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Cheap flights from Santo Domingo to Panama City from C$ 329

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 21/3. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — PTY
11 Apr — 18 Apr1
1 adult
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Santo Domingo Las Americas to Panama City Tocumen Intl are usually found in May or August, booked 41 days in advance, depart on a Friday or Wednesday and return on a Monday

Cheap flight deals from Santo Domingo to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Santo Domingo to Panama City
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 12 March 2026.

Tue 24/312:20 p.m.
SDQ
-
PTY
1 stop5h 35m
Multiple Airlines
Tue 24/32:55 a.m.
PTY
-
SDQ
2 stops12h 25m
Multiple Airlines
Deal found 11/3C$ 748
Fri 13/33:55 a.m.
SDQ
-
PTY
1 stop7h 34m
Multiple Airlines
Sun 15/310:40 p.m.
PTY
-
SDQ
1 stop24h 54m
Multiple Airlines
Deal found 11/3C$ 751
Sat 21/312:20 p.m.
SDQ
-
PTY
1 stop5h 35m
Avianca
Sat 21/32:55 a.m.
PTY
-
SDQ
1 stop12h 55m
Avianca
Deal found 11/3C$ 763
Wed 1/412:38 p.m.
SDQ
-
PTY
Nonstop2h 37m
Copa Airlines
Sat 4/47:24 a.m.
PTY
-
SDQ
Nonstop2h 30m
Copa Airlines
Deal found 9/3C$ 777
Tue 7/46:50 p.m.
SDQ
-
PTY
1 stop15h 25m
Avianca
Wed 8/45:55 p.m.
PTY
-
SDQ
1 stop16h 55m
Avianca
Deal found 11/3C$ 789
Sat 28/311:56 a.m.
SDQ
-
PTY
Nonstop2h 36m
Copa Airlines
Sun 5/49:42 a.m.
PTY
-
SDQ
Nonstop2h 30m
Copa Airlines
Deal found 9/3C$ 793
Fri 27/32:13 p.m.
SDQ
-
PTY
Nonstop2h 36m
Copa Airlines
Sun 29/312:44 p.m.
PTY
-
SDQ
Nonstop2h 30m
Copa Airlines
Deal found 7/3C$ 808
Tue 17/312:20 p.m.
SDQ
-
PTY
1 stop5h 35m
Avianca
Tue 17/32:55 a.m.
PTY
-
SDQ
1 stop12h 55m
Avianca
Deal found 11/3C$ 816
Tue 10/35:45 p.m.
SDQ
-
PTY
1 stop8h 15m
Avianca
Sat 14/39:45 a.m.
PTY
-
SDQ
1 stop6h 05m
Avianca
Deal found 9/3C$ 819
Thu 9/46:02 a.m.
SDQ
-
PTY
Nonstop2h 37m
Copa Airlines
Thu 16/48:11 a.m.
PTY
-
SDQ
Nonstop2h 30m
Copa Airlines
Deal found 10/3C$ 824
Tue 7/46:50 p.m.
SDQ
-
PTY
1 stop23h 10m
Avianca
Sun 19/410:10 a.m.
PTY
-
SDQ
1 stop6h 45m
Avianca
Deal found 12/3C$ 838

Find flight deals from Santo Domingo to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 12 March 2026.

Round-trip from

C$ 748

One-way from

C$ 329

Popular in

March

Cheapest in

May

Average price

C$ 744
24/3-24/3
  • 24/3-24/3
  • 3 total stops
  • 18h 00m total
  • Santo Domingo to Panama City
Search Deals
Avianca
  • Avianca
  • 21/3
  • 1 total stop
  • 13h 40m total
  • Santo Domingo to Panama City
Search Deals
Highest demand for flights based on searches. 2% potential increase in price (C$ 20 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease (C$ 9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 12 March 2026.
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 9/6

12:40 p.m.-2:15 p.m.

Nonstop2h 35m

Panama City Tocumen Intl

Tue 16/6

12:44 p.m.-4:15 p.m.

Nonstop2h 31m

C$ 777

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sat 25/7

6:42 p.m.-8:14 p.m.

Nonstop2h 32m

Panama City Tocumen Intl

Thu 30/7

8:11 a.m.-11:42 a.m.

Nonstop2h 31m

C$ 777

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sun 12/4

12:38 p.m.-2:15 p.m.

Nonstop2h 37m

Panama City Tocumen Intl

Mon 11/5

8:11 a.m.-11:42 a.m.

Nonstop2h 31m

C$ 777

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 11/8

6:42 p.m.-8:14 p.m.

Nonstop2h 32m

Panama City Tocumen Intl

Fri 11/9

8:11 a.m.-11:42 a.m.

Nonstop2h 31m

C$ 777

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 9/7

12:43 p.m.-2:15 p.m.

Nonstop2h 32m

Panama City Tocumen Intl

Mon 13/7

12:44 p.m.-4:15 p.m.

Nonstop2h 31m

C$ 777
Quickest round-trip

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 14/4

12:38 p.m.-2:15 p.m.

Nonstop2h 37m

Panama City Tocumen Intl

Fri 24/4

7:26 p.m.-10:47 p.m.

Nonstop2h 21m

C$ 777

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Mon 11/5

12:10 p.m.-1:45 p.m.

Nonstop2h 35m

Panama City Tocumen Intl

Sun 17/5

7:26 p.m.-10:56 p.m.

Nonstop2h 30m

C$ 777

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 15/4

12:38 p.m.-2:15 p.m.

Nonstop2h 37m

Panama City Tocumen Intl

Tue 21/4

9:42 a.m.-1:12 p.m.

Nonstop2h 30m

C$ 777

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Mon 1/6

6:39 p.m.-8:14 p.m.

Nonstop2h 35m

Panama City Tocumen Intl

Wed 1/7

9:42 a.m.-1:13 p.m.

Nonstop2h 31m

C$ 777

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 5/6

2:14 p.m.-3:49 p.m.

Nonstop2h 35m

Panama City Tocumen Intl

Wed 10/6

9:42 a.m.-1:13 p.m.

Nonstop2h 31m

C$ 777

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/3

Showing 1-10 of 24 resultsSorted by cheapest first
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Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Panama City. Price data was last updated on 6 March 2026.

The best time to book flights from Santo Domingo to Panama City is 41 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Currently, April is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of C$ 217). Flying from Santo Domingo to Panama City in March is currently the most expensive (average of C$ 489). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to PTY?

Find hourly flight availability from Santo Domingo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 12 March 2026.

It’s typically best to fly out from Santo Domingo to Panama City in the evening. Doing so could potentially save you 77% on the flight price compared to flying in the morning, which is usually more expensive.

How much does it cost to fly round-trip from Santo Domingo to Panama City?

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Santo Domingo to Panama City flight route?

    Flights from Santo Domingo Las Americas to Panama City Tocumen Intl have been viewed 65 times in the past calendar month.

  • How long is the flight from Santo Domingo to Panama City?

    Airlines like Copa Airlines fly from Santo Domingo to Panama City in about 2h 35m. The time it takes to get you to your destination is usually consistent. The distance from Santo Domingo to Panama City is about 1476 km. All flights are typically direct.

  • What are the most reliable airlines from Santo Domingo to Panama City?

    No one likes to see their flight delayed. When booking a flight from Santo Domingo to Panama City consider choosing Turkish Airlines (95%), Copa Airlines (92%) or KLM (91%) as they are the most reliable in getting you off to your destination on time.

  • Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.

  • Can I find deals for business class flights from Santo Domingo to Panama City?

    Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Panama City?

    Currently, April is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of C$ 217). Flying from Santo Domingo to Panama City in March is currently the most expensive (average of C$ 489). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Why should you use Cheapflights to find cheap flight tickets from Santo Domingo to Panama City?

Cheapflights simply makes it quick and affordable to book flights from Santo Domingo to Panama City by bringing together all flight options from hundreds of airlines and agencies online — and put it in one place for you to choose from. Plus, Cheapflights is 100% free to use for all.

Can Cheapflights find flights from Santo Domingo to Panama City with no change fees?

Certainly. Search results for flights to Panama City from Santo Domingo shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Santo Domingo to Panama City become cheaper?

Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Panama City from Santo Domingo today and book when prices fit your budget.

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