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Cheap flights from Mexico City to Santiago from C$ 400

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 24/3. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
13 Apr — 20 Apr1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Mexico City to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 14 March 2026.

Tue 21/412:40 a.m.
MEX
-
SCL
2 stops17h 06m
Multiple Airlines
Tue 28/48:20 p.m.
SCL
-
MEX
1 stop16h 50m
Multiple Airlines
Deal found 12/3C$ 837
Thu 16/41:20 a.m.
MEX
-
SCL
1 stop20h 06m
Copa Airlines
Sun 26/411:25 a.m.
SCL
-
MEX
1 stop14h 50m
Copa Airlines
Deal found 9/3C$ 850
Thu 7/55:50 a.m.
MEX
-
SCL
1 stop11h 33m
Copa Airlines
Mon 11/54:09 a.m.
SCL
-
MEX
1 stop22h 06m
Copa Airlines
Deal found 10/3C$ 894
Tue 10/35:55 a.m.
MEX
-
SCL
1 stop15h 39m
Copa Airlines
Mon 23/33:32 a.m.
SCL
-
MEX
1 stop18h 48m
Copa Airlines
Deal found 9/3C$ 907
Fri 15/51:20 a.m.
MEX
-
SCL
1 stop20h 06m
Copa Airlines
Sat 6/611:17 a.m.
SCL
-
MEX
1 stop12h 43m
Copa Airlines
Deal found 13/3C$ 914
Tue 7/41:20 a.m.
MEX
-
SCL
1 stop19h 23m
Copa Airlines
Wed 15/411:25 a.m.
SCL
-
MEX
1 stop14h 50m
Copa Airlines
Deal found 9/3C$ 921
Tue 14/41:20 a.m.
MEX
-
SCL
1 stop19h 23m
Copa Airlines
Wed 22/44:17 a.m.
SCL
-
MEX
1 stop16h 48m
Copa Airlines
Deal found 14/3C$ 936
Mon 25/51:20 a.m.
MEX
-
SCL
1 stop16h 03m
Copa Airlines
Mon 1/62:22 a.m.
SCL
-
MEX
1 stop11h 48m
Copa Airlines
Deal found 10/3C$ 950
Thu 19/31:20 a.m.
MEX
-
SCL
1 stop19h 29m
Copa Airlines
Sun 29/35:19 a.m.
SCL
-
MEX
1 stop12h 11m
Copa Airlines
Deal found 14/3C$ 965
Mon 30/31:20 a.m.
MEX
-
SCL
1 stop19h 19m
Copa Airlines
Fri 3/72:56 a.m.
SCL
-
MEX
1 stop21h 04m
Copa Airlines
Deal found 11/3C$ 978

Find flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 14 March 2026.

Round-trip from

C$ 837

One-way from

C$ 400

Popular in

December

Cheapest in

May

Average price

C$ 850
21/4-28/4
  • 21/4-28/4
  • 3 total stops
  • 33h 56m total
  • Mexico City to Santiago
Search Deals
Copa Airlines
  • Copa Airlines
  • 24/3
  • 1 total stop
  • 14h 52m total
  • Mexico City to Santiago
Search Deals
Highest demand for flights based on searches. 0% potential increase in price (C$ 2 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (C$ 14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 14 March 2026.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 16/4

1:20 a.m.-11:26 p.m.

1 stop20h 06m

Santiago Arturo Merino Benitez

Sun 26/4

11:25 a.m.-12:15 a.m.

1 stop14h 50m

C$ 850
Quickest round-trip

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 26/5

5:50 a.m.-11:26 p.m.

1 stop15h 36m

Santiago Arturo Merino Benitez

Tue 2/6

2:22 a.m.-12:10 p.m.

1 stop11h 48m

C$ 914

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 7/4

1:20 a.m.-10:43 p.m.

1 stop19h 23m

Santiago Arturo Merino Benitez

Wed 15/4

11:25 a.m.-12:15 a.m.

1 stop14h 50m

C$ 921

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 8/4

2:10 a.m.-7:23 p.m.

1 stop15h 13m

Santiago Arturo Merino Benitez

Sat 25/4

11:25 a.m.-12:15 a.m.

1 stop14h 50m

C$ 921

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 26/5

1:10 p.m.-3:00 a.m.

1 stop11h 50m

Santiago Arturo Merino Benitez

Fri 5/6

2:51 a.m.-10:05 p.m.

1 stop21h 14m

C$ 950

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 25/5

1:20 a.m.-7:23 p.m.

1 stop16h 03m

Santiago Arturo Merino Benitez

Mon 1/6

2:22 a.m.-12:10 p.m.

1 stop11h 48m

C$ 950

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 5/8

5:50 a.m.-7:23 p.m.

1 stop11h 33m

Santiago Arturo Merino Benitez

Sun 13/9

3:27 a.m.-10:05 p.m.

1 stop21h 38m

C$ 965

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 3/9

2:10 a.m.-10:39 p.m.

1 stop18h 29m

Santiago Arturo Merino Benitez

Sun 13/9

3:27 a.m.-10:05 p.m.

1 stop21h 38m

C$ 965

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 15/7

2:10 a.m.-7:23 p.m.

1 stop15h 13m

Santiago Arturo Merino Benitez

Wed 29/7

11:22 a.m.-1:00 a.m.

1 stop15h 38m

C$ 965

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 28/7

2:10 a.m.-10:43 p.m.

1 stop18h 33m

Santiago Arturo Merino Benitez

Wed 5/8

2:56 a.m.-12:10 p.m.

1 stop11h 14m

C$ 965

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/3

Showing 1-10 of 23 resultsSorted by cheapest first
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Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santiago. Price data was last updated on 6 March 2026.

The price you pay for your flight from Mexico City to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 90 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, April is the cheapest month in which you can book a flight from Mexico City to Santiago (average of C$ 360). Flying from Mexico City to Santiago in June is currently the most expensive (average of C$ 588). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 14 March 2026.

When flying from Mexico City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    This flight path from Mexico City Benito Juarez to Santiago Arturo Merino Benitez was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Mexico City to Santiago?

    There are many flights that can get you from Mexico City to Santiago in 16h 03m. Fly via Copa Airlines to get the fastest option. The distance between Mexico City and Santiago is about 6592 km.

  • What are the most reliable airlines from Mexico City to Santiago?

    Consider LATAM Airlines (92%), Wamos Air (92%) or WestJet (80%) when booking your flight. These represent the most reliable airlines when flying from Mexico City to Santiago.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Mexico City to Santiago (average of C$ 360). Flying from Mexico City to Santiago in June is currently the most expensive (average of C$ 588). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santiago?

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Can Cheapflights find flights from Mexico City to Santiago with no change fees?

Cheapflights does show flights with no change fees to all users. To see these options for flights from Mexico City to Santiago, users can toggle the no change fees filter when performing a flight search.

Can Cheapflights notify me if prices for flights from Mexico City to Santiago become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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