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Cheap flights from Panama City to Madrid, Spain from C$ 860

PTY — MAD
24 Nov — 1 Dec1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama City to Madrid

Enter your travel dates to find the best prices.

Cheapest flights from Panama City to Madrid

Sun 8/112:30 a.m. -
1 stop21h 40m
Tue 9/24:20 p.m. -
1 stop15h 00m
Deal found 24/10C$ 1,049
Thu 26/1110:00 a.m. -
1 stop17h 30m
Tue 8/1211:00 a.m. -
2 stops39h 02m
Deal found 21/10C$ 1,075
Mon 28/1211:55 p.m. -
2 stops26h 05m
Sun 7/211:15 a.m. -
2 stops33h 30m
Deal found 21/10C$ 1,080
Wed 18/1110:00 a.m. -
1 stop17h 30m
Tue 8/121:25 p.m. -
2 stops36h 37m
Deal found 21/10C$ 1,085
Fri 27/1110:00 a.m. -
1 stop17h 30m
Fri 11/1211:15 a.m. -
2 stops33h 30m
Deal found 21/10C$ 1,088
Mon 28/1211:55 p.m. -
2 stops26h 05m
Wed 20/11:25 p.m. -
2 stops31h 20m
Deal found 21/10C$ 1,091
Tue 24/114:41 p.m. -
2 stops33h 04m
Thu 10/1211:15 a.m. -
2 stops33h 30m
Deal found 21/10C$ 1,094
Sun 22/114:41 p.m. -
2 stops34h 49m
Mon 7/1212:00 p.m. -
2 stops38h 02m
Deal found 24/10C$ 1,098
Sun 25/106:45 p.m. -
1 stop18h 50m
Fri 22/16:05 a.m. -
1 stop19h 50m
Deal found 25/10C$ 1,101
Sun 22/114:41 p.m. -
2 stops34h 49m
Tue 1/126:25 a.m. -
2 stops19h 37m
Deal found 22/10C$ 1,102
Sun 22/114:41 p.m. -
2 stops34h 49m
Mon 7/126:25 a.m. -
2 stops19h 37m
Deal found 23/10C$ 1,103

Find flight deals from Panama City to Madrid

Round-trip from

C$ 1,049

One-way from

C$ 860

Popular in

July

Cheapest in

February

Average price

C$ 1,092

Good round-trip deal

C$ 912 or less
Avianca
  • Avianca
  • 8/11-9/2
  • 2 total stops
  • 36h 40m total
  • Panama City to Madrid
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KLM
  • KLM
  • 24/12-31/12
  • 1 total stop
  • 22h 50m total
  • Panama City to Madrid
Search Deals
Highest demand for flights based on searches. 9% potential increase in price (C$ 171 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease (C$ 23 potential savings vs. average RT price).
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Average for round-trip flights in October 2026
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Price to beat on a round-trip flight from Panama City Tocumen Intl to Madrid Barajas.
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Panama City to Madrid that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Thu 24/12

6:45 p.m.-11:35 p.m.

1 stop22h 50m

Madrid Barajas

Wed 31/12

12:00 a.m.-6:00 p.m.

Nonstop0h 00m

C$ 864

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Mon 30/11

6:45 p.m.-7:35 p.m.

1 stop18h 50m

Madrid Barajas

Wed 31/12

12:00 a.m.-6:00 p.m.

Nonstop0h 00m

C$ 864
Quickest round-trip

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Thu 3/12

6:45 p.m.-4:05 p.m.

1 stop15h 20m

Madrid Barajas

Wed 31/12

12:00 a.m.-6:00 p.m.

Nonstop0h 00m

C$ 864

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Wed 9/12

6:45 p.m.-11:35 p.m.

1 stop22h 50m

Madrid Barajas

Wed 31/12

12:00 a.m.-6:00 p.m.

Nonstop0h 00m

C$ 864

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Fri 4/12

6:45 p.m.-4:05 p.m.

1 stop15h 20m

Madrid Barajas

Wed 31/12

12:00 a.m.-6:00 p.m.

Nonstop0h 00m

C$ 864

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Sun 8/11

6:45 p.m.-7:35 p.m.

1 stop18h 50m

Madrid Barajas

Wed 31/12

12:00 a.m.-6:00 p.m.

Nonstop0h 00m

C$ 865

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Mon 9/11

6:45 p.m.-7:35 p.m.

1 stop18h 50m

Madrid Barajas

Wed 31/12

12:00 a.m.-6:00 p.m.

Nonstop0h 00m

C$ 865

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Thu 5/11

6:45 p.m.-11:35 p.m.

1 stop22h 50m

Madrid Barajas

Wed 31/12

12:00 a.m.-6:00 p.m.

Nonstop0h 00m

C$ 865

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Sun 28/2

4:10 p.m.-11:25 p.m.

1 stop25h 15m

Madrid Barajas

Wed 31/12

12:00 a.m.-6:00 p.m.

Nonstop0h 00m

C$ 899

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Mon 22/2

6:10 p.m.-11:25 p.m.

1 stop23h 15m

Madrid Barajas

Wed 31/12

12:00 a.m.-6:00 p.m.

Nonstop0h 00m

C$ 899

Flights are sorted by cheapest round-trip flights first.

Deals found on 24/10

Showing 1-10 of 21 resultsSorted by cheapest first
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Best time to book a flight from Panama City to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama City with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Panama City to Madrid

How far ahead should I book a flight from Panama City to Madrid?

The best time to book flights from Panama City to Madrid is 90 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Panama City to Madrid?

Currently, February is the cheapest month in which you can book a flight from Panama City to Madrid (average of C$ 1,063). Flying from Panama City to Madrid in July is currently the most expensive (average of C$ 1,357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MAD?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Madrid as you normally would.

How much does it cost to fly round-trip from Panama City to Madrid?

Airfare is typical for this route at the moment.

Panama City to Madrid flights typically cost between C$ 1,023 and C$ 1,295 in November.
The cheapest round-trip price found within the last 5 days was C$ 1,049 on Avianca (8 Nov-9 Feb).

Related info for your journey

  • How popular is this Panama City to Madrid flight route?

    This flight path from Panama City Tocumen Intl to Madrid Barajas was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Madrid?

    There are many flights that can get you from Panama City to Madrid in 26h 10m. Fly via United Airlines to get the fastest option. The distance from Panama City to Madrid is about 8151 km.

  • What are the most reliable airlines from Panama City to Madrid?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Panama City to Madrid on time: Air Europa (80%), Etihad Airways (80%), China Eastern (80%).

  • What are the cheapest flights from Panama City to Madrid?

    On average you can expect to pay C$ 2,432 for a flight from Panama City to Madrid. The cheapest flight overall is C$ 912 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at C$ 2,168.

  • Can I find deals for flights from Panama City to Madrid that include hotel bookings?

    Yes. In addition to deals on Panama City to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Madrid?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Madrid.

  • Can I find deals for business class flights from Panama City to Madrid?

    Yes. Cheapflights offers flight deals from Panama City to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Madrid?

    Currently, February is the cheapest month in which you can book a flight from Panama City to Madrid (average of C$ 1,063). Flying from Panama City to Madrid in July is currently the most expensive (average of C$ 1,357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Yes, Cheapflights offers price alerts on Panama City to Madrid flights so you can book your travel at the perfect time. Price Alerts can be enabled by clicking the bell icon next to the flight deals above and providing your email address where you want to receive the alerts.

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