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Cheap flights from Buffalo to Des Moines from C$ 268

BUF — DSM
1 Nov — 8 Nov1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Buffalo to Des Moines

Enter your travel dates to find the best prices.

Cheapest flights from Buffalo to Des Moines

Mon 26/105:57 p.m. -
1 stop5h 48m
Mon 2/111:58 p.m. -
1 stop6h 39m
Deal found 28/9C$ 463
Thu 12/116:35 a.m. -
1 stop4h 09m
Fri 13/116:13 a.m. -
1 stop4h 05m
Deal found 28/9C$ 498
Mon 26/102:50 p.m. -
2 stops9h 25m
Mon 2/115:25 a.m. -
2 stops8h 50m
Deal found 28/9C$ 595
Tue 20/107:00 a.m. -
1 stop4h 31m
Wed 21/101:24 p.m. -
1 stop6h 23m
Deal found 29/9C$ 605
Wed 25/118:50 a.m. -
1 stop8h 17m
Sun 29/119:00 p.m. -
1 stop4h 47m
Deal found 1/10C$ 645
Sat 19/125:10 a.m. -
1 stop9h 05m
Sat 2/15:20 a.m. -
1 stop8h 55m
Deal found 27/9C$ 726

Find flight deals from Buffalo to Des Moines

Round-trip from

C$ 463

One-way from

C$ 268

Popular in

March

Cheapest in

April

Average price

C$ 877
American Airlines
  • American Airlines
  • 26/10-2/11
  • 2 total stops
  • 12h 27m total
  • Buffalo to Des Moines
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United Airlines
  • United Airlines
  • 4/12-31/12
  • 1 total stop
  • 8h 56m total
  • Buffalo to Des Moines
Search Deals
Highest demand for flights based on searches. 7% potential increase in price (C$ 82 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease (C$ 57 potential savings vs. average RT price).
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Average for round-trip flights in October 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Buffalo to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloDes Moines

BUF Buffalo - DSM Des Moines

BUFDSM

Buffalo

Fri 4/12

8:17 a.m.-4:13 p.m.

1 stop8h 56m

Des Moines

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 268

BuffaloDes Moines

BUF Buffalo - DSM Des Moines

BUFDSM

Buffalo

Sat 26/12

12:07 p.m.-6:03 p.m.

1 stop6h 56m

Des Moines

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 298
Quickest round-trip

BuffaloDes Moines

BUF Buffalo - DSM Des Moines

BUFDSM

Buffalo

Wed 14/10

7:00 p.m.-10:00 p.m.

1 stop4h 00m

Des Moines

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 369

BuffaloDes Moines

BUF Buffalo - DSM Des Moines

BUFDSM

Buffalo

Sat 26/12

12:35 p.m.-10:55 p.m.

2 stops11h 20m

Des Moines

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 443

BuffaloDes Moines

BUF Buffalo - DSM Des Moines

BUFDSM

Buffalo

Mon 26/10

5:57 p.m.-10:45 p.m.

1 stop5h 48m

Des Moines

Mon 2/11

1:58 p.m.-9:37 p.m.

1 stop6h 39m

C$ 463

BuffaloDes Moines

BUF Buffalo - DSM Des Moines

BUFDSM

Buffalo

Thu 12/11

6:35 a.m.-9:44 a.m.

1 stop4h 09m

Des Moines

Fri 13/11

6:13 a.m.-11:18 a.m.

1 stop4h 05m

C$ 498

BuffaloDes Moines

BUF Buffalo - DSM Des Moines

BUFDSM

Buffalo

Mon 26/10

2:50 p.m.-11:15 p.m.

2 stops9h 25m

Des Moines

Mon 2/11

5:25 a.m.-3:15 p.m.

2 stops8h 50m

C$ 595

BuffaloDes Moines

BUF Buffalo - DSM Des Moines

BUFDSM

Buffalo

Tue 20/10

7:00 a.m.-10:31 a.m.

1 stop4h 31m

Des Moines

Wed 21/10

1:24 p.m.-8:47 p.m.

1 stop6h 23m

C$ 605

BuffaloDes Moines

BUF Buffalo - DSM Des Moines

BUFDSM

Buffalo

Wed 25/11

8:50 a.m.-4:07 p.m.

1 stop8h 17m

Des Moines

Sun 29/11

9:00 p.m.-2:47 a.m.

1 stop4h 47m

C$ 645

BuffaloDes Moines

BUF Buffalo - DSM Des Moines

BUFDSM

Buffalo

Sat 19/12

12:50 p.m.-10:55 p.m.

2 stops11h 05m

Des Moines

Sat 2/1

5:20 a.m.-3:15 p.m.

1 stop8h 55m

C$ 735

Flights are sorted by cheapest round-trip flights first.

Deals found on 28/9

Sorted by cheapest first

Best time to book a flight from Buffalo to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Buffalo with our price prediction graph.
Estimated round-trip price

Related info for your journey

  • How long is the flight from Buffalo to Des Moines?

    Departing from Buffalo to Des Moines will take you 4h 09m. Airlines will cover a distance of 1236 km. This flight may include one or multiple stops.

  • Can I find deals for flights from Buffalo to Des Moines that include hotel bookings?

    Yes. In addition to deals on Buffalo to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Des Moines.

  • Can I find deals for business class flights from Buffalo to Des Moines?

    Yes. Cheapflights offers flight deals from Buffalo to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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When you search for this flight from Buffalo to Des Moines, Cheapflights searches on 900+ travel sites to save you time finding great flight deals online. Additionally, we offer filter features so you can choose a preferred cabin class or airline, see different price ranges, and much more so you can book the flight for you.

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