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Cheap flights from Mexico City to Santa Cruz de la Sierra from C$ 430

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/10. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — VVI
16 Sep — 23 Sep1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Mexico City to Santa Cruz de la Sierra

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Mexico City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 17 August 2026.

Mon 28/92:10 a.m. -
1 stop18h 34m
Tue 6/1011:47 a.m. -
1 stop14h 28m
Deal found 13/8C$ 878
Mon 16/113:25 a.m. -
1 stop22h 12m
Sun 22/111:08 a.m. -
1 stop23h 17m
Deal found 14/8C$ 885
Tue 1/125:55 a.m. -
1 stop19h 47m
Thu 31/1211:42 a.m. -
1 stop12h 43m
Deal found 12/8C$ 921
Fri 23/101:20 a.m. -
1 stop19h 24m
Tue 24/111:08 a.m. -
1 stop22h 57m
Deal found 14/8C$ 927
Sun 29/111:20 a.m. -
1 stop19h 18m
Wed 13/11:14 a.m. -
1 stop22h 51m
Deal found 12/8C$ 963
Sun 15/113:25 a.m. -
1 stop17h 13m
Sat 21/111:08 a.m. -
1 stop22h 57m
Deal found 14/8C$ 968
Sat 21/118:50 a.m. -
2 stops17h 45m
Sat 5/125:30 a.m. -
2 stops16h 45m
Deal found 15/8C$ 1,000
Tue 29/92:00 p.m. -
1 stop10h 30m
Mon 5/103:35 a.m. -
2 stops33h 35m
Deal found 13/8C$ 1,028
Fri 11/98:45 a.m. -
2 stops17h 50m
Fri 18/95:25 a.m. -
2 stops25h 20m
Deal found 14/8C$ 1,115
Fri 16/108:45 a.m. -
2 stops17h 50m
Fri 23/105:25 a.m. -
2 stops25h 20m
Deal found 14/8C$ 1,126
Wed 30/98:45 a.m. -
2 stops17h 50m
Thu 15/105:25 a.m. -
2 stops16h 35m
Deal found 17/8C$ 1,133

Find flight deals from Mexico City to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 17 August 2026.

Round-trip from

C$ 878

One-way from

C$ 430

Popular in

December

Cheapest in

April

Average price

C$ 879
Copa Airlines
  • Copa Airlines
  • 28/9-6/10
  • 2 total stops
  • 33h 02m total
  • Mexico City to Santa Cruz de la Sierra
Search Deals
Copa Airlines
  • Copa Airlines
  • 29/8
  • 1 total stop
  • 14h 50m total
  • Mexico City to Santa Cruz de la Sierra
Search Deals
Highest demand for flights based on searches. 5% potential increase in price (C$ 74 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (C$ 23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 17 August 2026.
Use the filters below to find and compare flights from Mexico City to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Mon 28/9

2:10 a.m.-10:44 p.m.

1 stop18h 34m

Santa Cruz de la Sierra Viru Viru Intl

Tue 6/10

11:47 a.m.-12:15 a.m.

1 stop14h 28m

C$ 878

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Thu 8/10

2:10 a.m.-10:44 p.m.

1 stop18h 34m

Santa Cruz de la Sierra Viru Viru Intl

Thu 10/12

1:10 a.m.-10:05 p.m.

1 stop22h 55m

C$ 885

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Mon 16/11

3:25 a.m.-3:37 a.m.

1 stop22h 12m

Santa Cruz de la Sierra Viru Viru Intl

Sun 22/11

1:08 a.m.-10:25 p.m.

1 stop23h 17m

C$ 885

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Tue 10/11

1:20 a.m.-10:38 p.m.

1 stop19h 18m

Santa Cruz de la Sierra Viru Viru Intl

Sun 29/11

1:08 a.m.-10:25 p.m.

1 stop23h 17m

C$ 921

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Mon 30/11

1:20 a.m.-3:42 a.m.

1 stop24h 22m

Santa Cruz de la Sierra Viru Viru Intl

Thu 31/12

11:42 a.m.-10:25 p.m.

1 stop12h 43m

C$ 921

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Fri 23/10

1:20 a.m.-10:44 p.m.

1 stop19h 24m

Santa Cruz de la Sierra Viru Viru Intl

Tue 24/11

1:08 a.m.-10:05 p.m.

1 stop22h 57m

C$ 927
Cheapest one-way

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Sun 4/10

1:20 a.m.-10:44 p.m.

1 stop19h 24m

C$ 430

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Sun 18/10

2:10 a.m.-10:44 p.m.

1 stop18h 34m

C$ 430

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Wed 26/8

2:10 a.m.-10:40 p.m.

1 stop18h 30m

C$ 430
Quickest one-way

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Fri 12/2

3:30 p.m.-3:43 a.m.

1 stop10h 13m

C$ 544

Flights are sorted by cheapest round-trip flights first.

Deals found on 13/8

Sorted by cheapest first

Best time to book a flight from Mexico City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santa Cruz de la Sierra

How far ahead should I book a flight from Mexico City to Santa Cruz de la Sierra?

Booking 84 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santa Cruz de la Sierra. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

Currently, April is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 831). Flying from Mexico City to Santa Cruz de la Sierra in December is currently the most expensive (average of C$ 1,104). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Mexico City to Santa Cruz de la Sierra?

Airfare is typical for this route at the moment.

Mexico City to Santa Cruz de la Sierra flights typically cost between C$ 702 and C$ 975 in September.
The cheapest round-trip price found within the last 5 days was C$ 878 on Copa Airlines (28 Sep-6 Oct).

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mexico City to Santa Cruz de la Sierra?

    Copa Airlines can get you from Mexico City to Santa Cruz de la Sierra in just under 18h 34m. Your travel time can differ by up to . Airlines will cover a distance of 5687 km.

  • Can I find deals for flights from Mexico City to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Mexico City to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Mexico City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

    Currently, April is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 831). Flying from Mexico City to Santa Cruz de la Sierra in December is currently the most expensive (average of C$ 1,104). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Santa Cruz de la Sierra car rentals
Santa Cruz de la Sierra Viru Viru Intl Airport car rentals
La Paz car rentals

Fly with Cheapflights

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How does Cheapflights help users find flights from Mexico City to Santa Cruz de la Sierra?

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santa Cruz de la Sierra?

Cheapflights helps you find that perfect flight to Santa Cruz de la Sierra from Mexico City by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Mexico City to Santa Cruz de la Sierra with no change fees?

Yes! Cheapflights helps users easily find flights from Mexico City to Santa Cruz de la Sierra with no change fees.

Can Cheapflights notify me if prices for flights from Mexico City to Santa Cruz de la Sierra become cheaper?

Of course! You can now track prices for flights from Mexico City to Santa Cruz de la Sierra and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.

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