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Cheap flights from Mexico City to Santa Cruz de la Sierra from C$ 488

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 17/2. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — VVI
9 Mar — 16 Mar1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Mexico City to Santa Cruz de la Sierra

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Mexico City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 7 February 2026.

Sat 11/49:55 p.m.
MEX
-
VVI
2 stops28h 40m
Multiple Airlines
Sat 25/45:25 a.m.
VVI
-
MEX
2 stops25h 30m
Multiple Airlines
Deal found 6/2C$ 691
Sat 19/123:10 p.m.
MEX
-
VVI
1 stop11h 25m
Multiple Airlines
Sat 2/15:25 a.m.
VVI
-
MEX
2 stops19h 15m
Multiple Airlines
Deal found 6/2C$ 748
Thu 20/87:55 p.m.
MEX
-
VVI
2 stops30h 40m
Multiple Airlines
Thu 3/95:25 a.m.
VVI
-
MEX
2 stops16h 30m
Multiple Airlines
Deal found 6/2C$ 767
Fri 13/31:20 a.m.
MEX
-
VVI
1 stop19h 30m
Copa Airlines
Sat 21/311:54 a.m.
VVI
-
MEX
1 stop12h 11m
Copa Airlines
Deal found 4/2C$ 771
Mon 2/34:00 p.m.
MEX
-
VVI
1 stop10h 35m
Multiple Airlines
Mon 9/35:25 a.m.
VVI
-
MEX
2 stops16h 40m
Multiple Airlines
Deal found 5/2C$ 834
Wed 22/49:55 p.m.
MEX
-
VVI
2 stops28h 40m
Multiple Airlines
Mon 20/75:25 a.m.
VVI
-
MEX
2 stops16h 30m
Multiple Airlines
Deal found 6/2C$ 848
Wed 4/34:00 p.m.
MEX
-
VVI
1 stop10h 35m
Multiple Airlines
Fri 6/35:25 a.m.
VVI
-
MEX
2 stops26h 05m
Multiple Airlines
Deal found 4/2C$ 856
Mon 2/34:00 p.m.
MEX
-
VVI
1 stop10h 35m
Multiple Airlines
Sat 7/35:25 a.m.
VVI
-
MEX
2 stops26h 00m
Multiple Airlines
Deal found 5/2C$ 911
Tue 31/31:20 a.m.
MEX
-
VVI
1 stop19h 22m
Copa Airlines
Tue 7/411:48 a.m.
VVI
-
MEX
1 stop12h 17m
Copa Airlines
Deal found 3/2C$ 1,053

Find flight deals from Mexico City to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 7 February 2026.

Round-trip from

C$ 691

One-way from

C$ 488

Popular in

December

Cheapest in

May

Average price

C$ 779
11/4-25/4
  • 11/4-25/4
  • 4 total stops
  • 54h 10m total
  • Mexico City to Santa Cruz de la Sierra
Search Deals
Copa Airlines
  • Copa Airlines
  • 17/2
  • 1 total stop
  • 18h 50m total
  • Mexico City to Santa Cruz de la Sierra
Search Deals
Highest demand for flights based on searches. 14% potential increase in price (C$ 199 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease (C$ 37 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 7 February 2026.
Use the filters below to find and compare flights from Mexico City to Santa Cruz de la Sierra that are best for you.

Fly from

Mexico City

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sat 11/4

9:55 p.m.-4:35 a.m.

2 stops28h 40m

Santa Cruz de la Sierra Viru Viru Intl

Sat 25/4

5:25 a.m.-4:55 a.m.

2 stops25h 30m

C$ 691

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 17/3

9:25 a.m.-10:50 p.m.

1 stop11h 25m

Santa Cruz de la Sierra Viru Viru Intl

Sat 13/6

11:47 a.m.-1:00 a.m.

1 stop15h 13m

C$ 771

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 13/3

1:20 a.m.-10:50 p.m.

1 stop19h 30m

Santa Cruz de la Sierra Viru Viru Intl

Sat 21/3

11:54 a.m.-10:05 p.m.

1 stop12h 11m

C$ 771

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Mon 2/3

4:00 p.m.-4:35 a.m.

1 stop10h 35m

Santa Cruz de la Sierra Viru Viru Intl

Mon 9/3

5:25 a.m.-8:05 p.m.

2 stops16h 40m

C$ 834

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Wed 22/4

9:55 p.m.-4:35 a.m.

2 stops28h 40m

Santa Cruz de la Sierra Viru Viru Intl

Mon 20/7

5:25 a.m.-7:55 p.m.

2 stops16h 30m

C$ 848

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Wed 4/3

4:00 p.m.-4:35 a.m.

1 stop10h 35m

Santa Cruz de la Sierra Viru Viru Intl

Fri 6/3

5:25 a.m.-5:30 a.m.

2 stops26h 05m

C$ 856

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Mon 2/3

4:00 p.m.-4:35 a.m.

1 stop10h 35m

Santa Cruz de la Sierra Viru Viru Intl

Sat 7/3

5:25 a.m.-5:25 a.m.

2 stops26h 00m

C$ 911

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 31/3

1:20 a.m.-10:42 p.m.

1 stop19h 22m

Santa Cruz de la Sierra Viru Viru Intl

Tue 7/4

11:48 a.m.-10:05 p.m.

1 stop12h 17m

C$ 1,053

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 17/2

2:00 a.m.-10:50 p.m.

1 stop18h 50m

C$ 488

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/2

Best time to book a flight from Mexico City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santa Cruz de la Sierra

How far ahead should I book a flight from Mexico City to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santa Cruz de la Sierra. Price data was last updated on 30 January 2026.

Booking 85 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santa Cruz de la Sierra. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

Currently, September is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 566). Flying from Mexico City to Santa Cruz de la Sierra in November is currently the most expensive (average of C$ 699). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mexico City to Santa Cruz de la Sierra?

    Copa Airlines can get you from Mexico City to Santa Cruz de la Sierra in just under 11h 25m. Your travel time can differ by up to . Airlines will cover a distance of 5687 km.

  • Can I find deals for flights from Mexico City to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Mexico City to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Mexico City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

    Currently, September is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 566). Flying from Mexico City to Santa Cruz de la Sierra in November is currently the most expensive (average of C$ 699). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Santa Cruz de la Sierra car rentals
Santa Cruz de la Sierra Viru Viru Intl Airport car rentals

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How does Cheapflights help users find flights from Mexico City to Santa Cruz de la Sierra?

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santa Cruz de la Sierra?

Cheapflights helps you find that perfect flight to Santa Cruz de la Sierra from Mexico City by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Mexico City to Santa Cruz de la Sierra with no change fees?

Yes! Cheapflights helps users easily find flights from Mexico City to Santa Cruz de la Sierra with no change fees.

Can Cheapflights notify me if prices for flights from Mexico City to Santa Cruz de la Sierra become cheaper?

Of course! You can now track prices for flights from Mexico City to Santa Cruz de la Sierra and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.

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