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Cheap flights from Mexico City to Santiago from C$ 523

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 21/9. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
15 Jul — 22 Jul1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Mexico City to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 15 June 2026.

Tue 22/94:55 p.m.
MEX
-
SCL
2 stops18h 40m
Multiple Airlines
Tue 6/109:15 p.m.
SCL
-
MEX
1 stop16h 55m
Multiple Airlines
Deal found 12/6C$ 962
Tue 23/61:10 p.m.
MEX
-
SCL
1 stop11h 50m
Copa Airlines
Mon 6/74:21 a.m.
SCL
-
MEX
1 stop21h 54m
Copa Airlines
Deal found 14/6C$ 1,057
Tue 30/612:25 a.m.
MEX
-
SCL
1 stop24h 35m
Copa Airlines
Sun 5/74:21 a.m.
SCL
-
MEX
1 stop22h 39m
Copa Airlines
Deal found 10/6C$ 1,087
Tue 16/69:00 p.m.
MEX
-
SCL
2 stops20h 23m
Multiple Airlines
Tue 30/611:17 a.m.
SCL
-
MEX
1 stop12h 48m
Multiple Airlines
Deal found 12/6C$ 1,105
Thu 9/71:20 a.m.
MEX
-
SCL
1 stop20h 06m
Copa Airlines
Fri 24/74:21 a.m.
SCL
-
MEX
1 stop19h 44m
Copa Airlines
Deal found 10/6C$ 1,110
Thu 10/92:10 a.m.
MEX
-
SCL
1 stop15h 22m
Copa Airlines
Fri 18/91:43 a.m.
SCL
-
MEX
1 stop13h 27m
Copa Airlines
Deal found 15/6C$ 1,116

Find flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 15 June 2026.

Round-trip from

C$ 962

One-way from

C$ 523

Popular in

June

Cheapest in

November

Average price

C$ 1,085
22/9-6/10
  • 22/9-6/10
  • 3 total stops
  • 35h 35m total
  • Mexico City to Santiago
Search Deals
Avianca
  • Avianca
  • 6/10
  • 1 total stop
  • 12h 45m total
  • Mexico City to Santiago
Search Deals
Highest demand for flights based on searches. 10% potential increase in price (C$ 146 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (C$ 20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 15 June 2026.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 8/7

3:30 p.m.-5:14 a.m.

1 stop11h 44m

Santiago Arturo Merino Benitez

Wed 15/7

4:21 a.m.-1:00 a.m.

1 stop22h 39m

C$ 1,057

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 29/7

9:50 a.m.-11:26 p.m.

1 stop11h 36m

Santiago Arturo Merino Benitez

Wed 5/8

4:14 a.m.-1:00 a.m.

1 stop22h 46m

C$ 1,057

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 7/7

1:20 a.m.-3:00 a.m.

1 stop23h 40m

Santiago Arturo Merino Benitez

Thu 16/7

4:21 a.m.-12:15 a.m.

1 stop21h 54m

C$ 1,057

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 8/7

2:10 a.m.-7:36 p.m.

1 stop15h 26m

Santiago Arturo Merino Benitez

Thu 16/7

2:56 a.m.-2:30 p.m.

1 stop13h 34m

C$ 1,057

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 12/7

1:20 a.m.-1:50 a.m.

1 stop22h 30m

Santiago Arturo Merino Benitez

Mon 20/7

11:22 a.m.-12:15 a.m.

1 stop14h 53m

C$ 1,057

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 9/7

1:20 a.m.-7:36 p.m.

1 stop16h 16m

Santiago Arturo Merino Benitez

Thu 16/7

2:14 a.m.-2:30 p.m.

1 stop14h 16m

C$ 1,057

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 1/12

2:00 a.m.-8:11 p.m.

1 stop15h 11m

Santiago Arturo Merino Benitez

Fri 11/12

1:27 a.m.-10:00 p.m.

1 stop23h 33m

C$ 1,087

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 3/7

2:10 a.m.-10:43 p.m.

1 stop18h 33m

Santiago Arturo Merino Benitez

Thu 9/7

2:14 a.m.-1:00 a.m.

1 stop24h 46m

C$ 1,087
Quickest round-trip

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 27/6

1:10 p.m.-3:00 a.m.

1 stop11h 50m

Santiago Arturo Merino Benitez

Mon 29/6

11:17 a.m.-1:00 a.m.

1 stop15h 43m

C$ 1,087

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 29/6

1:20 a.m.-3:00 a.m.

1 stop23h 40m

Santiago Arturo Merino Benitez

Wed 1/7

11:22 a.m.-12:15 a.m.

1 stop14h 53m

C$ 1,087

Flights are sorted by cheapest round-trip flights first.

Deals found on 13/6

Showing 1-10 of 21 resultsSorted by cheapest first
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Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

The price you pay for your flight from Mexico City to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 89 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, November is the cheapest month in which you can book a flight from Mexico City to Santiago (average of C$ 807). Flying from Mexico City to Santiago in June is currently the most expensive (average of C$ 1,085). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 15 June 2026.

When flying from Mexico City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Mexico City to Santiago?

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    This flight path from Mexico City Benito Juarez to Santiago Arturo Merino Benitez was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Mexico City to Santiago?

    There are many flights that can get you from Mexico City to Santiago in 11h 44m. Fly via Copa Airlines to get the fastest option. The distance between Mexico City and Santiago is about 6592 km.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, November is the cheapest month in which you can book a flight from Mexico City to Santiago (average of C$ 807). Flying from Mexico City to Santiago in June is currently the most expensive (average of C$ 1,085). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Valparaíso
Viña del Mar

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santiago?

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Can Cheapflights find flights from Mexico City to Santiago with no change fees?

Cheapflights does show flights with no change fees to all users. To see these options for flights from Mexico City to Santiago, users can toggle the no change fees filter when performing a flight search.

Can Cheapflights notify me if prices for flights from Mexico City to Santiago become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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