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Cheap flights from Buffalo to South Carolina from C$ 115

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/5. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
21 Apr — 28 Apr1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Buffalo to South Carolina

Enter your travel dates to find the best prices.

Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 22 March 2026.

Fri 17/44:00 p.m.
BUF
-
SAV
1 stop5h 20m
Southwest
Tue 21/48:05 a.m.
SAV
-
BUF
1 stop6h 30m
Southwest
Deal found 19/3C$ 344
Sat 2/512:25 p.m.
BUF
-
CHS
1 stop4h 32m
JetBlue
Tue 5/56:00 a.m.
CHS
-
BUF
1 stop7h 33m
JetBlue
Deal found 17/3C$ 344
Tue 12/54:00 p.m.
BUF
-
CHS
1 stop4h 25m
Southwest
Thu 14/51:15 p.m.
CHS
-
BUF
1 stop4h 55m
Southwest
Deal found 17/3C$ 350
Fri 10/411:25 a.m.
BUF
-
SAV
2 stops9h 50m
Southwest
Fri 17/47:00 p.m.
SAV
-
BUF
1 stop4h 20m
Southwest
Deal found 19/3C$ 351
Sat 2/52:00 p.m.
BUF
-
CHS
1 stop7h 00m
Southwest
Sat 9/56:45 p.m.
CHS
-
BUF
1 stop4h 40m
Southwest
Deal found 21/3C$ 353
Sat 18/45:35 a.m.
BUF
-
SAV
2 stops11h 05m
Southwest
Tue 21/46:40 a.m.
SAV
-
BUF
2 stops7h 55m
Southwest
Deal found 19/3C$ 358
Sat 18/45:35 a.m.
BUF
-
SAV
2 stops11h 05m
Southwest
Sat 25/47:15 a.m.
SAV
-
BUF
1 stop10h 45m
Southwest
Deal found 18/3C$ 359
Mon 4/511:25 a.m.
BUF
-
SAV
1 stop4h 25m
Southwest
Mon 11/52:05 p.m.
SAV
-
BUF
1 stop5h 40m
Southwest
Deal found 20/3C$ 366
Mon 8/66:05 a.m.
BUF
-
CHS
1 stop3h 50m
Southwest
Sat 13/67:20 a.m.
CHS
-
BUF
1 stop6h 35m
Southwest
Deal found 20/3C$ 366
Sun 11/107:40 p.m.
BUF
-
SAV
1 stop4h 19m
Delta
Tue 13/107:50 p.m.
SAV
-
BUF
1 stop4h 05m
Delta
Deal found 20/3C$ 372
Fri 17/47:45 p.m.
BUF
-
SAV
1 stop4h 14m
United Airlines
Tue 21/49:15 a.m.
SAV
-
BUF
2 stops9h 34m
United Airlines
Deal found 21/3C$ 373
Sat 6/66:15 a.m.
BUF
-
CHS
1 stop5h 55m
Delta
Thu 11/612:15 p.m.
CHS
-
BUF
1 stop6h 26m
Delta
Deal found 17/3C$ 375

Find flight deals from Buffalo to South Carolina

Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated 22 March 2026.

Round-trip from

C$ 344

One-way from

C$ 115

Popular in

March

Cheapest in

September

Average price

C$ 610
Southwest
  • Southwest
  • 17/4-21/4
  • 2 total stops
  • 11h 50m total
  • Buffalo to South Carolina
Search Deals
Delta
  • Delta
  • 5/5
  • 1 total stop
  • 4h 37m total
  • Buffalo to South Carolina
Search Deals
Highest demand for flights based on searches. 13% potential increase in price (C$ 97 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (C$ 18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 22 March 2026.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Sat 18/4

5:35 a.m.-4:40 p.m.

2 stops11h 05m

Savannah/Hilton Head

Tue 21/4

6:40 a.m.-2:35 p.m.

2 stops7h 55m

C$ 358

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Tue 5/5

6:00 a.m.-10:46 a.m.

1 stop4h 46m

Charleston

Tue 12/5

5:55 p.m.-12:19 a.m.

1 stop6h 24m

C$ 377

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Mon 8/6

7:40 p.m.-11:57 p.m.

1 stop4h 17m

Charleston

Mon 15/6

5:30 a.m.-11:15 a.m.

1 stop5h 45m

C$ 380

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Sat 22/8

4:30 p.m.-9:47 p.m.

1 stop5h 17m

Charleston

Sun 30/8

5:55 p.m.-11:58 p.m.

1 stop6h 03m

C$ 380

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Mon 8/6

7:40 p.m.-11:57 p.m.

1 stop4h 17m

Charleston

Sat 13/6

6:30 p.m.-11:03 p.m.

1 stop4h 33m

C$ 380

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Tue 12/5

7:00 a.m.-3:13 p.m.

1 stop8h 13m

Savannah/Hilton Head

Thu 14/5

5:45 a.m.-9:53 a.m.

1 stop4h 08m

C$ 385

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Tue 25/8

6:00 a.m.-2:11 p.m.

2 stops8h 11m

Savannah/Hilton Head

Sat 5/9

7:15 p.m.-11:52 p.m.

1 stop4h 37m

C$ 392

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Mon 6/7

7:00 p.m.-11:52 p.m.

1 stop4h 52m

Savannah/Hilton Head

Sat 11/7

7:15 p.m.-11:59 p.m.

1 stop4h 44m

C$ 395

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Wed 10/6

11:00 a.m.-8:25 p.m.

2 stops9h 25m

Charleston

Mon 15/6

7:35 p.m.-12:10 a.m.

1 stop4h 35m

C$ 414

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Fri 3/4

7:48 p.m.-12:16 a.m.

1 stop4h 28m

Charleston

Fri 17/4

5:47 p.m.-12:50 a.m.

1 stop7h 03m

C$ 417

Flights are sorted by cheapest round-trip flights first.

Deals found on 20/3

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of C$ 66). Flying from Buffalo to South Carolina in August is currently the most expensive (average of C$ 162). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to SC?

Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 22 March 2026.

One of the essential ways to save on airfare from Buffalo to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 65% on airfare.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated 22 March 2026.
Get a feel of what it's like to fly with Southwest,Delta, andJetBlue from Buffalo to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,325 reviews
Check prices

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
8.0
Very good
4,325 reviews
Southwest
8.0
Very good
4,325 reviews
Check prices

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Delta
7.9
Good
8,317 reviews
Southwest
8.0
Very good
4,325 reviews
Check prices

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
JetBlue
7.2
Good
2,911 reviews
Southwest
8.0
Very good
4,325 reviews
Check prices

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
American Airlines
7.1
Good
11,485 reviews
Southwest
8.0
Very good
4,325 reviews
Check prices

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Buffalo to South Carolina?

    For a flight from Buffalo to South Carolina, you will be flying from Buffalo. Buffalo (BUF) is just 13.4 km from the centre of the city.

  • How long is the flight from Buffalo to South Carolina?

    Departing from Buffalo to South Carolina will take you 4h 46m. Airlines will cover a distance of 1122 km. This flight may include one or multiple stops.

  • What are the most popular routes from Buffalo to South Carolina?

    When deciding which route to take from Buffalo to South Carolina consider Buffalo - Myrtle Beach Intl, Buffalo - Charleston or Buffalo - Charlotte Douglas as they are the most popular.

  • Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

    Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.

  • Can I find deals for business class flights from Buffalo to South Carolina?

    Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to South Carolina?

    Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of C$ 66). Flying from Buffalo to South Carolina in August is currently the most expensive (average of C$ 162). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 4 airlines flying from Buffalo to South Carolina

Discover the top 4 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 22 March 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapestC$ 176AverageC$ 435FlexibilityNo cancel feeOn-timeN/A
Search Delta flights
JetBlueCheapestC$ 220AverageC$ 275FlexibilityNo cancel feeOn-time62%
Search JetBlue flights
SouthwestCheapestC$ 272AverageC$ 511FlexibilityNo cancel feeOn-time63%
Search Southwest flights
American AirlinesCheapestC$ 298AverageC$ 430FlexibilityNo cancel feeOn-time71%
Search American Airlines flights

Fly with Cheapflights

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How does Cheapflights help users find flights from Buffalo to South Carolina?

Cheapflights goes through 900+ travel sites to look for the best flight deals for flights from Buffalo to South Carolina. Too many options? Cheapflights also provides filters for things like airlines, price ranges, and number of stops to help you make a decision easily.

Why should you use Cheapflights to find cheap flight tickets from Buffalo to South Carolina?

Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Buffalo to South Carolina for you. Better yet — we are completely free to use.

Can Cheapflights find flights from Buffalo to South Carolina with no change fees?

Certainly. Search results for flights to South Carolina from Buffalo shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Buffalo to South Carolina become cheaper?

Yes, Cheapflights offers price alerts on Buffalo to South Carolina flights so you can book your travel at the perfect time. Price Alerts can be enabled by clicking the bell icon next to the flight deals above and providing your email address where you want to receive the alerts.

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