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Cheap flights from Mexico City to Santa Cruz de la Sierra from C$ 487

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 13/11. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — VVI
6 Dec — 13 Dec1
1 adult
1 adult, Economy, 0 bags

Find flight deals from Mexico City to Santa Cruz de la Sierra

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Mexico City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 6 November 2025.

Fri 5/125:55 a.m.MEX - VVI
1 stop19h 41mCopa Airlines
Sat 31/11:15 a.m.VVI - MEX
1 stop15h 15mCopa Airlines
Deal found 5/11C$ 782
Wed 3/129:00 p.m.MEX - VVI
2 stops29h 35mMultiple Airlines
Mon 8/125:25 a.m.VVI - MEX
1 stop10h 25mMultiple Airlines
Deal found 6/11C$ 834
Thu 4/121:01 a.m.MEX - VVI
2 stops25h 34mMultiple Airlines
Sun 1/25:25 a.m.VVI - MEX
1 stop10h 25mMultiple Airlines
Deal found 5/11C$ 853
Tue 2/121:20 a.m.MEX - VVI
1 stop19h 26mCopa Airlines
Mon 8/1211:40 a.m.VVI - MEX
1 stop14h 35mCopa Airlines
Deal found 6/11C$ 855
Thu 4/121:01 a.m.MEX - VVI
2 stops25h 34mMultiple Airlines
Wed 17/125:25 a.m.VVI - MEX
1 stop10h 25mMultiple Airlines
Deal found 4/11C$ 876
Sat 22/111:20 a.m.MEX - VVI
1 stop19h 26mCopa Airlines
Tue 2/121:09 a.m.VVI - MEX
1 stop20h 11mCopa Airlines
Deal found 4/11C$ 903
Sat 22/112:00 a.m.MEX - VVI
1 stop18h 46mCopa Airlines
Fri 12/121:09 a.m.VVI - MEX
1 stop15h 21mCopa Airlines
Deal found 6/11C$ 952

Cheap flight deals from Mexico City to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 6 November 2025.

Round-trip from

C$ 782

One-way from

C$ 487

Popular in

December

Cheapest in

May

Average price

C$ 825
Copa Airlines
  • Copa Airlines
  • 20/4-30/4
  • 2 total stops
  • 33h 21m total
  • Mexico City to Santa Cruz de la Sierra
Search Deals
Copa Airlines
  • Copa Airlines
  • 13/11
  • 1 total stop
  • 18h 46m total
  • Mexico City to Santa Cruz de la Sierra
Search Deals
Highest demand for flights based on searches. 5% potential increase in price (C$ 74 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (C$ 15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 6 November 2025.
Use the filters below to find and compare flights from Mexico City to Santa Cruz de la Sierra that are best for you.

Fly from

Mexico City

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Mon 20/4

2:00 a.m.-10:50 p.m.

1 stop18h 50m

Santa Cruz de la Sierra Viru Viru Intl

Thu 30/4

11:44 a.m.-12:15 a.m.

1 stop14h 31m

C$ 782

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 27/3

5:55 a.m.-3:38 a.m.

1 stop19h 43m

Santa Cruz de la Sierra Viru Viru Intl

Sat 11/4

1:15 a.m.-7:20 p.m.

1 stop20h 05m

C$ 782

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sat 14/3

9:25 a.m.-10:50 p.m.

1 stop11h 25m

Santa Cruz de la Sierra Viru Viru Intl

Sat 21/3

11:42 a.m.-12:15 a.m.

1 stop14h 33m

C$ 782

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 5/12

5:55 a.m.-3:36 a.m.

1 stop19h 41m

Santa Cruz de la Sierra Viru Viru Intl

Sat 31/1

1:15 a.m.-2:30 p.m.

1 stop15h 15m

C$ 782

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 31/3

1:40 a.m.-10:50 p.m.

1 stop19h 10m

Santa Cruz de la Sierra Viru Viru Intl

Mon 6/4

1:15 a.m.-2:30 p.m.

1 stop15h 15m

C$ 808

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Wed 29/4

1:40 a.m.-10:50 p.m.

1 stop19h 10m

Santa Cruz de la Sierra Viru Viru Intl

Mon 4/5

11:44 a.m.-12:15 a.m.

1 stop14h 31m

C$ 808

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Thu 13/11

2:00 a.m.-10:46 p.m.

1 stop18h 46m

C$ 487

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 19/12

1:20 a.m.-10:46 p.m.

1 stop19h 26m

C$ 1,154

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/11

Best time to book a flight from Mexico City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santa Cruz de la Sierra

How far ahead should I book a flight from Mexico City to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santa Cruz de la Sierra. Price data was last updated on 31 October 2025.

Booking 56 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santa Cruz de la Sierra. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

Currently, September is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 584). Flying from Mexico City to Santa Cruz de la Sierra in December is currently the most expensive (average of C$ 767). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mexico City to Santa Cruz de la Sierra?

    Copa Airlines can get you from Mexico City to Santa Cruz de la Sierra in just under 18h 50m. Your travel time can differ by up to . Airlines will cover a distance of 5687 km.

  • Can I find deals for flights from Mexico City to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Mexico City to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Mexico City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

    Currently, September is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 584). Flying from Mexico City to Santa Cruz de la Sierra in December is currently the most expensive (average of C$ 767). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Santa Cruz de la Sierra car rentals
Santa Cruz de la Sierra Viru Viru Intl Airport car rentals
La Paz car rentals

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How does Cheapflights help users find flights from Mexico City to Santa Cruz de la Sierra?

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santa Cruz de la Sierra?

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Can Cheapflights find flights from Mexico City to Santa Cruz de la Sierra with no change fees?

Yes! Cheapflights helps users easily find flights from Mexico City to Santa Cruz de la Sierra with no change fees.

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Of course! You can now track prices for flights from Mexico City to Santa Cruz de la Sierra and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.

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