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Cheap flights from Mexico City to Santiago from C$ 400

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/12. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
5 Aug — 12 Aug1
1 adult

Cheap flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 31 July 2025.

Round-trip from

C$ 783

One-way from

C$ 400

Popular in

December

Cheapest in

May

Average price

C$ 855
Copa Airlines
  • Copa Airlines
  • 13/8-24/8
  • 2 total stops
  • 32h 52m total
  • Mexico City to Santiago
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Avianca
  • Avianca
  • 8/12
  • 1 total stop
  • 44h 00m total
  • Mexico City to Santiago
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Highest demand for flights based on searches. 6% potential increase in price (C$ 88 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease (C$ 18 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Mexico City to Santiago

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 31 July 2025.

Wed 13/89:50 a.m.MEX - SCL
1 stop11h 18mCopa Airlines
Sun 24/82:26 a.m.SCL - MEX
1 stop21h 34mCopa Airlines
Deal found 30/7C$ 783
Mon 13/1012:40 a.m.MEX - SCL
1 stop19h 50mAvianca
Fri 24/107:10 a.m.SCL - MEX
1 stop22h 55mAvianca
Deal found 31/7C$ 880
Sat 16/85:20 p.m.MEX - SCL
1 stop26h 35mLATAM Airlines
Sat 23/88:20 a.m.SCL - MEX
Nonstop8h 35mLATAM Airlines
Deal found 30/7C$ 937

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 31 July 2025.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Mexico City

Fly to

Santiago

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 13/8

5:50 a.m.-11:08 p.m.

1 stop15h 18m

Santiago Arturo Merino Benitez

Wed 27/8

4:11 a.m.-2:30 p.m.

1 stop12h 19m

C$ 783

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 13/10

12:40 a.m.-11:30 p.m.

1 stop19h 50m

Santiago Arturo Merino Benitez

Fri 24/10

7:10 a.m.-3:05 a.m.

1 stop22h 55m

C$ 880

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 16/8

5:20 p.m.-9:55 p.m.

1 stop26h 35m

Santiago Arturo Merino Benitez

Sat 23/8

8:20 a.m.-2:55 p.m.

Nonstop8h 35m

C$ 937

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 8/12

12:40 a.m.-11:40 p.m.

1 stop44h 00m

C$ 400

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 9/11

9:55 p.m.-10:15 p.m.

1 stop21h 20m

C$ 418

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 10/8

1:40 a.m.-11:08 p.m.

1 stop19h 28m

C$ 606

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 9/11

10:00 a.m.-9:15 p.m.

Nonstop8h 15m

C$ 832

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 9/11

10:50 a.m.-11:05 a.m.

3 stops21h 15m

C$ 1,811

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 10/10

3:00 p.m.-3:05 p.m.

3 stops45h 05m

C$ 4,053

Flights are sorted by cheapest round-trip flights first.

Deals found on 30/7

Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santiago. Price data was last updated on 25 July 2025.

The price you pay for your flight from Mexico City to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 90 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, May is the cheapest month in which you can book a flight from Mexico City to Santiago (average of C$ 616). Flying from Mexico City to Santiago in December is currently the most expensive (average of C$ 906). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 31 July 2025.

When flying from Mexico City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated 31 July 2025.
Read reviews from past customers who have flown LATAM Airlines,Qantas Airways, andCopa Airlines from Mexico City to Santiago. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,822 reviews
Check prices

Entertainment

7.0

Overall

7.5

Boarding

7.6

Crew

8.1

Food

6.7

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
LATAM Airlines
7.5
Good
1,822 reviews
LATAM Airlines
7.5
Good
1,822 reviews
Check prices

Entertainment

7.0

Overall

7.5

Boarding

7.6

Crew

8.1

Food

6.7

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
Qantas Airways
7.5
Good
887 reviews
LATAM Airlines
7.5
Good
1,822 reviews
Check prices

Entertainment

7.0

Overall

7.5

Boarding

7.6

Crew

8.1

Food

6.7

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
Copa Airlines
7.5
Good
1,493 reviews
LATAM Airlines
7.5
Good
1,822 reviews
Check prices

Entertainment

7.0

Overall

7.5

Boarding

7.6

Crew

8.1

Food

6.7

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
Aeromexico
7.5
Good
1,721 reviews
LATAM Airlines
7.5
Good
1,822 reviews
Check prices

Entertainment

7.0

Overall

7.5

Boarding

7.6

Crew

8.1

Food

6.7

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
Avianca
6.7
Okay
2,388 reviews
LATAM Airlines
7.5
Good
1,822 reviews
Check prices

Entertainment

7.0

Overall

7.5

Boarding

7.6

Crew

8.1

Food

6.7

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    This flight path from Mexico City Benito Juarez to Santiago Arturo Merino Benitez was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines flying from Mexico City to Santiago round-trip?

    Flying on Copa Airlines is currently your cheapest option to Santiago, with prices starting at C$ 783. Additional round-trip tickets that might be worth considering are offered by Avianca and LATAM Airlines, with the lowest prices starting at C$ 880 and C$ 937, respectively. Users have found that Copa Airlines is 10% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Mexico City to Santiago one-way?

    To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at C$ 400. Copa Airlines flights start at C$ 606 while deals on Aeromexico start at C$ 832 one-way.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, May is the cheapest month in which you can book a flight from Mexico City to Santiago (average of C$ 616). Flying from Mexico City to Santiago in December is currently the most expensive (average of C$ 906). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Cheapflights does show flights with no change fees to all users. To see these options for flights from Mexico City to Santiago, users can toggle the no change fees filter when performing a flight search.

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