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Cheap flights from Buffalo to South Carolina from C$ 161

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/8. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
20 Jul — 27 Jul1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Buffalo to South Carolina

Enter your travel dates to find the best prices.

Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 20 June 2026.

Tue 1/96:00 a.m.
BUF
-
CHS
1 stop6h 10m
JetBlue
Wed 2/911:00 a.m.
CHS
-
BUF
1 stop7h 54m
JetBlue
Deal found 17/6C$ 286
Sat 22/86:00 a.m.
BUF
-
CHS
1 stop5h 31m
JetBlue
Wed 26/811:00 a.m.
CHS
-
BUF
1 stop7h 54m
JetBlue
Deal found 19/6C$ 320
Mon 13/77:00 a.m.
BUF
-
CHS
1 stop5h 15m
JetBlue
Thu 16/710:58 a.m.
CHS
-
BUF
1 stop7h 27m
JetBlue
Deal found 16/6C$ 327
Sun 9/89:33 p.m.
BUF
-
CLT
1 stop10h 18m
Frontier
Sat 15/812:24 p.m.
CLT
-
BUF
1 stop8h 43m
Frontier
Deal found 20/6C$ 361
Fri 31/76:00 a.m.
BUF
-
CHS
1 stop6h 15m
JetBlue
Mon 3/811:03 a.m.
CHS
-
BUF
1 stop7h 22m
JetBlue
Deal found 17/6C$ 364
Thu 30/76:00 a.m.
BUF
-
CHS
1 stop6h 15m
JetBlue
Fri 7/811:00 a.m.
CHS
-
BUF
1 stop7h 54m
JetBlue
Deal found 16/6C$ 371
Tue 14/79:09 p.m.
BUF
-
CLT
1 stop19h 49m
Frontier
Sat 18/78:02 p.m.
CLT
-
BUF
1 stop20h 30m
Frontier
Deal found 19/6C$ 374
Fri 17/77:57 p.m.
BUF
-
CLT
1 stop21h 01m
Frontier
Tue 21/712:24 p.m.
CLT
-
BUF
1 stop6h 42m
Frontier
Deal found 20/6C$ 375
Tue 22/910:00 a.m.
BUF
-
CHS
1 stop4h 39m
Delta
Sun 27/96:42 p.m.
CHS
-
BUF
1 stop5h 12m
Delta
Deal found 19/6C$ 378
Mon 13/77:57 p.m.
BUF
-
CLT
1 stop15h 32m
Frontier
Wed 15/78:02 p.m.
CLT
-
BUF
1 stop20h 30m
Frontier
Deal found 18/6C$ 391
Fri 11/92:10 p.m.
BUF
-
CHS
1 stop6h 32m
Delta
Sun 13/97:10 a.m.
CHS
-
BUF
1 stop4h 30m
Delta
Deal found 16/6C$ 392
Fri 3/74:12 p.m.
BUF
-
CHS
1 stop5h 51m
Delta
Wed 8/75:35 p.m.
CHS
-
BUF
1 stop7h 11m
Delta
Deal found 17/6C$ 406

Find flight deals from Buffalo to South Carolina

Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated 20 June 2026.

Round-trip from

C$ 286

One-way from

C$ 161

Popular in

March

Cheapest in

September

Average price

C$ 597
JetBlue
  • JetBlue
  • 1/9-2/9
  • 2 total stops
  • 14h 04m total
  • Buffalo to South Carolina
Search Deals
JetBlue
  • JetBlue
  • 11/8
  • 1 total stop
  • 6h 10m total
  • Buffalo to South Carolina
Search Deals
Highest demand for flights based on searches. 9% potential increase in price (C$ 78 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (C$ 20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 20 June 2026.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Tue 1/9

10:25 a.m.-5:46 p.m.

1 stop7h 21m

Charleston

Wed 2/9

11:00 a.m.-6:54 p.m.

1 stop7h 54m

C$ 286

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Tue 13/10

7:40 p.m.-11:56 p.m.

1 stop4h 16m

Charleston

Tue 20/10

5:55 p.m.-11:55 p.m.

1 stop6h 00m

C$ 378

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Fri 11/9

2:10 p.m.-8:42 p.m.

1 stop6h 32m

Charleston

Sun 13/9

7:10 a.m.-11:40 a.m.

1 stop4h 30m

C$ 378

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Fri 20/11

4:59 p.m.-9:46 p.m.

1 stop4h 47m

Charleston

Fri 27/11

6:00 a.m.-12:33 p.m.

1 stop6h 33m

C$ 415

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Thu 15/10

12:25 p.m.-7:30 p.m.

1 stop7h 05m

Myrtle Beach Intl

Tue 20/10

8:20 a.m.-2:50 p.m.

1 stop6h 30m

C$ 460

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Wed 11/11

4:59 p.m.-11:59 p.m.

1 stop7h 00m

Savannah/Hilton Head

Wed 18/11

11:00 a.m.-3:11 p.m.

1 stop4h 11m

C$ 469

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Tue 22/9

8:55 a.m.-1:50 p.m.

1 stop4h 55m

Myrtle Beach Intl

Sat 26/9

12:10 p.m.-9:05 p.m.

2 stops8h 55m

C$ 471

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Fri 23/10

4:30 p.m.-9:46 p.m.

1 stop5h 16m

Charleston

Sun 25/10

6:00 a.m.-12:33 p.m.

1 stop6h 33m

C$ 477

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Sat 22/8

3:30 p.m.-7:00 p.m.

1 stop3h 30m

Myrtle Beach Intl

Sat 29/8

11:55 a.m.-9:05 p.m.

2 stops9h 10m

C$ 486

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Tue 13/10

7:30 a.m.-5:25 p.m.

2 stops9h 55m

Charleston

Tue 20/10

6:30 a.m.-4:05 p.m.

2 stops9h 35m

C$ 491

Flights are sorted by cheapest round-trip flights first.

Deals found on 18/6

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

Currently, March is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of C$ 139). Flying from Buffalo to South Carolina in January is currently the most expensive (average of C$ 334). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Buffalo to South Carolina?

How far ahead should I book a flight from Buffalo to South Carolina?

The best time to book flights from Buffalo to South Carolina is 87 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated 20 June 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Buffalo to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
7.9
Good
4,243 reviews
Check prices

Boarding

8.1

Entertainment

7.5

Overall

7.9

Food

7.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
6.0
Good

Reza,Jun 2026

TPA - MDW

The seats were super cramped and couldn’t move without hitting other passengers
Southwest
7.9
Good
4,243 reviews
Southwest
7.9
Good
4,243 reviews
Check prices

Boarding

8.1

Entertainment

7.5

Overall

7.9

Food

7.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
6.0
Good

Reza,Jun 2026

TPA - MDW

The seats were super cramped and couldn’t move without hitting other passengers
Delta
7.8
Good
8,422 reviews
Southwest
7.9
Good
4,243 reviews
Check prices

Boarding

8.1

Entertainment

7.5

Overall

7.9

Food

7.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
6.0
Good

Reza,Jun 2026

TPA - MDW

The seats were super cramped and couldn’t move without hitting other passengers
American Airlines
7.1
Good
11,721 reviews
Southwest
7.9
Good
4,243 reviews
Check prices

Boarding

8.1

Entertainment

7.5

Overall

7.9

Food

7.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
6.0
Good

Reza,Jun 2026

TPA - MDW

The seats were super cramped and couldn’t move without hitting other passengers
JetBlue
7.1
Good
2,990 reviews
Southwest
7.9
Good
4,243 reviews
Check prices

Boarding

8.1

Entertainment

7.5

Overall

7.9

Food

7.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
6.0
Good

Reza,Jun 2026

TPA - MDW

The seats were super cramped and couldn’t move without hitting other passengers

Related info for your journey

Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Buffalo to South Carolina?

    For a flight from Buffalo to South Carolina, you will be flying from Buffalo. Buffalo (BUF) is just 13.4 km from the centre of the city.

  • How long is the flight from Buffalo to South Carolina?

    Departing from Buffalo to South Carolina will take you 6h 10m. Airlines will cover a distance of 1122 km. This flight may include one or multiple stops.

  • What are the most popular routes from Buffalo to South Carolina?

    When deciding which route to take from Buffalo to South Carolina consider Buffalo - Charlotte Douglas, Buffalo - Myrtle Beach Intl or Buffalo - Charleston as they are the most popular.

  • Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

    Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.

  • Can I find deals for business class flights from Buffalo to South Carolina?

    Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to South Carolina?

    Currently, March is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of C$ 139). Flying from Buffalo to South Carolina in January is currently the most expensive (average of C$ 334). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 4 airlines flying from Buffalo to South Carolina

Discover the top 4 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 20 June 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapestC$ 182AverageC$ 456FlexibilityNo cancel feeOn-timeN/A
Search Delta flights
American AirlinesCheapestC$ 224AverageC$ 448FlexibilityNo cancel feeOn-time71%
Search American Airlines flights
JetBlueCheapestC$ 255AverageC$ 600FlexibilityNo cancel feeOn-time62%
Search JetBlue flights
SouthwestCheapestC$ 281AverageC$ 445FlexibilityNo cancel feeOn-time63%
Search Southwest flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travelers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Buffalo to South Carolina?

Cheapflights goes through 900+ travel sites to look for the best flight deals for flights from Buffalo to South Carolina. Too many options? Cheapflights also provides filters for things like airlines, price ranges, and number of stops to help you make a decision easily.

Why should you use Cheapflights to find cheap flight tickets from Buffalo to South Carolina?

Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Buffalo to South Carolina for you. Better yet — we are completely free to use.

Can Cheapflights find flights from Buffalo to South Carolina with no change fees?

Certainly. Search results for flights to South Carolina from Buffalo shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Buffalo to South Carolina become cheaper?

Yes, Cheapflights offers price alerts on Buffalo to South Carolina flights so you can book your travel at the perfect time. Price Alerts can be enabled by clicking the bell icon next to the flight deals above and providing your email address where you want to receive the alerts.

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