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Cheap flights from Buffalo to Panama City, FL from C$ 240

BUF — ECP
12 Oct — 19 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Buffalo to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Buffalo to Panama City

Mon 5/106:59 p.m. -
1 stop5h 26m
Thu 8/109:19 a.m. -
1 stop4h 39m
Deal found 8/9C$ 478
Fri 2/106:59 p.m. -
1 stop5h 26m
Mon 5/106:19 p.m. -
1 stop4h 33m
Deal found 10/9C$ 510
Thu 29/1012:35 p.m. -
2 stops9h 20m
Mon 2/117:55 a.m. -
2 stops9h 40m
Deal found 10/9C$ 528
Fri 2/106:59 p.m. -
1 stop5h 26m
Tue 6/107:12 a.m. -
1 stop6h 41m
Deal found 11/9C$ 538
Sun 11/106:55 p.m. -
1 stop5h 23m
Sat 17/106:00 a.m. -
1 stop4h 16m
Deal found 9/9C$ 542
Sun 11/106:55 p.m. -
1 stop5h 23m
Tue 13/107:12 a.m. -
1 stop6h 41m
Deal found 8/9C$ 556
Wed 9/1212:45 p.m. -
2 stops6h 25m
Sun 13/127:55 a.m. -
1 stop6h 20m
Deal found 7/9C$ 567
Sat 24/1010:46 a.m. -
1 stop5h 28m
Wed 28/109:06 a.m. -
2 stops12h 53m
Deal found 10/9C$ 568

Find flight deals from Buffalo to Panama City

Round-trip from

C$ 464

One-way from

C$ 240

Popular in

April

Cheapest in

October

Average price

C$ 812
American Airlines
  • American Airlines
  • 17/2-23/2
  • 2 total stops
  • 11h 06m total
  • Buffalo to Panama City
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Delta
  • Delta
  • 13/10-31/12
  • 1 total stop
  • 5h 23m total
  • Buffalo to Panama City
Search Deals
Highest demand for flights based on searches. 15% potential increase in price (C$ 155 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease (C$ 41 potential savings vs. average RT price).
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Average for round-trip flights in September 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Buffalo to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Sat 24/10

10:46 a.m.-3:14 p.m.

1 stop5h 28m

Panama City NW Florida Beaches

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 274

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Sat 3/10

10:46 a.m.-10:18 p.m.

2 stops12h 32m

Panama City NW Florida Beaches

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 281

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Mon 9/11

12:40 p.m.-8:30 p.m.

2 stops8h 50m

Panama City NW Florida Beaches

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 296
Quickest round-trip

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Sun 11/10

6:55 p.m.-11:18 p.m.

1 stop5h 23m

Panama City NW Florida Beaches

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 317

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Sat 17/10

12:30 p.m.-7:55 p.m.

2 stops8h 25m

Panama City NW Florida Beaches

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 333

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Sat 17/10

7:00 a.m.-4:13 p.m.

2 stops10h 13m

Panama City NW Florida Beaches

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 421

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Mon 5/10

6:59 p.m.-11:25 p.m.

1 stop5h 26m

Panama City NW Florida Beaches

Tue 13/10

4:30 p.m.-11:59 p.m.

1 stop6h 29m

C$ 478

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Wed 7/10

3:59 p.m.-8:03 p.m.

1 stop5h 04m

Panama City NW Florida Beaches

Wed 14/10

7:12 a.m.-2:53 p.m.

1 stop6h 41m

C$ 478

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Fri 2/10

6:59 p.m.-11:25 p.m.

1 stop5h 26m

Panama City NW Florida Beaches

Mon 5/10

6:19 p.m.-11:52 p.m.

1 stop4h 33m

C$ 510

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Sun 11/10

6:55 p.m.-11:18 p.m.

1 stop5h 23m

Panama City NW Florida Beaches

Sat 17/10

6:00 a.m.-11:16 a.m.

1 stop4h 16m

C$ 542

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/9

Showing 1-10 of 18 resultsSorted by cheapest first
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Best time to book a flight from Buffalo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Buffalo with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Panama City

What is the cheapest month to book a flight from Buffalo to Panama City, Florida?

Currently, October is the cheapest month in which you can book a flight from Buffalo to Panama City, Florida (average of C$ 467). Flying from Buffalo to Panama City, Florida in April is currently the most expensive (average of C$ 937). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Buffalo to Panama City, Florida?

Airfare is below average for this route at the moment.

Buffalo to Panama City, Florida flights typically cost between C$ 560 and C$ 827 in February.
The cheapest round-trip price found within the last 5 days was C$ 464 on American Airlines (17 Feb-23 Feb).

Related info for your journey

  • How long is the flight from Buffalo to Panama City, Florida?

    Delta can get you from Buffalo to Panama City, Florida in just under 5h 26m. Your travel time can differ by up to . The distance from Buffalo to Panama City, Florida is about 1532 km.

  • Can I find deals for flights from Buffalo to Panama City that include hotel bookings?

    Yes. In addition to deals on Buffalo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Panama City.

  • Can I find deals for business class flights from Buffalo to Panama City?

    Yes. Cheapflights offers flight deals from Buffalo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Panama City, Florida?

    Currently, October is the cheapest month in which you can book a flight from Buffalo to Panama City, Florida (average of C$ 467). Flying from Buffalo to Panama City, Florida in April is currently the most expensive (average of C$ 937). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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