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Cheap flights from Mexico City to Santa Cruz de la Sierra from C$ 680

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 21/11. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — VVI
5 may. — 12 may.1
1 adult

Cheap flight deals from Mexico City to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 30 abril 2025.

Round-trip from

C$ 760

Popular in

December

Cheapest in

May

Average price

C$ 808
Copa Airlines
  • Copa Airlines
  • 15/9-30/9
  • 2 total stops
  • 30h 10m total
  • Mexico City to Santa Cruz de la Sierra
Search Deals
Highest demand for flights based on searches. 5% potential increase in price (C$ 69 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (C$ 14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2025
Search Deals

Find flight deals from Mexico City to Santa Cruz de la Sierra

Cheapest flights from Mexico City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Mexico City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 30 abril 2025.

vie. 21/114:05 p.m.MEX - VVI
1 stop10h 30mMultiple Airlines
sáb. 29/115:20 a.m.VVI - MEX
2 stops26h 20mMultiple Airlines
Deal found 27/4C$ 680
jue. 20/112:02 a.m.MEX - VVI
1 stop17h 42mCopa Airlines
sáb. 29/1112:25 p.m.VVI - MEX
1 stop14h 14mCopa Airlines
Deal found 27/4C$ 723

Cheapflights Fare Finder

Customize your flight search to find flights from Mexico City to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 30 abril 2025.
Use the filters below to find and compare flights from Mexico City to Santa Cruz de la Sierra that are best for you.

Fly from

Mexico City

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

lun. 15/9

2:00 a.m.-10:25 p.m.

1 stop18h 25m

Santa Cruz de la Sierra Viru Viru Intl

mar. 30/9

12:15 p.m.-10:00 p.m.

1 stop11h 45m

C$ 760

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

vie. 9/5

6:05 p.m.-4:35 a.m.

2 stops32h 30m

Santa Cruz de la Sierra Viru Viru Intl

vie. 16/5

5:20 a.m.-4:45 a.m.

2 stops25h 25m

C$ 821

Flights are sorted by cheapest round-trip flights first.

Deals found on 28/4

Best time to book a flight from Mexico City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santa Cruz de la Sierra

How far ahead should I book a flight from Mexico City to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santa Cruz de la Sierra. Price data was last updated on 25 April 2025.

Booking 56 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santa Cruz de la Sierra. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated 30 abril 2025.
Copa Airlines
7.5
Good
1,411 reviews
Check prices

Overall

7.5

Crew

8.1

Food

6.8

Boarding

7.8

Comfort

7.4

Entertainment

6.7

Reviews

1 / 20
4.0
Okay

Anonymous,Mar 2025

PTY - JFK

There was no chance for me to choose a seat even if I were willing to pay extra for it when I was doing the check-in on line. My seats were the last row on the plane and they didn't have enough food to give me. I had to eat what was left after everybody else had their choice of food. This is unacceptable. Everyone should have a choice. I paid money just like everybody else. Never had this happened on any other airlines even if my seats were last row on the plane.
Copa Airlines
7.5
Good
1,411 reviews
Copa Airlines
7.5
Good
1,411 reviews
Check prices

Overall

7.5

Crew

8.1

Food

6.8

Boarding

7.8

Comfort

7.4

Entertainment

6.7

Reviews

1 / 20
4.0
Okay

Anonymous,Mar 2025

PTY - JFK

There was no chance for me to choose a seat even if I were willing to pay extra for it when I was doing the check-in on line. My seats were the last row on the plane and they didn't have enough food to give me. I had to eat what was left after everybody else had their choice of food. This is unacceptable. Everyone should have a choice. I paid money just like everybody else. Never had this happened on any other airlines even if my seats were last row on the plane.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What is the cheapest airline to fly from Mexico City to Santa Cruz de la Sierra round-trip?

    Cheapflights users have booked flights from Mexico City to Santa Cruz de la Sierra round-trip from C$ 760. Users have found that Copa Airlines is 7% cheaper than the other options available to this destination.

  • Can I find deals for flights from Mexico City to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Mexico City to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Mexico City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Santa Cruz de la Sierra car rentals
Santa Cruz de la Sierra Viru Viru Intl Airport car rentals
La Paz car rentals

Top 2 airlines flying from Mexico City to Santa Cruz de la Sierra

Discover the top 2 airlines that operate flights from Mexico City to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 30 abril 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapestC$ 732AverageC$ 805FlexibilityNo cancel feeOn-time71%
Search Avianca flights
Copa AirlinesCheapestC$ 769AverageC$ 778FlexibilityNo cancel feeOn-time70%
Search Copa Airlines flights

Fly with Cheapflights

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How does Cheapflights help users find flights from Mexico City to Santa Cruz de la Sierra?

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santa Cruz de la Sierra?

Cheapflights helps you find that perfect flight to Santa Cruz de la Sierra from Mexico City by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Mexico City to Santa Cruz de la Sierra with no change fees?

Yes! Cheapflights helps users easily find flights from Mexico City to Santa Cruz de la Sierra with no change fees.

Can Cheapflights notify me if prices for flights from Mexico City to Santa Cruz de la Sierra become cheaper?

Of course! You can now track prices for flights from Mexico City to Santa Cruz de la Sierra and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.

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