What are the cheapest airlines to fly from Buffalo to South Carolina one-way?

The cheapest airlines for a one-way flight from Buffalo to South Carolina are JetBlue (C$ 139), Frontier (C$ 149), and Southwest (C$ 163).

In terms of precipitation, rainfall in South Carolina ranges from 76.0 - 165.0 mm per month. July is typically the wettest month, when rainfall can reach 165.0 mm. November is typically the driest time to visit South Carolina when rainfall is around 76.0 mm.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 26.0 C. Travellers hoping to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 7.0 C).

What are the most popular routes from Buffalo to South Carolina?

When deciding which route to take from Buffalo to South Carolina consider Buffalo - Charlotte Douglas, Buffalo - Myrtle Beach Intl or Buffalo - Charleston as they are the most popular.

What are the most popular airlines that fly from Buffalo to South Carolina?

The most popular airlines flying from Buffalo to South Carolina are American Airlines, Delta and United Airlines. Something to consider prior to booking your flight.

How far in advance should I book a flight from Buffalo to South Carolina?

To save on the cost of your flight from Buffalo to South Carolina, book at least 29 days before your planned departure. Booking around this time can save you about 101% on the cost of this flight compared to booking a flight leaving this week. We have found prices from C$ 484 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as C$ 818.

What is the cheapest month to fly from Buffalo to South Carolina?

Flights from Buffalo to South Carolina lean towards being more expensive in April. Prices are generally better when you fly from Buffalo to South Carolina in September, with the cheapest ticket starting at C$ 295.

What airport do you fly from for flights from Buffalo to South Carolina?

For a flight from Buffalo to South Carolina, you will be flying from Buffalo. Buffalo (BUF) is just 13.4 km from the centre of the city.

Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Buffalo to South Carolina?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.

Can I find deals for business class flights from Buffalo to South Carolina?

Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

C$ 137+ Flights from Buffalo to South Carolina

Cheap flight deals from Buffalo to South Carolina

Round-trip from	C$ 273
One-way from	C$ 139
Popular in	April
Cheapest in	September
Average price	C$ 519

Frontier
28/8-1/9
2 total stops
20h 35m total
Buffalo to South Carolina

Search Deals

JetBlue
14/9
1 total stop
4h 25m total
Buffalo to South Carolina

Search Deals

Highest demand for flights based on searches. 8% potential increase in price (C$ 66 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease (C$ 13 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in July 2025

Search Deals

Find flight deals from Buffalo to South Carolina

Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 30 July 2025.

Fri 31/105:14 a.m.BUF - MYR

1 stop6h 42mAmerican Airlines

Tue 4/1112:47 p.m.MYR - BUF

1 stop4h 06mAmerican Airlines

Deal found 28/7C$ 298

Sat 30/812:18 p.m.BUF - MYR

1 stop5h 29mDelta

Sat 6/96:35 p.m.MYR - BUF

1 stop4h 24mDelta

Deal found 28/7C$ 313

Fri 31/105:45 p.m.BUF - SAV

1 stop4h 46mDelta

Sun 2/115:40 a.m.SAV - BUF

1 stop4h 30mDelta

Deal found 30/7C$ 313

Thu 28/811:12 a.m.BUF - CLT

1 stop9h 34mFrontier

Mon 1/99:09 a.m.CLT - BUF

1 stop11h 01mFrontier

Deal found 28/7C$ 313

Sat 18/109:00 a.m.BUF - SAV

2 stops10h 40mSouthwest

Tue 21/102:10 p.m.SAV - BUF

1 stop6h 20mSouthwest

Deal found 30/7C$ 323

Fri 17/107:30 p.m.BUF - CHS

1 stop4h 29mDelta

Sun 19/1012:54 p.m.CHS - BUF

1 stop5h 31mDelta

Deal found 29/7C$ 327

Wed 3/97:40 a.m.BUF - CLT

2 stops8h 55mSouthwest

Tue 9/96:35 p.m.CLT - BUF

1 stop4h 25mSouthwest

Deal found 28/7C$ 334

Sat 18/106:10 a.m.BUF - CHS

1 stop3h 50mSouthwest

Tue 21/106:30 a.m.CHS - BUF

2 stops6h 00mSouthwest

Deal found 29/7C$ 334

Tue 2/92:21 p.m.BUF - CLT

1 stop7h 35mDelta

Wed 10/96:00 a.m.CLT - BUF

1 stop4h 55mDelta

Deal found 28/7C$ 377

Mon 25/85:50 a.m.BUF - MYR

1 stop4h 10mSouthwest

Sun 7/94:30 p.m.MYR - BUF

2 stops7h 00mSouthwest

Deal found 28/7C$ 378

Thu 28/811:54 a.m.BUF - CLT

Nonstop1h 56mAmerican Airlines

Mon 1/94:55 p.m.CLT - BUF

Nonstop1h 41mAmerican Airlines

Deal found 28/7C$ 401

Thu 28/88:00 p.m.BUF - CLT

1 stop3h 59mUnited Airlines

Wed 3/91:52 p.m.CLT - BUF

2 stops10h 06mUnited Airlines

Deal found 28/7C$ 411

Best flights from Buffalo to South Carolina
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated 30 July 2025.

Thu 28/811:12 a.m.BUF - CLT

1 stop9h 34mFrontier

Mon 1/99:09 a.m.CLT - BUF

1 stop11h 01mFrontier

Deal found 30/7C$ 273

Sat 30/812:18 p.m.BUF - MYR

1 stop5h 29mDelta

Sat 6/96:35 p.m.MYR - BUF

1 stop4h 24mDelta

Deal found 28/7C$ 313

Sat 18/109:00 a.m.BUF - SAV

2 stops10h 40mSouthwest

Tue 21/102:10 p.m.SAV - BUF

1 stop6h 20mSouthwest

Deal found 30/7C$ 323

Tue 19/810:04 a.m.BUF - MYR

1 stop4h 08mAmerican Airlines

Wed 20/84:34 p.m.MYR - BUF

1 stop5h 06mAmerican Airlines

Deal found 28/7C$ 324

Wed 29/1010:37 a.m.BUF - SAV

3 stops13h 19mUnited Airlines

Sat 1/114:21 p.m.SAV - BUF

1 stop6h 37mUnited Airlines

Deal found 30/7C$ 426

Fri 31/105:45 p.m.BUF - SAV

1 stop4h 46mDelta

Sun 2/115:40 a.m.SAV - BUF

1 stop4h 30mDelta

Deal found 30/7C$ 313

Wed 3/97:40 a.m.BUF - CLT

2 stops8h 55mSouthwest

Tue 9/96:35 p.m.CLT - BUF

1 stop4h 25mSouthwest

Deal found 29/7C$ 334

Fri 17/107:30 p.m.BUF - CHS

1 stop4h 29mDelta

Sun 19/1012:54 p.m.CHS - BUF

1 stop5h 31mDelta

Deal found 29/7C$ 327

Sat 27/1211:15 a.m.BUF - SAV

1 stop6h 59mJetBlue

Fri 2/17:09 p.m.SAV - BUF

1 stop4h 48mJetBlue

Deal found 29/7C$ 728

Sat 18/106:10 a.m.BUF - CHS

1 stop3h 50mSouthwest

Tue 21/106:30 a.m.CHS - BUF

2 stops6h 00mSouthwest

Deal found 29/7C$ 334

Thu 28/87:38 p.m.BUF - CLT

Nonstop1h 57mAmerican Airlines

Mon 1/99:10 a.m.CLT - BUF

Nonstop1h 40mAmerican Airlines

Deal found 29/7C$ 404

Sat 25/101:57 p.m.BUF - CLT

1 stop7h 44mUnited Airlines

Tue 28/106:40 a.m.CLT - BUF

2 stops7h 40mUnited Airlines

Deal found 29/7C$ 443

Last-minute flights from Buffalo to South Carolina
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated 30 July 2025 and is based on user searches.

Tue 5/86:28 a.m.BUF - CLT

Nonstop1h 57mAmerican Airlines

Sat 9/89:10 a.m.CLT - BUF

Nonstop1h 54mAmerican Airlines

Deal found 28/7C$ 528

Tue 5/81:20 p.m.BUF - CLT

1 stop6h 40mSouthwest

Wed 6/810:50 a.m.CLT - BUF

1 stop4h 25mSouthwest

Deal found 28/7C$ 557

Wed 6/86:04 a.m.BUF - CLT

1 stop5h 02mDelta

Wed 13/81:09 p.m.CLT - BUF

1 stop11h 34mDelta

Deal found 30/7C$ 538

Wed 6/810:15 a.m.BUF - MYR

2 stops9h 30mSouthwest

Wed 13/86:30 a.m.MYR - BUF

1 stop6h 00mSouthwest

Deal found 30/7C$ 542

Wed 6/86:00 a.m.BUF - SAV

2 stops8h 41mUnited Airlines

Fri 8/87:07 p.m.SAV - BUF

1 stop4h 37mUnited Airlines

Deal found 30/7C$ 652

Wed 6/86:00 a.m.BUF - CLT

2 stops6h 40mUnited Airlines

Wed 13/810:29 a.m.CLT - BUF

1 stop3h 43mUnited Airlines

Deal found 30/7C$ 688

Thu 7/89:07 p.m.BUF - CLT

1 stop16h 15mFrontier

Sun 10/87:03 p.m.CLT - BUF

1 stop12h 44mFrontier

Deal found 29/7C$ 440

Thu 7/812:25 p.m.BUF - CHS

2 stops10h 15mSouthwest

Sun 10/86:55 a.m.CHS - BUF

1 stop5h 20mSouthwest

Deal found 30/7C$ 599

Fri 8/812:50 p.m.BUF - SAV

1 stop7h 00mSouthwest

Mon 11/810:55 a.m.SAV - BUF

2 stops8h 40mSouthwest

Deal found 29/7C$ 659

Fri 8/810:30 a.m.BUF - MYR

1 stop3h 36mUnited Airlines

Sat 9/85:12 p.m.MYR - BUF

1 stop6h 27mUnited Airlines

Deal found 28/7C$ 786

Sat 9/85:03 p.m.BUF - MYR

1 stop5h 11mDelta

Wed 20/86:00 a.m.MYR - BUF

1 stop4h 57mDelta

Deal found 28/7C$ 508

Sat 9/87:38 p.m.BUF - MYR

1 stop4h 07mAmerican Airlines

Tue 19/86:10 a.m.MYR - BUF

2 stops6h 57mAmerican Airlines

Deal found 28/7C$ 568

One-way flights from Buffalo to South Carolina
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated 30 July 2025.

Thu 11/91:23 p.m.BUF - CLT

1 stop5h 42mFrontier

Deal found 28/7C$ 137

Sun 14/96:00 a.m.BUF - CHS

1 stop4h 25mJetBlue

Deal found 28/7C$ 139

Sat 13/96:50 p.m.BUF - MYR

1 stop4h 18mAmerican Airlines

Deal found 30/7C$ 163

Tue 26/85:50 a.m.BUF - CLT

1 stop4h 15mSouthwest

Deal found 27/7C$ 163

Tue 26/85:10 p.m.BUF - MYR

1 stop6h 39mDelta

Deal found 28/7C$ 164

Sat 6/91:00 p.m.BUF - SAV

1 stop5h 03mAmerican Airlines

Deal found 29/7C$ 164

Sat 30/86:50 p.m.BUF - CLT

1 stop4h 31mDelta

Deal found 28/7C$ 189

Sat 6/96:00 a.m.BUF - SAV

2 stops8h 43mUnited Airlines

Deal found 29/7C$ 218

Wed 15/106:00 a.m.BUF - CHS

2 stops7h 15mSouthwest

Deal found 30/7C$ 247

Thu 28/86:10 a.m.BUF - MYR

2 stops11h 00mSouthwest

Deal found 28/7C$ 261

Thu 23/104:15 p.m.BUF - SAV

2 stops6h 45mSouthwest

Deal found 30/7C$ 283

Tue 26/85:54 p.m.BUF - CLT

1 stop16h 32mUnited Airlines

Deal found 28/7C$ 308

Cheapflights Fare Finder

Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Thu 28/8

11:12 a.m.-8:46 p.m.

1 stop9h 34m

Charlotte Douglas

Mon 1/9

9:09 a.m.-8:10 p.m.

1 stop11h 01m

C$ 273

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Sat 30/8

12:18 p.m.-5:47 p.m.

1 stop5h 29m

Myrtle Beach Intl

Sat 6/9

6:35 p.m.-10:59 p.m.

1 stop4h 24m

C$ 313

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Fri 31/10

5:45 p.m.-10:31 p.m.

1 stop4h 46m

Savannah/Hilton Head

Sun 2/11

5:40 a.m.-10:10 a.m.

1 stop4h 30m

C$ 313

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Sat 18/10

9:00 a.m.-7:40 p.m.

2 stops10h 40m

Savannah/Hilton Head

Tue 21/10

2:10 p.m.-8:30 p.m.

1 stop6h 20m

C$ 323

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Tue 19/8

10:04 a.m.-2:12 p.m.

1 stop4h 08m

Myrtle Beach Intl

Wed 20/8

4:34 p.m.-9:40 p.m.

1 stop5h 06m

C$ 324

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Fri 17/10

7:30 p.m.-11:59 p.m.

1 stop4h 29m

Charleston

Sun 19/10

12:54 p.m.-6:25 p.m.

1 stop5h 31m

C$ 327

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Wed 3/9

7:40 a.m.-4:35 p.m.

2 stops8h 55m

Charlotte Douglas

Tue 9/9

6:35 p.m.-11:00 p.m.

1 stop4h 25m

C$ 334

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Sat 18/10

6:10 a.m.-10:00 a.m.

1 stop3h 50m

Charleston

Tue 21/10

6:30 a.m.-12:30 p.m.

2 stops6h 00m

C$ 334

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Sat 25/10

7:00 a.m.-1:23 p.m.

1 stop6h 23m

Charlotte Douglas

Tue 28/10

6:00 a.m.-12:09 p.m.

1 stop6h 09m

C$ 377

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Mon 25/8

5:50 a.m.-10:00 a.m.

1 stop4h 10m

Myrtle Beach Intl

Sun 7/9

4:30 p.m.-11:30 p.m.

2 stops7h 00m

C$ 378

Flights are sorted by cheapest round-trip flights first.

Deals found on 28/7

Showing 1-10 of 30 results

Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

Currently, September is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of C$ 407). Flying from Buffalo to South Carolina in March is currently the most expensive (average of C$ 503). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to SC?

When flying from Buffalo to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South Carolina

Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Buffalo to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,241 reviews

Check prices

Reviews

1 / 20

8.0

Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Southwest

8.0

Very good

4,241 reviews

Southwest

8.0

Very good

4,241 reviews

Check prices

Reviews

1 / 20

8.0

Excellent

Gina,Jul 2025

LAS - DEN

Delta

8.0

Very good

7,980 reviews

Southwest

8.0

Very good

4,241 reviews

Check prices

Reviews

1 / 20

8.0

Excellent

Gina,Jul 2025

LAS - DEN

United Airlines

7.4

Good

8,896 reviews

Southwest

8.0

Very good

4,241 reviews

Check prices

Reviews

1 / 20

8.0

Excellent

Gina,Jul 2025

LAS - DEN

JetBlue

7.3

Good

2,913 reviews

Southwest

8.0

Very good

4,241 reviews

Check prices

Reviews

1 / 20

8.0

Excellent

Gina,Jul 2025

LAS - DEN

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,241 reviews

Check prices

Reviews

1 / 20

8.0

Excellent

Gina,Jul 2025

LAS - DEN

Related info for your journey

What airport do you fly from for flights from Buffalo to South Carolina?
For a flight from Buffalo to South Carolina, you will be flying from Buffalo. Buffalo (BUF) is just 13.4 km from the centre of the city.
What are the cheapest airlines to fly from Buffalo to South Carolina one-way?
The cheapest airlines for a one-way flight from Buffalo to South Carolina are JetBlue (C$ 139), Frontier (C$ 149), and Southwest (C$ 163).
What are the most popular routes from Buffalo to South Carolina?
When deciding which route to take from Buffalo to South Carolina consider Buffalo - Charlotte Douglas, Buffalo - Myrtle Beach Intl or Buffalo - Charleston as they are the most popular.
Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?
Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Buffalo to South Carolina?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.
Can I find deals for business class flights from Buffalo to South Carolina?
Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, September is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of C$ 407). Flying from Buffalo to South Carolina in March is currently the most expensive (average of C$ 503). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

South Carolina car rentals

Charleston Airport car rentals

Myrtle Beach Intl Airport car rentals

Greenville Airport car rentals

Columbia Metropolitan Airport car rentals

Hilton Head Island Airport car rentals

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Direct flights to United States

Top 4 airlines flying from Buffalo to South Carolina

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	CheapestC$ 243	AverageC$ 428	FlexibilityNo cancel fee	On-time71%	Search American Airlines flights
Delta	CheapestC$ 263	AverageC$ 367	FlexibilityNo cancel fee	On-timeN/A	Search Delta flights
United Airlines	CheapestC$ 340	AverageC$ 871	FlexibilityNo cancel fee	On-time69%	Search United Airlines flights
Southwest	CheapestC$ 347	AverageC$ 533	FlexibilityNo cancel fee	On-time63%	Search Southwest flights

Fly with Cheapflights

How does Cheapflights help users find flights from Buffalo to South Carolina?

Cheapflights goes through 900+ travel sites to look for the best flight deals for flights from Buffalo to South Carolina. Too many options? Cheapflights also provides filters for things like airlines, price ranges, and number of stops to help you make a decision easily.

Why should you use Cheapflights to find cheap flight tickets from Buffalo to South Carolina?

Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Buffalo to South Carolina for you. Better yet — we are completely free to use.

Can Cheapflights find flights from Buffalo to South Carolina with no change fees?

Certainly. Search results for flights to South Carolina from Buffalo shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Buffalo to South Carolina become cheaper?

Yes, Cheapflights offers price alerts on Buffalo to South Carolina flights so you can book your travel at the perfect time. Price Alerts can be enabled by clicking the bell icon next to the flight deals above and providing your email address where you want to receive the alerts.

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Cheap flights from Buffalo to South Carolina from C$ 137

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/9. Fares are subject to change and may not be available on all flights or dates of travel.

Cheap flight deals from Buffalo to South Carolina

Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated 30 July 2025.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Buffalo to South Carolina

Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 30 July 2025.

Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 30 July 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

What is the cheapest time of day to fly from BUF to SC?

Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 30 July 2025.

Reviews of airlines servicing South Carolina

Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Buffalo to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly from for flights from Buffalo to South Carolina?

What are the cheapest airlines to fly from Buffalo to South Carolina one-way?

What are the most popular routes from Buffalo to South Carolina?

Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

How can I find direct flights from Buffalo to South Carolina?

Can I find deals for business class flights from Buffalo to South Carolina?

What is the cheapest month to book a flight from Buffalo to South Carolina?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Buffalo to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Buffalo to South Carolina

Fly with Cheapflights

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How does Cheapflights help users find flights from Buffalo to South Carolina?

Why should you use Cheapflights to find cheap flight tickets from Buffalo to South Carolina?

Can Cheapflights find flights from Buffalo to South Carolina with no change fees?

Can Cheapflights notify me if prices for flights from Buffalo to South Carolina become cheaper?

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Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 30 July 2025.