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Cheap flights from Detroit Metropolitan Wayne County Airport to St. Louis from C$ 178

DTW — STL
7 Oct — 14 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Detroit to St. Louis

Enter your travel dates to find the best prices.

Cheapest flights from Detroit to St. Louis

Wed 23/97:08 a.m. -
1 stop13h 09m
Fri 25/912:17 p.m. -
1 stop15h 38m
Deal found 3/9C$ 304
Mon 28/96:55 a.m. -
Nonstop1h 50m
Mon 5/107:50 p.m. -
Nonstop1h 35m
Deal found 3/9C$ 356
Mon 28/97:30 p.m. -
1 stop3h 40m
Wed 30/97:20 p.m. -
Nonstop1h 35m
Deal found 3/9C$ 369
Fri 16/108:10 p.m. -
Nonstop1h 41m
Wed 21/106:05 p.m. -
Nonstop1h 34m
Deal found 3/9C$ 380
Mon 28/95:30 a.m. -
1 stop5h 40m
Mon 28/92:45 p.m. -
2 stops6h 35m
Deal found 3/9C$ 390
Fri 16/104:25 p.m. -
1 stop9h 10m
Tue 20/1010:30 a.m. -
Nonstop1h 30m
Deal found 3/9C$ 394
Thu 29/105:25 a.m. -
2 stops7h 50m
Mon 2/111:05 p.m. -
2 stops8h 45m
Deal found 2/9C$ 397
Fri 13/117:58 p.m. -
1 stop4h 20m
Tue 17/115:22 p.m. -
1 stop5h 20m
Deal found 3/9C$ 408

Find flight deals from Detroit to St. Louis

Round-trip from

C$ 304

One-way from

C$ 178

Popular in

April

Cheapest in

September

Average price

C$ 441

Good round-trip deal

C$ 342 or less
Frontier
  • Frontier
  • 23/9-25/9
  • 2 total stops
  • 28h 47m total
  • Detroit to St. Louis
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Delta
  • Delta
  • 3/10-31/12
  • Nonstop
  • 1h 39m total
  • Detroit to St. Louis
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Highest demand for flights based on searches. 5% potential increase in price (C$ 43 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease (C$ 15 potential savings vs. average RT price).
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Average for round-trip flights in September 2026
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Price to beat on a round-trip flight from Detroit Metropolitan Wayne County to Lambert-St Louis.
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

DetroitSt. Louis

DTW Detroit Metropolitan Wayne County - STL Lambert-St Louis

DTWSTL

Detroit Metropolitan Wayne County

Mon 19/10

7:10 a.m.-7:45 a.m.

Nonstop1h 35m

Lambert-St Louis

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 178

DetroitSt. Louis

DTW Detroit Metropolitan Wayne County - STL Lambert-St Louis

DTWSTL

Detroit Metropolitan Wayne County

Sat 27/2

8:50 a.m.-9:36 a.m.

Nonstop1h 46m

Lambert-St Louis

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 178

DetroitSt. Louis

DTW Detroit Metropolitan Wayne County - STL Lambert-St Louis

DTWSTL

Detroit Metropolitan Wayne County

Mon 26/10

7:10 a.m.-7:45 a.m.

Nonstop1h 35m

Lambert-St Louis

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 178

DetroitSt. Louis

DTW Detroit Metropolitan Wayne County - STL Lambert-St Louis

DTWSTL

Detroit Metropolitan Wayne County

Mon 1/3

7:15 p.m.-7:55 p.m.

Nonstop1h 40m

Lambert-St Louis

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 178

DetroitSt. Louis

DTW Detroit Metropolitan Wayne County - STL Lambert-St Louis

DTWSTL

Detroit Metropolitan Wayne County

Wed 3/3

6:30 a.m.-10:48 a.m.

1 stop5h 18m

Lambert-St Louis

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 192

DetroitSt. Louis

DTW Detroit Metropolitan Wayne County - STL Lambert-St Louis

DTWSTL

Detroit Metropolitan Wayne County

Thu 31/12

2:15 p.m.-9:55 p.m.

2 stops8h 40m

Lambert-St Louis

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 199

DetroitSt. Louis

DTW Detroit Metropolitan Wayne County - STL Lambert-St Louis

DTWSTL

Detroit Metropolitan Wayne County

Wed 24/2

8:35 a.m.-1:50 p.m.

2 stops6h 15m

Lambert-St Louis

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 199

DetroitSt. Louis

DTW Detroit Metropolitan Wayne County - STL Lambert-St Louis

DTWSTL

Detroit Metropolitan Wayne County

Sat 3/10

5:45 a.m.-12:35 p.m.

2 stops7h 50m

Lambert-St Louis

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 199

DetroitSt. Louis

DTW Detroit Metropolitan Wayne County - STL Lambert-St Louis

DTWSTL

Detroit Metropolitan Wayne County

Fri 4/12

7:45 p.m.-8:32 p.m.

Nonstop1h 47m

Lambert-St Louis

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 203

DetroitSt. Louis

DTW Detroit Metropolitan Wayne County - STL Lambert-St Louis

DTWSTL

Detroit Metropolitan Wayne County

Fri 26/2

6:05 a.m.-1:55 p.m.

2 stops8h 50m

Lambert-St Louis

Wed 31/12

12:00 a.m.-1:00 a.m.

Nonstop0h 00m

C$ 224

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/9

Showing 1-10 of 22 resultsSorted by cheapest first
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Best time to book a flight from Detroit to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Detroit with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to St. Louis

How far ahead should I book a flight from Detroit Metropolitan Wayne County Airport to St. Louis?

To ensure you get the cheapest price possible for a flight from Detroit Metropolitan Wayne County Airport to St. Louis, you should look to book at least 44 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to St. Louis?

Currently, September is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to St. Louis (average of C$ 441). Flying from Detroit Metropolitan Wayne County Airport to St. Louis in April is currently the most expensive (average of C$ 616). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DTW to STL?

Unlike in the morning, when flights are generally more expensive, you can save up to 27% on flights from Detroit Metropolitan Wayne County Airport to St. Louis by exploring options for tickets at noon.

How much does it cost to fly round-trip from Detroit Metropolitan Wayne County Airport to St. Louis?

Airfare is below average for this route at the moment.

Detroit Metropolitan Wayne County Airport to St. Louis flights typically cost between C$ 325 and C$ 816 in September.
The cheapest round-trip price found within the last 5 days was C$ 304 on Frontier (23 Sep-25 Sep).

Related info for your journey

  • How long is the flight from Detroit Metropolitan Wayne County Airport to St. Louis?

    For as low as C$ 369, Southwest can have you in St. Louis from Detroit Metropolitan Wayne County Airport in 4h. Airlines will cover a distance of 707 km.

  • What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to St. Louis?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Detroit Metropolitan Wayne County Airport to St. Louis on time: Air France (87%), Korean Air (87%), WestJet (81%).

  • Can I find deals for flights from Detroit to St. Louis that include hotel bookings?

    Yes. In addition to deals on Detroit to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to St. Louis.

  • Can I find deals for business class flights from Detroit to St. Louis?

    Yes. Cheapflights offers flight deals from Detroit to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to St. Louis?

    Currently, September is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to St. Louis (average of C$ 441). Flying from Detroit Metropolitan Wayne County Airport to St. Louis in April is currently the most expensive (average of C$ 616). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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