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Cheap flights from Santo Domingo to Panama City from C$ 734

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 28/11. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — PTY
28 Nov — 5 Dec1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Santo Domingo to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 29 October 2025.

Round-trip from

C$ 734

Popular in

September

Cheapest in

May

Average price

C$ 728

Good round-trip deal

C$ 729 or less
Copa Airlines
  • Copa Airlines
  • 22/11-1/12
  • Nonstop
  • 5h 07m total
  • Santo Domingo to Panama City
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Highest demand for flights based on searches. 3% potential increase in price (C$ 37 potential increase over avg. RT price).
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Cheapest flight prices on average. 0% potential price decrease (C$ 8 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Price to beat on a round-trip flight from Santo Domingo Las Americas to Panama City Tocumen Intl.
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Find flight deals from Santo Domingo to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Santo Domingo to Panama City
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 29 October 2025.

Fri 28/1111:55 a.m.SDQ - PTY
Nonstop2h 37mCopa Airlines
Mon 8/1212:44 p.m.PTY - SDQ
Nonstop2h 31mCopa Airlines
Deal found 28/10C$ 734
Thu 20/1111:55 a.m.SDQ - PTY
Nonstop2h 37mCopa Airlines
Sun 23/119:42 a.m.PTY - SDQ
Nonstop2h 30mCopa Airlines
Deal found 28/10C$ 749
Mon 17/1111:55 a.m.SDQ - PTY
Nonstop2h 37mCopa Airlines
Fri 21/116:55 p.m.PTY - SDQ
Nonstop2h 30mCopa Airlines
Deal found 27/10C$ 759
Thu 6/1111:55 a.m.SDQ - PTY
Nonstop2h 37mCopa Airlines
Mon 10/1110:55 p.m.PTY - SDQ
Nonstop2h 31mCopa Airlines
Deal found 29/10C$ 921
Fri 14/1111:55 a.m.SDQ - PTY
Nonstop2h 37mCopa Airlines
Thu 20/119:42 a.m.PTY - SDQ
Nonstop2h 30mCopa Airlines
Deal found 28/10C$ 942
Mon 3/1111:55 a.m.SDQ - PTY
Nonstop2h 37mCopa Airlines
Fri 7/117:28 a.m.PTY - SDQ
Nonstop2h 30mCopa Airlines
Deal found 27/10C$ 946
Fri 31/1012:00 p.m.SDQ - PTY
Nonstop2h 32mCopa Airlines
Thu 13/1112:44 p.m.PTY - SDQ
Nonstop2h 31mCopa Airlines
Deal found 28/10C$ 1,034
Sat 1/112:15 p.m.SDQ - PTY
Nonstop2h 35mCopa Airlines
Thu 6/1112:44 p.m.PTY - SDQ
Nonstop2h 31mCopa Airlines
Deal found 28/10C$ 1,037
Tue 28/102:15 p.m.SDQ - PTY
Nonstop2h 32mCopa Airlines
Tue 4/116:55 p.m.PTY - SDQ
Nonstop2h 30mCopa Airlines
Deal found 27/10C$ 1,101
Sun 30/116:00 a.m.SDQ - PTY
Nonstop2h 37mCopa Airlines
Sun 30/1112:44 p.m.PTY - SDQ
Nonstop2h 31mCopa Airlines
Deal found 29/10C$ 1,102
Thu 30/102:15 p.m.SDQ - PTY
Nonstop2h 32mCopa Airlines
Sat 1/116:55 p.m.PTY - SDQ
Nonstop2h 30mCopa Airlines
Deal found 29/10C$ 1,650

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 29 October 2025.
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Fly from

Santo Domingo

Fly to

Panama City

Route

Depart

Return

Price

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sat 22/11

11:55 a.m.-1:32 p.m.

Nonstop2h 37m

Panama City Tocumen Intl

Mon 1/12

7:26 p.m.-10:56 p.m.

Nonstop2h 30m

C$ 734

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 19/11

8:55 a.m.-10:30 a.m.

Nonstop2h 35m

Panama City Tocumen Intl

Sat 29/11

12:44 p.m.-4:15 p.m.

Nonstop2h 31m

C$ 734

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 4/2

2:11 p.m.-3:47 p.m.

Nonstop2h 36m

Panama City Tocumen Intl

Sun 15/3

12:44 p.m.-4:14 p.m.

Nonstop2h 30m

C$ 734

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sat 6/12

8:55 a.m.-10:30 a.m.

Nonstop2h 35m

Panama City Tocumen Intl

Sat 3/1

2:37 p.m.-6:05 p.m.

Nonstop2h 28m

C$ 734

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 27/2

8:50 a.m.-10:30 a.m.

Nonstop2h 40m

Panama City Tocumen Intl

Tue 3/3

7:10 p.m.-10:40 p.m.

Nonstop2h 30m

C$ 734

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sun 1/2

2:11 p.m.-3:47 p.m.

Nonstop2h 36m

Panama City Tocumen Intl

Mon 16/2

7:28 a.m.-10:50 a.m.

Nonstop2h 22m

C$ 734

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 26/12

12:40 p.m.-2:17 p.m.

Nonstop2h 37m

Panama City Tocumen Intl

Sat 3/1

7:26 p.m.-10:55 p.m.

Nonstop2h 29m

C$ 734

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 26/11

11:55 a.m.-1:32 p.m.

Nonstop2h 37m

Panama City Tocumen Intl

Fri 12/12

8:10 a.m.-11:40 a.m.

Nonstop2h 30m

C$ 734

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 19/2

6:39 p.m.-8:14 p.m.

Nonstop2h 35m

Panama City Tocumen Intl

Tue 24/2

7:10 p.m.-10:39 p.m.

Nonstop2h 29m

C$ 734

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 28/11

11:55 a.m.-1:32 p.m.

Nonstop2h 37m

Panama City Tocumen Intl

Wed 10/12

7:26 p.m.-10:56 p.m.

Nonstop2h 30m

C$ 734

Flights are sorted by cheapest round-trip flights first.

Deals found on 27/10

Showing 1-10 of 18 results
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Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Panama City. Price data was last updated on 24 October 2025.

The best time to book flights from Santo Domingo to Panama City is 41 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Currently, April is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of C$ 225). Flying from Santo Domingo to Panama City in February is currently the most expensive (average of C$ 581). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to PTY?

Find hourly flight availability from Santo Domingo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 29 October 2025.

When flying from Santo Domingo to Panama City, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Santo Domingo to Panama City flight route?

    Flights from Santo Domingo Las Americas to Panama City Tocumen Intl have been viewed 22 times in the past calendar month.

  • How long is the flight from Santo Domingo to Panama City?

    Airlines like Copa Airlines fly from Santo Domingo to Panama City in about 2h 37m. The time it takes to get you to your destination is usually consistent. The distance from Santo Domingo to Panama City is about 1476 km. All flights are typically direct.

  • What are the most reliable airlines from Santo Domingo to Panama City?

    No one likes to see their flight delayed. When booking a flight from Santo Domingo to Panama City consider choosing KLM (93%), Air France (92%) or Copa Airlines (92%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Santo Domingo to Panama City?

    The cheapest flight price from Santo Domingo to Panama City is C$ 222. On average you can expect to pay C$ 1,340. The most popular route, (Santo Domingo Las Americas - Panama City Tocumen Intl), can usually be booked for C$ 725.

  • Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.

  • Can I find deals for business class flights from Santo Domingo to Panama City?

    Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Panama City?

    Currently, April is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of C$ 225). Flying from Santo Domingo to Panama City in February is currently the most expensive (average of C$ 581). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Why should you use Cheapflights to find cheap flight tickets from Santo Domingo to Panama City?

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Can Cheapflights find flights from Santo Domingo to Panama City with no change fees?

Certainly. Search results for flights to Panama City from Santo Domingo shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Santo Domingo to Panama City become cheaper?

Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Panama City from Santo Domingo today and book when prices fit your budget.

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