How long is the flight from Buffalo to South Carolina?

Departing from Buffalo to South Carolina will take you 4h 24m. Airlines will cover a distance of 1221 km. This flight may include one or multiple stops.

In terms of precipitation, rainfall in South Carolina ranges from 76.0 - 165.0 mm per month. July is typically the wettest month, when rainfall can reach 165.0 mm. November is typically the driest time to visit South Carolina when rainfall is around 76.0 mm.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 26.0 C. Travellers hoping to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 7.0 C).

What are the most popular routes from Buffalo to South Carolina?

When deciding which route to take from Buffalo to South Carolina consider Buffalo - Charlotte Douglas, Buffalo - Charleston or Buffalo - Myrtle Beach Intl as they are the most popular.

What are the most popular airlines that fly from Buffalo to South Carolina?

The most popular airlines flying from Buffalo to South Carolina are Southwest, American Airlines and Delta. Something to consider prior to booking your flight.

What airport do you fly from for flights from Buffalo to South Carolina?

For a flight from Buffalo to South Carolina, you will be flying from Buffalo. Buffalo (BUF) is just 13.4 km from the centre of the city.

Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Buffalo to South Carolina?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.

Can I find deals for business class flights from Buffalo to South Carolina?

Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

C$ 135+ Flights from Buffalo to South Carolina

Cheap flight deals from Buffalo to South Carolina

Enter your travel dates to find the best prices.

Cheapest

Best

Direct

Last-minute

One-way

Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 4 February 2026.

Wed 25/26:01 a.m.

BUF

CLT

1 stop6h 18m

Delta

Mon 2/37:00 a.m.

CLT

BUF

1 stop7h 08m

Delta

Deal found 3/2C$ 244

Thu 20/87:40 p.m.

BUF

SAV

1 stop4h 24m

Delta

Thu 3/98:45 a.m.

SAV

BUF

1 stop6h 45m

Delta

Deal found 3/2C$ 268

Mon 23/211:28 a.m.

BUF

CHS

1 stop4h 50m

American Airlines

Mon 2/37:03 p.m.

CHS

BUF

1 stop4h 47m

American Airlines

Deal found 2/2C$ 268

Sat 11/46:08 p.m.

BUF

SAV

1 stop5h 48m

Delta

Sat 18/47:00 a.m.

SAV

BUF

1 stop7h 52m

Delta

Deal found 3/2C$ 269

Thu 12/37:38 p.m.

BUF

CHS

1 stop4h 38m

Delta

Mon 16/36:58 p.m.

CHS

BUF

1 stop4h 15m

Delta

Deal found 3/2C$ 269

Fri 20/25:09 p.m.

BUF

CLT

1 stop16h 12m

Frontier

Sat 28/210:16 a.m.

CLT

BUF

1 stop7h 29m

Frontier

Deal found 3/2C$ 272

Mon 2/35:29 p.m.

BUF

CHS

1 stop4h 19m

American Airlines

Mon 9/36:45 p.m.

CHS

BUF

1 stop5h 05m

American Airlines

Deal found 2/2C$ 273

Sat 18/45:17 p.m.

BUF

CHS

1 stop4h 38m

Delta

Sat 25/46:39 p.m.

CHS

BUF

1 stop4h 00m

Delta

Deal found 2/2C$ 275

Sat 28/26:25 p.m.

BUF

SAV

1 stop5h 01m

United Airlines

Thu 5/37:20 p.m.

SAV

BUF

1 stop4h 22m

United Airlines

Deal found 3/2C$ 277

Sat 28/210:00 a.m.

BUF

CHS

1 stop4h 49m

United Airlines

Tue 3/31:11 p.m.

CHS

BUF

2 stops10h 33m

United Airlines

Deal found 1/2C$ 281

Wed 4/310:30 a.m.

BUF

SAV

1 stop5h 52m

JetBlue

Sat 7/35:20 p.m.

SAV

BUF

1 stop6h 12m

JetBlue

Deal found 2/2C$ 296

Fri 24/76:00 a.m.

BUF

SAV

1 stop4h 37m

United Airlines

Sun 26/711:30 a.m.

SAV

BUF

1 stop5h 10m

United Airlines

Deal found 3/2C$ 314

Best flights from Buffalo to South Carolina
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated 4 February 2026.

Sat 11/46:08 p.m.

BUF

SAV

1 stop5h 48m

Delta

Wed 15/46:50 a.m.

SAV

BUF

1 stop4h 11m

Delta

Deal found 3/2C$ 269

Sat 28/210:00 a.m.

BUF

CHS

1 stop4h 49m

United Airlines

Tue 3/31:11 p.m.

CHS

BUF

2 stops10h 33m

United Airlines

Deal found 1/2C$ 281

Wed 4/310:30 a.m.

BUF

SAV

1 stop5h 52m

JetBlue

Sat 7/35:20 p.m.

SAV

BUF

1 stop6h 12m

JetBlue

Deal found 2/2C$ 296

Wed 4/312:20 p.m.

BUF

CHS

2 stops6h 50m

Southwest

Wed 11/36:30 p.m.

CHS

BUF

1 stop4h 10m

Southwest

Deal found 2/2C$ 366

Fri 24/77:40 p.m.

BUF

SAV

1 stop4h 24m

Delta

Mon 27/77:50 p.m.

SAV

BUF

1 stop4h 08m

Delta

Deal found 2/2C$ 269

Fri 24/47:37 p.m.

BUF

SAV

1 stop4h 22m

Delta

Tue 28/46:21 p.m.

SAV

BUF

1 stop4h 18m

Delta

Deal found 3/2C$ 269

Mon 20/44:59 p.m.

BUF

SAV

1 stop7h 00m

Delta

Thu 30/45:35 a.m.

SAV

BUF

1 stop5h 26m

Delta

Deal found 2/2C$ 269

Wed 13/57:34 p.m.

BUF

SAV

1 stop4h 11m

Delta

Mon 18/57:59 p.m.

SAV

BUF

1 stop4h 00m

Delta

Deal found 3/2C$ 269

Fri 24/47:45 p.m.

BUF

SAV

1 stop4h 14m

United Airlines

Tue 28/49:15 a.m.

SAV

BUF

2 stops9h 34m

United Airlines

Deal found 3/2C$ 372

Wed 13/56:05 a.m.

BUF

SAV

1 stop4h 50m

Southwest

Mon 18/52:05 p.m.

SAV

BUF

2 stops8h 40m

Southwest

Deal found 3/2C$ 378

Sat 18/45:17 p.m.

BUF

CHS

1 stop6h 33m

Delta

Sat 25/46:39 p.m.

CHS

BUF

1 stop4h 00m

Delta

Deal found 3/2C$ 269

Sat 7/37:30 p.m.

BUF

CLT

1 stop4h 27m

United Airlines

Tue 10/36:15 a.m.

CLT

BUF

2 stops7h 59m

United Airlines

Deal found 1/2C$ 391

Sat 23/54:55 p.m.

BUF

CHS

1 stop6h 01m

Delta

Sat 30/56:38 p.m.

CHS

BUF

1 stop5h 21m

Delta

Deal found 2/2C$ 269

Sat 28/24:45 p.m.

BUF

CLT

1 stop4h 50m

Southwest

Tue 3/37:45 a.m.

CLT

BUF

2 stops8h 30m

Southwest

Deal found 1/2C$ 395

Thu 12/37:38 p.m.

BUF

CHS

1 stop4h 38m

Delta

Mon 16/36:58 p.m.

CHS

BUF

1 stop4h 15m

Delta

Deal found 3/2C$ 269

Sat 11/712:35 p.m.

BUF

CLT

1 stop8h 10m

Southwest

Sat 8/88:25 a.m.

CLT

BUF

1 stop9h 10m

Southwest

Deal found 1/2C$ 402

Sat 27/67:00 a.m.

BUF

CLT

1 stop6h 54m

United Airlines

Sat 25/77:52 p.m.

CLT

BUF

1 stop4h 00m

United Airlines

Deal found 1/2C$ 419

Wed 25/25:50 a.m.

BUF

MYR

1 stop4h 25m

Southwest

Wed 4/38:15 a.m.

MYR

BUF

1 stop4h 15m

Southwest

Deal found 2/2C$ 406

Thu 25/66:00 a.m.

BUF

CLT

1 stop3h 49m

United Airlines

Sat 25/71:05 p.m.

CLT

BUF

1 stop7h 57m

United Airlines

Deal found 1/2C$ 419

Sat 28/28:35 a.m.

BUF

CLT

2 stops8h 45m

Southwest

Sat 4/43:50 p.m.

CLT

BUF

1 stop8h 05m

Southwest

Deal found 1/2C$ 406

Thu 16/47:37 p.m.

BUF

SAV

1 stop4h 22m

Delta

Tue 28/46:21 p.m.

SAV

BUF

1 stop4h 18m

Delta

Deal found 3/2C$ 325

Sat 11/712:35 p.m.

BUF

CLT

1 stop8h 10m

Southwest

Sat 18/78:15 a.m.

CLT

BUF

1 stop3h 40m

Southwest

Deal found 1/2C$ 407

Sat 11/46:08 p.m.

BUF

SAV

1 stop5h 48m

Delta

Sat 18/45:35 a.m.

SAV

BUF

1 stop5h 26m

Delta

Deal found 2/2C$ 329

Sat 28/24:45 p.m.

BUF

MYR

1 stop4h 35m

Southwest

Tue 3/311:05 a.m.

MYR

BUF

2 stops10h 50m

Southwest

Deal found 2/2C$ 412

Fri 29/54:55 p.m.

BUF

CHS

1 stop4h 44m

Delta

Mon 1/66:38 p.m.

CHS

BUF

1 stop5h 21m

Delta

Deal found 3/2C$ 339

Mon 6/47:48 p.m.

BUF

CHS

1 stop4h 28m

Delta

Thu 9/46:00 a.m.

CHS

BUF

1 stop4h 57m

Delta

Deal found 3/2C$ 339

Sat 6/61:30 p.m.

BUF

CHS

1 stop5h 54m

Delta

Thu 11/68:30 a.m.

CHS

BUF

1 stop7h 00m

Delta

Deal found 2/2C$ 355

Sun 1/36:01 a.m.

BUF

CHS

1 stop4h 55m

Delta

Sun 8/36:00 a.m.

CHS

BUF

1 stop4h 57m

Delta

Deal found 1/2C$ 355

Tue 17/22:58 p.m.

BUF

CLT

1 stop7h 19m

Delta

Tue 24/21:11 p.m.

CLT

BUF

1 stop3h 48m

Delta

Deal found 3/2C$ 358

Sat 7/31:21 p.m.

BUF

CLT

1 stop5h 33m

Delta

Tue 10/312:45 p.m.

CLT

BUF

1 stop4h 24m

Delta

Deal found 1/2C$ 384

Find flight deals from Buffalo to South Carolina

Round-trip from	C$ 244
One-way from	C$ 135
Popular in	April
Cheapest in	September
Average price	C$ 473

Delta
25/2-1/3
2 total stops
12h 14m total
Buffalo to South Carolina

Search Deals

Delta
3/5
1 total stop
4h 22m total
Buffalo to South Carolina

Search Deals

Highest demand for flights based on searches. 9% potential increase in price (C$ 64 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease (C$ 14 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in February 2026

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Sat 11/4

6:08 p.m.-11:56 p.m.

1 stop5h 48m

Savannah/Hilton Head

Wed 15/4

6:50 a.m.-11:01 a.m.

1 stop4h 11m

C$ 269

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Fri 24/7

7:40 p.m.-12:04 a.m.

1 stop4h 24m

Savannah/Hilton Head

Mon 27/7

7:50 p.m.-11:58 p.m.

1 stop4h 08m

C$ 269

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Fri 24/4

7:37 p.m.-11:59 p.m.

1 stop4h 22m

Savannah/Hilton Head

Tue 28/4

6:21 p.m.-10:39 p.m.

1 stop4h 18m

C$ 269

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Mon 20/4

4:59 p.m.-11:59 p.m.

1 stop7h 00m

Savannah/Hilton Head

Thu 30/4

5:35 a.m.-11:01 a.m.

1 stop5h 26m

C$ 269

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Wed 13/5

7:34 p.m.-11:45 p.m.

1 stop4h 11m

Savannah/Hilton Head

Mon 18/5

7:59 p.m.-11:59 p.m.

1 stop4h 00m

C$ 269

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Sat 18/4

5:17 p.m.-11:50 p.m.

1 stop6h 33m

Charleston

Sat 25/4

6:39 p.m.-10:39 p.m.

1 stop4h 00m

C$ 269

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Sat 23/5

4:55 p.m.-10:56 p.m.

1 stop6h 01m

Charleston

Sat 30/5

6:38 p.m.-11:59 p.m.

1 stop5h 21m

C$ 269

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Thu 12/3

7:38 p.m.-12:16 a.m.

1 stop4h 38m

Charleston

Mon 16/3

6:58 p.m.-11:13 p.m.

1 stop4h 15m

C$ 269

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Sat 28/2

10:00 a.m.-2:49 p.m.

1 stop4h 49m

Charleston

Tue 3/3

1:11 p.m.-11:44 p.m.

2 stops10h 33m

C$ 281

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Wed 4/3

10:30 a.m.-4:22 p.m.

1 stop5h 52m

Savannah/Hilton Head

Sat 7/3

5:20 p.m.-11:32 p.m.

1 stop6h 12m

C$ 296

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/2

Showing 1-10 of 60 results

...

Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.

BUF-CLT

BUF-CHS

BUF-SAV

BUF-MYR

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

BUF-USSC

BUF-CLT

BUF-CHS

BUF-SAV

BUF-MYR

What is the cheapest month to book a flight from Buffalo to South Carolina?

Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of C$ 64). Flying from Buffalo to South Carolina in March is currently the most expensive (average of C$ 164). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to SC?

One of the essential ways to save on airfare from Buffalo to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 65% on airfare.

Reviews of airlines servicing South Carolina

Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Buffalo to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,272 reviews

Check prices

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Southwest

8.0

Very good

4,272 reviews

Southwest

8.0

Very good

4,272 reviews

Check prices

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Delta

7.9

Good

8,138 reviews

Southwest

8.0

Very good

4,272 reviews

Check prices

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

American Airlines

7.2

Good

11,218 reviews

Southwest

8.0

Very good

4,272 reviews

Check prices

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

JetBlue

7.2

Good

2,893 reviews

Southwest

8.0

Very good

4,272 reviews

Check prices

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

What airport do you fly from for flights from Buffalo to South Carolina?
For a flight from Buffalo to South Carolina, you will be flying from Buffalo. Buffalo (BUF) is just 13.4 km from the centre of the city.
How long is the flight from Buffalo to South Carolina?
Departing from Buffalo to South Carolina will take you 4h 24m. Airlines will cover a distance of 1221 km. This flight may include one or multiple stops.
What are the most popular routes from Buffalo to South Carolina?
When deciding which route to take from Buffalo to South Carolina consider Buffalo - Charlotte Douglas, Buffalo - Charleston or Buffalo - Myrtle Beach Intl as they are the most popular.
Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?
Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Buffalo to South Carolina?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.
Can I find deals for business class flights from Buffalo to South Carolina?
Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of C$ 64). Flying from Buffalo to South Carolina in March is currently the most expensive (average of C$ 164). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Buffalo to South Carolina

Airline	Cheapest	Average	Flexibility	On-time
JetBlue	CheapestC$ 137	AverageC$ 274	FlexibilityNo cancel fee	On-time62%	Search JetBlue flights
Delta	CheapestC$ 176	AverageC$ 352	FlexibilityNo cancel fee	On-timeN/A	Search Delta flights
Southwest	CheapestC$ 271	AverageC$ 530	FlexibilityNo cancel fee	On-time63%	Search Southwest flights
American Airlines	CheapestC$ 297	AverageC$ 428	FlexibilityNo cancel fee	On-time71%	Search American Airlines flights

Fly with Cheapflights

How does Cheapflights help users find flights from Buffalo to South Carolina?

Cheapflights goes through 900+ travel sites to look for the best flight deals for flights from Buffalo to South Carolina. Too many options? Cheapflights also provides filters for things like airlines, price ranges, and number of stops to help you make a decision easily.

Why should you use Cheapflights to find cheap flight tickets from Buffalo to South Carolina?

Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Buffalo to South Carolina for you. Better yet — we are completely free to use.

Can Cheapflights find flights from Buffalo to South Carolina with no change fees?

Certainly. Search results for flights to South Carolina from Buffalo shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Buffalo to South Carolina become cheaper?

Yes, Cheapflights offers price alerts on Buffalo to South Carolina flights so you can book your travel at the perfect time. Price Alerts can be enabled by clicking the bell icon next to the flight deals above and providing your email address where you want to receive the alerts.

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Cheap flights from Buffalo to South Carolina from C$ 135

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 25/4. Fares are subject to change and may not be available on all flights or dates of travel.

Cheap flight deals from Buffalo to South Carolina

Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 4 February 2026.

Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 4 February 2026.

Best flights from Buffalo to South CarolinaDiscover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated 4 February 2026.

Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated 4 February 2026.

Direct flights from Buffalo to South CarolinaExplore direct flight options from Buffalo to South Carolina based on user searches, and compare prices and availability for your desired travel dates. Data last updated 4 February 2026.

Explore direct flight options from Buffalo to South Carolina based on user searches, and compare prices and availability for your desired travel dates. Data last updated 4 February 2026.

Last-minute flights from Buffalo to South CarolinaDiscover last-minute flight deals from Buffalo to South Carolina. Data last updated 4 February 2026 and is based on user searches.

Discover last-minute flight deals from Buffalo to South Carolina. Data last updated 4 February 2026 and is based on user searches.

One-way flights from Buffalo to South CarolinaSearch for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated 4 February 2026.

Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated 4 February 2026.

Find flight deals from Buffalo to South Carolina

Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated 4 February 2026.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

What is the cheapest time of day to fly from BUF to SC?

Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 4 February 2026.

Reviews of airlines servicing South Carolina

Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Buffalo to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly from for flights from Buffalo to South Carolina?

How long is the flight from Buffalo to South Carolina?

What are the most popular routes from Buffalo to South Carolina?

Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

How can I find direct flights from Buffalo to South Carolina?

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Buffalo and South Carolina flights

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Buffalo to South Carolina flights

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Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 4 February 2026.

Best flights from Buffalo to South Carolina
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated 4 February 2026.

Direct flights from Buffalo to South Carolina
Explore direct flight options from Buffalo to South Carolina based on user searches, and compare prices and availability for your desired travel dates. Data last updated 4 February 2026.

Last-minute flights from Buffalo to South Carolina
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated 4 February 2026 and is based on user searches.

One-way flights from Buffalo to South Carolina
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated 4 February 2026.