to find cheap flight tickets from Santo Domingo to Panama City?

Cheapflights simply makes it quick and affordable to book flights from Santo Domingo to Panama City by bringing together all flight options from hundreds of airlines and agencies online — and put it in one place for you to choose from. Plus, Cheapflights is 100% free to use for all.

Can Cheapflights find flights from Santo Domingo to Panama City with no change fees?

Certainly. Search results for flights to Panama City from Santo Domingo shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Santo Domingo to Panama City become cheaper?

Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Panama City from Santo Domingo today and book when prices fit your budget.

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