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Cheap flights from Mexico City to Santa Cruz de la Sierra from C$ 525

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 26/1. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — VVI
17 Oct — 24 Oct1
1 adult
1 adult, Economy

Cheap flight deals from Mexico City to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 17 September 2025.

Round-trip from

C$ 629

One-way from

C$ 525

Popular in

December

Cheapest in

May

Average price

C$ 798
Copa Airlines
  • Copa Airlines
  • 27/11-7/12
  • 2 total stops
  • 39h 37m total
  • Mexico City to Santa Cruz de la Sierra
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Copa Airlines
  • Copa Airlines
  • 26/1
  • 1 total stop
  • 18h 50m total
  • Mexico City to Santa Cruz de la Sierra
Search Deals
Highest demand for flights based on searches. 6% potential increase in price (C$ 79 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease (C$ 16 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Mexico City to Santa Cruz de la Sierra

Cheapest flights from Mexico City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Mexico City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 17 September 2025.

Thu 27/111:20 a.m.MEX - VVI
1 stop19h 26mCopa Airlines
Mon 8/1211:40 a.m.VVI - MEX
1 stop15h 20mCopa Airlines
Deal found 16/9C$ 629
Wed 1/101:05 p.m.MEX - VVI
1 stop12h 31mCopa Airlines
Thu 16/1011:59 a.m.VVI - MEX
1 stop14h 16mCopa Airlines
Deal found 16/9C$ 713
Fri 19/92:00 a.m.MEX - VVI
1 stop18h 25mCopa Airlines
Sat 27/912:15 p.m.VVI - MEX
1 stop11h 50mCopa Airlines
Deal found 16/9C$ 728
Fri 31/105:35 p.m.MEX - VVI
2 stops33h 00mMultiple Airlines
Fri 7/115:25 a.m.VVI - MEX
2 stops16h 50mMultiple Airlines
Deal found 16/9C$ 783
Sat 29/112:00 a.m.MEX - VVI
1 stop18h 46mCopa Airlines
Tue 3/31:14 a.m.VVI - MEX
1 stop20h 06mCopa Airlines
Deal found 16/9C$ 791
Fri 14/119:00 p.m.MEX - VVI
2 stops29h 35mMultiple Airlines
Mon 24/115:25 a.m.VVI - MEX
2 stops16h 50mMultiple Airlines
Deal found 16/9C$ 796
Thu 30/102:00 a.m.MEX - VVI
1 stop18h 40mCopa Airlines
Thu 6/111:09 a.m.VVI - MEX
1 stop20h 11mCopa Airlines
Deal found 16/9C$ 845
Wed 1/103:10 p.m.MEX - VVI
1 stop11h 25mMultiple Airlines
Wed 15/105:20 a.m.VVI - MEX
2 stops16h 50mMultiple Airlines
Deal found 16/9C$ 878
Sun 9/118:55 p.m.MEX - VVI
2 stops29h 40mMultiple Airlines
Sun 23/115:25 a.m.VVI - MEX
1 stop10h 25mMultiple Airlines
Deal found 17/9C$ 919

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 17 September 2025.
Use the filters below to find and compare flights from Mexico City to Santa Cruz de la Sierra that are best for you.

Fly from

Mexico City

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Thu 2/10

9:50 a.m.-10:40 p.m.

1 stop10h 50m

Santa Cruz de la Sierra Viru Viru Intl

Tue 14/10

11:59 a.m.-1:00 a.m.

1 stop15h 01m

C$ 713

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 28/11

3:30 p.m.-3:36 a.m.

1 stop10h 06m

Santa Cruz de la Sierra Viru Viru Intl

Mon 8/12

11:40 a.m.-12:15 a.m.

1 stop14h 35m

C$ 713

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 31/10

5:35 p.m.-4:35 a.m.

2 stops33h 00m

Santa Cruz de la Sierra Viru Viru Intl

Fri 7/11

5:25 a.m.-8:15 p.m.

2 stops16h 50m

C$ 783

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sat 29/11

2:00 a.m.-10:46 p.m.

1 stop18h 46m

Santa Cruz de la Sierra Viru Viru Intl

Tue 3/3

1:14 a.m.-7:20 p.m.

1 stop20h 06m

C$ 791

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 14/11

9:00 p.m.-4:35 a.m.

2 stops29h 35m

Santa Cruz de la Sierra Viru Viru Intl

Mon 24/11

5:25 a.m.-8:15 p.m.

2 stops16h 50m

C$ 796

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 10/2

1:20 a.m.-10:50 p.m.

1 stop19h 30m

Santa Cruz de la Sierra Viru Viru Intl

Tue 24/2

11:44 a.m.-12:15 a.m.

1 stop14h 31m

C$ 798

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Thu 30/10

2:00 a.m.-10:40 p.m.

1 stop18h 40m

Santa Cruz de la Sierra Viru Viru Intl

Thu 6/11

1:09 a.m.-7:20 p.m.

1 stop20h 11m

C$ 845

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 2/12

1:20 a.m.-10:46 p.m.

1 stop19h 26m

Santa Cruz de la Sierra Viru Viru Intl

Tue 13/1

1:15 a.m.-7:20 p.m.

1 stop20h 05m

C$ 845

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sat 14/3

5:55 a.m.-10:50 p.m.

1 stop14h 55m

Santa Cruz de la Sierra Viru Viru Intl

Sat 21/3

11:42 a.m.-12:15 a.m.

1 stop14h 33m

C$ 856

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Mon 26/1

2:00 a.m.-10:50 p.m.

1 stop18h 50m

C$ 525

Flights are sorted by cheapest round-trip flights first.

Deals found on 17/9

Showing 1-10 of 11 results
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Best time to book a flight from Mexico City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santa Cruz de la Sierra

How far ahead should I book a flight from Mexico City to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santa Cruz de la Sierra. Price data was last updated on 12 September 2025.

Booking 56 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santa Cruz de la Sierra. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mexico City to Santa Cruz de la Sierra?

    Copa Airlines can get you from Mexico City to Santa Cruz de la Sierra in just under 10h 50m. Your travel time can differ by up to . Airlines will cover a distance of 5687 km.

  • Can I find deals for flights from Mexico City to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Mexico City to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Mexico City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Santa Cruz de la Sierra car rentals
Santa Cruz de la Sierra Viru Viru Intl Airport car rentals
La Paz car rentals

Fly with Cheapflights

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How does Cheapflights help users find flights from Mexico City to Santa Cruz de la Sierra?

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santa Cruz de la Sierra?

Cheapflights helps you find that perfect flight to Santa Cruz de la Sierra from Mexico City by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Mexico City to Santa Cruz de la Sierra with no change fees?

Yes! Cheapflights helps users easily find flights from Mexico City to Santa Cruz de la Sierra with no change fees.

Can Cheapflights notify me if prices for flights from Mexico City to Santa Cruz de la Sierra become cheaper?

Of course! You can now track prices for flights from Mexico City to Santa Cruz de la Sierra and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.

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