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Cheap flights from Mexico City to Santa Cruz de la Sierra from C$ 436

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 19/4. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — VVI
10 May — 17 May1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Mexico City to Santa Cruz de la Sierra

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Mexico City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 10 April 2026.

Sat 25/412:25 a.m.
MEX
-
VVI
1 stop20h 17m
Copa Airlines
Mon 11/511:47 a.m.
VVI
-
MEX
1 stop14h 28m
Copa Airlines
Deal found 7/4C$ 837
Wed 29/41:10 p.m.
MEX
-
VVI
1 stop12h 30m
Copa Airlines
Mon 4/511:47 a.m.
VVI
-
MEX
1 stop26h 23m
Copa Airlines
Deal found 6/4C$ 866
Tue 21/49:50 a.m.
MEX
-
VVI
1 stop10h 52m
Copa Airlines
Thu 30/411:48 a.m.
VVI
-
MEX
1 stop15h 12m
Copa Airlines
Deal found 6/4C$ 870
Tue 30/612:25 a.m.
MEX
-
VVI
1 stop25h 10m
Copa Airlines
Thu 16/71:12 a.m.
VVI
-
MEX
1 stop25h 48m
Copa Airlines
Deal found 5/4C$ 923
Thu 15/1012:30 a.m.
MEX
-
VVI
2 stops26h 05m
Multiple Airlines
Fri 23/105:25 a.m.
VVI
-
MEX
2 stops30h 00m
Multiple Airlines
Deal found 5/4C$ 974
Thu 9/411:35 a.m.
MEX
-
VVI
2 stops15h 00m
Multiple Airlines
Mon 20/45:25 a.m.
VVI
-
MEX
2 stops25h 30m
Multiple Airlines
Deal found 6/4C$ 1,046
Sun 5/71:20 a.m.
MEX
-
VVI
1 stop24h 15m
Copa Airlines
Sun 26/71:12 a.m.
VVI
-
MEX
1 stop19h 53m
Copa Airlines
Deal found 6/4C$ 1,133

Find flight deals from Mexico City to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 10 April 2026.

Round-trip from

C$ 837

One-way from

C$ 436

Popular in

December

Cheapest in

June

Average price

C$ 816
Copa Airlines
  • Copa Airlines
  • 25/4-11/5
  • 2 total stops
  • 34h 45m total
  • Mexico City to Santa Cruz de la Sierra
Search Deals
Avianca
  • Avianca
  • 19/4
  • 1 total stop
  • 10h 30m total
  • Mexico City to Santa Cruz de la Sierra
Search Deals
Highest demand for flights based on searches. 11% potential increase in price (C$ 162 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (C$ 35 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 10 April 2026.
Use the filters below to find and compare flights from Mexico City to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sat 25/4

12:25 a.m.-10:42 p.m.

1 stop20h 17m

Santa Cruz de la Sierra Viru Viru Intl

Mon 11/5

11:47 a.m.-12:15 a.m.

1 stop14h 28m

C$ 837

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sat 23/5

1:20 a.m.-10:38 p.m.

1 stop19h 18m

Santa Cruz de la Sierra Viru Viru Intl

Sat 30/5

11:47 a.m.-1:00 a.m.

1 stop15h 13m

C$ 837

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sat 2/5

5:50 a.m.-10:38 p.m.

1 stop14h 48m

Santa Cruz de la Sierra Viru Viru Intl

Mon 18/5

11:47 a.m.-12:15 a.m.

1 stop14h 28m

C$ 837

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Wed 29/4

1:10 p.m.-3:40 a.m.

1 stop12h 30m

Santa Cruz de la Sierra Viru Viru Intl

Mon 4/5

11:47 a.m.-12:10 p.m.

1 stop26h 23m

C$ 866
Quickest round-trip

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 21/4

9:50 a.m.-10:42 p.m.

1 stop10h 52m

Santa Cruz de la Sierra Viru Viru Intl

Thu 30/4

11:48 a.m.-1:00 a.m.

1 stop15h 12m

C$ 870

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 30/6

12:25 a.m.-3:35 a.m.

1 stop25h 10m

Santa Cruz de la Sierra Viru Viru Intl

Thu 16/7

1:12 a.m.-1:00 a.m.

1 stop25h 48m

C$ 923

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sun 5/7

1:20 a.m.-3:35 a.m.

1 stop24h 15m

Santa Cruz de la Sierra Viru Viru Intl

Sun 26/7

1:12 a.m.-7:05 p.m.

1 stop19h 53m

C$ 1,133
Cheapest one-way
Quickest one-way

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sun 19/4

2:00 p.m.-2:30 a.m.

1 stop10h 30m

C$ 436

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sat 20/6

9:50 a.m.-10:38 p.m.

1 stop10h 48m

C$ 523

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 12/5

5:50 a.m.-10:38 p.m.

1 stop14h 48m

C$ 523

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/4

Sorted by cheapest first

Best time to book a flight from Mexico City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santa Cruz de la Sierra

How far ahead should I book a flight from Mexico City to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santa Cruz de la Sierra. Price data was last updated on 3 April 2026.

Booking 85 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santa Cruz de la Sierra. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

Currently, April is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 578). Flying from Mexico City to Santa Cruz de la Sierra in February is currently the most expensive (average of C$ 732). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Mexico City to Santa Cruz de la Sierra?

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mexico City to Santa Cruz de la Sierra?

    Copa Airlines can get you from Mexico City to Santa Cruz de la Sierra in just under 20h 17m. Your travel time can differ by up to . Airlines will cover a distance of 5687 km.

  • Can I find deals for flights from Mexico City to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Mexico City to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Mexico City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

    Currently, April is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 578). Flying from Mexico City to Santa Cruz de la Sierra in February is currently the most expensive (average of C$ 732). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Santa Cruz de la Sierra car rentals
Santa Cruz de la Sierra Viru Viru Intl Airport car rentals
La Paz car rentals

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How does Cheapflights help users find flights from Mexico City to Santa Cruz de la Sierra?

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santa Cruz de la Sierra?

Cheapflights helps you find that perfect flight to Santa Cruz de la Sierra from Mexico City by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Mexico City to Santa Cruz de la Sierra with no change fees?

Yes! Cheapflights helps users easily find flights from Mexico City to Santa Cruz de la Sierra with no change fees.

Can Cheapflights notify me if prices for flights from Mexico City to Santa Cruz de la Sierra become cheaper?

Of course! You can now track prices for flights from Mexico City to Santa Cruz de la Sierra and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.

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