Find flights
Deals
When to book
FAQs

Cheap flights from Mexico City to Santiago from C$ 369

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 29/12. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
29 Nov — 6 Dec1
1 adult
1 adult, Economy, 0 bags

Find flight deals from Mexico City to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 30 October 2025.

Wed 24/125:55 a.m.MEX - SCL
1 stop11h 26mCopa Airlines
Mon 30/33:24 a.m.SCL - MEX
1 stop18h 56mCopa Airlines
Deal found 29/10C$ 758
Tue 2/121:20 a.m.MEX - SCL
1 stop19h 21mCopa Airlines
Thu 11/1212:20 p.m.SCL - MEX
1 stop15h 40mCopa Airlines
Deal found 30/10C$ 788
Mon 1/121:20 a.m.MEX - SCL
1 stop20h 04mCopa Airlines
Mon 8/121:08 a.m.SCL - MEX
1 stop21h 12mCopa Airlines
Deal found 29/10C$ 817
Mon 1/121:20 a.m.MEX - SCL
1 stop19h 21mCopa Airlines
Sat 13/125:12 a.m.SCL - MEX
1 stop19h 53mCopa Airlines
Deal found 30/10C$ 853
Wed 5/115:55 a.m.MEX - SCL
1 stop14h 46mCopa Airlines
Sun 9/115:12 a.m.SCL - MEX
1 stop22h 03mCopa Airlines
Deal found 29/10C$ 855
Sat 15/113:10 a.m.MEX - SCL
1 stop17h 56mCopa Airlines
Sun 23/1112:20 p.m.SCL - MEX
1 stop14h 55mCopa Airlines
Deal found 29/10C$ 894
Sun 16/111:20 a.m.MEX - SCL
1 stop19h 46mCopa Airlines
Thu 27/113:23 a.m.SCL - MEX
1 stop18h 57mCopa Airlines
Deal found 30/10C$ 922
Sun 23/112:00 a.m.MEX - SCL
1 stop15h 21mCopa Airlines
Wed 3/121:29 a.m.SCL - MEX
1 stop20h 51mCopa Airlines
Deal found 29/10C$ 926
Mon 8/122:00 a.m.MEX - SCL
1 stop19h 24mCopa Airlines
Mon 4/52:34 a.m.SCL - MEX
1 stop11h 36mCopa Airlines
Deal found 29/10C$ 938
Mon 10/115:55 a.m.MEX - SCL
1 stop18h 48mCopa Airlines
Sun 16/115:12 a.m.SCL - MEX
1 stop19h 53mCopa Airlines
Deal found 29/10C$ 958
Sat 13/125:55 a.m.MEX - SCL
1 stop18h 48mCopa Airlines
Mon 22/123:23 a.m.SCL - MEX
1 stop18h 57mCopa Airlines
Deal found 28/10C$ 990

Cheap flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 30 October 2025.

Round-trip from

C$ 758

One-way from

C$ 369

Popular in

February

Cheapest in

May

Average price

C$ 856

Good one-way deal

C$ 929 or less
Copa Airlines
  • Copa Airlines
  • 24/12-30/3
  • 2 total stops
  • 30h 22m total
  • Mexico City to Santiago
Search Deals
Copa Airlines
  • Copa Airlines
  • 6/1
  • 1 total stop
  • 11h 18m total
  • Mexico City to Santiago
Search Deals
Highest demand for flights based on searches. 7% potential increase in price (C$ 104 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (C$ 20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals
Price to beat on a one-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 30 October 2025.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Mexico City

Fly to

Santiago

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 5/1

1:20 a.m.-8:20 p.m.

1 stop16h 00m

Santiago Arturo Merino Benitez

Tue 17/3

1:17 a.m.-2:30 p.m.

1 stop16h 13m

C$ 758

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 2/12

2:00 a.m.-11:41 p.m.

1 stop18h 41m

Santiago Arturo Merino Benitez

Wed 10/12

12:20 p.m.-1:00 a.m.

1 stop15h 40m

C$ 788

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 3/12

9:25 a.m.-6:01 a.m.

1 stop17h 36m

Santiago Arturo Merino Benitez

Wed 10/12

1:08 a.m.-7:20 p.m.

1 stop21h 12m

C$ 788

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 25/11

1:20 a.m.-8:21 p.m.

1 stop16h 01m

Santiago Arturo Merino Benitez

Mon 8/12

12:20 p.m.-1:00 a.m.

1 stop15h 40m

C$ 788

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 11/3

1:20 a.m.-12:34 a.m.

1 stop20h 14m

Santiago Arturo Merino Benitez

Tue 24/3

12:28 p.m.-12:15 a.m.

1 stop14h 47m

C$ 788

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 10/3

1:20 a.m.-12:34 a.m.

1 stop20h 14m

Santiago Arturo Merino Benitez

Wed 18/3

1:38 a.m.-7:20 p.m.

1 stop20h 42m

C$ 788

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 12/3

9:25 a.m.-11:49 p.m.

1 stop11h 24m

Santiago Arturo Merino Benitez

Wed 18/3

3:32 a.m.-7:20 p.m.

1 stop18h 48m

C$ 788

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 1/12

1:20 a.m.-8:21 p.m.

1 stop16h 01m

Santiago Arturo Merino Benitez

Tue 9/12

5:44 a.m.-7:20 p.m.

1 stop16h 36m

C$ 788

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 16/3

9:25 a.m.-11:49 p.m.

1 stop11h 24m

Santiago Arturo Merino Benitez

Tue 24/3

3:32 a.m.-10:05 p.m.

1 stop21h 33m

C$ 788

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 29/12

1:20 a.m.-11:41 p.m.

1 stop19h 21m

C$ 369

Flights are sorted by cheapest round-trip flights first.

Deals found on 29/10

Showing 1-10 of 19 results
1
2

Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santiago. Price data was last updated on 24 October 2025.

The price you pay for your flight from Mexico City to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 90 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, December is the cheapest month in which you can book a flight from Mexico City to Santiago (average of C$ 427). Flying from Mexico City to Santiago in February is currently the most expensive (average of C$ 693). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 30 October 2025.

When flying from Mexico City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Mexico City to Santiago?

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    This flight path from Mexico City Benito Juarez to Santiago Arturo Merino Benitez was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Mexico City to Santiago?

    There are many flights that can get you from Mexico City to Santiago in 16h. Fly via Copa Airlines to get the fastest option. The distance between Mexico City and Santiago is about 6592 km.

  • What are the cheapest flights from Mexico City to Santiago?

    On average you can expect to pay C$ 929 for a flight from Mexico City to Santiago. The cheapest flight overall is C$ 929 while the most popular route, (Mexico City Benito Juarez - Santiago Arturo Merino Benitez) is currently priced at C$ 888.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, December is the cheapest month in which you can book a flight from Mexico City to Santiago (average of C$ 427). Flying from Mexico City to Santiago in February is currently the most expensive (average of C$ 693). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travelers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Mexico City to Santiago?

Deals for Mexico City to Santiago flights are sourced from 900+ travel sites when you use Cheapflights. When all flight results come back, Cheapflights lets you sort and filter flights using different criteria to choose better, like price, airport, cabin class, and plenty of other options.

Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santiago?

Cheapflights simply makes it quick and affordable to book flights from Mexico City to Santiago by bringing together all flight options from hundreds of airlines and agencies online — and put it in one place for you to choose from. Plus, Cheapflights is 100% free to use for all.

Can Cheapflights find flights from Mexico City to Santiago with no change fees?

Cheapflights does show flights with no change fees to all users. To see these options for flights from Mexico City to Santiago, users can toggle the no change fees filter when performing a flight search.

Can Cheapflights notify me if prices for flights from Mexico City to Santiago become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.