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Cheap flights from Buffalo to South Carolina from C$ 149

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/9. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
5 Sep — 12 Sep1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Buffalo to South Carolina

Enter your travel dates to find the best prices.

Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 6 August 2026.

Wed 26/86:54 p.m. -
1 stop18h 56m
Sat 29/89:52 p.m. -
1 stop11h 31m
Deal found 5/8C$ 305
Sat 5/95:13 p.m. -
1 stop6h 46m
Fri 11/911:39 a.m. -
1 stop5h 57m
Deal found 5/8C$ 350
Thu 27/89:29 p.m. -
1 stop10h 32m
Mon 31/89:52 p.m. -
1 stop11h 31m
Deal found 5/8C$ 351
Sat 5/93:30 p.m. -
1 stop3h 55m
Fri 11/97:00 a.m. -
2 stops7h 50m
Deal found 5/8C$ 357
Tue 1/96:05 a.m. -
1 stop7h 06m
Sat 5/94:15 p.m. -
1 stop5h 17m
Deal found 5/8C$ 358
Sat 22/86:54 p.m. -
1 stop18h 56m
Tue 25/89:52 p.m. -
1 stop20h 17m
Deal found 5/8C$ 362
Tue 1/912:00 p.m. -
2 stops9h 10m
Sat 5/95:20 p.m. -
1 stop3h 50m
Deal found 4/8C$ 365
Thu 27/86:05 a.m. -
1 stop4h 15m
Thu 27/83:50 p.m. -
1 stop7h 39m
Deal found 4/8C$ 367
Mon 24/85:00 a.m. -
1 stop5h 32m
Thu 27/812:00 p.m. -
1 stop5h 29m
Deal found 1/8C$ 369
Sat 29/86:12 a.m. -
2 stops7h 46m
Sat 5/96:30 a.m. -
2 stops7h 48m
Deal found 1/8C$ 372
Thu 27/86:00 a.m. -
2 stops9h 10m
Fri 28/87:51 p.m. -
1 stop3h 53m
Deal found 4/8C$ 374
Mon 31/85:40 a.m. -
2 stops7h 00m
Wed 2/97:35 a.m. -
2 stops10h 10m
Deal found 4/8C$ 381

Find flight deals from Buffalo to South Carolina

Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated 6 August 2026.

Round-trip from

C$ 305

One-way from

C$ 149

Popular in

March

Cheapest in

October

Average price

C$ 515
Frontier
  • Frontier
  • 26/8-29/8
  • 2 total stops
  • 30h 27m total
  • Buffalo to South Carolina
Search Deals
Frontier
  • Frontier
  • 1/9
  • 1 total stop
  • 10h 32m total
  • Buffalo to South Carolina
Search Deals
Highest demand for flights based on searches. 7% potential increase in price (C$ 55 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (C$ 17 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 6 August 2026.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Tue 1/9

6:05 a.m.-1:11 p.m.

1 stop7h 06m

Charleston

Sat 5/9

4:15 p.m.-9:32 p.m.

1 stop5h 17m

C$ 358

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Wed 11/11

11:25 a.m.-4:13 p.m.

1 stop4h 48m

Charleston

Sat 14/11

6:00 a.m.-10:30 a.m.

1 stop4h 30m

C$ 369

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Mon 31/8

5:40 a.m.-12:40 p.m.

2 stops7h 00m

Charleston

Wed 2/9

7:35 a.m.-5:45 p.m.

2 stops10h 10m

C$ 381

BuffaloSavannah

BUF Buffalo - SAV Savannah/Hilton Head

BUFSAV

Buffalo

Sun 20/9

6:00 a.m.-1:06 p.m.

1 stop7h 06m

Savannah/Hilton Head

Mon 28/9

2:05 p.m.-6:58 p.m.

1 stop4h 53m

C$ 397

BuffaloSavannah

BUF Buffalo - SAV Savannah/Hilton Head

BUFSAV

Buffalo

Tue 13/10

3:10 p.m.-11:57 p.m.

1 stop8h 47m

Savannah/Hilton Head

Thu 15/10

2:20 p.m.-7:01 p.m.

1 stop4h 41m

C$ 400

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Wed 19/8

10:30 a.m.-3:10 p.m.

1 stop4h 40m

Charleston

Sat 22/8

10:14 a.m.-2:18 p.m.

1 stop4h 04m

C$ 413

BuffaloSavannah

BUF Buffalo - SAV Savannah/Hilton Head

BUFSAV

Buffalo

Mon 31/8

6:01 a.m.-11:25 a.m.

1 stop5h 24m

Savannah/Hilton Head

Sun 6/9

6:37 p.m.-11:59 p.m.

1 stop5h 22m

C$ 428
Quickest round-trip

BuffaloSavannah

BUF Buffalo - SAV Savannah/Hilton Head

BUFSAV

Buffalo

Sat 29/8

6:27 a.m.-10:37 a.m.

1 stop4h 10m

Savannah/Hilton Head

Sat 5/9

6:46 p.m.-11:09 p.m.

1 stop4h 23m

C$ 431

BuffaloSavannah

BUF Buffalo - SAV Savannah/Hilton Head

BUFSAV

Buffalo

Wed 16/9

6:20 a.m.-10:40 a.m.

1 stop4h 20m

Savannah/Hilton Head

Thu 24/9

6:00 a.m.-1:25 p.m.

1 stop7h 25m

C$ 431

BuffaloSavannah

BUF Buffalo - SAV Savannah/Hilton Head

BUFSAV

Buffalo

Tue 19/1

8:10 a.m.-4:45 p.m.

2 stops8h 35m

Savannah/Hilton Head

Tue 16/2

1:35 p.m.-8:25 p.m.

1 stop6h 50m

C$ 438

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/8

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

Currently, September is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of C$ 419). Flying from Buffalo to South Carolina in March is currently the most expensive (average of C$ 608). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Buffalo to South Carolina?

Airfare is below average for this route at the moment.
Buffalo to South Carolina flights typically cost between C$ 374 and C$ 486 in September.
The cheapest round-trip price found within the last 5 days was C$ 350 on Delta (5 Sep-11 Sep).

How far ahead should I book a flight from Buffalo to South Carolina?

The best time to book flights from Buffalo to South Carolina is 85 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated 6 August 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Buffalo to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,221 reviews
Check prices

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Libby,Jun 2026

TUS - LAS

One delay in a 2 layover flight=a good trip. The crew was great.
Southwest
8.0
Very good
4,221 reviews
Southwest
8.0
Very good
4,221 reviews
Check prices

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Libby,Jun 2026

TUS - LAS

One delay in a 2 layover flight=a good trip. The crew was great.
Delta
7.8
Good
8,492 reviews
Southwest
8.0
Very good
4,221 reviews
Check prices

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Libby,Jun 2026

TUS - LAS

One delay in a 2 layover flight=a good trip. The crew was great.
American Airlines
7.1
Good
11,863 reviews
Southwest
8.0
Very good
4,221 reviews
Check prices

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Libby,Jun 2026

TUS - LAS

One delay in a 2 layover flight=a good trip. The crew was great.
JetBlue
7.1
Good
3,024 reviews
Southwest
8.0
Very good
4,221 reviews
Check prices

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Libby,Jun 2026

TUS - LAS

One delay in a 2 layover flight=a good trip. The crew was great.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Buffalo to South Carolina?

    For a flight from Buffalo to South Carolina, you will be flying from Buffalo. Buffalo (BUF) is just 13.4 km from the centre of the city.

  • How long is the flight from Buffalo to South Carolina?

    Departing from Buffalo to South Carolina will take you 7h. Airlines will cover a distance of 1122 km. This flight may include one or multiple stops.

  • What are the most popular routes from Buffalo to South Carolina?

    When deciding which route to take from Buffalo to South Carolina consider Buffalo - Charlotte Douglas, Buffalo - Savannah/Hilton Head or Buffalo - Myrtle Beach Intl as they are the most popular.

  • Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

    Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.

  • Can I find deals for business class flights from Buffalo to South Carolina?

    Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to South Carolina?

    Currently, September is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of C$ 419). Flying from Buffalo to South Carolina in March is currently the most expensive (average of C$ 608). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 4 airlines flying from Buffalo to South Carolina

Discover the top 4 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 6 August 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapestC$ 181AverageC$ 483FlexibilityNo cancel feeOn-timeN/A
Search Delta flights
American AirlinesCheapestC$ 222AverageC$ 453FlexibilityNo cancel feeOn-time71%
Search American Airlines flights
JetBlueCheapestC$ 253AverageC$ 596FlexibilityNo cancel feeOn-time62%
Search JetBlue flights
SouthwestCheapestC$ 304AverageC$ 526FlexibilityNo cancel feeOn-time63%
Search Southwest flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travelers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Buffalo to South Carolina?

Cheapflights goes through 900+ travel sites to look for the best flight deals for flights from Buffalo to South Carolina. Too many options? Cheapflights also provides filters for things like airlines, price ranges, and number of stops to help you make a decision easily.

Why should you use Cheapflights to find cheap flight tickets from Buffalo to South Carolina?

Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Buffalo to South Carolina for you. Better yet — we are completely free to use.

Can Cheapflights find flights from Buffalo to South Carolina with no change fees?

Certainly. Search results for flights to South Carolina from Buffalo shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Buffalo to South Carolina become cheaper?

Yes, Cheapflights offers price alerts on Buffalo to South Carolina flights so you can book your travel at the perfect time. Price Alerts can be enabled by clicking the bell icon next to the flight deals above and providing your email address where you want to receive the alerts.

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