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Cheap flights from Mexico City to Santa Cruz de la Sierra from C$ 402

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/5. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — VVI
19 May — 26 May1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Mexico City to Santa Cruz de la Sierra

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Mexico City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 19 April 2026.

Fri 29/53:10 p.m.
MEX
-
VVI
1 stop11h 25m
Multiple Airlines
Mon 1/65:25 a.m.
VVI
-
MEX
2 stops25h 30m
Multiple Airlines
Deal found 19/4C$ 821
Sun 26/45:50 a.m.
MEX
-
VVI
1 stop14h 52m
Copa Airlines
Mon 11/511:47 a.m.
VVI
-
MEX
1 stop15h 13m
Copa Airlines
Deal found 14/4C$ 828
Tue 14/72:10 a.m.
MEX
-
VVI
1 stop18h 30m
Copa Airlines
Wed 29/711:47 a.m.
VVI
-
MEX
1 stop15h 13m
Copa Airlines
Deal found 16/4C$ 857
Tue 21/45:50 a.m.
MEX
-
VVI
1 stop14h 52m
Copa Airlines
Thu 30/411:48 a.m.
VVI
-
MEX
1 stop15h 12m
Copa Airlines
Deal found 18/4C$ 883
Tue 7/71:10 p.m.
MEX
-
VVI
1 stop12h 25m
Copa Airlines
Mon 13/711:47 a.m.
VVI
-
MEX
1 stop15h 13m
Copa Airlines
Deal found 16/4C$ 913
Tue 28/71:20 a.m.
MEX
-
VVI
1 stop19h 20m
Copa Airlines
Tue 11/81:12 a.m.
VVI
-
MEX
1 stop15h 18m
Copa Airlines
Deal found 16/4C$ 968
Tue 8/123:10 p.m.
MEX
-
VVI
1 stop11h 25m
Multiple Airlines
Sun 13/125:25 a.m.
VVI
-
MEX
2 stops16h 40m
Multiple Airlines
Deal found 17/4C$ 969
Tue 7/71:20 a.m.
MEX
-
VVI
1 stop19h 20m
Copa Airlines
Wed 15/711:47 a.m.
VVI
-
MEX
1 stop15h 13m
Copa Airlines
Deal found 15/4C$ 996
Sat 3/1012:25 a.m.
MEX
-
VVI
1 stop20h 19m
Copa Airlines
Sat 10/101:12 a.m.
VVI
-
MEX
1 stop19h 53m
Copa Airlines
Deal found 16/4C$ 1,105
Fri 18/129:00 p.m.
MEX
-
VVI
2 stops29h 35m
Multiple Airlines
Sun 10/15:25 a.m.
VVI
-
MEX
2 stops26h 05m
Multiple Airlines
Deal found 19/4C$ 1,202

Find flight deals from Mexico City to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 19 April 2026.

Round-trip from

C$ 821

One-way from

C$ 402

Popular in

December

Cheapest in

June

Average price

C$ 820
29/5-1/6
  • 29/5-1/6
  • 3 total stops
  • 36h 55m total
  • Mexico City to Santa Cruz de la Sierra
Search Deals
Copa Airlines
  • Copa Airlines
  • 5/5
  • 1 total stop
  • 10h 48m total
  • Mexico City to Santa Cruz de la Sierra
Search Deals
Highest demand for flights based on searches. 11% potential increase in price (C$ 158 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease (C$ 35 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 19 April 2026.
Use the filters below to find and compare flights from Mexico City to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 29/5

3:10 p.m.-4:35 a.m.

1 stop11h 25m

Santa Cruz de la Sierra Viru Viru Intl

Mon 1/6

5:25 a.m.-4:55 a.m.

2 stops25h 30m

C$ 821

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 14/7

2:10 a.m.-10:40 p.m.

1 stop18h 30m

Santa Cruz de la Sierra Viru Viru Intl

Wed 29/7

11:47 a.m.-1:00 a.m.

1 stop15h 13m

C$ 857

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 7/7

1:10 p.m.-3:35 a.m.

1 stop12h 25m

Santa Cruz de la Sierra Viru Viru Intl

Mon 13/7

11:47 a.m.-1:00 a.m.

1 stop15h 13m

C$ 913

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 28/7

1:20 a.m.-10:40 p.m.

1 stop19h 20m

Santa Cruz de la Sierra Viru Viru Intl

Tue 11/8

1:12 a.m.-2:30 p.m.

1 stop15h 18m

C$ 968
Quickest round-trip

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Wed 16/9

9:50 a.m.-10:44 p.m.

1 stop10h 54m

Santa Cruz de la Sierra Viru Viru Intl

Sat 24/10

11:47 a.m.-10:05 p.m.

1 stop12h 18m

C$ 968

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 7/7

1:20 a.m.-10:40 p.m.

1 stop19h 20m

Santa Cruz de la Sierra Viru Viru Intl

Wed 15/7

11:47 a.m.-1:00 a.m.

1 stop15h 13m

C$ 996

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sat 3/10

12:25 a.m.-10:44 p.m.

1 stop20h 19m

Santa Cruz de la Sierra Viru Viru Intl

Sat 10/10

1:12 a.m.-7:05 p.m.

1 stop19h 53m

C$ 1,105
Cheapest one-way

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 5/5

9:50 a.m.-10:38 p.m.

1 stop10h 48m

C$ 402

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 4/8

1:20 a.m.-10:40 p.m.

1 stop19h 20m

C$ 402
Quickest one-way

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Mon 27/4

3:30 p.m.-3:40 a.m.

1 stop10h 10m

C$ 402

Flights are sorted by cheapest round-trip flights first.

Deals found on 16/4

Showing 1-10 of 14 resultsSorted by cheapest first
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Best time to book a flight from Mexico City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santa Cruz de la Sierra

How far ahead should I book a flight from Mexico City to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santa Cruz de la Sierra. Price data was last updated on 17 April 2026.

Booking 85 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santa Cruz de la Sierra. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

Currently, June is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 741). Flying from Mexico City to Santa Cruz de la Sierra in December is currently the most expensive (average of C$ 1,120). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Mexico City to Santa Cruz de la Sierra?

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mexico City to Santa Cruz de la Sierra?

    Copa Airlines can get you from Mexico City to Santa Cruz de la Sierra in just under 18h 30m. Your travel time can differ by up to . Airlines will cover a distance of 5687 km.

  • Can I find deals for flights from Mexico City to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Mexico City to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Mexico City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

    Currently, June is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 741). Flying from Mexico City to Santa Cruz de la Sierra in December is currently the most expensive (average of C$ 1,120). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Santa Cruz de la Sierra car rentals
Santa Cruz de la Sierra Viru Viru Intl Airport car rentals
La Paz car rentals

Fly with Cheapflights

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How does Cheapflights help users find flights from Mexico City to Santa Cruz de la Sierra?

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santa Cruz de la Sierra?

Cheapflights helps you find that perfect flight to Santa Cruz de la Sierra from Mexico City by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Mexico City to Santa Cruz de la Sierra with no change fees?

Yes! Cheapflights helps users easily find flights from Mexico City to Santa Cruz de la Sierra with no change fees.

Can Cheapflights notify me if prices for flights from Mexico City to Santa Cruz de la Sierra become cheaper?

Of course! You can now track prices for flights from Mexico City to Santa Cruz de la Sierra and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.

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