Find flights
Deals
When to book
FAQs

Cheap flights from Santo Domingo to Panama City from C$ 374

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/2. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — PTY
26 Feb — 5 Mar1
1 adult
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Santo Domingo Las Americas to Panama City Tocumen Intl are usually found in May or June, booked 41 days in advance, depart on a Wednesday or Friday and return on a Monday

Cheap flight deals from Santo Domingo to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Santo Domingo to Panama City
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 27 January 2026.

Mon 23/25:45 p.m.
SDQ
-
PTY
1 stop16h 05m
Avianca
Sun 1/32:55 a.m.
PTY
-
SDQ
1 stop12h 55m
Avianca
Deal found 26/1C$ 623
Mon 23/212:41 p.m.
SDQ
-
PTY
2 stops12h 59m
Multiple Airlines
Mon 2/39:45 a.m.
PTY
-
SDQ
1 stop6h 05m
Multiple Airlines
Deal found 26/1C$ 693
Wed 4/35:45 p.m.
SDQ
-
PTY
1 stop7h 55m
Avianca
Fri 13/35:50 p.m.
PTY
-
SDQ
1 stop16h 35m
Avianca
Deal found 26/1C$ 694
Mon 2/311:56 a.m.
SDQ
-
PTY
Nonstop2h 36m
Copa Airlines
Fri 6/37:10 p.m.
PTY
-
SDQ
Nonstop2h 30m
Copa Airlines
Deal found 27/1C$ 750
Sat 28/32:13 p.m.
SDQ
-
PTY
Nonstop2h 36m
Copa Airlines
Sun 5/412:44 p.m.
PTY
-
SDQ
Nonstop2h 30m
Copa Airlines
Deal found 27/1C$ 793
Tue 27/106:39 p.m.
SDQ
-
PTY
Nonstop2h 35m
Copa Airlines
Sat 31/1010:55 p.m.
PTY
-
SDQ
Nonstop2h 22m
Copa Airlines
Deal found 26/1C$ 842
Mon 2/35:45 p.m.
SDQ
-
PTY
1 stop7h 55m
Avianca
Mon 9/32:55 a.m.
PTY
-
SDQ
1 stop7h 30m
Avianca
Deal found 26/1C$ 843
Fri 6/28:50 a.m.
SDQ
-
PTY
Nonstop2h 40m
Copa Airlines
Sun 15/22:37 p.m.
PTY
-
SDQ
Nonstop2h 28m
Copa Airlines
Deal found 26/1C$ 935
Mon 2/28:50 a.m.
SDQ
-
PTY
Nonstop2h 40m
Copa Airlines
Mon 16/210:55 p.m.
PTY
-
SDQ
Nonstop2h 22m
Copa Airlines
Deal found 26/1C$ 1,024
Sun 1/28:50 a.m.
SDQ
-
PTY
Nonstop2h 40m
Copa Airlines
Thu 5/22:37 p.m.
PTY
-
SDQ
Nonstop2h 28m
Copa Airlines
Deal found 27/1C$ 1,047

Find flight deals from Santo Domingo to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 27 January 2026.

Round-trip from

C$ 623

One-way from

C$ 374

Popular in

January

Cheapest in

May

Average price

C$ 718

Good round-trip deal

C$ 497 or less

Good one-way deal

C$ 371 or less
Avianca
  • Avianca
  • 23/2-1/3
  • 2 total stops
  • 29h 00m total
  • Santo Domingo to Panama City
Search Deals
Avianca
  • Avianca
  • 2/2
  • 1 total stop
  • 24h 10m total
  • Santo Domingo to Panama City
Search Deals
Highest demand for flights based on searches. 3% potential increase in price (C$ 33 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease (C$ 6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a round-trip flight from Santo Domingo Las Americas to Panama City Tocumen Intl.
Search Deals
Price to beat on a one-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 27 January 2026.
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Fly from

Santo Domingo

Fly to

Panama City

Route

Depart

Return

Price

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 4/3

5:45 p.m.-8:50 a.m.

1 stop16h 05m

Panama City Tocumen Intl

Sun 15/3

2:55 a.m.-4:50 p.m.

1 stop12h 55m

C$ 694

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 4/3

5:45 p.m.-8:50 a.m.

1 stop16h 05m

Panama City Tocumen Intl

Wed 11/3

2:55 a.m.-4:50 p.m.

1 stop12h 55m

C$ 694

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 3/3

12:20 p.m.-4:55 p.m.

1 stop5h 35m

Panama City Tocumen Intl

Thu 12/3

2:55 a.m.-4:50 p.m.

1 stop12h 55m

C$ 694

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 4/3

5:45 p.m.-8:50 a.m.

1 stop16h 05m

Panama City Tocumen Intl

Tue 17/3

9:45 a.m.-4:50 p.m.

1 stop6h 05m

C$ 694

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 6/3

5:45 p.m.-8:50 a.m.

1 stop16h 05m

Panama City Tocumen Intl

Fri 13/3

2:55 a.m.-4:50 p.m.

1 stop12h 55m

C$ 694

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 10/3

12:20 p.m.-4:55 p.m.

1 stop5h 35m

Panama City Tocumen Intl

Fri 13/3

2:55 a.m.-11:25 a.m.

1 stop7h 30m

C$ 694

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 3/3

5:45 p.m.-8:50 a.m.

1 stop16h 05m

Panama City Tocumen Intl

Mon 9/3

2:55 a.m.-11:25 a.m.

1 stop7h 30m

C$ 694

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Mon 9/3

5:45 p.m.-8:50 a.m.

1 stop16h 05m

Panama City Tocumen Intl

Mon 16/3

5:50 p.m.-11:25 a.m.

1 stop16h 35m

C$ 694

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 10/3

12:20 p.m.-4:55 p.m.

1 stop5h 35m

Panama City Tocumen Intl

Wed 11/3

9:45 a.m.-4:50 p.m.

1 stop6h 05m

C$ 694

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 3/3

12:20 p.m.-1:00 a.m.

1 stop13h 40m

Panama City Tocumen Intl

Wed 11/3

2:55 a.m.-11:25 a.m.

1 stop7h 30m

C$ 694

Flights are sorted by cheapest round-trip flights first.

Deals found on 25/1

Showing 1-10 of 22 results
1
2
3

Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Panama City. Price data was last updated on 23 January 2026.

The best time to book flights from Santo Domingo to Panama City is 41 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Currently, April is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of C$ 219). Flying from Santo Domingo to Panama City in September is currently the most expensive (average of C$ 433). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to PTY?

Find hourly flight availability from Santo Domingo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 27 January 2026.

It’s typically best to fly out from Santo Domingo to Panama City in the evening. Doing so could potentially save you 77% on the flight price compared to flying in the morning, which is usually more expensive.

How much does it cost to fly round-trip from Santo Domingo to Panama City?

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Santo Domingo to Panama City flight route?

    Flights from Santo Domingo Las Americas to Panama City Tocumen Intl have been viewed 67 times in the past calendar month.

  • How long is the flight from Santo Domingo to Panama City?

    Airlines like Avianca fly from Santo Domingo to Panama City in about 16h 05m. The time it takes to get you to your destination can typically vary by up to . The distance from Santo Domingo to Panama City is about 1476 km.

  • What are the most reliable airlines from Santo Domingo to Panama City?

    No one likes to see their flight delayed. When booking a flight from Santo Domingo to Panama City consider choosing Webjet Linhas Aereas (92%), Turkish Airlines (92%) or Copa Airlines (90%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Santo Domingo to Panama City?

    The cheapest flight price from Santo Domingo to Panama City is C$ 219. On average you can expect to pay C$ 522. The most popular route, (Santo Domingo Las Americas - Panama City Tocumen Intl), can usually be booked for C$ 668.

  • Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.

  • Can I find deals for business class flights from Santo Domingo to Panama City?

    Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Panama City?

    Currently, April is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of C$ 219). Flying from Santo Domingo to Panama City in September is currently the most expensive (average of C$ 433). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travelers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Santo Domingo to Panama City?

Deals for Santo Domingo to Panama City flights are sourced from 900+ travel sites when you use Cheapflights. When all flight results come back, Cheapflights lets you sort and filter flights using different criteria to choose better, like price, airport, cabin class, and plenty of other options.

Why should you use Cheapflights to find cheap flight tickets from Santo Domingo to Panama City?

Cheapflights simply makes it quick and affordable to book flights from Santo Domingo to Panama City by bringing together all flight options from hundreds of airlines and agencies online — and put it in one place for you to choose from. Plus, Cheapflights is 100% free to use for all.

Can Cheapflights find flights from Santo Domingo to Panama City with no change fees?

Certainly. Search results for flights to Panama City from Santo Domingo shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Santo Domingo to Panama City become cheaper?

Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Panama City from Santo Domingo today and book when prices fit your budget.

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.