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Cheap flights from Mexico City to Santa Cruz de la Sierra from C$ 426

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 16/9. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — VVI
30 Jul — 6 Aug1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Mexico City to Santa Cruz de la Sierra

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Mexico City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 30 June 2026.

Tue 15/91:20 a.m.
MEX
-
VVI
1 stop19h 24m
Copa Airlines
Sat 3/101:12 a.m.
VVI
-
MEX
1 stop25h 48m
Copa Airlines
Deal found 29/6C$ 876
Mon 30/112:00 a.m.
MEX
-
VVI
1 stop23h 42m
Copa Airlines
Thu 31/1211:42 a.m.
VVI
-
MEX
1 stop14h 33m
Copa Airlines
Deal found 29/6C$ 906
Fri 4/91:00 p.m.
MEX
-
VVI
2 stops13h 35m
Multiple Airlines
Sat 19/95:25 a.m.
VVI
-
MEX
1 stop10h 25m
Multiple Airlines
Deal found 26/6C$ 911
Thu 2/71:20 a.m.
MEX
-
VVI
1 stop19h 20m
Copa Airlines
Mon 10/811:47 a.m.
VVI
-
MEX
1 stop26h 23m
Copa Airlines
Deal found 29/6C$ 936
Sun 29/111:20 a.m.
MEX
-
VVI
1 stop19h 18m
Copa Airlines
Thu 14/111:53 a.m.
VVI
-
MEX
1 stop14h 22m
Copa Airlines
Deal found 29/6C$ 948
Fri 9/101:20 a.m.
MEX
-
VVI
1 stop19h 24m
Copa Airlines
Fri 30/101:12 a.m.
VVI
-
MEX
1 stop22h 53m
Copa Airlines
Deal found 30/6C$ 1,001
Sun 19/71:20 a.m.
MEX
-
VVI
1 stop19h 20m
Copa Airlines
Thu 13/81:12 a.m.
VVI
-
MEX
1 stop19h 53m
Copa Airlines
Deal found 28/6C$ 1,163
Sun 19/71:20 a.m.
MEX
-
VVI
1 stop19h 20m
Copa Airlines
Tue 4/811:47 a.m.
VVI
-
MEX
1 stop14h 28m
Copa Airlines
Deal found 26/6C$ 1,193
Wed 16/121:20 a.m.
MEX
-
VVI
1 stop19h 28m
Copa Airlines
Sat 9/11:14 a.m.
VVI
-
MEX
1 stop25h 46m
Copa Airlines
Deal found 28/6C$ 1,235

Find flight deals from Mexico City to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 30 June 2026.

Round-trip from

C$ 876

One-way from

C$ 426

Popular in

December

Cheapest in

September

Average price

C$ 1,075
Copa Airlines
  • Copa Airlines
  • 15/9-3/10
  • 2 total stops
  • 45h 12m total
  • Mexico City to Santa Cruz de la Sierra
Search Deals
Copa Airlines
  • Copa Airlines
  • 16/9
  • 1 total stop
  • 19h 48m total
  • Mexico City to Santa Cruz de la Sierra
Search Deals
Highest demand for flights based on searches. 7% potential increase in price (C$ 104 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (C$ 28 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 30 June 2026.
Use the filters below to find and compare flights from Mexico City to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 15/9

1:20 a.m.-10:44 p.m.

1 stop19h 24m

Santa Cruz de la Sierra Viru Viru Intl

Sat 3/10

1:12 a.m.-1:00 a.m.

1 stop25h 48m

C$ 876

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sat 3/10

12:25 a.m.-3:38 a.m.

1 stop25h 13m

Santa Cruz de la Sierra Viru Viru Intl

Sun 11/10

1:12 a.m.-7:05 p.m.

1 stop19h 53m

C$ 876

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 1/12

3:30 p.m.-3:42 a.m.

1 stop10h 12m

Santa Cruz de la Sierra Viru Viru Intl

Thu 3/12

1:10 a.m.-1:00 a.m.

1 stop25h 50m

C$ 876

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Mon 30/11

2:00 a.m.-3:42 a.m.

1 stop23h 42m

Santa Cruz de la Sierra Viru Viru Intl

Thu 31/12

11:42 a.m.-12:15 a.m.

1 stop14h 33m

C$ 906

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 4/8

1:20 a.m.-3:35 a.m.

1 stop24h 15m

Santa Cruz de la Sierra Viru Viru Intl

Tue 18/8

1:12 a.m.-1:00 a.m.

1 stop25h 48m

C$ 906

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 4/9

1:00 p.m.-4:35 a.m.

2 stops13h 35m

Santa Cruz de la Sierra Viru Viru Intl

Sat 19/9

5:25 a.m.-4:00 p.m.

2 stops36h 35m

C$ 911

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 9/10

1:20 a.m.-10:44 p.m.

1 stop19h 24m

Santa Cruz de la Sierra Viru Viru Intl

Fri 30/10

1:12 a.m.-10:05 p.m.

1 stop22h 53m

C$ 1,001
Quickest round-trip

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sun 19/7

1:20 a.m.-10:40 p.m.

1 stop19h 20m

Santa Cruz de la Sierra Viru Viru Intl

Tue 4/8

11:47 a.m.-12:15 a.m.

1 stop14h 28m

C$ 1,193
Cheapest one-way

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Wed 16/9

5:50 a.m.-3:38 a.m.

1 stop19h 48m

C$ 426
Quickest one-way

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sun 27/9

1:20 a.m.-10:44 p.m.

1 stop19h 24m

C$ 426

Flights are sorted by cheapest round-trip flights first.

Deals found on 25/6

Showing 1-10 of 11 resultsSorted by cheapest first
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Best time to book a flight from Mexico City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santa Cruz de la Sierra

How far ahead should I book a flight from Mexico City to Santa Cruz de la Sierra?

Booking 84 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santa Cruz de la Sierra. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

Currently, September is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 789). Flying from Mexico City to Santa Cruz de la Sierra in December is currently the most expensive (average of C$ 1,144). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Mexico City to Santa Cruz de la Sierra?

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mexico City to Santa Cruz de la Sierra?

    Copa Airlines can get you from Mexico City to Santa Cruz de la Sierra in just under 19h 24m. Your travel time can differ by up to . Airlines will cover a distance of 5687 km.

  • Can I find deals for flights from Mexico City to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Mexico City to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Mexico City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

    Currently, September is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 789). Flying from Mexico City to Santa Cruz de la Sierra in December is currently the most expensive (average of C$ 1,144). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Santa Cruz de la Sierra car rentals
Santa Cruz de la Sierra Viru Viru Intl Airport car rentals
La Paz car rentals

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How does Cheapflights help users find flights from Mexico City to Santa Cruz de la Sierra?

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santa Cruz de la Sierra?

Cheapflights helps you find that perfect flight to Santa Cruz de la Sierra from Mexico City by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Mexico City to Santa Cruz de la Sierra with no change fees?

Yes! Cheapflights helps users easily find flights from Mexico City to Santa Cruz de la Sierra with no change fees.

Can Cheapflights notify me if prices for flights from Mexico City to Santa Cruz de la Sierra become cheaper?

Of course! You can now track prices for flights from Mexico City to Santa Cruz de la Sierra and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.

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