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Cheap flights from Mexico City to Santiago from C$ 540

MEX — SCL
9 Oct — 16 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Mexico City to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santiago

Mon 30/111:10 p.m. -
1 stop11h 33m
Sun 6/123:19 a.m. -
1 stop22h 06m
Deal found 7/9C$ 958
Sat 12/1210:00 p.m. -
1 stop11h 40m
Sat 9/111:27 a.m. -
1 stop26h 43m
Deal found 9/9C$ 1,019
Sat 12/1210:00 p.m. -
1 stop11h 40m
Fri 8/19:02 p.m. -
1 stop17h 08m
Deal found 9/9C$ 1,020
Mon 14/1210:00 p.m. -
1 stop11h 40m
Sat 9/111:27 a.m. -
1 stop26h 43m
Deal found 9/9C$ 1,022
Tue 15/129:05 p.m. -
2 stops23h 30m
Wed 6/16:07 a.m. -
1 stop32h 03m
Deal found 9/9C$ 1,037
Sat 3/1010:00 p.m. -
1 stop21h 10m
Sat 10/109:30 a.m. -
Nonstop9h 15m
Deal found 5/9C$ 1,042
Sun 13/1210:00 p.m. -
1 stop21h 35m
Sat 9/111:27 a.m. -
1 stop26h 43m
Deal found 9/9C$ 1,045
Sun 13/1210:00 p.m. -
1 stop21h 35m
Fri 8/19:02 p.m. -
1 stop17h 08m
Deal found 9/9C$ 1,046
Sat 12/1210:00 p.m. -
1 stop11h 40m
Mon 4/112:32 p.m. -
1 stop25h 38m
Deal found 9/9C$ 1,048
Mon 14/1210:00 p.m. -
1 stop11h 40m
Mon 4/112:32 p.m. -
1 stop25h 38m
Deal found 9/9C$ 1,049
Tue 15/1211:10 p.m. -
2 stops21h 25m
Fri 8/19:02 p.m. -
1 stop17h 08m
Deal found 9/9C$ 1,053

Find flight deals from Mexico City to Santiago

Round-trip from

C$ 958

One-way from

C$ 540

Popular in

July

Cheapest in

January

Average price

C$ 983
Copa Airlines
  • Copa Airlines
  • 30/11-6/12
  • 2 total stops
  • 33h 39m total
  • Mexico City to Santiago
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31/10-31/12
  • 31/10-31/12
  • 2 total stops
  • 23h 09m total
  • Mexico City to Santiago
Search Deals
Highest demand for flights based on searches. 7% potential increase in price (C$ 112 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease (C$ 14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Sat 24/10

1:20 a.m.-12:22 a.m.

1 stop20h 02m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-9:00 p.m.

Nonstop0h 00m

C$ 542

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Sat 26/9

1:20 a.m.-11:39 p.m.

1 stop19h 19m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-9:00 p.m.

Nonstop0h 00m

C$ 860

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Fri 25/9

1:20 a.m.-12:22 a.m.

1 stop20h 02m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-9:00 p.m.

Nonstop0h 00m

C$ 860
Quickest round-trip

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Thu 17/9

5:50 a.m.-11:39 p.m.

1 stop14h 49m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-9:00 p.m.

Nonstop0h 00m

C$ 860

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Thu 15/10

1:20 a.m.-12:22 a.m.

1 stop20h 02m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-9:00 p.m.

Nonstop0h 00m

C$ 860

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Fri 9/10

1:20 a.m.-12:22 a.m.

1 stop20h 02m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-9:00 p.m.

Nonstop0h 00m

C$ 860

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Wed 23/9

5:50 a.m.-3:56 a.m.

1 stop19h 06m

Santiago Arturo Merino Benitez

Wed 14/10

12:23 p.m.-1:00 a.m.

1 stop15h 37m

C$ 1,059

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Wed 23/9

1:20 a.m.-8:32 p.m.

1 stop16h 12m

Santiago Arturo Merino Benitez

Mon 5/10

12:23 p.m.-12:15 a.m.

1 stop14h 52m

C$ 1,059

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Sat 3/10

10:00 p.m.-10:10 p.m.

1 stop21h 10m

Santiago Arturo Merino Benitez

Sun 11/10

6:00 a.m.-2:55 p.m.

1 stop35h 55m

C$ 1,099

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Thu 1/10

1:20 a.m.-8:32 p.m.

1 stop16h 12m

Santiago Arturo Merino Benitez

Sat 10/10

3:15 a.m.-1:00 a.m.

1 stop24h 45m

C$ 1,102

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/9

Showing 1-10 of 13 resultsSorted by cheapest first
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Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

The price you pay for your flight from Mexico City to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 59 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, January is the cheapest month in which you can book a flight from Mexico City to Santiago (average of C$ 834). Flying from Mexico City to Santiago in July is currently the most expensive (average of C$ 1,066). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

When flying from Mexico City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Mexico City to Santiago?

Airfare is typical for this route at the moment.

Mexico City to Santiago flights typically cost between C$ 834 and C$ 1,097 in November.
The cheapest round-trip price found within the last 5 days was C$ 958 on Copa Airlines (30 Nov-6 Dec).

Related info for your journey

  • How popular is this Mexico City to Santiago flight route?

    This flight path from Mexico City Benito Juarez to Santiago Arturo Merino Benitez was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Mexico City to Santiago?

    There are many flights that can get you from Mexico City to Santiago in 19h 06m. Fly via Copa Airlines to get the fastest option. The distance between Mexico City and Santiago is about 6592 km.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, January is the cheapest month in which you can book a flight from Mexico City to Santiago (average of C$ 834). Flying from Mexico City to Santiago in July is currently the most expensive (average of C$ 1,066). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Valparaíso
Viña del Mar

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santiago?

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Cheapflights does show flights with no change fees to all users. To see these options for flights from Mexico City to Santiago, users can toggle the no change fees filter when performing a flight search.

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Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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