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Cheap flights from Santo Domingo to Panama City from C$ 645

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 15/5. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — PTY
28 May — 4 Jun1
1 adult
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Santo Domingo Las Americas to Panama City Tocumen Intl are usually found in June or August, booked 41 days in advance, depart on a Wednesday or Friday and return on a Monday

Cheap flight deals from Santo Domingo to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Santo Domingo to Panama City
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 28 April 2026.

Mon 6/712:43 p.m.
SDQ
-
PTY
Nonstop2h 32m
Copa Airlines
Tue 14/77:26 p.m.
PTY
-
SDQ
Nonstop2h 30m
Copa Airlines
Deal found 26/4C$ 829
Fri 15/512:40 p.m.
SDQ
-
PTY
Nonstop2h 35m
Copa Airlines
Sun 24/57:26 p.m.
PTY
-
SDQ
Nonstop2h 30m
Copa Airlines
Deal found 24/4C$ 845
Wed 6/58:45 a.m.
SDQ
-
PTY
Nonstop2h 35m
Copa Airlines
Tue 26/512:44 p.m.
PTY
-
SDQ
Nonstop2h 31m
Copa Airlines
Deal found 23/4C$ 1,013
Thu 30/412:08 p.m.
SDQ
-
PTY
Nonstop2h 37m
Copa Airlines
Sun 3/59:42 a.m.
PTY
-
SDQ
Nonstop2h 31m
Copa Airlines
Deal found 23/4C$ 1,037
Fri 1/52:14 p.m.
SDQ
-
PTY
Nonstop2h 35m
Copa Airlines
Thu 7/57:24 a.m.
PTY
-
SDQ
Nonstop2h 31m
Copa Airlines
Deal found 24/4C$ 1,077
Fri 22/512:40 p.m.
SDQ
-
PTY
Nonstop2h 35m
Copa Airlines
Mon 25/57:24 a.m.
PTY
-
SDQ
Nonstop2h 31m
Copa Airlines
Deal found 25/4C$ 1,078
Thu 21/58:45 a.m.
SDQ
-
PTY
Nonstop2h 35m
Copa Airlines
Sun 24/512:44 p.m.
PTY
-
SDQ
Nonstop2h 31m
Copa Airlines
Deal found 25/4C$ 1,099
Wed 29/48:43 a.m.
SDQ
-
PTY
Nonstop2h 37m
Copa Airlines
Fri 29/59:42 a.m.
PTY
-
SDQ
Nonstop2h 31m
Copa Airlines
Deal found 24/4C$ 1,149
Thu 30/412:08 p.m.
SDQ
-
PTY
Nonstop2h 37m
Copa Airlines
Tue 5/58:11 a.m.
PTY
-
SDQ
Nonstop2h 31m
Copa Airlines
Deal found 28/4C$ 1,190
Sun 26/412:38 p.m.
SDQ
-
PTY
Nonstop2h 37m
Copa Airlines
Sun 3/512:44 p.m.
PTY
-
SDQ
Nonstop2h 31m
Copa Airlines
Deal found 25/4C$ 1,215
Wed 29/48:43 a.m.
SDQ
-
PTY
Nonstop2h 37m
Copa Airlines
Thu 30/48:11 a.m.
PTY
-
SDQ
Nonstop2h 30m
Copa Airlines
Deal found 25/4C$ 1,254

Find flight deals from Santo Domingo to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 28 April 2026.

Round-trip from

C$ 829

One-way from

C$ 645

Popular in

March

Cheapest in

June

Average price

C$ 766

Good one-way deal

C$ 266 or less
Copa Airlines
  • Copa Airlines
  • 6/7-13/7
  • Nonstop
  • 5h 02m total
  • Santo Domingo to Panama City
Search Deals
Avianca
  • Avianca
  • 15/5
  • 2 total stops
  • 27h 10m total
  • Santo Domingo to Panama City
Search Deals
Highest demand for flights based on searches. 7% potential increase in price (C$ 76 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (C$ 15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals
Price to beat on a one-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 28 April 2026.
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 9/7

12:13 p.m.-1:45 p.m.

Nonstop2h 32m

Panama City Tocumen Intl

Sun 12/7

7:26 p.m.-10:56 p.m.

Nonstop2h 30m

C$ 829

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sun 24/5

12:40 p.m.-2:15 p.m.

Nonstop2h 35m

Panama City Tocumen Intl

Sun 31/5

9:42 a.m.-1:13 p.m.

Nonstop2h 31m

C$ 829

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 24/6

2:11 p.m.-3:46 p.m.

Nonstop2h 35m

Panama City Tocumen Intl

Sun 12/7

9:42 a.m.-1:13 p.m.

Nonstop2h 31m

C$ 829

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sun 7/6

12:40 p.m.-2:15 p.m.

Nonstop2h 35m

Panama City Tocumen Intl

Sun 14/6

8:11 a.m.-11:42 a.m.

Nonstop2h 31m

C$ 829

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 28/7

6:07 a.m.-7:39 a.m.

Nonstop2h 32m

Panama City Tocumen Intl

Fri 31/7

7:26 p.m.-10:56 p.m.

Nonstop2h 30m

C$ 829

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 24/9

2:16 p.m.-3:49 p.m.

Nonstop2h 33m

Panama City Tocumen Intl

Mon 28/9

9:42 a.m.-1:13 p.m.

Nonstop2h 31m

C$ 829

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Mon 1/6

8:45 a.m.-10:20 a.m.

Nonstop2h 35m

Panama City Tocumen Intl

Wed 1/7

8:11 a.m.-11:42 a.m.

Nonstop2h 31m

C$ 829

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 6/8

8:48 a.m.-10:20 a.m.

Nonstop2h 32m

Panama City Tocumen Intl

Thu 13/8

7:26 p.m.-10:56 p.m.

Nonstop2h 30m

C$ 829

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 1/7

8:53 a.m.-10:25 a.m.

Nonstop2h 32m

Panama City Tocumen Intl

Sun 5/7

8:11 a.m.-11:42 a.m.

Nonstop2h 31m

C$ 829

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 23/6

8:45 a.m.-10:20 a.m.

Nonstop2h 35m

Panama City Tocumen Intl

Mon 20/7

7:24 a.m.-10:55 a.m.

Nonstop2h 31m

C$ 829

Flights are sorted by cheapest round-trip flights first.

Deals found on 23/4

Showing 1-10 of 19 resultsSorted by cheapest first
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Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

The best time to book flights from Santo Domingo to Panama City is 40 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Currently, June is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of C$ 631). Flying from Santo Domingo to Panama City in March is currently the most expensive (average of C$ 817). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to PTY?

Find hourly flight availability from Santo Domingo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 28 April 2026.

It’s typically best to fly out from Santo Domingo to Panama City in the evening. Doing so could potentially save you 77% on the flight price compared to flying in the morning, which is usually more expensive.

How much does it cost to fly round-trip from Santo Domingo to Panama City?

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Santo Domingo to Panama City flight route?

    Flights from Santo Domingo Las Americas to Panama City Tocumen Intl have been viewed 64 times in the past calendar month.

  • How long is the flight from Santo Domingo to Panama City?

    Airlines like Copa Airlines fly from Santo Domingo to Panama City in about 2h 35m. The time it takes to get you to your destination is usually consistent. The distance from Santo Domingo to Panama City is about 1476 km. All flights are typically direct.

  • What are the most reliable airlines from Santo Domingo to Panama City?

    No one likes to see their flight delayed. When booking a flight from Santo Domingo to Panama City consider choosing Copa Airlines (94%), KLM (91%) or Turkish Airlines (90%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Santo Domingo to Panama City?

    The cheapest flight price from Santo Domingo to Panama City is C$ 261. On average you can expect to pay C$ 290. The most popular route, (Santo Domingo Las Americas - Panama City Tocumen Intl), can usually be booked for C$ 829.

  • Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.

  • Can I find deals for business class flights from Santo Domingo to Panama City?

    Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Panama City?

    Currently, June is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of C$ 631). Flying from Santo Domingo to Panama City in March is currently the most expensive (average of C$ 817). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Why should you use Cheapflights to find cheap flight tickets from Santo Domingo to Panama City?

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Can Cheapflights find flights from Santo Domingo to Panama City with no change fees?

Certainly. Search results for flights to Panama City from Santo Domingo shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Santo Domingo to Panama City become cheaper?

Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Panama City from Santo Domingo today and book when prices fit your budget.

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