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Cheap flights from Panama City to Mexico City from C$ 280

PTY — MEX
10 Oct — 17 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama City to Mexico City

Enter your travel dates to find the best prices.

Cheapest flights from Panama City to Mexico City

Fri 25/129:19 a.m. -
Nonstop3h 51m
Fri 1/19:10 a.m. -
Nonstop3h 44m
Deal found 10/9C$ 517
Fri 9/109:28 p.m. -
Nonstop3h 47m
Fri 16/105:50 a.m. -
Nonstop3h 51m
Deal found 10/9C$ 532
Sun 25/109:28 p.m. -
Nonstop3h 47m
Sun 1/115:55 a.m. -
Nonstop3h 52m
Deal found 10/9C$ 547
Sun 25/109:28 p.m. -
Nonstop3h 47m
Fri 6/115:55 a.m. -
Nonstop3h 52m
Deal found 10/9C$ 563
Fri 25/910:12 p.m. -
Nonstop3h 48m
Thu 1/102:10 a.m. -
Nonstop3h 41m
Deal found 10/9C$ 586
Tue 29/1211:44 a.m. -
Nonstop3h 46m
Sat 2/15:55 a.m. -
Nonstop3h 43m
Deal found 7/9C$ 600
Sun 18/109:29 a.m. -
Nonstop3h 41m
Sun 25/103:30 p.m. -
Nonstop3h 44m
Deal found 10/9C$ 619
Sun 1/117:18 p.m. -
Nonstop4h 07m
Wed 11/119:10 a.m. -
Nonstop3h 53m
Deal found 10/9C$ 640
Sat 26/99:27 p.m. -
Nonstop3h 48m
Sat 3/105:50 a.m. -
Nonstop3h 51m
Deal found 10/9C$ 654
Sun 1/117:18 p.m. -
Nonstop4h 07m
Sat 7/111:20 a.m. -
Nonstop3h 44m
Deal found 10/9C$ 655

Find flight deals from Panama City to Mexico City

Round-trip from

C$ 517

One-way from

C$ 280

Popular in

October

Cheapest in

December

Average price

C$ 569
Copa Airlines
  • Copa Airlines
  • 25/12-1/1
  • Nonstop
  • 7h 35m total
  • Panama City to Mexico City
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Copa Airlines
  • Copa Airlines
  • 24/12-31/12
  • Nonstop
  • 3h 59m total
  • Panama City to Mexico City
Search Deals
Highest demand for flights based on searches. 5% potential increase in price (C$ 45 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease (C$ 15 potential savings vs. average RT price).
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Average for round-trip flights in September 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Panama City to Mexico City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Sun 4/10

10:13 p.m.-1:00 a.m.

Nonstop3h 47m

Mexico City Benito Juarez

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 382

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Sat 26/9

4:12 p.m.-7:05 p.m.

Nonstop3h 53m

Mexico City Benito Juarez

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 382
Quickest round-trip

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Sat 10/10

11:53 a.m.-2:30 p.m.

Nonstop3h 37m

Mexico City Benito Juarez

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 382

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Mon 16/11

9:31 p.m.-12:15 a.m.

Nonstop3h 44m

Mexico City Benito Juarez

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 382

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Wed 7/10

4:12 p.m.-7:05 p.m.

Nonstop3h 53m

Mexico City Benito Juarez

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 382

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Tue 26/1

9:27 p.m.-12:15 a.m.

Nonstop3h 48m

Mexico City Benito Juarez

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 382

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Sun 1/11

9:31 p.m.-12:15 a.m.

Nonstop3h 44m

Mexico City Benito Juarez

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 382

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Fri 23/10

4:12 p.m.-7:05 p.m.

Nonstop3h 53m

Mexico City Benito Juarez

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 382

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Wed 23/9

9:27 p.m.-12:15 a.m.

Nonstop3h 48m

Mexico City Benito Juarez

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 382

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Fri 25/12

9:19 a.m.-12:10 p.m.

Nonstop3h 51m

Mexico City Benito Juarez

Fri 1/1

9:10 a.m.-1:54 p.m.

Nonstop3h 44m

C$ 517

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/9

Showing 1-10 of 20 resultsSorted by cheapest first
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Best time to book a flight from Panama City to Mexico City

Have a flexible travel schedule? Discover the best time to fly to Mexico City from Panama City with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Panama City to Mexico City

How far ahead should I book a flight from Panama City to Mexico City?

To ensure you get the cheapest price possible for a flight from Panama City to Mexico City, you should look to book at least 3 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Panama City to Mexico City?

Currently, December is the cheapest month in which you can book a flight from Panama City to Mexico City (average of C$ 472). Flying from Panama City to Mexico City in October is currently the most expensive (average of C$ 670). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MEX?

When flying from Panama City to Mexico City, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 68% versus a flight in the afternoon.

How much does it cost to fly round-trip from Panama City to Mexico City?

Airfare is typical for this route at the moment.

Panama City to Mexico City flights typically cost between C$ 506 and C$ 666 in December.
The cheapest round-trip price found within the last 5 days was C$ 517 on Copa Airlines (25 Dec-1 Jan).

Related info for your journey

  • How popular is this Panama City to Mexico City flight route?

    Flights from Panama City Tocumen Intl to Mexico City Benito Juarez have been viewed 1 times in the past calendar month.

  • How long is the flight from Panama City to Mexico City?

    Copa Airlines can get you from Panama City to Mexico City in just under 3h 51m. Your travel time will be generally consistent. There are 2409 km between Panama City and Mexico City. Generally, flights for this route are direct.

  • What are the most reliable airlines from Panama City to Mexico City?

    The top 3 most reliable airlines when flying from Panama City to Mexico City are AeroMexico Connect (88%), Copa Airlines (87%) and Aeromexico (87%).

  • Can I find deals for flights from Panama City to Mexico City that include hotel bookings?

    Yes. In addition to deals on Panama City to Mexico City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Mexico City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Mexico City.

  • Can I find deals for business class flights from Panama City to Mexico City?

    Yes. Cheapflights offers flight deals from Panama City to Mexico City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Mexico City?

    Currently, December is the cheapest month in which you can book a flight from Panama City to Mexico City (average of C$ 472). Flying from Panama City to Mexico City in October is currently the most expensive (average of C$ 670). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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