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Cheap flights from Mexico City to Santa Cruz de la Sierra from C$ 430

MEX — VVI
28 Sep — 5 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Mexico City to Santa Cruz de la Sierra

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santa Cruz de la Sierra

Tue 15/91:20 a.m. -
1 stop19h 24m
Sat 3/101:12 a.m. -
1 stop25h 48m
Deal found 25/8C$ 885
Wed 11/115:55 a.m. -
1 stop14h 43m
Sun 29/111:08 a.m. -
1 stop23h 17m
Deal found 28/8C$ 935
Sun 29/111:20 a.m. -
1 stop19h 18m
Thu 14/111:53 a.m. -
1 stop12h 12m
Deal found 27/8C$ 977
Tue 25/85:50 a.m. -
1 stop14h 50m
Tue 1/911:47 a.m. -
1 stop26h 23m
Deal found 24/8C$ 1,075
Tue 10/111:10 p.m. -
1 stop12h 27m
Thu 26/1111:49 a.m. -
1 stop9h 31m
Deal found 27/8C$ 1,154
Thu 17/912:20 a.m. -
2 stops26h 15m
Mon 28/95:25 a.m. -
2 stops25h 20m
Deal found 28/8C$ 1,348

Find flight deals from Mexico City to Santa Cruz de la Sierra

Round-trip from

C$ 885

One-way from

C$ 430

Popular in

December

Cheapest in

April

Average price

C$ 879
Copa Airlines
  • Copa Airlines
  • 15/9-3/10
  • 2 total stops
  • 45h 12m total
  • Mexico City to Santa Cruz de la Sierra
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Copa Airlines
  • Copa Airlines
  • 27/9
  • 1 total stop
  • 24h 18m total
  • Mexico City to Santa Cruz de la Sierra
Search Deals
Highest demand for flights based on searches. 5% potential increase in price (C$ 78 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease (C$ 24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Mexico City to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Thu 8/10

1:20 a.m.-3:38 a.m.

1 stop24h 18m

Santa Cruz de la Sierra Viru Viru Intl

Thu 10/12

1:10 a.m.-10:05 p.m.

1 stop22h 55m

C$ 885

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Mon 12/10

2:10 a.m.-10:44 p.m.

1 stop18h 34m

Santa Cruz de la Sierra Viru Viru Intl

Sat 21/11

11:49 a.m.-10:05 p.m.

1 stop12h 16m

C$ 899

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Tue 15/9

1:20 a.m.-10:44 p.m.

1 stop19h 24m

Santa Cruz de la Sierra Viru Viru Intl

Sat 3/10

1:12 a.m.-1:00 a.m.

1 stop25h 48m

C$ 899

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Wed 11/11

5:55 a.m.-10:38 p.m.

1 stop14h 43m

Santa Cruz de la Sierra Viru Viru Intl

Sun 29/11

1:08 a.m.-10:25 p.m.

1 stop23h 17m

C$ 935

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Fri 5/2

4:00 p.m.-4:35 a.m.

1 stop10h 35m

Santa Cruz de la Sierra Viru Viru Intl

Sat 13/2

5:30 a.m.-8:10 p.m.

2 stops16h 40m

C$ 990
Quickest round-trip

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Tue 10/11

1:10 p.m.-3:37 a.m.

1 stop12h 27m

Santa Cruz de la Sierra Viru Viru Intl

Thu 26/11

11:49 a.m.-7:20 p.m.

1 stop9h 31m

C$ 1,154

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Thu 17/9

12:20 a.m.-4:35 a.m.

2 stops26h 15m

Santa Cruz de la Sierra Viru Viru Intl

Mon 28/9

5:25 a.m.-4:45 a.m.

2 stops25h 20m

C$ 1,348
Cheapest one-way

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Sun 27/9

1:20 a.m.-3:38 a.m.

1 stop24h 18m

C$ 430
Quickest one-way

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Sun 18/10

2:10 a.m.-10:44 p.m.

1 stop18h 34m

C$ 430

Mexico CitySanta Cruz de la Sierra

MEX Mexico City Benito Juarez - VVI Santa Cruz de la Sierra Viru Viru Intl

MEXVVI

Mexico City Benito Juarez

Thu 15/10

1:20 a.m.-10:44 p.m.

1 stop19h 24m

C$ 430

Flights are sorted by cheapest round-trip flights first.

Deals found on 25/8

Showing 1-10 of 11 resultsSorted by cheapest first
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Best time to book a flight from Mexico City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Mexico City with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santa Cruz de la Sierra

How far ahead should I book a flight from Mexico City to Santa Cruz de la Sierra?

Booking 84 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santa Cruz de la Sierra. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

Currently, April is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 831). Flying from Mexico City to Santa Cruz de la Sierra in December is currently the most expensive (average of C$ 1,118). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Mexico City to Santa Cruz de la Sierra?

Airfare is typical for this route at the moment.

Mexico City to Santa Cruz de la Sierra flights typically cost between C$ 762 and C$ 903 in September.
The cheapest round-trip price found within the last 5 days was C$ 885 on Copa Airlines (15 Sep-3 Oct).

Related info for your journey

  • How long is the flight from Mexico City to Santa Cruz de la Sierra?

    Copa Airlines can get you from Mexico City to Santa Cruz de la Sierra in just under 24h 18m. Your travel time can differ by up to . Airlines will cover a distance of 5687 km.

  • Can I find deals for flights from Mexico City to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Mexico City to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Mexico City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

    Currently, April is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 831). Flying from Mexico City to Santa Cruz de la Sierra in December is currently the most expensive (average of C$ 1,118). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Santa Cruz de la Sierra car rentals
Santa Cruz de la Sierra Viru Viru Intl Airport car rentals
La Paz car rentals

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