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Cheap flights from Buffalo to Missouri from C$ 160

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/5. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — STL
24 Apr — 1 May1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Buffalo to Missouri

Enter your travel dates to find the best prices.

Cheapest flights from Buffalo to Missouri
Explore the most affordable flight options available from Buffalo to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 25 March 2026.

Tue 14/49:45 a.m.
BUF
-
STL
1 stop6h 30m
Southwest
Tue 21/410:25 a.m.
STL
-
BUF
1 stop3h 55m
Southwest
Deal found 24/3C$ 304
Tue 21/46:55 p.m.
BUF
-
STL
1 stop4h 15m
Southwest
Tue 28/45:35 a.m.
STL
-
BUF
1 stop3h 45m
Southwest
Deal found 23/3C$ 334
Tue 14/411:00 a.m.
BUF
-
STL
1 stop5h 15m
Southwest
Sat 18/410:55 a.m.
STL
-
BUF
2 stops6h 05m
Southwest
Deal found 24/3C$ 363
Sat 18/43:01 p.m.
BUF
-
STL
1 stop6h 08m
American Airlines
Mon 20/48:54 a.m.
STL
-
BUF
1 stop4h 27m
American Airlines
Deal found 23/3C$ 364
Mon 13/44:00 p.m.
BUF
-
STL
2 stops7h 45m
Southwest
Wed 22/45:35 a.m.
STL
-
BUF
1 stop3h 45m
Southwest
Deal found 23/3C$ 378
Thu 4/67:00 a.m.
BUF
-
MCI
1 stop4h 29m
United Airlines
Tue 9/61:50 p.m.
MCI
-
BUF
1 stop8h 08m
United Airlines
Deal found 25/3C$ 414
Thu 7/58:00 p.m.
BUF
-
STL
1 stop3h 45m
Southwest
Sat 9/510:55 a.m.
STL
-
BUF
2 stops6h 05m
Southwest
Deal found 24/3C$ 419
Fri 17/412:08 p.m.
BUF
-
STL
1 stop19h 42m
Frontier
Tue 21/44:59 p.m.
STL
-
BUF
2 stops18h 43m
Frontier
Deal found 23/3C$ 422
Wed 10/611:00 a.m.
BUF
-
STL
2 stops7h 30m
Southwest
Sun 14/65:50 a.m.
STL
-
BUF
1 stop3h 30m
Southwest
Deal found 23/3C$ 426
Thu 7/511:31 a.m.
BUF
-
MCI
1 stop6h 55m
American Airlines
Mon 11/54:51 p.m.
MCI
-
BUF
1 stop5h 28m
American Airlines
Deal found 24/3C$ 436
Mon 1/67:39 p.m.
BUF
-
MCI
1 stop16h 37m
Delta
Tue 9/65:40 p.m.
MCI
-
BUF
1 stop4h 23m
Delta
Deal found 20/3C$ 440
Thu 7/58:49 p.m.
BUF
-
MCI
1 stop21h 34m
Multiple Airlines
Mon 11/52:34 p.m.
MCI
-
BUF
2 stops19h 07m
Multiple Airlines
Deal found 21/3C$ 455

Find flight deals from Buffalo to Missouri

Keep the following information in mind while searching for Buffalo to Missouri flight deals. Data was last updated 25 March 2026.

Round-trip from

C$ 304

One-way from

C$ 160

Popular in

January

Cheapest in

September

Average price

C$ 545
Southwest
  • Southwest
  • 14/4-21/4
  • 2 total stops
  • 10h 25m total
  • Buffalo to Missouri
Search Deals
Frontier
  • Frontier
  • 9/5
  • 2 total stops
  • 12h 40m total
  • Buffalo to Missouri
Search Deals
Highest demand for flights based on searches. 3% potential increase in price (C$ 24 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (C$ 17 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 25 March 2026.
Use the filters below to find and compare flights from Buffalo to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Tue 14/4

9:45 a.m.-3:15 p.m.

1 stop6h 30m

Lambert-St Louis

Tue 21/4

10:25 a.m.-3:20 p.m.

1 stop3h 55m

C$ 304

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Tue 14/4

9:45 a.m.-6:00 p.m.

2 stops9h 15m

Lambert-St Louis

Sat 18/4

6:10 a.m.-4:35 p.m.

2 stops9h 25m

C$ 370

BuffaloKansas City

BUF - MCI

BUFMCI

Buffalo

Fri 8/5

5:20 p.m.-10:40 p.m.

1 stop6h 20m

Kansas City

Wed 13/5

5:25 a.m.-10:20 a.m.

1 stop3h 55m

C$ 437

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Sat 18/4

2:00 p.m.-7:10 p.m.

2 stops6h 10m

Lambert-St Louis

Mon 20/4

7:45 p.m.-7:50 a.m.

1 stop11h 05m

C$ 437

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Tue 21/4

4:00 p.m.-10:10 p.m.

2 stops7h 10m

Lambert-St Louis

Tue 28/4

1:45 p.m.-10:15 p.m.

2 stops7h 30m

C$ 512

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Mon 4/5

5:55 p.m.-9:13 p.m.

1 stop4h 18m

Lambert-St Louis

Tue 5/5

11:15 a.m.-4:54 p.m.

1 stop4h 39m

C$ 521

BuffaloKansas City

BUF - MCI

BUFMCI

Buffalo

Thu 16/7

6:07 a.m.-9:44 a.m.

1 stop4h 37m

Kansas City

Mon 20/7

6:42 p.m.-11:11 a.m.

1 stop15h 29m

C$ 524

BuffaloSpringfield

BUF - SGF

BUFSGF

Buffalo

Tue 26/5

5:52 p.m.-11:12 p.m.

1 stop6h 20m

Springfield-Branson

Tue 2/6

3:07 p.m.-9:03 p.m.

1 stop4h 56m

C$ 527

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Thu 18/6

5:52 p.m.-9:16 p.m.

1 stop4h 24m

Lambert-St Louis

Sun 21/6

9:23 a.m.-4:52 p.m.

1 stop6h 29m

C$ 532

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Thu 10/9

6:30 a.m.-12:00 p.m.

1 stop6h 30m

Lambert-St Louis

Thu 24/9

6:05 a.m.-11:10 a.m.

1 stop4h 05m

C$ 532

Flights are sorted by cheapest round-trip flights first.

Deals found on 24/3

Showing 1-10 of 42 resultsSorted by cheapest first
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Best time to book a flight from Buffalo to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Missouri

What is the cheapest month to book a flight from Buffalo to Missouri?

Currently, August is the cheapest month in which you can book a flight from Buffalo to Missouri (average of C$ 154). Flying from Buffalo to Missouri in February is currently the most expensive (average of C$ 381). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Buffalo to Missouri?

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated 25 March 2026.
Check out reviews from past customers who have flown with Southwest and Delta from Buffalo to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,333 reviews
Check prices

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
8.0
Very good
4,333 reviews
Southwest
8.0
Very good
4,333 reviews
Check prices

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Delta
7.9
Good
8,326 reviews
Southwest
8.0
Very good
4,333 reviews
Check prices

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Buffalo to Missouri?

    For a flight from Buffalo to Missouri, you will be flying from Buffalo. Buffalo (BUF) is just 13.4 km from the centre of the city.

  • How long is the flight from Buffalo to Missouri?

    Departing from Buffalo to Missouri will take you 4h 18m. Buffalo and Missouri are separated by a distance of 1081 km. When browsing for deals, the options you’ll see will be for both direct flights and flights with stops.

  • What are the most popular routes from Buffalo to Missouri?

    When deciding which route to take from Buffalo to Missouri consider Buffalo - Kansas City, Buffalo - Lambert-St Louis or Buffalo - Joplin as they are the most popular.

  • Can I find deals for flights from Buffalo to Missouri that include hotel bookings?

    Yes. In addition to deals on Buffalo to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Missouri.

  • Can I find deals for business class flights from Buffalo to Missouri?

    Yes. Cheapflights offers flight deals from Buffalo to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Buffalo to Missouri (average of C$ 154). Flying from Buffalo to Missouri in February is currently the most expensive (average of C$ 381). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Buffalo to Missouri

Discover the top 2 airlines that operate flights from Buffalo to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 25 March 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapestC$ 312AverageC$ 361FlexibilityNo cancel feeOn-timeN/A
Search Delta flights
SouthwestCheapestC$ 386AverageC$ 537FlexibilityNo cancel feeOn-time63%
Search Southwest flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travelers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Buffalo to Missouri?

Deals for Buffalo to Missouri flights are sourced from 900+ travel sites when you use Cheapflights. When all flight results come back, Cheapflights lets you sort and filter flights using different criteria to choose better, like price, airport, cabin class, and plenty of other options.

Why should you use Cheapflights to find cheap flight tickets from Buffalo to Missouri?

Cheapflights helps you find that perfect flight to Missouri from Buffalo by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Buffalo to Missouri with no change fees?

Users can book flights with no change fees policies with our dedicated filters. Book flights from Buffalo to Missouri flexibly with Cheapflights today.

Can Cheapflights notify me if prices for flights from Buffalo to Missouri become cheaper?

Yes, Cheapflights offers price alerts on Buffalo to Missouri flights so you can book your travel at the perfect time. Price Alerts can be enabled by clicking the bell icon next to the flight deals above and providing your email address where you want to receive the alerts.

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