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Cheap flights from Mexico City to Santiago from C$ 359

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 22/3. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
2 Mar — 9 Mar1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Mexico City to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 31 January 2026.

Wed 18/35:55 a.m.
MEX
-
SCL
1 stop15h 39m
Copa Airlines
Thu 2/45:17 a.m.
SCL
-
MEX
1 stop16h 48m
Copa Airlines
Deal found 30/1C$ 748
Sat 21/311:00 a.m.
MEX
-
SCL
1 stop32h 00m
Multiple Airlines
Mon 30/33:33 p.m.
SCL
-
MEX
2 stops25h 17m
Multiple Airlines
Deal found 28/1C$ 791
Fri 6/37:50 p.m.
MEX
-
SCL
Nonstop8h 40m
Multiple Airlines
Fri 13/39:30 a.m.
SCL
-
MEX
1 stop25h 05m
Multiple Airlines
Deal found 29/1C$ 809
Mon 6/45:50 a.m.
MEX
-
SCL
1 stop15h 36m
Copa Airlines
Sun 19/411:25 a.m.
SCL
-
MEX
1 stop14h 50m
Copa Airlines
Deal found 30/1C$ 815
Thu 12/21:10 p.m.
MEX
-
SCL
1 stop12h 04m
Copa Airlines
Thu 28/54:41 a.m.
SCL
-
MEX
1 stop16h 24m
Copa Airlines
Deal found 30/1C$ 871
Sun 9/811:20 p.m.
MEX
-
SCL
1 stop12h 55m
Avianca
Wed 26/86:40 a.m.
SCL
-
MEX
1 stop13h 25m
Avianca
Deal found 30/1C$ 887
Sat 31/11:20 a.m.
MEX
-
SCL
1 stop20h 12m
Copa Airlines
Fri 27/312:28 p.m.
SCL
-
MEX
1 stop12h 37m
Copa Airlines
Deal found 30/1C$ 899
Fri 14/811:20 p.m.
MEX
-
SCL
1 stop21h 10m
Avianca
Mon 17/86:10 a.m.
SCL
-
MEX
1 stop13h 55m
Avianca
Deal found 29/1C$ 914
Tue 3/29:25 a.m.
MEX
-
SCL
1 stop14h 52m
Copa Airlines
Tue 10/23:34 a.m.
SCL
-
MEX
1 stop21h 31m
Copa Airlines
Deal found 29/1C$ 928
Sun 1/34:00 p.m.
MEX
-
SCL
1 stop19h 05m
Multiple Airlines
Sun 8/39:30 a.m.
SCL
-
MEX
1 stop31h 50m
Multiple Airlines
Deal found 30/1C$ 950
Wed 29/75:50 a.m.
MEX
-
SCL
1 stop19h 10m
Copa Airlines
Tue 4/82:27 a.m.
SCL
-
MEX
1 stop14h 03m
Copa Airlines
Deal found 30/1C$ 964

Find flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 31 January 2026.

Round-trip from

C$ 748

One-way from

C$ 359

Popular in

February

Cheapest in

May

Average price

C$ 832
Copa Airlines
  • Copa Airlines
  • 18/3-2/4
  • 2 total stops
  • 32h 27m total
  • Mexico City to Santiago
Search Deals
Copa Airlines
  • Copa Airlines
  • 22/3
  • 1 total stop
  • 14h 54m total
  • Mexico City to Santiago
Search Deals
Highest demand for flights based on searches. 6% potential increase in price (C$ 78 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (C$ 21 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 31 January 2026.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Mexico City

Fly to

Santiago

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 18/3

5:55 a.m.-12:34 a.m.

1 stop15h 39m

Santiago Arturo Merino Benitez

Thu 2/4

5:17 a.m.-7:05 p.m.

1 stop16h 48m

C$ 748

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 20/3

1:20 a.m.-12:34 a.m.

1 stop20h 14m

Santiago Arturo Merino Benitez

Mon 30/3

12:28 p.m.-12:15 a.m.

1 stop14h 47m

C$ 748

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 21/3

11:00 a.m.-10:00 p.m.

1 stop32h 00m

Santiago Arturo Merino Benitez

Mon 30/3

3:33 p.m.-1:50 p.m.

2 stops25h 17m

C$ 791

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 6/3

7:50 p.m.-7:30 a.m.

Nonstop8h 40m

Santiago Arturo Merino Benitez

Fri 13/3

9:30 a.m.-7:35 a.m.

1 stop25h 05m

C$ 809

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 26/4

5:50 a.m.-10:43 p.m.

1 stop14h 53m

Santiago Arturo Merino Benitez

Sun 3/5

4:09 a.m.-10:05 p.m.

1 stop19h 56m

C$ 815

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 7/5

3:30 p.m.-5:10 a.m.

1 stop11h 40m

Santiago Arturo Merino Benitez

Sun 10/5

2:22 a.m.-10:05 p.m.

1 stop21h 43m

C$ 815

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 6/4

5:50 a.m.-11:26 p.m.

1 stop15h 36m

Santiago Arturo Merino Benitez

Sun 19/4

11:25 a.m.-12:15 a.m.

1 stop14h 50m

C$ 815

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 28/4

1:20 a.m.-7:23 p.m.

1 stop16h 03m

Santiago Arturo Merino Benitez

Tue 12/5

4:09 a.m.-7:05 p.m.

1 stop16h 56m

C$ 815

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 2/5

12:25 a.m.-7:23 p.m.

1 stop16h 58m

Santiago Arturo Merino Benitez

Tue 12/5

4:09 a.m.-7:05 p.m.

1 stop16h 56m

C$ 815

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 12/2

1:10 p.m.-4:14 a.m.

1 stop12h 04m

Santiago Arturo Merino Benitez

Thu 28/5

4:41 a.m.-7:05 p.m.

1 stop16h 24m

C$ 871

Flights are sorted by cheapest round-trip flights first.

Deals found on 29/1

Showing 1-10 of 16 results
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Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santiago. Price data was last updated on 23 January 2026.

The price you pay for your flight from Mexico City to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 90 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, November is the cheapest month in which you can book a flight from Mexico City to Santiago (average of C$ 417). Flying from Mexico City to Santiago in June is currently the most expensive (average of C$ 584). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 31 January 2026.

When flying from Mexico City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    This flight path from Mexico City Benito Juarez to Santiago Arturo Merino Benitez was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Mexico City to Santiago?

    There are many flights that can get you from Mexico City to Santiago in 15h 39m. Fly via Copa Airlines to get the fastest option. The distance between Mexico City and Santiago is about 6592 km.

  • What are the most reliable airlines from Mexico City to Santiago?

    Consider LATAM Airlines (95%), Wamos Air (95%) or Aeromexico (86%) when booking your flight. These represent the most reliable airlines when flying from Mexico City to Santiago.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, November is the cheapest month in which you can book a flight from Mexico City to Santiago (average of C$ 417). Flying from Mexico City to Santiago in June is currently the most expensive (average of C$ 584). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar

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Deals for Mexico City to Santiago flights are sourced from 900+ travel sites when you use Cheapflights. When all flight results come back, Cheapflights lets you sort and filter flights using different criteria to choose better, like price, airport, cabin class, and plenty of other options.

Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santiago?

Cheapflights simply makes it quick and affordable to book flights from Mexico City to Santiago by bringing together all flight options from hundreds of airlines and agencies online — and put it in one place for you to choose from. Plus, Cheapflights is 100% free to use for all.

Can Cheapflights find flights from Mexico City to Santiago with no change fees?

Cheapflights does show flights with no change fees to all users. To see these options for flights from Mexico City to Santiago, users can toggle the no change fees filter when performing a flight search.

Can Cheapflights notify me if prices for flights from Mexico City to Santiago become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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