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Cheap flights from Panama City to Madrid, Spain from C$ 842

PTY — MAD
11 Oct — 18 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama City to Madrid

Enter your travel dates to find the best prices.

Cheapest flights from Panama City to Madrid

Tue 3/119:30 p.m. -
Nonstop9h 35m
Fri 20/113:10 p.m. -
Nonstop10h 35m
Deal found 11/9C$ 1,007
Thu 12/119:30 p.m. -
Nonstop9h 35m
Thu 19/113:10 p.m. -
Nonstop10h 35m
Deal found 11/9C$ 1,009
Wed 4/119:30 p.m. -
Nonstop9h 35m
Wed 25/113:10 p.m. -
Nonstop10h 35m
Deal found 10/9C$ 1,010
Thu 5/119:30 p.m. -
Nonstop9h 35m
Mon 16/113:10 p.m. -
Nonstop10h 35m
Deal found 11/9C$ 1,014
Tue 3/112:30 a.m. -
1 stop23h 40m
Wed 18/118:10 a.m. -
1 stop15h 05m
Deal found 11/9C$ 1,036
Mon 9/119:30 p.m. -
Nonstop9h 35m
Mon 16/113:10 p.m. -
Nonstop10h 35m
Deal found 11/9C$ 1,052
Fri 23/108:25 p.m. -
Nonstop9h 50m
Thu 5/113:10 p.m. -
Nonstop10h 35m
Deal found 11/9C$ 1,054
Tue 3/1110:00 a.m. -
1 stop17h 30m
Fri 20/1111:00 a.m. -
2 stops57h 45m
Deal found 11/9C$ 1,063
Fri 30/107:55 a.m. -
2 stops19h 35m
Wed 11/1111:00 a.m. -
2 stops38h 38m
Deal found 10/9C$ 1,064
Mon 26/109:30 a.m. -
1 stop17h 45m
Sun 15/111:25 p.m. -
2 stops36h 13m
Deal found 10/9C$ 1,068
Sun 11/109:45 a.m. -
1 stop16h 15m
Fri 23/1010:50 a.m. -
1 stop15h 41m
Deal found 7/9C$ 1,070

Find flight deals from Panama City to Madrid

Round-trip from

C$ 1,007

One-way from

C$ 842

Popular in

December

Cheapest in

February

Average price

C$ 1,236

Good round-trip deal

C$ 3,900 or less
Air Europa
  • Air Europa
  • 3/11-20/11
  • Nonstop
  • 20h 10m total
  • Panama City to Madrid
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KLM
  • KLM
  • 3/12-31/12
  • 1 total stop
  • 15h 20m total
  • Panama City to Madrid
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Highest demand for flights based on searches. 1% potential increase in price (C$ 29 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease (C$ 23 potential savings vs. average RT price).
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Average for round-trip flights in September 2026
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Price to beat on a round-trip flight from Panama City Tocumen Intl to Madrid Barajas.
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Panama City to Madrid that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Tue 1/12

9:55 p.m.-7:35 p.m.

1 stop15h 40m

Madrid Barajas

Wed 31/12

12:00 a.m.-6:00 p.m.

Nonstop0h 00m

C$ 842

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Mon 12/10

9:55 p.m.-11:25 p.m.

2 stops18h 30m

Madrid Barajas

Wed 31/12

12:00 a.m.-6:00 p.m.

Nonstop0h 00m

C$ 888

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Wed 30/9

9:05 p.m.-2:10 p.m.

Nonstop10h 05m

Madrid Barajas

Wed 31/12

12:00 a.m.-6:00 p.m.

Nonstop0h 00m

C$ 902
Quickest round-trip

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Sat 6/2

9:30 p.m.-1:05 p.m.

Nonstop9h 35m

Madrid Barajas

Wed 31/12

12:00 a.m.-6:00 p.m.

Nonstop0h 00m

C$ 931

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Wed 30/9

10:20 p.m.-1:35 p.m.

1 stop32h 15m

Madrid Barajas

Wed 31/12

12:00 a.m.-6:00 p.m.

Nonstop0h 00m

C$ 996

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Mon 12/10

10:20 p.m.-10:25 a.m.

1 stop29h 05m

Madrid Barajas

Wed 31/12

12:00 a.m.-6:00 p.m.

Nonstop0h 00m

C$ 996

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Thu 5/11

9:30 p.m.-1:05 p.m.

Nonstop9h 35m

Madrid Barajas

Tue 17/11

3:10 p.m.-7:45 p.m.

Nonstop10h 35m

C$ 1,050

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Thu 5/11

9:30 p.m.-1:05 p.m.

Nonstop9h 35m

Madrid Barajas

Fri 20/11

3:10 p.m.-7:45 p.m.

Nonstop10h 35m

C$ 1,050

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Wed 4/11

9:30 p.m.-1:05 p.m.

Nonstop9h 35m

Madrid Barajas

Thu 19/11

3:10 p.m.-7:45 p.m.

Nonstop10h 35m

C$ 1,050

Panama CityMadrid

PTY Panama City Tocumen Intl - MAD Madrid Barajas

PTYMAD

Panama City Tocumen Intl

Mon 16/11

9:30 p.m.-1:05 p.m.

Nonstop9h 35m

Madrid Barajas

Sun 22/11

3:10 p.m.-7:45 p.m.

Nonstop10h 35m

C$ 1,054

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/9

Showing 1-10 of 18 resultsSorted by cheapest first
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Best time to book a flight from Panama City to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama City with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Panama City to Madrid

How far ahead should I book a flight from Panama City to Madrid?

The best time to book flights from Panama City to Madrid is 90 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Panama City to Madrid?

Currently, February is the cheapest month in which you can book a flight from Panama City to Madrid (average of C$ 1,038). Flying from Panama City to Madrid in December is currently the most expensive (average of C$ 1,348). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MAD?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Madrid as you normally would.

How much does it cost to fly round-trip from Panama City to Madrid?

Airfare is below average for this route at the moment.

Panama City to Madrid flights typically cost between C$ 1,078 and C$ 1,448 in November.
The cheapest round-trip price found within the last 5 days was C$ 1,007 on Air Europa (3 Nov-20 Nov).

Related info for your journey

  • How popular is this Panama City to Madrid flight route?

    This flight path from Panama City Tocumen Intl to Madrid Barajas was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Madrid?

    There are many flights that can get you from Panama City to Madrid in 9h 35m. Fly via Air Europa or United Airlines to get the fastest option. The distance from Panama City to Madrid is about 8151 km. This flight may include one or multiple stops.

  • What are the most reliable airlines from Panama City to Madrid?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Panama City to Madrid on time: Air Europa (85%), Etihad Airways (85%), China Eastern (85%).

  • What are the cheapest flights from Panama City to Madrid?

    On average you can expect to pay C$ 3,909 for a flight from Panama City to Madrid. The cheapest flight overall is C$ 2,777 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at C$ 1,063.

  • Can I find deals for flights from Panama City to Madrid that include hotel bookings?

    Yes. In addition to deals on Panama City to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Madrid?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Madrid.

  • Can I find deals for business class flights from Panama City to Madrid?

    Yes. Cheapflights offers flight deals from Panama City to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Madrid?

    Currently, February is the cheapest month in which you can book a flight from Panama City to Madrid (average of C$ 1,038). Flying from Panama City to Madrid in December is currently the most expensive (average of C$ 1,348). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Yes, Cheapflights offers price alerts on Panama City to Madrid flights so you can book your travel at the perfect time. Price Alerts can be enabled by clicking the bell icon next to the flight deals above and providing your email address where you want to receive the alerts.

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