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Cheap flights from Mexico City to Santa Cruz de la Sierra from C$ 493

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 17/4. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — VVI
7 Feb — 14 Feb1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Mexico City to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 8 January 2026.

Round-trip from

C$ 795

One-way from

C$ 493

Popular in

December

Cheapest in

May

Average price

C$ 901
Avianca
  • Avianca
  • 8/2-14/2
  • 2 total stops
  • 21h 15m total
  • Mexico City to Santa Cruz de la Sierra
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Copa Airlines
  • Copa Airlines
  • 17/4
  • 1 total stop
  • 10h 52m total
  • Mexico City to Santa Cruz de la Sierra
Search Deals
Highest demand for flights based on searches. 14% potential increase in price (C$ 202 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease (C$ 38 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
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Find flight deals from Mexico City to Santa Cruz de la Sierra

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Mexico City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 8 January 2026.

Sun 8/21:50 p.m.MEX - VVI
1 stop10h 45mAvianca
Sat 14/23:40 a.m.VVI - MEX
1 stop10h 30mAvianca
Deal found 7/1C$ 795
Tue 31/32:10 a.m.MEX - VVI
1 stop18h 32mCopa Airlines
Wed 15/41:15 a.m.VVI - MEX
1 stop19h 50mCopa Airlines
Deal found 7/1C$ 804
Mon 19/15:55 a.m.MEX - VVI
1 stop19h 49mCopa Airlines
Thu 29/111:44 a.m.VVI - MEX
1 stop14h 31mCopa Airlines
Deal found 8/1C$ 806
Tue 31/32:10 a.m.MEX - VVI
1 stop18h 32mCopa Airlines
Tue 7/411:48 a.m.VVI - MEX
1 stop15h 12mCopa Airlines
Deal found 7/1C$ 832
Fri 10/48:55 a.m.MEX - VVI
2 stops17h 40mMultiple Airlines
Fri 24/45:25 a.m.VVI - MEX
2 stops25h 20mMultiple Airlines
Deal found 8/1C$ 843
Wed 1/43:10 p.m.MEX - VVI
1 stop11h 25mMultiple Airlines
Thu 16/45:25 a.m.VVI - MEX
2 stops25h 20mMultiple Airlines
Deal found 7/1C$ 857
Sat 18/712:25 a.m.MEX - VVI
1 stop20h 15mCopa Airlines
Sat 25/711:47 a.m.VVI - MEX
1 stop15h 13mCopa Airlines
Deal found 7/1C$ 868
Sun 19/73:10 p.m.MEX - VVI
1 stop11h 25mMultiple Airlines
Sat 25/75:25 a.m.VVI - MEX
2 stops25h 20mMultiple Airlines
Deal found 7/1C$ 925
Mon 20/79:50 a.m.MEX - VVI
1 stop10h 50mCopa Airlines
Wed 22/71:12 a.m.VVI - MEX
1 stop19h 53mCopa Airlines
Deal found 7/1C$ 940
Tue 10/21:20 a.m.MEX - VVI
1 stop19h 30mCopa Airlines
Tue 24/211:44 a.m.VVI - MEX
1 stop14h 31mCopa Airlines
Deal found 7/1C$ 959
Wed 28/14:00 p.m.MEX - VVI
1 stop10h 35mMultiple Airlines
Wed 18/25:20 a.m.VVI - MEX
2 stops26h 10mMultiple Airlines
Deal found 7/1C$ 1,013

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 8 January 2026.
Use the filters below to find and compare flights from Mexico City to Santa Cruz de la Sierra that are best for you.

Fly from

Mexico City

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sun 8/2

1:50 p.m.-2:35 a.m.

1 stop10h 45m

Santa Cruz de la Sierra Viru Viru Intl

Sat 14/2

3:40 a.m.-12:10 p.m.

1 stop10h 30m

C$ 795

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 31/3

2:10 a.m.-10:42 p.m.

1 stop18h 32m

Santa Cruz de la Sierra Viru Viru Intl

Mon 6/4

1:15 a.m.-12:10 p.m.

1 stop12h 55m

C$ 804

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 31/3

2:10 a.m.-10:42 p.m.

1 stop18h 32m

Santa Cruz de la Sierra Viru Viru Intl

Wed 15/4

1:15 a.m.-7:05 p.m.

1 stop19h 50m

C$ 804

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 20/1

9:25 a.m.-10:50 p.m.

1 stop11h 25m

Santa Cruz de la Sierra Viru Viru Intl

Thu 29/1

11:44 a.m.-10:05 p.m.

1 stop12h 21m

C$ 806

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Mon 19/1

5:55 a.m.-10:50 p.m.

1 stop14h 55m

Santa Cruz de la Sierra Viru Viru Intl

Thu 29/1

11:44 a.m.-12:15 a.m.

1 stop14h 31m

C$ 806

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 10/4

8:55 a.m.-4:35 a.m.

2 stops17h 40m

Santa Cruz de la Sierra Viru Viru Intl

Fri 24/4

5:25 a.m.-4:45 a.m.

2 stops25h 20m

C$ 843

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 10/2

1:20 a.m.-10:50 p.m.

1 stop19h 30m

Santa Cruz de la Sierra Viru Viru Intl

Tue 24/2

11:44 a.m.-12:15 a.m.

1 stop14h 31m

C$ 959

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 31/3

12:25 a.m.-4:35 a.m.

2 stops26h 10m

Santa Cruz de la Sierra Viru Viru Intl

Thu 16/4

5:25 a.m.-4:45 a.m.

2 stops25h 20m

C$ 991

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Wed 28/1

4:00 p.m.-4:35 a.m.

1 stop10h 35m

Santa Cruz de la Sierra Viru Viru Intl

Wed 18/2

5:20 a.m.-5:30 a.m.

2 stops26h 10m

C$ 1,013

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 17/4

9:50 a.m.-10:42 p.m.

1 stop10h 52m

C$ 493

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/1

Showing 1-10 of 14 results
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Best time to book a flight from Mexico City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santa Cruz de la Sierra

How far ahead should I book a flight from Mexico City to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santa Cruz de la Sierra. Price data was last updated on 2 January 2026.

Booking 85 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santa Cruz de la Sierra. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

Currently, September is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 572). Flying from Mexico City to Santa Cruz de la Sierra in November is currently the most expensive (average of C$ 706). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Mexico City to Santa Cruz de la Sierra?

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mexico City to Santa Cruz de la Sierra?

    Avianca and Copa Airlines can get you from Mexico City to Santa Cruz de la Sierra in just under 10h 45m. Your travel time can differ by up to 7h 47m. Airlines will cover a distance of 5687 km. This flight may include one or multiple stops.

  • Can I find deals for flights from Mexico City to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Mexico City to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Mexico City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

    Currently, September is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 572). Flying from Mexico City to Santa Cruz de la Sierra in November is currently the most expensive (average of C$ 706). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Santa Cruz de la Sierra car rentals
Santa Cruz de la Sierra Viru Viru Intl Airport car rentals

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How does Cheapflights help users find flights from Mexico City to Santa Cruz de la Sierra?

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santa Cruz de la Sierra?

Cheapflights helps you find that perfect flight to Santa Cruz de la Sierra from Mexico City by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Mexico City to Santa Cruz de la Sierra with no change fees?

Yes! Cheapflights helps users easily find flights from Mexico City to Santa Cruz de la Sierra with no change fees.

Can Cheapflights notify me if prices for flights from Mexico City to Santa Cruz de la Sierra become cheaper?

Of course! You can now track prices for flights from Mexico City to Santa Cruz de la Sierra and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.

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