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Cheap flights from Mexico City to Santiago from C$ 364

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/1. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
14 Jan — 21 Jan1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Mexico City to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 15 December 2025.

Wed 24/121:10 p.m.MEX - SCL
1 stop11h 33mCopa Airlines
Wed 31/125:44 a.m.SCL - MEX
1 stop11h 46mCopa Airlines
Deal found 14/12C$ 719
Wed 24/121:10 p.m.MEX - SCL
1 stop13h 51mCopa Airlines
Tue 10/35:21 a.m.SCL - MEX
1 stop21h 54mCopa Airlines
Deal found 14/12C$ 728
Mon 22/129:25 a.m.MEX - SCL
1 stop11h 16mCopa Airlines
Mon 29/125:12 a.m.SCL - MEX
1 stop22h 03mCopa Airlines
Deal found 15/12C$ 1,027
Tue 30/121:20 a.m.MEX - SCL
1 stop20h 04mCopa Airlines
Thu 8/15:20 a.m.SCL - MEX
1 stop21h 55mCopa Airlines
Deal found 14/12C$ 1,035
Mon 15/121:10 p.m.MEX - SCL
1 stop11h 33mCopa Airlines
Tue 30/121:08 a.m.SCL - MEX
1 stop16h 22mCopa Airlines
Deal found 14/12C$ 1,075
Fri 19/121:20 a.m.MEX - SCL
1 stop20h 04mCopa Airlines
Mon 29/123:23 a.m.SCL - MEX
1 stop14h 07mCopa Airlines
Deal found 15/12C$ 1,104
Wed 17/123:30 p.m.MEX - SCL
1 stop11h 31mCopa Airlines
Sat 31/15:44 a.m.SCL - MEX
1 stop16h 36mCopa Airlines
Deal found 15/12C$ 1,114
Tue 23/129:25 a.m.MEX - SCL
1 stop15h 18mCopa Airlines
Sat 17/15:20 a.m.SCL - MEX
1 stop19h 45mCopa Airlines
Deal found 15/12C$ 1,126
Fri 26/122:00 a.m.MEX - SCL
1 stop19h 24mCopa Airlines
Wed 7/15:20 a.m.SCL - MEX
1 stop21h 55mCopa Airlines
Deal found 14/12C$ 1,135
Wed 17/121:20 a.m.MEX - SCL
1 stop20h 04mCopa Airlines
Wed 31/121:46 a.m.SCL - MEX
1 stop13h 24mCopa Airlines
Deal found 14/12C$ 1,143
Wed 17/121:20 a.m.MEX - SCL
1 stop19h 21mCopa Airlines
Thu 25/1212:20 p.m.SCL - MEX
1 stop14h 55mCopa Airlines
Deal found 13/12C$ 1,146
Sat 27/122:00 a.m.MEX - SCL
1 stop18h 41mCopa Airlines
Wed 7/15:20 a.m.SCL - MEX
1 stop21h 55mCopa Airlines
Deal found 15/12C$ 1,197

Find flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 15 December 2025.

Round-trip from

C$ 757

One-way from

C$ 364

Popular in

February

Cheapest in

May

Average price

C$ 958
Copa Airlines
  • Copa Airlines
  • 5/1-28/1
  • 2 total stops
  • 31h 56m total
  • Mexico City to Santiago
Search Deals
Copa Airlines
  • Copa Airlines
  • 1/1
  • 1 total stop
  • 16h 00m total
  • Mexico City to Santiago
Search Deals
Highest demand for flights based on searches. 8% potential increase in price (C$ 107 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (C$ 22 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 15 December 2025.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Mexico City

Fly to

Santiago

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 5/1

2:00 a.m.-8:20 p.m.

1 stop15h 20m

Santiago Arturo Merino Benitez

Wed 28/1

5:44 a.m.-7:20 p.m.

1 stop16h 36m

C$ 757

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 9/1

5:55 a.m.-3:17 a.m.

1 stop18h 22m

Santiago Arturo Merino Benitez

Sat 24/1

5:44 a.m.-7:20 p.m.

1 stop16h 36m

C$ 757

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 18/1

5:55 a.m.-4:14 a.m.

1 stop19h 19m

Santiago Arturo Merino Benitez

Sat 31/1

5:44 a.m.-10:05 p.m.

1 stop19h 21m

C$ 786

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 24/1

1:20 a.m.-8:20 p.m.

1 stop16h 00m

Santiago Arturo Merino Benitez

Wed 4/2

5:20 a.m.-2:30 p.m.

1 stop12h 10m

C$ 814

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 24/1

9:25 a.m.-11:43 p.m.

1 stop11h 18m

Santiago Arturo Merino Benitez

Sat 7/2

5:44 a.m.-10:05 p.m.

1 stop19h 21m

C$ 850

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 2/1

1:20 a.m.-12:32 a.m.

1 stop20h 12m

Santiago Arturo Merino Benitez

Sat 31/1

1:46 a.m.-7:20 p.m.

1 stop20h 34m

C$ 935

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 26/1

1:20 a.m.-8:20 p.m.

1 stop16h 00m

Santiago Arturo Merino Benitez

Sun 1/2

5:44 a.m.-7:20 p.m.

1 stop16h 36m

C$ 964

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 3/1

9:25 a.m.-12:32 a.m.

1 stop12h 07m

Santiago Arturo Merino Benitez

Tue 20/1

5:20 a.m.-10:05 p.m.

1 stop19h 45m

C$ 998

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 6/1

5:55 a.m.-6:00 a.m.

1 stop21h 05m

Santiago Arturo Merino Benitez

Wed 14/1

12:28 p.m.-1:00 a.m.

1 stop15h 32m

C$ 998

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 8/1

1:20 a.m.-11:43 p.m.

1 stop19h 23m

Santiago Arturo Merino Benitez

Tue 13/1

5:44 a.m.-7:20 p.m.

1 stop16h 36m

C$ 998

Flights are sorted by cheapest round-trip flights first.

Deals found on 15/12

Showing 1-10 of 20 results
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Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santiago. Price data was last updated on 12 December 2025.

The price you pay for your flight from Mexico City to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 90 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, November is the cheapest month in which you can book a flight from Mexico City to Santiago (average of C$ 425). Flying from Mexico City to Santiago in April is currently the most expensive (average of C$ 650). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 15 December 2025.

When flying from Mexico City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    This flight path from Mexico City Benito Juarez to Santiago Arturo Merino Benitez was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Mexico City to Santiago?

    There are many flights that can get you from Mexico City to Santiago in 15h 20m. Fly via Copa Airlines to get the fastest option. The distance between Mexico City and Santiago is about 6592 km.

  • What are the most reliable airlines from Mexico City to Santiago?

    Consider Aeromexico (100%), LATAM Airlines (93%) or Wamos Air (93%) when booking your flight. These represent the most reliable airlines when flying from Mexico City to Santiago.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, November is the cheapest month in which you can book a flight from Mexico City to Santiago (average of C$ 425). Flying from Mexico City to Santiago in April is currently the most expensive (average of C$ 650). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Deals for Mexico City to Santiago flights are sourced from 900+ travel sites when you use Cheapflights. When all flight results come back, Cheapflights lets you sort and filter flights using different criteria to choose better, like price, airport, cabin class, and plenty of other options.

Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santiago?

Cheapflights simply makes it quick and affordable to book flights from Mexico City to Santiago by bringing together all flight options from hundreds of airlines and agencies online — and put it in one place for you to choose from. Plus, Cheapflights is 100% free to use for all.

Can Cheapflights find flights from Mexico City to Santiago with no change fees?

Cheapflights does show flights with no change fees to all users. To see these options for flights from Mexico City to Santiago, users can toggle the no change fees filter when performing a flight search.

Can Cheapflights notify me if prices for flights from Mexico City to Santiago become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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