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Cheap flights from Santo Domingo to Santiago from C$ 414

SDQ — SCL
23 Oct — 30 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Santo Domingo to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Santo Domingo to Santiago

Tue 6/101:45 p.m. -
1 stop12h 50m
Mon 12/106:00 a.m. -
1 stop11h 55m
Deal found 22/9C$ 822
Tue 27/108:57 a.m. -
1 stop10h 22m
Sun 1/1112:15 p.m. -
1 stop25h 55m
Deal found 23/9C$ 1,069
Fri 2/108:55 a.m. -
1 stop14h 00m
Fri 9/105:00 a.m. -
1 stop11h 45m
Deal found 18/9C$ 1,090
Thu 8/1012:12 p.m. -
1 stop10h 27m
Tue 13/105:22 a.m. -
1 stop11h 52m
Deal found 18/9C$ 1,256
Tue 15/122:14 p.m. -
1 stop14h 38m
Wed 23/1212:20 p.m. -
1 stop24h 22m
Deal found 23/9C$ 1,294
Thu 10/1212:09 p.m. -
1 stop16h 43m
Mon 28/1212:20 p.m. -
1 stop14h 48m
Deal found 21/9C$ 1,350
Mon 28/128:55 a.m. -
1 stop13h 40m
Sun 3/13:53 a.m. -
1 stop23h 11m
Deal found 22/9C$ 1,426
Mon 7/124:18 p.m. -
2 stops39h 32m
Mon 28/1210:45 p.m. -
2 stops39h 56m
Deal found 22/9C$ 2,508
Thu 22/103:20 p.m. -
2 stops63h 30m
Mon 26/109:45 p.m. -
2 stops39h 56m
Deal found 21/9C$ 2,687
Wed 4/114:18 p.m. -
2 stops63h 32m
Wed 11/1110:45 p.m. -
2 stops41h 21m
Deal found 20/9C$ 3,095

Find flight deals from Santo Domingo to Santiago

Round-trip from

C$ 822

One-way from

C$ 414

Popular in

January

Cheapest in

June

Average price

C$ 993
6/10-12/10
  • 6/10-12/10
  • 2 total stops
  • 24h 45m total
  • Santo Domingo to Santiago
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6/10-31/12
  • 6/10-31/12
  • 1 total stop
  • 12h 50m total
  • Santo Domingo to Santiago
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Highest demand for flights based on searches. 10% potential increase in price (C$ 158 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease (C$ 22 potential savings vs. average RT price).
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Average for round-trip flights in September 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Santo Domingo to Santiago that are best for you.

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Cheapest round-trip

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Tue 3/11

1:40 p.m.-3:35 a.m.

1 stop12h 55m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:30 p.m.

Nonstop0h 00m

C$ 492

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Sun 25/10

3:25 p.m.-4:55 a.m.

1 stop12h 30m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:30 p.m.

Nonstop0h 00m

C$ 492

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Tue 27/10

5:55 a.m.-5:55 a.m.

1 stop23h 00m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:30 p.m.

Nonstop0h 00m

C$ 625
Quickest round-trip

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Mon 5/10

12:42 p.m.-11:39 p.m.

1 stop9h 57m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:30 p.m.

Nonstop0h 00m

C$ 625

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Mon 19/10

12:42 p.m.-2:46 a.m.

1 stop13h 04m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:30 p.m.

Nonstop0h 00m

C$ 625

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Fri 6/11

12:45 p.m.-2:48 a.m.

1 stop13h 03m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:30 p.m.

Nonstop0h 00m

C$ 625

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Sat 21/11

7:06 p.m.-12:19 a.m.

1 stop28h 13m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:30 p.m.

Nonstop0h 00m

C$ 625

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Mon 21/12

7:03 p.m.-8:11 p.m.

1 stop24h 08m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:30 p.m.

Nonstop0h 00m

C$ 625

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Fri 6/11

12:45 p.m.-2:48 a.m.

1 stop13h 03m

Santiago Arturo Merino Benitez

Mon 9/11

3:48 a.m.-4:12 p.m.

1 stop13h 24m

C$ 1,069

Santo DomingoSantiago

SDQ Santo Domingo Las Americas - SCL Santiago Arturo Merino Benitez

SDQSCL

Santo Domingo Las Americas

Thu 8/10

12:12 p.m.-11:39 p.m.

1 stop10h 27m

Santiago Arturo Merino Benitez

Tue 13/10

5:22 a.m.-4:14 p.m.

1 stop11h 52m

C$ 1,256

Flights are sorted by cheapest round-trip flights first.

Deals found on 20/9

Showing 1-10 of 14 resultsSorted by cheapest first
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Best time to book a flight from Santo Domingo to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Santo Domingo with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Santiago

How far ahead should I book a flight from Santo Domingo to Santiago?

The price you pay for your flight from Santo Domingo to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 61 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Santo Domingo to Santiago?

Currently, June is the cheapest month in which you can book a flight from Santo Domingo to Santiago (average of C$ 569). Flying from Santo Domingo to Santiago in January is currently the most expensive (average of C$ 1,148). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Santo Domingo to Santiago?

Airfare is typical for this route at the moment.

Santo Domingo to Santiago flights typically cost between C$ 724 and C$ 1,106 in October.
The cheapest round-trip price found within the last 5 days was C$ 822 on Multiple Airlines (6 Oct-12 Oct).

Related info for your journey

  • How long is the flight from Santo Domingo to Santiago?

    A quick flight from Santo Domingo to Santiago can take about 13h 03m. Copa Airlines provides one of the quickest options available for as low as C$ 1,069. There are 5760 km between Santo Domingo and Santiago.

  • Can I find deals for flights from Santo Domingo to Santiago that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Santiago.

  • Can I find deals for business class flights from Santo Domingo to Santiago?

    Yes. Cheapflights offers flight deals from Santo Domingo to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Santiago?

    Currently, June is the cheapest month in which you can book a flight from Santo Domingo to Santiago (average of C$ 569). Flying from Santo Domingo to Santiago in January is currently the most expensive (average of C$ 1,148). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Santiago?

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Valparaíso
Viña del Mar

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Yes, Cheapflights offers price alerts on Santo Domingo to Santiago flights so you can book your travel at the perfect time. Price Alerts can be enabled by clicking the bell icon next to the flight deals above and providing your email address where you want to receive the alerts.

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