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Cheap flights from Buffalo to Panama City, FL from C$ 321

BUF — ECP
25 Nov — 2 Dec1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Buffalo to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Buffalo to Panama City

Sat 5/1211:00 a.m. -
1 stop7h 35m
Wed 9/127:55 a.m. -
1 stop6h 20m
Deal found 21/10C$ 412
Sat 5/126:00 a.m. -
1 stop5h 34m
Wed 9/129:23 a.m. -
1 stop7h 13m
Deal found 24/10C$ 531
Fri 20/116:36 p.m. -
1 stop5h 48m
Tue 24/115:16 p.m. -
1 stop5h 43m
Deal found 26/10C$ 597
Sat 5/1211:23 a.m. -
2 stops11h 15m
Wed 9/129:05 a.m. -
2 stops13h 29m
Deal found 21/10C$ 608
Wed 9/127:05 a.m. -
2 stops9h 05m
Mon 14/1210:05 a.m. -
2 stops10h 55m
Deal found 22/10C$ 654
Fri 6/115:20 p.m. -
1 stop6h 58m
Tue 10/115:16 p.m. -
1 stop5h 43m
Deal found 22/10C$ 668
Tue 3/116:00 a.m. -
1 stop4h 07m
Tue 10/116:00 a.m. -
1 stop4h 06m
Deal found 21/10C$ 726
Fri 20/117:20 a.m. -
2 stops8h 05m
Tue 24/116:15 a.m. -
1 stop7h 10m
Deal found 26/10C$ 728

Find flight deals from Buffalo to Panama City

Round-trip from

C$ 412

One-way from

C$ 321

Popular in

April

Cheapest in

August

Average price

C$ 501
Southwest
  • Southwest
  • 5/12-9/12
  • 2 total stops
  • 13h 55m total
  • Buffalo to Panama City
Search Deals
Southwest
  • Southwest
  • 23/3-31/12
  • 1 total stop
  • 4h 10m total
  • Buffalo to Panama City
Search Deals
Highest demand for flights based on searches. 18% potential increase in price (C$ 194 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease (C$ 46 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Buffalo to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Mon 22/3

6:16 a.m.-12:31 p.m.

1 stop7h 15m

Panama City NW Florida Beaches

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 335
Quickest round-trip

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Sat 20/3

6:45 p.m.-10:47 p.m.

1 stop5h 02m

Panama City NW Florida Beaches

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 335

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Mon 22/3

7:20 a.m.-3:55 p.m.

2 stops9h 35m

Panama City NW Florida Beaches

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 370

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Sat 20/3

12:25 p.m.-8:55 p.m.

2 stops9h 30m

Panama City NW Florida Beaches

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 370

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Fri 19/3

7:20 a.m.-2:20 p.m.

2 stops8h 00m

Panama City NW Florida Beaches

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 426

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Mon 28/12

4:30 p.m.-9:00 p.m.

1 stop5h 30m

Panama City NW Florida Beaches

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 448

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Tue 2/2

6:05 a.m.-10:18 a.m.

1 stop5h 13m

Panama City NW Florida Beaches

Tue 16/2

5:30 p.m.-11:55 p.m.

1 stop5h 25m

C$ 525

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Sat 5/12

6:00 a.m.-10:34 a.m.

1 stop5h 34m

Panama City NW Florida Beaches

Wed 9/12

9:23 a.m.-5:36 p.m.

1 stop7h 13m

C$ 531

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Sun 7/2

6:00 a.m.-11:04 a.m.

1 stop6h 04m

Panama City NW Florida Beaches

Fri 26/2

4:10 p.m.-11:55 p.m.

1 stop6h 45m

C$ 573

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Fri 30/10

2:20 p.m.-10:15 p.m.

2 stops8h 55m

Panama City NW Florida Beaches

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 611

Flights are sorted by cheapest round-trip flights first.

Deals found on 24/10

Showing 1-10 of 16 resultsSorted by cheapest first
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Best time to book a flight from Buffalo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Buffalo with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Panama City

What is the cheapest month to book a flight from Buffalo to Panama City, Florida?

Currently, August is the cheapest month in which you can book a flight from Buffalo to Panama City, Florida (average of C$ 476). Flying from Buffalo to Panama City, Florida in April is currently the most expensive (average of C$ 975). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Buffalo to Panama City, Florida?

Airfare is below average for this route at the moment.

Buffalo to Panama City, Florida flights typically cost between C$ 463 and C$ 762 in December.
The cheapest round-trip price found within the last 5 days was C$ 412 on Southwest (5 Dec-9 Dec).

Related info for your journey

  • How long is the flight from Buffalo to Panama City, Florida?

    Delta can get you from Buffalo to Panama City, Florida in just under 5h 13m. Your travel time can differ by up to . The distance from Buffalo to Panama City, Florida is about 1532 km.

  • Can I find deals for flights from Buffalo to Panama City that include hotel bookings?

    Yes. In addition to deals on Buffalo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Panama City.

  • Can I find deals for business class flights from Buffalo to Panama City?

    Yes. Cheapflights offers flight deals from Buffalo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Panama City, Florida?

    Currently, August is the cheapest month in which you can book a flight from Buffalo to Panama City, Florida (average of C$ 476). Flying from Buffalo to Panama City, Florida in April is currently the most expensive (average of C$ 975). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Need flexible booking options for your flight to Panama City from Buffalo? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

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