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Cheap flights from Mexico City to Santiago from C$ 378

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/10. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
11 Oct — 18 Oct1
1 adult
1 adult, Economy

Cheap flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 11 September 2025.

Round-trip from

C$ 734

One-way from

C$ 378

Popular in

December

Cheapest in

May

Average price

C$ 876

Good one-way deal

C$ 922 or less
Avianca
  • Avianca
  • 29/10-13/11
  • 2 total stops
  • 25h 15m total
  • Mexico City to Santiago
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Avianca
  • Avianca
  • 4/10
  • 1 total stop
  • 15h 35m total
  • Mexico City to Santiago
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Highest demand for flights based on searches. 7% potential increase in price (C$ 90 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease (C$ 19 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a one-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
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Find flight deals from Mexico City to Santiago

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 11 September 2025.

Wed 29/1012:40 a.m.MEX - SCL
1 stop11h 40mAvianca
Thu 13/114:25 p.m.SCL - MEX
1 stop13h 35mAvianca
Deal found 11/9C$ 734
Tue 7/107:05 p.m.MEX - SCL
2 stops15h 15mMultiple Airlines
Mon 13/106:30 p.m.SCL - MEX
1 stop23h 25mMultiple Airlines
Deal found 10/9C$ 740
Thu 30/108:00 p.m.MEX - SCL
1 stop23h 00mMultiple Airlines
Tue 4/119:30 p.m.SCL - MEX
2 stops43h 20mMultiple Airlines
Deal found 10/9C$ 751
Tue 28/101:10 p.m.MEX - SCL
1 stop11h 15mCopa Airlines
Mon 10/1112:20 p.m.SCL - MEX
1 stop14h 55mCopa Airlines
Deal found 11/9C$ 752
Wed 24/95:50 a.m.MEX - SCL
1 stop15h 14mCopa Airlines
Mon 3/115:12 a.m.SCL - MEX
1 stop17h 08mCopa Airlines
Deal found 11/9C$ 757
Sat 22/118:55 p.m.MEX - SCL
1 stop21h 55mMultiple Airlines
Sun 30/119:15 a.m.SCL - MEX
Nonstop8h 40mMultiple Airlines
Deal found 10/9C$ 758
Wed 29/109:25 a.m.MEX - SCL
1 stop11h 40mCopa Airlines
Mon 10/1112:20 p.m.SCL - MEX
1 stop14h 55mCopa Airlines
Deal found 11/9C$ 766
Fri 31/105:55 a.m.MEX - SCL
1 stop15h 10mCopa Airlines
Fri 14/1112:20 p.m.SCL - MEX
1 stop15h 40mCopa Airlines
Deal found 11/9C$ 768
Mon 17/111:20 a.m.MEX - SCL
1 stop19h 21mCopa Airlines
Thu 27/111:12 a.m.SCL - MEX
1 stop21h 08mCopa Airlines
Deal found 10/9C$ 769
Mon 17/112:00 a.m.MEX - SCL
1 stop15h 21mCopa Airlines
Mon 24/111:12 a.m.SCL - MEX
1 stop21h 08mCopa Airlines
Deal found 11/9C$ 770
Tue 28/107:50 p.m.MEX - SCL
Nonstop8h 40mMultiple Airlines
Tue 11/114:25 p.m.SCL - MEX
1 stop13h 35mMultiple Airlines
Deal found 11/9C$ 772
Mon 27/109:00 a.m.MEX - SCL
2 stops18h 25mLATAM Airlines
Wed 12/115:15 a.m.SCL - MEX
1 stop11h 35mLATAM Airlines
Deal found 11/9C$ 775

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 11 September 2025.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Mexico City

Fly to

Santiago

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 5/3

3:00 p.m.-10:00 p.m.

1 stop28h 00m

Santiago Arturo Merino Benitez

Tue 10/3

10:15 p.m.-1:50 p.m.

1 stop18h 35m

C$ 741

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 11/11

2:00 a.m.-12:06 a.m.

1 stop19h 06m

Santiago Arturo Merino Benitez

Tue 2/12

12:20 p.m.-1:00 a.m.

1 stop15h 40m

C$ 757

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 17/11

2:00 a.m.-11:41 p.m.

1 stop18h 41m

Santiago Arturo Merino Benitez

Thu 27/11

3:23 a.m.-10:05 p.m.

1 stop21h 42m

C$ 757

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 12/10

2:00 a.m.-8:20 p.m.

1 stop15h 20m

Santiago Arturo Merino Benitez

Mon 10/11

5:12 a.m.-7:20 p.m.

1 stop17h 08m

C$ 757

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 2/10

1:05 p.m.-3:42 a.m.

1 stop11h 37m

Santiago Arturo Merino Benitez

Mon 13/10

4:47 a.m.-10:05 p.m.

1 stop20h 18m

C$ 757

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 28/10

2:00 a.m.-8:20 p.m.

1 stop15h 20m

Santiago Arturo Merino Benitez

Thu 13/11

1:29 a.m.-2:30 p.m.

1 stop16h 01m

C$ 757

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 25/9

9:50 a.m.-3:42 a.m.

1 stop14h 52m

Santiago Arturo Merino Benitez

Mon 6/10

3:35 a.m.-10:05 p.m.

1 stop21h 30m

C$ 757

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 22/11

5:55 a.m.-11:41 p.m.

1 stop14h 46m

Santiago Arturo Merino Benitez

Sat 29/11

5:12 a.m.-2:30 p.m.

1 stop12h 18m

C$ 757

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 1/10

3:30 p.m.-6:00 a.m.

1 stop11h 30m

Santiago Arturo Merino Benitez

Tue 7/10

3:35 a.m.-10:05 p.m.

1 stop21h 30m

C$ 757

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 4/10

4:55 a.m.-11:30 p.m.

1 stop15h 35m

C$ 378

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/9

Showing 1-10 of 20 results
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Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santiago. Price data was last updated on 29 August 2025.

The price you pay for your flight from Mexico City to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 90 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, August is the cheapest month in which you can book a flight from Mexico City to Santiago (average of C$ 605). Flying from Mexico City to Santiago in December is currently the most expensive (average of C$ 881). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 11 September 2025.

When flying from Mexico City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Mexico City to Santiago?

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    This flight path from Mexico City Benito Juarez to Santiago Arturo Merino Benitez was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Mexico City to Santiago?

    There are many flights that can get you from Mexico City to Santiago in 19h 06m. Fly via Copa Airlines to get the fastest option. The distance between Mexico City and Santiago is about 6592 km.

  • What are the cheapest flights from Mexico City to Santiago?

    On average you can expect to pay C$ 922 for a flight from Mexico City to Santiago. The cheapest flight overall is C$ 922 while the most popular route, (Mexico City Benito Juarez - Santiago Arturo Merino Benitez) is currently priced at C$ 1,048.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, August is the cheapest month in which you can book a flight from Mexico City to Santiago (average of C$ 605). Flying from Mexico City to Santiago in December is currently the most expensive (average of C$ 881). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santiago?

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Can Cheapflights find flights from Mexico City to Santiago with no change fees?

Cheapflights does show flights with no change fees to all users. To see these options for flights from Mexico City to Santiago, users can toggle the no change fees filter when performing a flight search.

Can Cheapflights notify me if prices for flights from Mexico City to Santiago become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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