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Cheap flights from Buffalo to Santo Domingo from C$ 271

BUF — SDQ
26 Nov — 3 Dec1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Buffalo to Santo Domingo

Enter your travel dates to find the best prices.

Cheapest flights from Buffalo to Santo Domingo

Mon 26/102:09 p.m. -
1 stop11h 44m
Sun 1/114:15 a.m. -
1 stop10h 04m
Deal found 23/10C$ 590
Tue 3/116:00 a.m. -
1 stop12h 06m
Thu 19/113:57 p.m. -
2 stops17h 23m
Deal found 22/10C$ 597
Tue 3/117:00 a.m. -
1 stop11h 06m
Wed 18/117:02 a.m. -
1 stop8h 33m
Deal found 22/10C$ 598
Mon 2/117:49 p.m. -
1 stop16h 48m
Thu 19/112:55 p.m. -
1 stop8h 58m
Deal found 22/10C$ 611
Mon 2/117:49 p.m. -
1 stop16h 48m
Wed 18/117:02 a.m. -
1 stop8h 33m
Deal found 22/10C$ 620
Tue 3/117:00 a.m. -
1 stop11h 06m
Fri 20/118:55 p.m. -
1 stop14h 40m
Deal found 22/10C$ 638
Mon 2/115:58 p.m. -
2 stops18h 43m
Tue 17/114:18 p.m. -
2 stops18h 36m
Deal found 26/10C$ 641
Tue 27/106:00 a.m. -
1 stop6h 41m
Fri 30/101:53 p.m. -
2 stops19h 28m
Deal found 23/10C$ 643

Find flight deals from Buffalo to Santo Domingo

Round-trip from

C$ 500

One-way from

C$ 271

Popular in

April

Cheapest in

October

Average price

C$ 555
JetBlue
  • JetBlue
  • 20/1-4/2
  • 2 total stops
  • 18h 10m total
  • Buffalo to Santo Domingo
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JetBlue
  • JetBlue
  • 6/1-31/12
  • 1 total stop
  • 12h 54m total
  • Buffalo to Santo Domingo
Search Deals
Highest demand for flights based on searches. 4% potential increase in price (C$ 57 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease (C$ 80 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Buffalo to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloSanto Domingo

BUF Buffalo - SDQ Santo Domingo Las Americas

BUFSDQ

Buffalo

Wed 6/1

7:54 p.m.-9:48 a.m.

1 stop12h 54m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-11:30 p.m.

Nonstop0h 00m

C$ 271

BuffaloSanto Domingo

BUF Buffalo - SDQ Santo Domingo Las Americas

BUFSDQ

Buffalo

Tue 10/11

10:51 a.m.-11:46 p.m.

1 stop11h 55m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-11:30 p.m.

Nonstop0h 00m

C$ 293

BuffaloSanto Domingo

BUF Buffalo - SDQ Santo Domingo Las Americas

BUFSDQ

Buffalo

Tue 10/11

11:25 a.m.-2:14 a.m.

1 stop13h 49m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-11:30 p.m.

Nonstop0h 00m

C$ 293

BuffaloSanto Domingo

BUF Buffalo - SDQ Santo Domingo Las Americas

BUFSDQ

Buffalo

Wed 30/12

7:52 p.m.-10:45 p.m.

2 stops49h 53m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-11:30 p.m.

Nonstop0h 00m

C$ 404
Quickest round-trip

BuffaloSanto Domingo

BUF Buffalo - SDQ Santo Domingo Las Americas

BUFSDQ

Buffalo

Tue 1/12

7:00 a.m.-4:20 p.m.

1 stop8h 20m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-11:30 p.m.

Nonstop0h 00m

C$ 447

BuffaloSanto Domingo

BUF Buffalo - SDQ Santo Domingo Las Americas

BUFSDQ

Buffalo

Tue 5/1

5:43 p.m.-1:41 p.m.

3 stops42h 58m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-11:30 p.m.

Nonstop0h 00m

C$ 474

BuffaloSanto Domingo

BUF Buffalo - SDQ Santo Domingo Las Americas

BUFSDQ

Buffalo

Wed 20/1

7:30 a.m.-5:02 p.m.

1 stop8h 32m

Santo Domingo Las Americas

Thu 4/2

3:00 p.m.-11:38 p.m.

1 stop9h 38m

C$ 500

BuffaloSanto Domingo

BUF Buffalo - SDQ Santo Domingo Las Americas

BUFSDQ

Buffalo

Tue 15/12

2:10 p.m.-3:56 a.m.

1 stop12h 46m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-11:30 p.m.

Nonstop0h 00m

C$ 559

BuffaloSanto Domingo

BUF Buffalo - SDQ Santo Domingo Las Americas

BUFSDQ

Buffalo

Sun 17/1

7:03 a.m.-11:46 p.m.

1 stop15h 43m

Santo Domingo Las Americas

Fri 12/2

2:53 p.m.-10:02 p.m.

1 stop8h 09m

C$ 570

BuffaloSanto Domingo

BUF Buffalo - SDQ Santo Domingo Las Americas

BUFSDQ

Buffalo

Fri 5/3

2:44 p.m.-1:41 p.m.

3 stops45h 57m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-11:30 p.m.

Nonstop0h 00m

C$ 635

Flights are sorted by cheapest round-trip flights first.

Deals found on 26/10

Showing 1-10 of 19 resultsSorted by cheapest first
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Best time to book a flight from Buffalo to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Buffalo with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Santo Domingo

How much does it cost to fly round-trip from Buffalo to Santo Domingo?

Airfare is below average for this route at the moment.

Buffalo to Santo Domingo flights typically cost between C$ 559 and C$ 627 in January.
The cheapest round-trip price found within the last 5 days was C$ 500 on JetBlue (20 Jan-4 Feb).

Related info for your journey

  • How long is the flight from Buffalo to Santo Domingo?

    Airlines like JetBlue, United Airlines, and Delta fly from Buffalo to Santo Domingo in about 8h 32m. The time it takes to get you to your destination can typically vary by up to 8h 42m. The distance from Buffalo to Santo Domingo is about 2853 km. When browsing for deals, the options you’ll see will be for both direct flights and flights with stops.

  • Can I find deals for flights from Buffalo to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Buffalo to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Santo Domingo.

  • Can I find deals for business class flights from Buffalo to Santo Domingo?

    Yes. Cheapflights offers flight deals from Buffalo to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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