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Cheap flights from Santo Domingo to Santiago from C$ 454

SDQ — SCL
10 Dec — 17 Dec1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Santo Domingo to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Santo Domingo to Santiago

Sun 15/117:06 p.m. -
1 stop28h 18m
Mon 30/1112:15 p.m. -
1 stop28h 58m
Deal found 5/11C$ 1,277
Thu 10/1212:43 p.m. -
1 stop16h 09m
Mon 28/125:07 a.m. -
1 stop22h 01m
Deal found 5/11C$ 1,316
Wed 23/1212:09 p.m. -
1 stop16h 43m
Fri 25/123:48 a.m. -
1 stop10h 26m
Deal found 8/11C$ 1,449
Fri 20/112:20 p.m. -
1 stop11h 28m
Sat 28/1112:15 p.m. -
1 stop24h 30m
Deal found 8/11C$ 1,774
Fri 6/1112:45 p.m. -
1 stop10h 39m
Tue 10/1112:15 p.m. -
1 stop24h 30m
Deal found 6/11C$ 1,809
Sun 15/114:18 p.m. -
2 stops39h 32m
Mon 30/1110:45 p.m. -
2 stops26h 01m
Deal found 9/11C$ 3,112
Mon 7/122:53 p.m. -
2 stops40h 57m
Mon 28/1210:45 p.m. -
2 stops39h 56m
Deal found 7/11C$ 3,125
Fri 4/124:18 p.m. -
2 stops63h 32m
Fri 11/1210:45 p.m. -
2 stops50h 01m
Deal found 6/11C$ 3,223

Find flight deals from Santo Domingo to Santiago

Round-trip from

C$ 1,277

One-way from

C$ 454

Popular in

November

Cheapest in

June

Average price

C$ 1,226
Copa Airlines
  • Copa Airlines
  • 25/11-2/12
  • 2 total stops
  • 25h 08m total
  • Santo Domingo to Santiago
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17/11-31/12
  • 17/11-31/12
  • 1 total stop
  • 12h 55m total
  • Santo Domingo to Santiago
Search Deals
Highest demand for flights based on searches. 10% potential increase in price (C$ 177 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (C$ 26 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Santo Domingo to Santiago that are best for you.

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Cheapest round-trip

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Sun 15/11

3:55 p.m.-5:00 a.m.

1 stop12h 05m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:30 p.m.

Nonstop0h 00m

C$ 577

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Fri 8/1

12:42 p.m.-11:40 p.m.

1 stop9h 58m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:30 p.m.

Nonstop0h 00m

C$ 635

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Fri 15/1

8:52 a.m.-5:57 a.m.

1 stop20h 05m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:30 p.m.

Nonstop0h 00m

C$ 635
Quickest round-trip

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Mon 14/12

12:43 p.m.-11:35 p.m.

1 stop9h 52m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:30 p.m.

Nonstop0h 00m

C$ 635

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Sat 5/12

12:43 p.m.-11:35 p.m.

1 stop9h 52m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:30 p.m.

Nonstop0h 00m

C$ 635

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Thu 17/12

2:14 p.m.-8:11 p.m.

1 stop28h 57m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:30 p.m.

Nonstop0h 00m

C$ 635

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Thu 10/12

5:53 a.m.-12:23 a.m.

1 stop17h 30m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:30 p.m.

Nonstop0h 00m

C$ 635

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Sat 28/11

7:06 p.m.-12:24 a.m.

1 stop28h 18m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:30 p.m.

Nonstop0h 00m

C$ 635

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Wed 25/11

8:55 a.m.-8:15 p.m.

1 stop10h 20m

Santiago Arturo Merino Benitez

Wed 2/12

12:20 p.m.-2:08 a.m.

1 stop14h 48m

C$ 1,277

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Thu 10/12

5:53 a.m.-8:11 p.m.

1 stop13h 18m

Santiago Arturo Merino Benitez

Wed 16/12

3:19 a.m.-10:58 p.m.

1 stop20h 39m

C$ 1,316

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/11

Showing 1-10 of 16 resultsSorted by cheapest first
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Best time to book a flight from Santo Domingo to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Santo Domingo with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Santiago

How far ahead should I book a flight from Santo Domingo to Santiago?

The price you pay for your flight from Santo Domingo to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 61 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Santo Domingo to Santiago?

Currently, June is the cheapest month in which you can book a flight from Santo Domingo to Santiago (average of C$ 571). Flying from Santo Domingo to Santiago in November is currently the most expensive (average of C$ 1,226). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Santo Domingo to Santiago?

Airfare is typical for this route at the moment.

Santo Domingo to Santiago flights typically cost between C$ 635 and C$ 1,333 in November.
The cheapest round-trip price found within the last 5 days was C$ 1,277 on Copa Airlines (25 Nov-2 Dec).

Related info for your journey

  • How long is the flight from Santo Domingo to Santiago?

    A quick flight from Santo Domingo to Santiago can take about 10h 20m. Copa Airlines provides one of the quickest options available for as low as C$ 1,277. There are 5760 km between Santo Domingo and Santiago.

  • Can I find deals for flights from Santo Domingo to Santiago that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Santiago.

  • Can I find deals for business class flights from Santo Domingo to Santiago?

    Yes. Cheapflights offers flight deals from Santo Domingo to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Santiago?

    Currently, June is the cheapest month in which you can book a flight from Santo Domingo to Santiago (average of C$ 571). Flying from Santo Domingo to Santiago in November is currently the most expensive (average of C$ 1,226). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Valparaíso
Viña del Mar

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