How long is the flight from Mexico City to Santa Cruz de la Sierra?

Copa Airlines can get you from Mexico City to Santa Cruz de la Sierra in just under 11h 21m. Your travel time can differ by up to . Airlines will cover a distance of 5687 km.

What is the cheapest time of day to fly from MEX to VVI?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mexico City to Santa Cruz de la Sierra as you normally would.

How can I find direct flights from Mexico City to Santa Cruz de la Sierra?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santa Cruz de la Sierra.

Can I find deals for business class flights from Mexico City to Santa Cruz de la Sierra?

Yes. Cheapflights offers flight deals from Mexico City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

C$ 356+ Flights from Mexico City to Santa Cruz de la Sierra

Q: How much does it cost to fly round-trip from Mexico City to Santa Cruz de la Sierra?

Airfare is below average for this route at the moment. Mexico City to Santa Cruz de la Sierra flights typically cost between C$ 785 and C$ 959 in March. The cheapest round-trip price found within the last 3 days was C$ 721 on Multiple Airlines (17 Mar-30 May).

Find flight deals from Mexico City to Santa Cruz de la Sierra

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Mexico City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 23 October 2025.

Mon 1/123:30 p.m.MEX - VVI

1 stop10h 06mCopa Airlines

Thu 11/1211:40 a.m.VVI - MEX

1 stop15h 20mCopa Airlines

Deal found 22/10C$ 738

Thu 20/111:20 a.m.MEX - VVI

1 stop19h 26mCopa Airlines

Sat 22/111:09 a.m.VVI - MEX

1 stop20h 11mCopa Airlines

Deal found 23/10C$ 757

Wed 19/111:20 a.m.MEX - VVI

1 stop19h 26mCopa Airlines

Thu 27/111:09 a.m.VVI - MEX

1 stop20h 11mCopa Airlines

Deal found 22/10C$ 776

Sun 30/111:20 a.m.MEX - VVI

1 stop19h 26mCopa Airlines

Fri 12/121:09 a.m.VVI - MEX

1 stop20h 11mCopa Airlines

Deal found 21/10C$ 794

Sat 29/111:20 a.m.MEX - VVI

1 stop19h 26mCopa Airlines

Tue 3/31:14 a.m.VVI - MEX

1 stop20h 06mCopa Airlines

Deal found 23/10C$ 799

Wed 12/112:00 a.m.MEX - VVI

1 stop18h 46mCopa Airlines

Thu 27/1111:40 a.m.VVI - MEX

1 stop15h 20mCopa Airlines

Deal found 21/10C$ 813

Mon 1/121:50 p.m.MEX - VVI

1 stop10h 45mAvianca

Tue 9/123:40 a.m.VVI - MEX

1 stop16h 30mAvianca

Deal found 22/10C$ 822

Mon 1/127:55 p.m.MEX - VVI

2 stops30h 40mLATAM Airlines

Thu 11/125:25 a.m.VVI - MEX

1 stop10h 25mLATAM Airlines

Deal found 22/10C$ 823

Thu 13/116:40 p.m.MEX - VVI

2 stops31h 55mMultiple Airlines

Sun 23/115:25 a.m.VVI - MEX

2 stops26h 05mMultiple Airlines

Deal found 20/10C$ 829

Wed 3/121:50 p.m.MEX - VVI

1 stop10h 45mAvianca

Mon 8/123:40 a.m.VVI - MEX

1 stop10h 30mAvianca

Deal found 22/10C$ 843

Wed 12/119:25 a.m.MEX - VVI

1 stop16h 11mCopa Airlines

Tue 18/1111:40 a.m.VVI - MEX

1 stop12h 25mCopa Airlines

Deal found 21/10C$ 848

Best flights from Mexico City to Santa Cruz de la Sierra
Discover carefully curated flight deals from Mexico City to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated 23 October 2025.

Thu 20/111:20 a.m.MEX - VVI

1 stop19h 26mCopa Airlines

Sat 22/111:09 a.m.VVI - MEX

1 stop20h 11mCopa Airlines

Deal found 23/10C$ 757

Sat 21/29:25 a.m.MEX - VVI

1 stop11h 25mCopa Airlines

Fri 27/21:15 a.m.VVI - MEX

1 stop15h 15mCopa Airlines

Deal found 21/10C$ 776

Mon 17/112:00 a.m.MEX - VVI

1 stop18h 46mCopa Airlines

Tue 25/1111:40 a.m.VVI - MEX

1 stop15h 20mCopa Airlines

Deal found 21/10C$ 776

Mon 20/42:00 a.m.MEX - VVI

1 stop18h 50mCopa Airlines

Thu 30/411:44 a.m.VVI - MEX

1 stop14h 31mCopa Airlines

Deal found 20/10C$ 776

Sat 14/35:55 a.m.MEX - VVI

1 stop14h 55mCopa Airlines

Sat 21/311:42 a.m.VVI - MEX

1 stop12h 23mCopa Airlines

Deal found 23/10C$ 776

Last-minute flights from Mexico City to Santa Cruz de la Sierra
Discover last-minute flight deals from Mexico City to Santa Cruz de la Sierra. Data last updated 23 October 2025 and is based on user searches.

Thu 30/102:00 a.m.MEX - VVI

1 stop18h 40mCopa Airlines

Fri 27/21:15 a.m.VVI - MEX

1 stop20h 05mCopa Airlines

Deal found 22/10C$ 892

Wed 12/112:00 a.m.MEX - VVI

1 stop18h 46mCopa Airlines

Thu 27/1111:40 a.m.VVI - MEX

1 stop15h 20mCopa Airlines

Deal found 21/10C$ 813

Wed 12/119:25 a.m.MEX - VVI

1 stop16h 11mCopa Airlines

Tue 18/1111:40 a.m.VVI - MEX

1 stop12h 25mCopa Airlines

Deal found 21/10C$ 848

Thu 13/116:40 p.m.MEX - VVI

2 stops31h 55mMultiple Airlines

Sun 23/115:25 a.m.VVI - MEX

2 stops26h 05mMultiple Airlines

Deal found 20/10C$ 829

Wed 19/111:20 a.m.MEX - VVI

1 stop19h 26mCopa Airlines

Sat 29/111:09 a.m.VVI - MEX

1 stop15h 21mCopa Airlines

Deal found 21/10C$ 776

Thu 20/111:20 a.m.MEX - VVI

1 stop19h 26mCopa Airlines

Sat 22/111:09 a.m.VVI - MEX

1 stop20h 11mCopa Airlines

Deal found 23/10C$ 757

Sat 29/111:20 a.m.MEX - VVI

1 stop19h 26mCopa Airlines

Tue 3/31:14 a.m.VVI - MEX

1 stop20h 06mCopa Airlines

Deal found 23/10C$ 799

Sat 29/111:50 p.m.MEX - VVI

1 stop10h 45mAvianca

Mon 8/123:40 a.m.VVI - MEX

1 stop10h 30mAvianca

Deal found 22/10C$ 883

Sat 29/111:50 p.m.MEX - VVI

1 stop10h 45mAvianca

Tue 9/123:40 a.m.VVI - MEX

1 stop16h 30mAvianca

Deal found 22/10C$ 921

Sun 30/111:20 a.m.MEX - VVI

1 stop19h 26mCopa Airlines

Fri 12/121:09 a.m.VVI - MEX

1 stop20h 11mCopa Airlines

Deal found 21/10C$ 794

Sun 30/111:20 a.m.MEX - VVI

1 stop19h 26mCopa Airlines

Tue 9/121:09 a.m.VVI - MEX

1 stop20h 11mCopa Airlines

Deal found 22/10C$ 872

One-way flights from Mexico City to Santa Cruz de la Sierra
Search for one-way flight options from Mexico City to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated 23 October 2025.

Fri 31/101:50 p.m.MEX - VVI

1 stop10h 45mAvianca

Deal found 22/10C$ 356

Thu 30/102:00 a.m.MEX - VVI

1 stop18h 40mCopa Airlines

Deal found 22/10C$ 483

Sat 20/126:35 p.m.MEX - VVI

2 stops32h 00mMultiple Airlines

Deal found 23/10C$ 837

Thu 30/1012:40 a.m.MEX - VVI

2 stops26h 10mMultiple Airlines

Deal found 22/10C$ 994

Fri 19/121:20 a.m.MEX - VVI

1 stop19h 26mCopa Airlines

Deal found 23/10C$ 1,145

Cheap flight deals from Mexico City to Santa Cruz de la Sierra

Round-trip from	C$ 721
One-way from	C$ 356
Popular in	December
Cheapest in	May
Average price	C$ 895

LATAM Airlines
17/3-30/5
3 total stops
36h 15m total
Mexico City to Santa Cruz de la Sierra

Search Deals

Avianca
31/10
1 total stop
10h 45m total
Mexico City to Santa Cruz de la Sierra

Search Deals

Highest demand for flights based on searches. 6% potential increase in price (C$ 74 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease (C$ 14 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in October 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Mexico City to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Thu 20/11

1:20 a.m.-10:46 p.m.

1 stop19h 26m

Santa Cruz de la Sierra Viru Viru Intl

Sat 22/11

1:09 a.m.-7:20 p.m.

1 stop20h 11m

C$ 757

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sat 21/2

9:25 a.m.-10:50 p.m.

1 stop11h 25m

Santa Cruz de la Sierra Viru Viru Intl

Fri 27/2

1:15 a.m.-2:30 p.m.

1 stop15h 15m

C$ 776

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Mon 17/11

2:00 a.m.-10:46 p.m.

1 stop18h 46m

Santa Cruz de la Sierra Viru Viru Intl

Tue 25/11

11:40 a.m.-1:00 a.m.

1 stop15h 20m

C$ 776

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Mon 20/4

2:00 a.m.-10:50 p.m.

1 stop18h 50m

Santa Cruz de la Sierra Viru Viru Intl

Thu 30/4

11:44 a.m.-12:15 a.m.

1 stop14h 31m

C$ 776

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sat 14/3

5:55 a.m.-10:50 p.m.

1 stop14h 55m

Santa Cruz de la Sierra Viru Viru Intl

Sat 21/3

11:42 a.m.-10:05 p.m.

1 stop12h 23m

C$ 776

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 31/10

1:50 p.m.-2:35 a.m.

1 stop10h 45m

C$ 356

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Wed 19/11

1:20 a.m.-10:46 p.m.

1 stop19h 26m

C$ 483

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Thu 30/10

2:00 a.m.-10:40 p.m.

1 stop18h 40m

C$ 483

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sat 20/12

6:35 p.m.-4:35 a.m.

2 stops32h 00m

C$ 837

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Thu 30/10

12:40 a.m.-4:50 a.m.

2 stops26h 10m

C$ 994

Flights are sorted by cheapest round-trip flights first.

Deals found on 22/10

Best time to book a flight from Mexico City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Mexico City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santa Cruz de la Sierra

How far ahead should I book a flight from Mexico City to Santa Cruz de la Sierra?

Booking 56 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santa Cruz de la Sierra. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

Currently, September is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 580). Flying from Mexico City to Santa Cruz de la Sierra in December is currently the most expensive (average of C$ 762). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Mexico City to Santa Cruz de la Sierra?

Related info for your journey

How long is the flight from Mexico City to Santa Cruz de la Sierra?
Copa Airlines can get you from Mexico City to Santa Cruz de la Sierra in just under 11h 21m. Your travel time can differ by up to . Airlines will cover a distance of 5687 km.
Can I find deals for flights from Mexico City to Santa Cruz de la Sierra that include hotel bookings?
Yes. In addition to deals on Mexico City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Mexico City to Santa Cruz de la Sierra?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santa Cruz de la Sierra.
Can I find deals for business class flights from Mexico City to Santa Cruz de la Sierra?
Yes. Cheapflights offers flight deals from Mexico City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?
Currently, September is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 580). Flying from Mexico City to Santa Cruz de la Sierra in December is currently the most expensive (average of C$ 762). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Santa Cruz de la Sierra car rentals

Santa Cruz de la Sierra Viru Viru Intl Airport car rentals

La Paz car rentals

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How does Cheapflights help users find flights from Mexico City to Santa Cruz de la Sierra?

900+ travel sites are searched through when a user searches for a flight using Cheapflights. From the search interface, users can use filters to choose airlines, airports, flight times, cabin classes and more to their preference. Book your flight to Santa Cruz de la Sierra from Mexico City today with Cheapflights!

Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santa Cruz de la Sierra?

Cheapflights helps you find that perfect flight to Santa Cruz de la Sierra from Mexico City by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Mexico City to Santa Cruz de la Sierra with no change fees?

Yes! Cheapflights helps users easily find flights from Mexico City to Santa Cruz de la Sierra with no change fees.

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Cheap flights from Mexico City to Santa Cruz de la Sierra from C$ 356

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 31/10. Fares are subject to change and may not be available on all flights or dates of travel.

Find flight deals from Mexico City to Santa Cruz de la Sierra

Cheapest flights from Mexico City to Santa Cruz de la SierraExplore the most affordable flight options available from Mexico City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 23 October 2025.

Explore the most affordable flight options available from Mexico City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 23 October 2025.

Cheap flight deals from Mexico City to Santa Cruz de la Sierra

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Mexico City to Santa Cruz de la Sierra that are best for you.

Best time to book a flight from Mexico City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Mexico City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santa Cruz de la Sierra

How far ahead should I book a flight from Mexico City to Santa Cruz de la Sierra?

What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

How much does it cost to fly round-trip from Mexico City to Santa Cruz de la Sierra?

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Mexico City to Santa Cruz de la Sierra?

Can I find deals for flights from Mexico City to Santa Cruz de la Sierra that include hotel bookings?

How can I find direct flights from Mexico City to Santa Cruz de la Sierra?

Can I find deals for business class flights from Mexico City to Santa Cruz de la Sierra?

What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travelers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Mexico City to Santa Cruz de la Sierra?

Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santa Cruz de la Sierra?

Can Cheapflights find flights from Mexico City to Santa Cruz de la Sierra with no change fees?

Can Cheapflights notify me if prices for flights from Mexico City to Santa Cruz de la Sierra become cheaper?

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Cheapest flights from Mexico City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Mexico City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 23 October 2025.