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Cheap flights from Santiago to Santo Domingo from C$ 400

SCL — SDQ
26 Oct — 2 Nov1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Santiago to Santo Domingo

Enter your travel dates to find the best prices.

Cheapest flights from Santiago to Santo Domingo

Fri 4/123:19 a.m. -
1 stop23h 49m
Thu 10/1212:09 p.m. -
1 stop11h 09m
Deal found 23/9C$ 812
Wed 23/125:00 a.m. -
1 stop12h 20m
Tue 23/21:40 p.m. -
1 stop12h 55m
Deal found 22/9C$ 842
Sat 19/125:07 a.m. -
1 stop22h 01m
Sun 10/18:52 a.m. -
1 stop17h 54m
Deal found 25/9C$ 844
Thu 31/1210:00 a.m. -
1 stop12h 40m
Thu 7/12:05 p.m. -
1 stop12h 30m
Deal found 21/9C$ 871
Mon 21/1212:20 p.m. -
1 stop28h 53m
Thu 4/212:05 p.m. -
1 stop10h 36m
Deal found 25/9C$ 877
Thu 31/1210:00 a.m. -
1 stop12h 40m
Sun 28/23:55 p.m. -
1 stop12h 00m
Deal found 26/9C$ 890
Thu 26/111:02 a.m. -
1 stop11h 43m
Fri 8/18:52 a.m. -
1 stop14h 31m
Deal found 23/9C$ 915
Sun 11/1012:23 p.m. -
1 stop28h 51m
Sun 18/106:41 p.m. -
1 stop28h 41m
Deal found 23/9C$ 948
Mon 7/121:27 a.m. -
1 stop15h 46m
Sat 19/128:55 a.m. -
1 stop13h 40m
Deal found 25/9C$ 959

Find flight deals from Santiago to Santo Domingo

Round-trip from

C$ 805

One-way from

C$ 400

Popular in

January

Cheapest in

November

Average price

C$ 917
18/2-25/2
  • 18/2-25/2
  • 2 total stops
  • 25h 10m total
  • Santiago to Santo Domingo
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9/10-31/12
  • 9/10-31/12
  • 1 total stop
  • 11h 45m total
  • Santiago to Santo Domingo
Search Deals
Highest demand for flights based on searches. 8% potential increase in price (C$ 124 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease (C$ 15 potential savings vs. average RT price).
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Average for round-trip flights in September 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Santiago to Santo Domingo that are best for you.

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Price

Cheapest round-trip

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Mon 5/10

6:00 a.m.-4:55 p.m.

1 stop11h 55m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-1:30 a.m.

Nonstop0h 00m

C$ 412

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Mon 12/10

6:00 a.m.-4:55 p.m.

1 stop11h 55m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-1:30 a.m.

Nonstop0h 00m

C$ 412

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Thu 24/12

10:00 a.m.-9:40 p.m.

1 stop12h 40m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-1:30 a.m.

Nonstop0h 00m

C$ 412
Quickest round-trip

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Fri 30/10

5:00 a.m.-3:45 p.m.

1 stop11h 45m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-1:30 a.m.

Nonstop0h 00m

C$ 430

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Fri 23/10

5:00 a.m.-3:45 p.m.

1 stop11h 45m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-1:30 a.m.

Nonstop0h 00m

C$ 448

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Wed 7/10

5:00 a.m.-3:55 p.m.

1 stop11h 55m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-1:30 a.m.

Nonstop0h 00m

C$ 448

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Thu 31/12

10:00 a.m.-9:40 p.m.

1 stop12h 40m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-1:30 a.m.

Nonstop0h 00m

C$ 448

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Wed 14/10

5:00 a.m.-3:55 p.m.

1 stop11h 55m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-1:30 a.m.

Nonstop0h 00m

C$ 505

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Fri 11/12

5:07 a.m.-10:58 p.m.

1 stop18h 51m

Santo Domingo Las Americas

Wed 31/12

12:00 a.m.-1:30 a.m.

Nonstop0h 00m

C$ 513

SantiagoSanto Domingo

SCL Santiago Arturo Merino Benitez - SDQ Santo Domingo Las Americas

SCLSDQ

Santiago Arturo Merino Benitez

Sat 5/12

5:07 a.m.-2:08 a.m.

1 stop22h 01m

Santo Domingo Las Americas

Sat 12/12

8:55 a.m.-8:11 p.m.

1 stop10h 16m

C$ 812

Flights are sorted by cheapest round-trip flights first.

Deals found on 25/9

Showing 1-10 of 20 resultsSorted by cheapest first
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Best time to book a flight from Santiago to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Santiago with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Santiago to Santo Domingo

How far ahead should I book a flight from Santiago to Santo Domingo?

Booking 41 days in advance of your planned departure date is, on average, the best time to get cheap flights from Santiago to Santo Domingo. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Santiago to Santo Domingo?

Currently, November is the cheapest month in which you can book a flight from Santiago to Santo Domingo (average of C$ 779). Flying from Santiago to Santo Domingo in January is currently the most expensive (average of C$ 1,003). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Santiago to Santo Domingo?

Airfare is typical for this route at the moment.

Santiago to Santo Domingo flights typically cost between C$ 757 and C$ 900 in February.
The cheapest round-trip price found within the last 5 days was C$ 805 on Multiple Airlines (18 Feb-25 Feb).

Related info for your journey

  • How long is the flight from Santiago to Santo Domingo?

    There are many flights that can get you from Santiago to Santo Domingo in 22h 01m. Fly via Copa Airlines to get the fastest option. The distance from Santiago to Santo Domingo is about 5760 km.

  • Can I find deals for flights from Santiago to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Santiago to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Santo Domingo.

  • Can I find deals for business class flights from Santiago to Santo Domingo?

    Yes. Cheapflights offers flight deals from Santiago to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to Santo Domingo?

    Currently, November is the cheapest month in which you can book a flight from Santiago to Santo Domingo (average of C$ 779). Flying from Santiago to Santo Domingo in January is currently the most expensive (average of C$ 1,003). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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