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Cheap flights from Buffalo to South Carolina from C$ 150

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 17/12. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
2 Dec — 9 Dec1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Buffalo to South Carolina

Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated 2 November 2025.

Round-trip from

C$ 276

One-way from

C$ 150

Popular in

April

Cheapest in

September

Average price

C$ 509
Delta
  • Delta
  • 5/12-6/12
  • 2 total stops
  • 12h 24m total
  • Buffalo to South Carolina
Search Deals
JetBlue
  • JetBlue
  • 17/12
  • 1 total stop
  • 4h 56m total
  • Buffalo to South Carolina
Search Deals
Highest demand for flights based on searches. 9% potential increase in price (C$ 70 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (C$ 14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Find flight deals from Buffalo to South Carolina

Enter your travel dates to find the best prices.

Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 2 November 2025.

Fri 5/126:25 p.m.BUF - CHS
1 stop5h 25mDelta
Sun 7/125:25 a.m.CHS - BUF
1 stop5h 39mDelta
Deal found 31/10C$ 276
Fri 5/126:12 a.m.BUF - SAV
1 stop4h 48mDelta
Sun 7/126:41 a.m.SAV - BUF
1 stop4h 23mDelta
Deal found 31/10C$ 279
Fri 5/121:00 p.m.BUF - CHS
1 stop3h 46mAmerican Airlines
Mon 8/125:05 p.m.CHS - BUF
1 stop6h 39mAmerican Airlines
Deal found 1/11C$ 280
Mon 1/126:10 a.m.BUF - CHS
1 stop7h 15mDelta
Mon 8/126:00 a.m.CHS - BUF
1 stop4h 41mDelta
Deal found 1/11C$ 282
Sat 15/117:10 p.m.BUF - CHS
1 stop4h 32mUnited Airlines
Wed 19/116:15 a.m.CHS - BUF
2 stops8h 05mUnited Airlines
Deal found 31/10C$ 283
Sat 20/1211:21 a.m.BUF - CHS
1 stop8h 03mJetBlue
Tue 30/1212:21 p.m.CHS - BUF
1 stop7h 07mJetBlue
Deal found 31/10C$ 293
Sat 6/123:18 p.m.BUF - CLT
1 stop16h 39mMultiple Airlines
Fri 19/129:34 p.m.CLT - BUF
1 stop23h 16mMultiple Airlines
Deal found 31/10C$ 305
Thu 11/1212:10 p.m.BUF - SAV
1 stop4h 06mDelta
Sun 14/125:30 a.m.SAV - BUF
1 stop5h 34mDelta
Deal found 1/11C$ 312
Tue 18/1112:17 p.m.BUF - CHS
2 stops8h 51mUnited Airlines
Wed 3/122:51 p.m.CHS - BUF
2 stops8h 43mUnited Airlines
Deal found 31/10C$ 371
Sat 6/126:00 a.m.BUF - CLT
Nonstop2h 07mAmerican Airlines
Fri 19/124:48 p.m.CLT - BUF
Nonstop1h 42mAmerican Airlines
Deal found 31/10C$ 382
Sat 15/117:00 a.m.BUF - SAV
1 stop5h 28mUnited Airlines
Wed 19/1110:00 a.m.SAV - BUF
1 stop6h 48mUnited Airlines
Deal found 1/11C$ 385
Sun 7/1212:05 p.m.BUF - CHS
2 stops22h 55mMultiple Airlines
Sat 13/128:10 p.m.CHS - BUF
1 stop19h 50mMultiple Airlines
Deal found 31/10C$ 385

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 2 November 2025.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Fly from

Buffalo

Fly to

South Carolina

Route

Depart

Return

Price

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Fri 5/12

6:25 p.m.-11:50 p.m.

1 stop5h 25m

Charleston

Sat 6/12

5:00 p.m.-11:59 p.m.

1 stop6h 59m

C$ 276

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Thu 5/2

11:51 a.m.-5:13 p.m.

1 stop5h 22m

Charleston

Sun 8/2

5:53 p.m.-12:16 a.m.

1 stop6h 23m

C$ 276

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Sun 7/12

6:12 a.m.-10:46 a.m.

1 stop4h 34m

Charleston

Sat 13/12

5:00 p.m.-11:59 p.m.

1 stop6h 59m

C$ 276

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Thu 29/1

11:51 a.m.-5:13 p.m.

1 stop5h 22m

Charleston

Sun 1/2

6:00 a.m.-11:11 a.m.

1 stop5h 11m

C$ 276

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Sat 15/11

12:05 p.m.-7:10 p.m.

1 stop7h 05m

Charleston

Wed 19/11

6:55 p.m.-10:57 p.m.

1 stop4h 02m

C$ 276

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Tue 3/2

11:51 a.m.-4:46 p.m.

1 stop4h 55m

Savannah/Hilton Head

Sat 7/2

6:50 a.m.-1:11 p.m.

1 stop6h 21m

C$ 277

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Fri 5/12

6:12 a.m.-11:00 a.m.

1 stop4h 48m

Savannah/Hilton Head

Sun 7/12

6:41 a.m.-11:04 a.m.

1 stop4h 23m

C$ 279

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Thu 11/12

6:25 p.m.-11:59 p.m.

1 stop5h 34m

Savannah/Hilton Head

Sun 14/12

7:10 p.m.-11:59 p.m.

1 stop4h 49m

C$ 279

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Fri 5/12

1:00 p.m.-4:46 p.m.

1 stop3h 46m

Charleston

Sun 7/12

6:01 a.m.-12:00 p.m.

1 stop5h 59m

C$ 280

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Fri 5/12

1:00 p.m.-4:46 p.m.

1 stop3h 46m

Charleston

Mon 8/12

5:05 p.m.-11:44 p.m.

1 stop6h 39m

C$ 280

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/11

Showing 1-10 of 50 results
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Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of C$ 66). Flying from Buffalo to South Carolina in March is currently the most expensive (average of C$ 230). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to SC?

Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 2 November 2025.

One of the essential ways to save on airfare from Buffalo to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 24% on airfare.

What is the cheapest day to fly from Buffalo to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Buffalo to South Carolina. Price data was last updated on 16 December 2024.

Travelers seeking maximum savings on their Buffalo to South Carolina flight should consider departing on Tuesday evenings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated 2 November 2025.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Buffalo to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews
Check prices

Comfort

8.0

Crew

8.6

Food

7.0

Boarding

8.1

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews
Check prices

Comfort

8.0

Crew

8.6

Food

7.0

Boarding

8.1

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
7,997 reviews
Southwest
8.0
Very good
4,241 reviews
Check prices

Comfort

8.0

Crew

8.6

Food

7.0

Boarding

8.1

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,033 reviews
Southwest
8.0
Very good
4,241 reviews
Check prices

Comfort

8.0

Crew

8.6

Food

7.0

Boarding

8.1

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Buffalo to South Carolina?

    For a flight from Buffalo to South Carolina, you will be flying from Buffalo. Buffalo (BUF) is just 13.4 km from the centre of the city.

  • How long is the flight from Buffalo to South Carolina?

    Departing from Buffalo to South Carolina will take you 2h 07m. Airlines will cover a distance of 879 km. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Buffalo to South Carolina one-way?

    The cheapest airlines for a one-way flight from Buffalo to South Carolina are JetBlue (C$ 150), Delta (C$ 157), and United Airlines (C$ 157).

  • What are the most popular routes from Buffalo to South Carolina?

    When deciding which route to take from Buffalo to South Carolina consider Buffalo - Charlotte Douglas, Buffalo - Myrtle Beach Intl or Buffalo - Savannah/Hilton Head as they are the most popular.

  • Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

    Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.

  • Can I find deals for business class flights from Buffalo to South Carolina?

    Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to South Carolina?

    Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of C$ 66). Flying from Buffalo to South Carolina in March is currently the most expensive (average of C$ 230). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Buffalo to South Carolina

Discover the top 3 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 2 November 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapestC$ 267AverageC$ 395FlexibilityNo cancel feeOn-timeN/A
Search Delta flights
SouthwestCheapestC$ 278AverageC$ 574FlexibilityNo cancel feeOn-time63%
Search Southwest flights
American AirlinesCheapestC$ 282AverageC$ 408FlexibilityNo cancel feeOn-time71%
Search American Airlines flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travelers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Buffalo to South Carolina?

Cheapflights goes through 900+ travel sites to look for the best flight deals for flights from Buffalo to South Carolina. Too many options? Cheapflights also provides filters for things like airlines, price ranges, and number of stops to help you make a decision easily.

Why should you use Cheapflights to find cheap flight tickets from Buffalo to South Carolina?

Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Buffalo to South Carolina for you. Better yet — we are completely free to use.

Can Cheapflights find flights from Buffalo to South Carolina with no change fees?

Certainly. Search results for flights to South Carolina from Buffalo shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Buffalo to South Carolina become cheaper?

Yes, Cheapflights offers price alerts on Buffalo to South Carolina flights so you can book your travel at the perfect time. Price Alerts can be enabled by clicking the bell icon next to the flight deals above and providing your email address where you want to receive the alerts.

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