What are the cheapest airlines to fly from Buffalo to South Carolina one-way?

The cheapest airlines for a one-way flight from Buffalo to South Carolina are JetBlue (C$ 111), Delta (C$ 163), and United Airlines (C$ 204).

What are the most popular routes from Buffalo to South Carolina?

When deciding which route to take from Buffalo to South Carolina consider Buffalo - Charlotte Douglas, Buffalo - Myrtle Beach Intl or Buffalo - Charleston as they are the most popular.

What are the most popular airlines that fly from Buffalo to South Carolina?

The most popular airlines flying from Buffalo to South Carolina are American Airlines, United Airlines and Southwest. Something to consider prior to booking your flight.

How far in advance should I book a flight from Buffalo to South Carolina?

To save on the cost of your flight from Buffalo to South Carolina, book at least 29 days before your planned departure. Booking around this time can save you about 92% on the cost of this flight compared to booking a flight leaving this week. We have found prices from C$ 480 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as C$ 811.

What is the cheapest month to fly from Buffalo to South Carolina?

Flights from Buffalo to South Carolina lean towards being more expensive in April. Prices are generally better when you fly from Buffalo to South Carolina in September, with the cheapest ticket starting at C$ 283.

What airport do you fly from for flights from Buffalo to South Carolina?

For a flight from Buffalo to South Carolina, you will be flying from Buffalo. Buffalo (BUF) is just 13.4 km from the centre of the city.

Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Buffalo to South Carolina?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.

Can I find deals for business class flights from Buffalo to South Carolina?

Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

C$ 111+ Flights from Buffalo to South Carolina

Cheap flight deals from Buffalo to South Carolina

Round-trip from	C$ 220
One-way from	C$ 111
Popular in	April
Cheapest in	September
Average price	C$ 473

JetBlue
8/7-15/7
2 total stops
9h 40m total
Buffalo to South Carolina

Search Deals

JetBlue
8/7
1 total stop
4h 40m total
Buffalo to South Carolina

Search Deals

Highest demand for flights based on searches. 7% potential increase in price (C$ 58 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease (C$ 12 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in June 2025

Search Deals

Find flight deals from Buffalo to South Carolina

Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 12 June 2025.

Tue 8/75:35 a.m.BUF - CHS

1 stop4h 40mJetBlue

Tue 15/76:59 p.m.CHS - BUF

1 stop5h 00mJetBlue

Deal found 9/6C$ 220

Thu 14/811:54 a.m.BUF - CHS

1 stop5h 22mAmerican Airlines

Sun 24/86:38 a.m.CHS - BUF

1 stop6h 05mAmerican Airlines

Deal found 11/6C$ 310

Tue 26/86:04 a.m.BUF - MYR

1 stop5h 28mDelta

Sat 30/86:35 p.m.MYR - BUF

1 stop4h 24mDelta

Deal found 10/6C$ 319

Tue 22/76:00 a.m.BUF - CHS

1 stop4h 14mUnited Airlines

Thu 24/73:51 p.m.CHS - BUF

1 stop5h 10mUnited Airlines

Deal found 10/6C$ 324

Tue 16/95:50 a.m.BUF - CLT

1 stop4h 15mSouthwest

Tue 23/97:40 a.m.CLT - BUF

1 stop4h 20mSouthwest

Deal found 9/6C$ 331

Sat 6/95:39 a.m.BUF - MYR

1 stop4h 53mAmerican Airlines

Sat 13/95:29 p.m.MYR - BUF

1 stop4h 24mAmerican Airlines

Deal found 10/6C$ 340

Sat 1/1112:45 p.m.BUF - SAV

1 stop6h 44mJetBlue

Mon 3/1110:44 a.m.SAV - BUF

1 stop8h 37mJetBlue

Deal found 11/6C$ 340

Sat 30/82:19 p.m.BUF - CLT

1 stop4h 57mDelta

Tue 2/99:00 a.m.CLT - BUF

1 stop4h 41mDelta

Deal found 11/6C$ 343

Sat 6/93:25 p.m.BUF - MYR

1 stop4h 00mSouthwest

Sat 13/96:10 a.m.MYR - BUF

2 stops10h 05mSouthwest

Deal found 10/6C$ 347

Wed 23/76:28 a.m.BUF - CLT

Nonstop1h 57mAmerican Airlines

Wed 6/810:23 a.m.CLT - BUF

Nonstop1h 41mAmerican Airlines

Deal found 12/6C$ 347

Wed 8/105:30 a.m.BUF - CHS

1 stop5h 20mSouthwest

Sun 12/106:25 a.m.CHS - BUF

1 stop11h 00mSouthwest

Deal found 10/6C$ 360

Tue 2/98:00 p.m.BUF - CLT

1 stop3h 59mUnited Airlines

Tue 9/91:52 p.m.CLT - BUF

2 stops9h 42mUnited Airlines

Deal found 10/6C$ 372

Best flights from Buffalo to South Carolina
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated 12 June 2025.

Tue 8/75:35 a.m.BUF - CHS

1 stop4h 40mJetBlue

Tue 15/76:59 p.m.CHS - BUF

1 stop5h 00mJetBlue

Deal found 9/6C$ 220

Thu 14/811:54 a.m.BUF - CHS

1 stop5h 22mAmerican Airlines

Sun 24/86:38 a.m.CHS - BUF

1 stop6h 05mAmerican Airlines

Deal found 11/6C$ 310

Tue 26/86:04 a.m.BUF - MYR

1 stop5h 28mDelta

Sat 30/86:35 p.m.MYR - BUF

1 stop4h 24mDelta

Deal found 10/6C$ 319

Tue 22/76:00 a.m.BUF - CHS

1 stop4h 14mUnited Airlines

Thu 24/73:51 p.m.CHS - BUF

1 stop5h 10mUnited Airlines

Deal found 10/6C$ 324

Tue 16/95:50 a.m.BUF - CLT

1 stop4h 15mSouthwest

Tue 23/97:40 a.m.CLT - BUF

1 stop4h 20mSouthwest

Deal found 9/6C$ 331

Thu 28/85:28 p.m.BUF - CLT

1 stop14h 46mFrontier

Mon 1/99:09 a.m.CLT - BUF

1 stop11h 01mFrontier

Deal found 10/6C$ 418

Sat 6/95:39 a.m.BUF - MYR

1 stop4h 53mAmerican Airlines

Sat 13/95:29 p.m.MYR - BUF

1 stop4h 24mAmerican Airlines

Deal found 10/6C$ 340

Sat 1/1112:45 p.m.BUF - SAV

1 stop6h 44mJetBlue

Mon 3/1110:44 a.m.SAV - BUF

1 stop8h 37mJetBlue

Deal found 11/6C$ 340

Sat 30/82:19 p.m.BUF - CLT

1 stop4h 57mDelta

Tue 2/99:00 a.m.CLT - BUF

1 stop4h 41mDelta

Deal found 11/6C$ 343

Sat 6/93:25 p.m.BUF - MYR

1 stop4h 00mSouthwest

Sat 13/96:10 a.m.MYR - BUF

2 stops10h 05mSouthwest

Deal found 10/6C$ 347

Tue 2/98:00 p.m.BUF - CLT

1 stop3h 59mUnited Airlines

Tue 9/91:52 p.m.CLT - BUF

2 stops9h 42mUnited Airlines

Deal found 10/6C$ 372

Wed 23/76:28 a.m.BUF - CLT

Nonstop1h 57mAmerican Airlines

Wed 6/810:23 a.m.CLT - BUF

Nonstop1h 41mAmerican Airlines

Deal found 12/6C$ 347

Last-minute flights from Buffalo to South Carolina
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated 12 June 2025 and is based on user searches.

Tue 17/66:00 a.m.BUF - CLT

1 stop6h 35mSouthwest

Sat 28/611:00 a.m.CLT - BUF

1 stop5h 05mSouthwest

Deal found 11/6C$ 551

Tue 17/68:30 a.m.BUF - CLT

1 stop4h 39mUnited Airlines

Sat 21/610:31 a.m.CLT - BUF

1 stop3h 38mUnited Airlines

Deal found 11/6C$ 649

Wed 18/65:40 a.m.BUF - SAV

1 stop4h 55mJetBlue

Tue 24/61:35 p.m.SAV - BUF

1 stop7h 40mJetBlue

Deal found 11/6C$ 685

Wed 18/66:15 a.m.BUF - CHS

1 stop3h 59mUnited Airlines

Thu 19/66:30 a.m.CHS - BUF

2 stops12h 26mUnited Airlines

Deal found 11/6C$ 689

Thu 19/66:30 a.m.BUF - CHS

1 stop4h 05mDelta

Mon 23/65:15 p.m.CHS - BUF

1 stop6h 36mDelta

Deal found 10/6C$ 488

Thu 19/612:15 p.m.BUF - CHS

2 stops10h 10mSouthwest

Mon 23/65:20 a.m.CHS - BUF

1 stop5h 05mSouthwest

Deal found 11/6C$ 593

Thu 19/63:52 p.m.BUF - CLT

1 stop5h 58mDelta

Mon 23/67:29 p.m.CLT - BUF

1 stop5h 20mDelta

Deal found 12/6C$ 626

Thu 19/67:55 p.m.BUF - SAV

1 stop23h 32mUnited Airlines

Sun 22/610:00 a.m.SAV - BUF

1 stop6h 55mUnited Airlines

Deal found 12/6C$ 857

Sat 21/65:10 p.m.BUF - MYR

1 stop5h 05mDelta

Sat 28/65:57 p.m.MYR - BUF

1 stop5h 54mDelta

Deal found 12/6C$ 530

Sat 21/66:00 a.m.BUF - MYR

2 stops7h 10mSouthwest

Sat 28/61:35 p.m.MYR - BUF

2 stops9h 40mSouthwest

Deal found 12/6C$ 588

Sun 22/69:12 p.m.BUF - CLT

1 stop13h 24mFrontier

Sun 29/65:28 p.m.CLT - BUF

1 stop19h 47mFrontier

Deal found 11/6C$ 530

Sun 22/61:48 p.m.BUF - CLT

Nonstop1h 52mAmerican Airlines

Sun 29/611:15 a.m.CLT - BUF

Nonstop1h 42mAmerican Airlines

Deal found 11/6C$ 660

One-way flights from Buffalo to South Carolina
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated 12 June 2025.

Tue 8/75:35 a.m.BUF - CHS

1 stop4h 40mJetBlue

Deal found 10/6C$ 111

Sun 20/76:30 a.m.BUF - CHS

1 stop4h 08mDelta

Deal found 9/6C$ 163

Fri 11/77:22 a.m.BUF - SAV

1 stop5h 18mJetBlue

Deal found 12/6C$ 185

Thu 3/76:30 a.m.BUF - MYR

1 stop3h 55mDelta

Deal found 11/6C$ 198

Tue 4/1110:37 a.m.BUF - CHS

2 stops8h 46mUnited Airlines

Deal found 10/6C$ 204

Thu 25/95:50 a.m.BUF - CLT

1 stop4h 00mSouthwest

Deal found 11/6C$ 212

Sat 12/77:50 p.m.BUF - CLT

1 stop24h 32mFrontier

Deal found 10/6C$ 231

Thu 3/712:35 p.m.BUF - MYR

2 stops10h 50mSouthwest

Deal found 11/6C$ 237

Thu 21/812:25 p.m.BUF - CHS

2 stops10h 15mSouthwest

Deal found 10/6C$ 239

Tue 22/72:05 p.m.BUF - SAV

2 stops8h 00mSouthwest

Deal found 11/6C$ 249

Sun 27/76:00 a.m.BUF - SAV

1 stop4h 39mAmerican Airlines

Deal found 12/6C$ 252

Thu 24/711:23 a.m.BUF - CHS

2 stops26h 52mMultiple Airlines

Deal found 10/6C$ 282

Cheapflights Fare Finder

Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Tue 8/7

5:35 a.m.-10:15 a.m.

1 stop4h 40m

Charleston

Tue 15/7

6:59 p.m.-11:59 p.m.

1 stop5h 00m

C$ 220

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Thu 14/8

11:54 a.m.-5:16 p.m.

1 stop5h 22m

Charleston

Sun 24/8

6:38 a.m.-12:43 p.m.

1 stop6h 05m

C$ 310

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Tue 26/8

6:04 a.m.-11:32 a.m.

1 stop5h 28m

Myrtle Beach Intl

Sat 30/8

6:35 p.m.-10:59 p.m.

1 stop4h 24m

C$ 319

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Tue 22/7

6:00 a.m.-10:14 a.m.

1 stop4h 14m

Charleston

Thu 24/7

3:51 p.m.-9:01 p.m.

1 stop5h 10m

C$ 324

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Tue 16/9

5:50 a.m.-10:05 a.m.

1 stop4h 15m

Charlotte Douglas

Tue 23/9

7:40 a.m.-12:00 p.m.

1 stop4h 20m

C$ 331

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Sat 6/9

5:39 a.m.-10:32 a.m.

1 stop4h 53m

Myrtle Beach Intl

Sat 13/9

5:29 p.m.-9:53 p.m.

1 stop4h 24m

C$ 340

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Sat 1/11

12:45 p.m.-7:29 p.m.

1 stop6h 44m

Savannah/Hilton Head

Mon 3/11

10:44 a.m.-7:21 p.m.

1 stop8h 37m

C$ 340

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Sat 30/8

7:00 a.m.-1:25 p.m.

1 stop6h 25m

Charlotte Douglas

Sat 6/9

5:32 p.m.-12:53 a.m.

1 stop7h 21m

C$ 343

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Sat 6/9

3:25 p.m.-7:25 p.m.

1 stop4h 00m

Myrtle Beach Intl

Sat 13/9

6:10 a.m.-4:15 p.m.

2 stops10h 05m

C$ 347

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Wed 23/7

6:28 a.m.-8:25 a.m.

Nonstop1h 57m

Charlotte Douglas

Wed 6/8

10:23 a.m.-12:04 p.m.

Nonstop1h 41m

C$ 347

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/6

Showing 1-10 of 37 results

Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

Currently, September is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of C$ 407). Flying from Buffalo to South Carolina in March is currently the most expensive (average of C$ 499). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to SC?

When flying from Buffalo to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South Carolina by month

In terms of precipitation, rainfall in South Carolina ranges from 76.0 - 165.0 mm per month. July is typically the wettest month, when rainfall can reach 165.0 mm. November is typically the driest time to visit South Carolina when rainfall is around 76.0 mm.

Temperature in South Carolina by month

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 26.0 C. Travellers hoping to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 7.0 C).

Reviews of airlines servicing South Carolina

Peruse reviews from past customers who have flown with Southwest, Delta and United Airlines from Buffalo to South Carolina to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,287 reviews

Check prices

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Southwest

8.0

Very good

4,287 reviews

Southwest

8.0

Very good

4,287 reviews

Check prices

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Delta

8.0

Very good

7,950 reviews

Southwest

8.0

Very good

4,287 reviews

Check prices

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

United Airlines

7.4

Good

8,790 reviews

Southwest

8.0

Very good

4,287 reviews

Check prices

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

JetBlue

7.3

Good

2,925 reviews

Southwest

8.0

Very good

4,287 reviews

Check prices

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,287 reviews

Check prices

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

What airport do you fly from for flights from Buffalo to South Carolina?
For a flight from Buffalo to South Carolina, you will be flying from Buffalo. Buffalo (BUF) is just 13.4 km from the centre of the city.
What are the cheapest airlines to fly from Buffalo to South Carolina one-way?
The cheapest airlines for a one-way flight from Buffalo to South Carolina are JetBlue (C$ 111), Delta (C$ 163), and United Airlines (C$ 204).
What are the most popular routes from Buffalo to South Carolina?
When deciding which route to take from Buffalo to South Carolina consider Buffalo - Charlotte Douglas, Buffalo - Myrtle Beach Intl or Buffalo - Charleston as they are the most popular.
Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?
Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Buffalo to South Carolina?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.
Can I find deals for business class flights from Buffalo to South Carolina?
Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, September is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of C$ 407). Flying from Buffalo to South Carolina in March is currently the most expensive (average of C$ 499). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

South Carolina car rentals

Charleston Airport car rentals

Myrtle Beach Intl Airport car rentals

Greenville Airport car rentals

Columbia Metropolitan Airport car rentals

Hilton Head Island Airport car rentals

Florence Airport car rentals

Myrtle Beach car rentals

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Direct flights to United States

Top 4 airlines flying from Buffalo to South Carolina

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	CheapestC$ 241	AverageC$ 434	FlexibilityNo cancel fee	On-time71%	Search American Airlines flights
Delta	CheapestC$ 252	AverageC$ 431	FlexibilityNo cancel fee	On-timeN/A	Search Delta flights
United Airlines	CheapestC$ 337	AverageC$ 935	FlexibilityNo cancel fee	On-time69%	Search United Airlines flights
Southwest	CheapestC$ 344	AverageC$ 526	FlexibilityNo cancel fee	On-time63%	Search Southwest flights

Fly with Cheapflights

How does Cheapflights help users find flights from Buffalo to South Carolina?

Cheapflights goes through 900+ travel sites to look for the best flight deals for flights from Buffalo to South Carolina. Too many options? Cheapflights also provides filters for things like airlines, price ranges, and number of stops to help you make a decision easily.

Why should you use Cheapflights to find cheap flight tickets from Buffalo to South Carolina?

Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Buffalo to South Carolina for you. Better yet — we are completely free to use.

Can Cheapflights find flights from Buffalo to South Carolina with no change fees?

Certainly. Search results for flights to South Carolina from Buffalo shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Buffalo to South Carolina become cheaper?

Yes, Cheapflights offers price alerts on Buffalo to South Carolina flights so you can book your travel at the perfect time. Price Alerts can be enabled by clicking the bell icon next to the flight deals above and providing your email address where you want to receive the alerts.

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Cheap flights from Buffalo to South Carolina from C$ 111

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/7. Fares are subject to change and may not be available on all flights or dates of travel.

Cheap flight deals from Buffalo to South Carolina

Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated 12 June 2025.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Buffalo to South Carolina

Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 12 June 2025.

Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 12 June 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

What is the cheapest time of day to fly from BUF to SC?

Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 12 June 2025.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

Reviews of airlines servicing South Carolina

Peruse reviews from past customers who have flown with Southwest, Delta and United Airlines from Buffalo to South Carolina to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly from for flights from Buffalo to South Carolina?

What are the cheapest airlines to fly from Buffalo to South Carolina one-way?

What are the most popular routes from Buffalo to South Carolina?

Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

How can I find direct flights from Buffalo to South Carolina?

Can I find deals for business class flights from Buffalo to South Carolina?

What is the cheapest month to book a flight from Buffalo to South Carolina?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Buffalo to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Buffalo to South Carolina

Fly with Cheapflights

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How does Cheapflights help users find flights from Buffalo to South Carolina?

Why should you use Cheapflights to find cheap flight tickets from Buffalo to South Carolina?

Can Cheapflights find flights from Buffalo to South Carolina with no change fees?

Can Cheapflights notify me if prices for flights from Buffalo to South Carolina become cheaper?

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Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 12 June 2025.