Where can you fly direct from St. Louis?

Currently, the most popular direct flight destination from St. Louis is Chicago Midway Airport.

What is the best time of year to fly direct from St. Louis?

If you're seeking the lowest price on a direct flight from St. Louis, November is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, August offers travelers the most options.

Direct flights from St. Louis

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Quickest round-trip

St. LouisChicago

STL Lambert-St Louis - MDW Chicago Midway

STLMDW

Lambert-St Louis

Thu 19/11

2:25 p.m.-3:30 p.m.

Nonstop1h 05m

Chicago Midway

Wed 31/12

12:00 a.m.-12:00 a.m.

Nonstop0h 00m

C$ 83

St. LouisChicago

STL Lambert-St Louis - MDW Chicago Midway

STLMDW

Lambert-St Louis

Mon 21/12

9:50 p.m.-11:00 p.m.

Nonstop1h 10m

Chicago Midway

Wed 31/12

12:00 a.m.-12:00 a.m.

Nonstop0h 00m

C$ 83

St. LouisChicago

STL Lambert-St Louis - MDW Chicago Midway

STLMDW

Lambert-St Louis

Tue 17/11

10:55 a.m.-12:05 p.m.

Nonstop1h 10m

Chicago Midway

Wed 31/12

12:00 a.m.-12:00 a.m.

Nonstop0h 00m

C$ 83

St. LouisChicago

STL Lambert-St Louis - MDW Chicago Midway

STLMDW

Lambert-St Louis

Fri 27/11

9:35 p.m.-10:45 p.m.

Nonstop1h 10m

Chicago Midway

Wed 31/12

12:00 a.m.-12:00 a.m.

Nonstop0h 00m

C$ 83

St. LouisChicago

STL Lambert-St Louis - MDW Chicago Midway

STLMDW

Lambert-St Louis

Fri 11/12

7:15 p.m.-8:20 p.m.

Nonstop1h 05m

Chicago Midway

Wed 31/12

12:00 a.m.-12:00 a.m.

Nonstop0h 00m

C$ 83

St. LouisChicago

STL Lambert-St Louis - MDW Chicago Midway

STLMDW

Lambert-St Louis

Wed 25/11

5:30 a.m.-6:35 a.m.

Nonstop1h 05m

Chicago Midway

Wed 31/12

12:00 a.m.-12:00 a.m.

Nonstop0h 00m

C$ 83

St. LouisChicago

STL Lambert-St Louis - MDW Chicago Midway

STLMDW

Lambert-St Louis

Sat 21/11

9:50 p.m.-11:00 p.m.

Nonstop1h 10m

Chicago Midway

Wed 31/12

12:00 a.m.-12:00 a.m.

Nonstop0h 00m

C$ 83

St. LouisChicago

STL Lambert-St Louis - MDW Chicago Midway

STLMDW

Lambert-St Louis

Thu 10/12

6:20 a.m.-7:25 a.m.

Nonstop1h 05m

Chicago Midway

Wed 31/12

12:00 a.m.-12:00 a.m.

Nonstop0h 00m

C$ 83

St. LouisDenver

STL Lambert-St Louis - DEN Denver Intl

STLDEN

Lambert-St Louis

Tue 24/11

9:50 p.m.-11:20 p.m.

Nonstop2h 30m

Denver Intl

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 104

St. LouisDenver

STL Lambert-St Louis - DEN Denver Intl

STLDEN

Lambert-St Louis

Fri 1/1

6:09 p.m.-7:45 p.m.

Nonstop2h 36m

Denver Intl

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 124

Flights are sorted by cheapest round-trip flights first.

Deals found on 25/10

Showing 1-10 of 60 resultsSorted by cheapest first

...

Best time to book a flight from St. Louis

Have a flexible travel schedule? Discover the best time to fly from St. Louis with our price prediction graph.

STL-YYZ

STL-DEN

STL-MDW

STL-DTW

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines flying non-stop to St. Louis

Read through reviews of airlines serving St. Louis, such as Air Canada. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Air Canada

7.1

Good

11,832 reviews

Check prices

Reviews

1 / 20

2.0

Mediocre

Shawna,Sep 2025

DCA - YYZ

Business class cabin was *freezing*. Landing was so hard it injured my back - no apology or explanation given

Air Canada

7.1

Good

11,832 reviews

Air Canada

7.1

Good

11,832 reviews

Check prices

Reviews

1 / 20

2.0

Mediocre

Shawna,Sep 2025

DCA - YYZ

Business class cabin was *freezing*. Landing was so hard it injured my back - no apology or explanation given

Related info for your journey

Where can you fly direct from St. Louis?
Currently, the most popular direct flight destination from St. Louis is Chicago Midway Airport.
What is the best time of year to fly direct from St. Louis?
If you're seeking the lowest price on a direct flight from St. Louis, November is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, August offers travelers the most options.

Browse thousands of different options on Cheapflights for your next trip

Non-stop flights from Missouri

Popular North America origins

Popular St. Louis routes

Popular United States origins

United States destinations

Direct flights from Missouri cities

Direct flights from Springfield

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 27/11. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.

Find direct flights from St. Louis within your budget

Best time to book a flight from St. Louis

Have a flexible travel schedule? Discover the best time to fly from St. Louis with our price prediction graph.

Reviews of airlines flying non-stop to St. Louis

Read through reviews of airlines serving St. Louis, such as Air Canada. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Where can you fly direct from St. Louis?

What is the best time of year to fly direct from St. Louis?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Direct flights from Missouri cities

Book a direct flight from one of these other cities located in Missouri.

Direct flights from North America cities

Book a direct flight from one of these popular origins located in North America.

Flights to and from St. Louis

Consider one of these popular flight routes traveling to and from St. Louis

Non-stop flights from United States

Book a direct flight from one of these popular origins located in United States.

Direct flights to United States

Consider flying direct to one of these destinations in United States

100% Free

Book with Flexibility

Travel Smart

C$ 83+ Direct flights from St. Louis

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 27/11. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.

Find direct flights from St. Louis within your budget

Best time to book a flight from St. Louis

Have a flexible travel schedule? Discover the best time to fly from St. Louis with our price prediction graph.

Reviews of airlines flying non-stop to St. Louis

Read through reviews of airlines serving St. Louis, such as Air Canada. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Where can you fly direct from St. Louis?

What is the best time of year to fly direct from St. Louis?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Direct flights from Missouri cities

Book a direct flight from one of these other cities located in Missouri.

Direct flights from North America cities

Book a direct flight from one of these popular origins located in North America.

Flights to and from St. Louis

Consider one of these popular flight routes traveling to and from St. Louis

Non-stop flights from United States

Book a direct flight from one of these popular origins located in United States.

Direct flights to United States

Consider flying direct to one of these destinations in United States

100% Free

Book with Flexibility

Travel Smart