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Cheap flights from Santo Domingo to Panama City from C$ 317

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 30/9. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — PTY
11 Oct — 18 Oct1
1 adult
1 adult, Economy

Cheap flight deals from Santo Domingo to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 11 September 2025.

Round-trip from

C$ 693

One-way from

C$ 317

Popular in

March

Cheapest in

October

Average price

C$ 664

Good one-way deal

C$ 566 or less
Avianca
  • Avianca
  • 30/12-14/1
  • 2 total stops
  • 23h 35m total
  • Santo Domingo to Panama City
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Avianca
  • Avianca
  • 30/9
  • 1 total stop
  • 17h 00m total
  • Santo Domingo to Panama City
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Highest demand for flights based on searches. 4% potential increase in price (C$ 41 potential increase over avg. RT price).
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Cheapest flight prices on average. 0% potential price decrease (C$ 6 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a one-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl.
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Find flight deals from Santo Domingo to Panama City

Cheapest flights from Santo Domingo to Panama City
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 11 September 2025.

Tue 30/125:45 p.m.SDQ - PTY
1 stop16h 05mAvianca
Wed 14/12:55 a.m.PTY - SDQ
1 stop7h 30mAvianca
Deal found 11/9C$ 693
Thu 25/92:09 p.m.SDQ - PTY
Nonstop2h 33mCopa Airlines
Sun 28/96:55 p.m.PTY - SDQ
Nonstop2h 31mCopa Airlines
Deal found 10/9C$ 723
Wed 1/108:58 a.m.SDQ - PTY
Nonstop2h 32mCopa Airlines
Tue 13/112:44 p.m.PTY - SDQ
Nonstop2h 28mCopa Airlines
Deal found 10/9C$ 725
Sat 1/1111:55 a.m.SDQ - PTY
Nonstop2h 37mCopa Airlines
Thu 6/1112:44 p.m.PTY - SDQ
Nonstop2h 31mCopa Airlines
Deal found 11/9C$ 728
Mon 22/126:39 p.m.SDQ - PTY
Nonstop2h 35mCopa Airlines
Sun 4/18:10 a.m.PTY - SDQ
Nonstop2h 22mCopa Airlines
Deal found 11/9C$ 743
Mon 29/125:45 p.m.SDQ - PTY
1 stop7h 55mAvianca
Wed 14/12:55 a.m.PTY - SDQ
1 stop12h 55mAvianca
Deal found 11/9C$ 787
Sun 21/95:25 a.m.SDQ - PTY
Nonstop2h 33mCopa Airlines
Fri 3/107:26 a.m.PTY - SDQ
Nonstop2h 30mCopa Airlines
Deal found 11/9C$ 910
Sun 21/95:25 a.m.SDQ - PTY
Nonstop2h 33mCopa Airlines
Sun 21/128:10 a.m.PTY - SDQ
Nonstop2h 30mCopa Airlines
Deal found 11/9C$ 912
Mon 15/96:17 p.m.SDQ - PTY
Nonstop2h 33mCopa Airlines
Fri 19/97:26 a.m.PTY - SDQ
Nonstop2h 32mCopa Airlines
Deal found 11/9C$ 1,024
Fri 12/98:59 a.m.SDQ - PTY
Nonstop2h 31mCopa Airlines
Fri 19/912:44 p.m.PTY - SDQ
Nonstop2h 33mCopa Airlines
Deal found 11/9C$ 1,089
Tue 2/122:53 p.m.SDQ - PTY
2 stops16h 20mUnited Airlines
Tue 16/1210:29 p.m.PTY - SDQ
2 stops15h 37mUnited Airlines
Deal found 10/9C$ 3,409
Sun 5/103:20 p.m.SDQ - PTY
2 stops15h 53mUnited Airlines
Sat 11/109:13 a.m.PTY - SDQ
2 stops15h 37mUnited Airlines
Deal found 11/9C$ 3,485

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 11 September 2025.
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Fly from

Santo Domingo

Fly to

Panama City

Route

Depart

Return

Price

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 30/12

5:45 p.m.-1:00 a.m.

1 stop8h 15m

Panama City Tocumen Intl

Thu 15/1

9:45 a.m.-4:50 p.m.

1 stop6h 05m

C$ 693

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 30/12

5:45 p.m.-1:00 a.m.

1 stop8h 15m

Panama City Tocumen Intl

Tue 13/1

2:55 a.m.-4:50 p.m.

1 stop12h 55m

C$ 693

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sun 5/10

5:25 a.m.-6:58 a.m.

Nonstop2h 33m

Panama City Tocumen Intl

Sat 11/10

11:13 p.m.-2:43 a.m.

Nonstop2h 30m

C$ 723

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 25/9

8:59 a.m.-10:30 a.m.

Nonstop2h 31m

Panama City Tocumen Intl

Tue 30/9

6:55 p.m.-10:26 p.m.

Nonstop2h 31m

C$ 723

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 17/10

11:57 a.m.-1:29 p.m.

Nonstop2h 32m

Panama City Tocumen Intl

Sun 19/10

12:44 p.m.-4:15 p.m.

Nonstop2h 31m

C$ 723

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sun 5/10

11:57 a.m.-1:29 p.m.

Nonstop2h 32m

Panama City Tocumen Intl

Thu 16/10

7:26 a.m.-10:56 a.m.

Nonstop2h 30m

C$ 723

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sun 28/9

5:25 a.m.-6:58 a.m.

Nonstop2h 33m

Panama City Tocumen Intl

Sat 18/10

11:13 p.m.-2:43 a.m.

Nonstop2h 30m

C$ 723

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sat 4/10

2:10 p.m.-3:42 p.m.

Nonstop2h 32m

Panama City Tocumen Intl

Sat 18/10

6:55 p.m.-10:25 p.m.

Nonstop2h 30m

C$ 723

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 2/10

2:10 p.m.-3:42 p.m.

Nonstop2h 32m

Panama City Tocumen Intl

Mon 6/10

11:13 p.m.-2:43 a.m.

Nonstop2h 30m

C$ 723

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Mon 3/11

5:45 p.m.-8:50 a.m.

1 stop16h 05m

C$ 319

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Showing 1-10 of 19 results
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Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Panama City. Price data was last updated on 29 August 2025.

The best time to book flights from Santo Domingo to Panama City is 41 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of C$ 542). Flying from Santo Domingo to Panama City in December is currently the most expensive (average of C$ 874). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to PTY?

Find hourly flight availability from Santo Domingo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 11 September 2025.

It’s typically best to fly out from Santo Domingo to Panama City at noon. Doing so could potentially save you 41% on the flight price compared to flying in the morning, which is usually more expensive.

How much does it cost to fly round-trip from Santo Domingo to Panama City?

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Santo Domingo to Panama City flight route?

    Flights from Santo Domingo Las Americas to Panama City Tocumen Intl have been viewed 22 times in the past calendar month.

  • How long is the flight from Santo Domingo to Panama City?

    Airlines like Avianca and Copa Airlines fly from Santo Domingo to Panama City in about 2h 33m. The time it takes to get you to your destination can typically vary by up to 5h 42m. The distance from Santo Domingo to Panama City is about 1476 km. This flight may include one or multiple stops.

  • What are the most reliable airlines from Santo Domingo to Panama City?

    No one likes to see their flight delayed. When booking a flight from Santo Domingo to Panama City consider choosing KLM (96%), Air France (96%) or Copa Airlines (95%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Santo Domingo to Panama City?

    The cheapest flight price from Santo Domingo to Panama City is C$ 240. On average you can expect to pay C$ 596. The most popular route, (Santo Domingo Las Americas - Panama City Tocumen Intl), can usually be booked for C$ 723.

  • Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.

  • Can I find deals for business class flights from Santo Domingo to Panama City?

    Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Panama City?

    Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of C$ 542). Flying from Santo Domingo to Panama City in December is currently the most expensive (average of C$ 874). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Why should you use Cheapflights to find cheap flight tickets from Santo Domingo to Panama City?

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Can Cheapflights find flights from Santo Domingo to Panama City with no change fees?

Certainly. Search results for flights to Panama City from Santo Domingo shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Santo Domingo to Panama City become cheaper?

Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Panama City from Santo Domingo today and book when prices fit your budget.

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