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Cheap flights from Panama City to Madrid, Spain from C$ 910

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 25/10. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
27 Aug — 3 Sep1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama City to Madrid

Enter your travel dates to find the best prices.

Cheapest flights from Panama City to Madrid
Explore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 28 July 2026.

Sun 2/89:55 p.m.
PTY
-
MAD
2 stops18h 30m
Multiple Airlines
Thu 20/86:00 a.m.
MAD
-
PTY
1 stop20h 45m
Multiple Airlines
Deal found 26/7C$ 1,077
Sun 26/79:55 p.m.
PTY
-
MAD
2 stops18h 30m
Multiple Airlines
Sun 30/86:00 a.m.
MAD
-
PTY
1 stop20h 45m
Multiple Airlines
Deal found 24/7C$ 1,080
Thu 24/99:45 a.m.
PTY
-
MAD
1 stop16h 15m
United Airlines
Sat 10/1011:15 a.m.
MAD
-
PTY
2 stops38h 22m
United Airlines
Deal found 27/7C$ 1,086
Sat 10/109:45 a.m.
PTY
-
MAD
1 stop16h 15m
United Airlines
Mon 26/1011:15 a.m.
MAD
-
PTY
1 stop37h 47m
United Airlines
Deal found 28/7C$ 1,087
Mon 14/99:45 a.m.
PTY
-
MAD
1 stop16h 15m
United Airlines
Mon 28/911:15 a.m.
MAD
-
PTY
2 stops33h 59m
United Airlines
Deal found 24/7C$ 1,089
Thu 1/103:30 p.m.
PTY
-
MAD
2 stops33h 35m
United Airlines
Tue 13/1010:50 a.m.
MAD
-
PTY
2 stops38h 47m
United Airlines
Deal found 28/7C$ 1,090
Thu 29/107:55 a.m.
PTY
-
MAD
2 stops17h 50m
United Airlines
Tue 10/111:25 p.m.
MAD
-
PTY
2 stops60h 37m
United Airlines
Deal found 28/7C$ 1,094
Wed 16/99:45 a.m.
PTY
-
MAD
1 stop16h 15m
United Airlines
Thu 1/1010:50 a.m.
MAD
-
PTY
1 stop15h 41m
United Airlines
Deal found 28/7C$ 1,096
Fri 2/109:45 a.m.
PTY
-
MAD
1 stop16h 15m
United Airlines
Mon 19/1012:45 p.m.
MAD
-
PTY
2 stops37h 46m
United Airlines
Deal found 28/7C$ 1,101

Find flight deals from Panama City to Madrid

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Madrid (MAD). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 28 July 2026.

Round-trip from

C$ 1,080

One-way from

C$ 910

Popular in

December

Cheapest in

February

Average price

C$ 1,369

Good round-trip deal

C$ 3,970 or less

Good one-way deal

C$ 964 or less
Air France
  • Air France
  • 7/8-21/8
  • 3 total stops
  • 32h 55m total
  • Panama City to Madrid
Search Deals
KLM
  • KLM
  • 25/10
  • 1 total stop
  • 18h 50m total
  • Panama City to Madrid
Search Deals
Highest demand for flights based on searches. 2% potential increase in price (C$ 36 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (C$ 25 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to Madrid Barajas.
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to Madrid Barajas.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 28 July 2026.
Use the filters below to find and compare flights from Panama City to Madrid that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 31/10

3:41 p.m.-9:15 a.m.

2 stops35h 34m

Madrid Barajas

Sun 8/11

11:15 a.m.-2:45 p.m.

2 stops33h 30m

C$ 1,090

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 2/10

10:00 a.m.-8:05 a.m.

2 stops39h 05m

Madrid Barajas

Fri 16/10

10:50 a.m.-7:31 p.m.

1 stop15h 41m

C$ 1,090

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 21/9

9:45 a.m.-9:00 a.m.

1 stop16h 15m

Madrid Barajas

Wed 30/9

11:15 a.m.-6:37 p.m.

2 stops38h 22m

C$ 1,090

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 18/10

9:45 a.m.-9:00 a.m.

1 stop16h 15m

Madrid Barajas

Sun 25/10

11:00 a.m.-7:02 p.m.

2 stops38h 02m

C$ 1,090

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 4/11

4:41 p.m.-9:15 a.m.

2 stops34h 34m

Madrid Barajas

Sun 22/11

11:15 a.m.-7:38 p.m.

2 stops38h 23m

C$ 1,090

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 2/10

10:00 a.m.-8:05 a.m.

2 stops39h 05m

Madrid Barajas

Wed 14/10

11:15 a.m.-6:37 p.m.

2 stops38h 22m

C$ 1,090

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 18/11

8:55 a.m.-7:45 a.m.

2 stops40h 50m

Madrid Barajas

Tue 1/12

11:15 a.m.-5:12 p.m.

2 stops35h 57m

C$ 1,090
Quickest round-trip

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 16/9

9:45 a.m.-9:00 a.m.

1 stop16h 15m

Madrid Barajas

Wed 23/9

12:45 p.m.-7:31 p.m.

2 stops37h 46m

C$ 1,101

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 2/11

4:41 p.m.-9:15 a.m.

2 stops34h 34m

Madrid Barajas

Fri 13/11

11:00 a.m.-2:45 p.m.

2 stops33h 45m

C$ 1,108

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 1/11

4:41 p.m.-7:45 a.m.

2 stops33h 04m

Madrid Barajas

Mon 16/11

11:00 a.m.-2:45 p.m.

2 stops33h 45m

C$ 1,108

Flights are sorted by cheapest round-trip flights first.

Deals found on 28/7

Showing 1-10 of 16 resultsSorted by cheapest first
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Best time to book a flight from Panama City to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Madrid

How far ahead should I book a flight from Panama City to Madrid?

The best time to book flights from Panama City to Madrid is 90 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Panama City to Madrid?

Currently, February is the cheapest month in which you can book a flight from Panama City to Madrid (average of C$ 1,048). Flying from Panama City to Madrid in December is currently the most expensive (average of C$ 1,372). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MAD?

Find hourly flight availability from Panama City to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 28 July 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Madrid as you normally would.

How much does it cost to fly round-trip from Panama City to Madrid?

Airfare is below average for this route at the moment.

Panama City to Madrid flights typically cost between C$ 1,162 and C$ 1,622 in August.
The cheapest round-trip price found within the last 5 days was C$ 1,080 on Multiple Airlines (7 Aug-21 Aug).

Related info for your journey

Find useful and relevant information for your journey from Panama City to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Panama City to Madrid flight route?

    This flight path from Panama City Tocumen Intl to Madrid Barajas was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Madrid?

    There are many flights that can get you from Panama City to Madrid in 35h 34m. Fly via United Airlines to get the fastest option. The distance from Panama City to Madrid is about 8151 km.

  • What are the most reliable airlines from Panama City to Madrid?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Panama City to Madrid on time: Air Europa (80%), Etihad Airways (80%), China Eastern (80%).

  • What are the cheapest flights from Panama City to Madrid?

    On average you can expect to pay C$ 2,471 for a flight from Panama City to Madrid. The cheapest flight overall is C$ 964 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at C$ 1,082.

  • Can I find deals for flights from Panama City to Madrid that include hotel bookings?

    Yes. In addition to deals on Panama City to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Madrid?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Madrid.

  • Can I find deals for business class flights from Panama City to Madrid?

    Yes. Cheapflights offers flight deals from Panama City to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Madrid?

    Currently, February is the cheapest month in which you can book a flight from Panama City to Madrid (average of C$ 1,048). Flying from Panama City to Madrid in December is currently the most expensive (average of C$ 1,372). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Need flexible booking options for your flight to Madrid from Panama City? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

Can Cheapflights notify me if prices for flights from Panama City to Madrid become cheaper?

Yes, Cheapflights offers price alerts on Panama City to Madrid flights so you can book your travel at the perfect time. Price Alerts can be enabled by clicking the bell icon next to the flight deals above and providing your email address where you want to receive the alerts.

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