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Cheap flights from Mexico City to Santa Cruz de la Sierra from C$ 383

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 16/4. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — VVI
9 Apr — 16 Apr1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Mexico City to Santa Cruz de la Sierra

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Mexico City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 10 March 2026.

Mon 20/42:10 a.m.
MEX
-
VVI
1 stop18h 32m
Copa Airlines
Thu 30/411:48 a.m.
VVI
-
MEX
1 stop12h 17m
Copa Airlines
Deal found 9/3C$ 752
Sun 14/63:10 p.m.
MEX
-
VVI
1 stop11h 25m
Multiple Airlines
Mon 31/85:25 a.m.
VVI
-
MEX
2 stops25h 20m
Multiple Airlines
Deal found 8/3C$ 780
Wed 10/65:55 p.m.
MEX
-
VVI
2 stops32h 40m
Multiple Airlines
Sat 8/85:25 a.m.
VVI
-
MEX
2 stops25h 20m
Multiple Airlines
Deal found 9/3C$ 787
Sat 14/39:25 a.m.
MEX
-
VVI
1 stop11h 25m
Copa Airlines
Sat 21/311:54 a.m.
VVI
-
MEX
1 stop9h 26m
Copa Airlines
Deal found 9/3C$ 817
Thu 2/43:10 p.m.
MEX
-
VVI
1 stop11h 25m
Multiple Airlines
Thu 7/55:25 a.m.
VVI
-
MEX
2 stops16h 45m
Multiple Airlines
Deal found 9/3C$ 847
Sun 24/52:00 p.m.
MEX
-
VVI
1 stop10h 30m
Avianca
Sat 30/53:35 a.m.
VVI
-
MEX
1 stop10h 35m
Avianca
Deal found 6/3C$ 860
Sun 7/612:55 p.m.
MEX
-
VVI
2 stops13h 40m
Multiple Airlines
Fri 3/75:25 a.m.
VVI
-
MEX
2 stops30h 30m
Multiple Airlines
Deal found 9/3C$ 902
Sun 24/52:00 p.m.
MEX
-
VVI
1 stop10h 30m
Avianca
Thu 4/63:35 a.m.
VVI
-
MEX
1 stop25h 30m
Avianca
Deal found 6/3C$ 951
Sun 24/52:00 p.m.
MEX
-
VVI
1 stop10h 30m
Avianca
Mon 1/63:35 a.m.
VVI
-
MEX
1 stop10h 35m
Avianca
Deal found 6/3C$ 955

Find flight deals from Mexico City to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 10 March 2026.

Round-trip from

C$ 752

One-way from

C$ 383

Popular in

December

Cheapest in

June

Average price

C$ 794
Copa Airlines
  • Copa Airlines
  • 21/4-30/4
  • 2 total stops
  • 27h 09m total
  • Mexico City to Santa Cruz de la Sierra
Search Deals
Avianca
  • Avianca
  • 16/4
  • 1 total stop
  • 10h 30m total
  • Mexico City to Santa Cruz de la Sierra
Search Deals
Highest demand for flights based on searches. 12% potential increase in price (C$ 160 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (C$ 34 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 10 March 2026.
Use the filters below to find and compare flights from Mexico City to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 21/4

5:50 a.m.-10:42 p.m.

1 stop14h 52m

Santa Cruz de la Sierra Viru Viru Intl

Thu 30/4

11:48 a.m.-10:05 p.m.

1 stop12h 17m

C$ 752

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Wed 10/6

5:55 p.m.-4:35 a.m.

2 stops32h 40m

Santa Cruz de la Sierra Viru Viru Intl

Sat 8/8

5:25 a.m.-4:45 a.m.

2 stops25h 20m

C$ 787

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sun 14/6

11:45 a.m.-4:35 a.m.

2 stops14h 50m

Santa Cruz de la Sierra Viru Viru Intl

Mon 31/8

5:25 a.m.-4:45 a.m.

2 stops25h 20m

C$ 801

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sun 7/6

12:55 p.m.-4:35 a.m.

2 stops13h 40m

Santa Cruz de la Sierra Viru Viru Intl

Fri 3/7

5:25 a.m.-9:55 a.m.

2 stops30h 30m

C$ 902
Quickest round-trip

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 29/5

2:00 p.m.-2:30 a.m.

1 stop10h 30m

Santa Cruz de la Sierra Viru Viru Intl

Mon 1/6

3:35 a.m.-12:10 p.m.

1 stop10h 35m

C$ 955

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Sat 13/6

12:25 a.m.-10:38 p.m.

1 stop20h 13m

Santa Cruz de la Sierra Viru Viru Intl

Mon 15/6

11:47 a.m.-1:00 a.m.

1 stop15h 13m

C$ 976

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Tue 31/3

2:10 a.m.-10:42 p.m.

1 stop18h 32m

Santa Cruz de la Sierra Viru Viru Intl

Mon 6/4

1:15 a.m.-7:05 p.m.

1 stop19h 50m

C$ 1,022

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Wed 8/4

8:55 a.m.-4:35 a.m.

2 stops17h 40m

Santa Cruz de la Sierra Viru Viru Intl

Wed 15/4

8:41 a.m.-1:50 p.m.

2 stops31h 09m

C$ 1,105

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Fri 20/3

1:50 p.m.-2:35 a.m.

1 stop10h 45m

Santa Cruz de la Sierra Viru Viru Intl

Mon 23/3

3:40 a.m.-12:10 p.m.

1 stop10h 30m

C$ 1,122
Cheapest one-way
Quickest one-way

Mexico CitySanta Cruz de la Sierra

MEX - VVI

MEXVVI

Mexico City Benito Juarez

Thu 16/4

2:00 p.m.-2:30 a.m.

1 stop10h 30m

C$ 383

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/3

Showing 1-10 of 12 resultsSorted by cheapest first
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Best time to book a flight from Mexico City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santa Cruz de la Sierra

How far ahead should I book a flight from Mexico City to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Santa Cruz de la Sierra. Price data was last updated on 6 March 2026.

Booking 85 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santa Cruz de la Sierra. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

Currently, June is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 578). Flying from Mexico City to Santa Cruz de la Sierra in February is currently the most expensive (average of C$ 718). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mexico City to Santa Cruz de la Sierra?

    Copa Airlines can get you from Mexico City to Santa Cruz de la Sierra in just under 14h 52m. Your travel time can differ by up to . Airlines will cover a distance of 5687 km.

  • Can I find deals for flights from Mexico City to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Mexico City to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Mexico City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santa Cruz de la Sierra?

    Currently, June is the cheapest month in which you can book a flight from Mexico City to Santa Cruz de la Sierra (average of C$ 578). Flying from Mexico City to Santa Cruz de la Sierra in February is currently the most expensive (average of C$ 718). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Santa Cruz de la Sierra car rentals
Santa Cruz de la Sierra Viru Viru Intl Airport car rentals
La Paz car rentals

Fly with Cheapflights

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How does Cheapflights help users find flights from Mexico City to Santa Cruz de la Sierra?

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santa Cruz de la Sierra?

Cheapflights helps you find that perfect flight to Santa Cruz de la Sierra from Mexico City by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Mexico City to Santa Cruz de la Sierra with no change fees?

Yes! Cheapflights helps users easily find flights from Mexico City to Santa Cruz de la Sierra with no change fees.

Can Cheapflights notify me if prices for flights from Mexico City to Santa Cruz de la Sierra become cheaper?

Of course! You can now track prices for flights from Mexico City to Santa Cruz de la Sierra and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.

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