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Cheap flights from Santiago to Santo Domingo from C$ 438

SCL — SDQ
9 Dec — 16 Dec1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Santiago to Santo Domingo

Enter your travel dates to find the best prices.

Cheapest flights from Santiago to Santo Domingo

Sat 5/127:30 a.m. -
1 stop11h 20m
Sat 12/1212:45 p.m. -
1 stop11h 20m
Deal found 6/11C$ 973
Sat 14/119:25 a.m. -
1 stop13h 15m
Sun 22/113:55 p.m. -
1 stop12h 05m
Deal found 5/11C$ 987
Tue 8/121:07 a.m. -
1 stop22h 51m
Tue 12/112:42 p.m. -
1 stop9h 58m
Deal found 8/11C$ 1,031
Sat 19/125:07 a.m. -
1 stop14h 22m
Sun 10/18:52 a.m. -
1 stop20h 05m
Deal found 4/11C$ 1,064
Mon 14/121:31 a.m. -
1 stop22h 27m
Sat 2/17:05 p.m. -
1 stop28h 23m
Deal found 8/11C$ 1,075
Fri 18/121:07 a.m. -
1 stop13h 07m
Fri 22/112:42 p.m. -
1 stop10h 46m
Deal found 8/11C$ 1,096
Sat 19/121:07 a.m. -
1 stop22h 51m
Sat 27/212:05 p.m. -
1 stop10h 36m
Deal found 4/11C$ 1,140
Mon 21/121:07 a.m. -
1 stop11h 35m
Fri 8/112:42 p.m. -
1 stop13h 11m
Deal found 4/11C$ 1,175
Fri 25/123:48 a.m. -
1 stop13h 25m
Sun 31/15:50 a.m. -
1 stop21h 00m
Deal found 5/11C$ 1,208
Mon 21/1212:20 p.m. -
1 stop25h 54m
Mon 4/17:05 p.m. -
1 stop28h 23m
Deal found 4/11C$ 1,219
Sat 5/1212:20 p.m. -
1 stop11h 38m
Sat 12/1212:45 p.m. -
2 stops35h 28m
Deal found 6/11C$ 1,225

Find flight deals from Santiago to Santo Domingo

Round-trip from

C$ 855

One-way from

C$ 438

Popular in

January

Cheapest in

March

Average price

C$ 809
Avianca
  • Avianca
  • 8/2-21/2
  • 2 total stops
  • 46h 00m total
  • Santiago to Santo Domingo
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Avianca
  • Avianca
  • 4/4-31/12
  • 1 total stop
  • 11h 15m total
  • Santiago to Santo Domingo
Search Deals
Highest demand for flights based on searches. 8% potential increase in price (C$ 116 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease (C$ 14 potential savings vs. average RT price).
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Average for round-trip flights in November 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Santiago to Santo Domingo that are best for you.

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Route

Depart

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Price

Cheapest round-trip

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Sat 28/11

9:25 a.m.-9:40 p.m.

1 stop13h 15m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-1:30 a.m.

Nonstop0h 00m

C$ 462

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Mon 30/11

6:00 a.m.-4:45 p.m.

1 stop11h 45m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-1:30 a.m.

Nonstop0h 00m

C$ 490
Quickest round-trip

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Thu 10/12

3:48 a.m.-1:14 p.m.

1 stop10h 26m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-1:30 a.m.

Nonstop0h 00m

C$ 520

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Tue 17/11

3:19 a.m.-10:58 p.m.

1 stop20h 39m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-1:30 a.m.

Nonstop0h 00m

C$ 520

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Mon 23/11

12:15 p.m.-1:10 p.m.

1 stop25h 55m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-1:30 a.m.

Nonstop0h 00m

C$ 520

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Tue 1/12

12:20 p.m.-1:14 p.m.

1 stop25h 54m

Santo Domingo Las Americas

Sun 10/1

8:52 a.m.-11:40 p.m.

1 stop13h 48m

C$ 1,031

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Tue 8/12

1:07 a.m.-11:42 a.m.

1 stop11h 35m

Santo Domingo Las Americas

Tue 12/1

8:52 a.m.-3:46 a.m.

1 stop17h 54m

C$ 1,031

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Sat 5/12

5:07 a.m.-10:58 p.m.

1 stop18h 51m

Santo Domingo Las Americas

Sat 12/12

7:03 p.m.-8:11 p.m.

1 stop24h 08m

C$ 1,031

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Tue 29/12

1:31 a.m.-2:08 a.m.

1 stop25h 37m

Santo Domingo Las Americas

Wed 13/1

2:19 p.m.-3:46 a.m.

1 stop12h 27m

C$ 1,096

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Sun 10/1

3:53 a.m.-1:08 p.m.

1 stop10h 15m

Santo Domingo Las Americas

Wed 20/1

7:05 p.m.-11:40 p.m.

1 stop27h 35m

C$ 1,096

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/11

Showing 1-10 of 15 resultsSorted by cheapest first
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Best time to book a flight from Santiago to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Santiago with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Santiago to Santo Domingo

How far ahead should I book a flight from Santiago to Santo Domingo?

Booking 66 days in advance of your planned departure date is, on average, the best time to get cheap flights from Santiago to Santo Domingo. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Santiago to Santo Domingo?

Currently, March is the cheapest month in which you can book a flight from Santiago to Santo Domingo (average of C$ 807). Flying from Santiago to Santo Domingo in January is currently the most expensive (average of C$ 1,003). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Santiago to Santo Domingo?

Airfare is typical for this route at the moment.

Santiago to Santo Domingo flights typically cost between C$ 759 and C$ 874 in February.
The cheapest round-trip price found within the last 5 days was C$ 855 on Avianca (8 Feb-21 Feb).

Related info for your journey

  • How long is the flight from Santiago to Santo Domingo?

    There are many flights that can get you from Santiago to Santo Domingo in 11h 35m. Fly via Copa Airlines to get the fastest option. The distance from Santiago to Santo Domingo is about 5760 km.

  • Can I find deals for flights from Santiago to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Santiago to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Santo Domingo.

  • Can I find deals for business class flights from Santiago to Santo Domingo?

    Yes. Cheapflights offers flight deals from Santiago to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to Santo Domingo?

    Currently, March is the cheapest month in which you can book a flight from Santiago to Santo Domingo (average of C$ 807). Flying from Santiago to Santo Domingo in January is currently the most expensive (average of C$ 1,003). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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