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Cheap flights from Mexico City to Panama City from C$ 222

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/4. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — PTY
14 Apr — 21 Apr1
1 adult
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Mexico City Benito Juarez to Panama City Tocumen Intl are usually found in August or July, booked 72 days in advance, depart on a Thursday or Monday and return on a Tuesday

Cheap flight deals from Mexico City to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Panama City
Explore the most affordable flight options available from Mexico City to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 15 March 2026.

Fri 10/48:40 a.m.
MEX
-
PTY
Nonstop3h 50m
Aeromexico
Fri 17/43:00 p.m.
PTY
-
MEX
Nonstop4h 00m
Aeromexico
Deal found 11/3C$ 449
Fri 3/41:10 p.m.
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Mon 6/410:11 p.m.
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Deal found 12/3C$ 455
Mon 6/48:40 a.m.
MEX
-
PTY
Nonstop3h 50m
Aeromexico
Mon 13/43:00 p.m.
PTY
-
MEX
Nonstop4h 00m
Aeromexico
Deal found 10/3C$ 477
Fri 3/71:20 a.m.
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Sun 19/77:02 p.m.
PTY
-
MEX
Nonstop4h 03m
Copa Airlines
Deal found 13/3C$ 505
Mon 6/43:30 p.m.
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Sat 11/410:11 p.m.
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Deal found 12/3C$ 509
Sat 20/61:20 a.m.
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Sun 28/610:13 p.m.
PTY
-
MEX
Nonstop3h 47m
Copa Airlines
Deal found 13/3C$ 519
Fri 10/48:40 a.m.
MEX
-
PTY
Nonstop3h 50m
Multiple Airlines
Fri 17/43:10 p.m.
PTY
-
MEX
1 stop8h 50m
Multiple Airlines
Deal found 11/3C$ 521
Thu 16/41:10 p.m.
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Sun 26/49:19 a.m.
PTY
-
MEX
Nonstop3h 51m
Copa Airlines
Deal found 13/3C$ 541

Find flight deals from Mexico City to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 15 March 2026.

Round-trip from

C$ 449

One-way from

C$ 222

Popular in

April

Cheapest in

August

Average price

C$ 554

Good round-trip deal

C$ 842 or less

Good one-way deal

C$ 395 or less
Aeromexico
  • Aeromexico
  • 10/4-17/4
  • Nonstop
  • 7h 50m total
  • Mexico City to Panama City
Search Deals
Copa Airlines
  • Copa Airlines
  • 7/4
  • Nonstop
  • 3h 43m total
  • Mexico City to Panama City
Search Deals
Highest demand for flights based on searches. 8% potential increase in price (C$ 67 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (C$ 9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals
Price to beat on a round-trip flight from Mexico City Benito Juarez to Panama City Tocumen Intl.
Search Deals
Price to beat on a one-way flight from Mexico City Benito Juarez to Panama City Tocumen Intl.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 15 March 2026.
Use the filters below to find and compare flights from Mexico City to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 4/9

3:30 p.m.-8:14 p.m.

Nonstop3h 44m

Panama City Tocumen Intl

Sun 13/9

11:47 a.m.-2:30 p.m.

Nonstop3h 43m

C$ 505

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 14/8

1:20 a.m.-6:01 a.m.

Nonstop3h 41m

Panama City Tocumen Intl

Sun 23/8

4:12 p.m.-7:05 p.m.

Nonstop3h 53m

C$ 505

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Tue 30/6

12:25 a.m.-5:08 a.m.

Nonstop3h 43m

Panama City Tocumen Intl

Thu 16/7

9:25 a.m.-12:10 p.m.

Nonstop3h 45m

C$ 505

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 29/7

1:20 a.m.-6:03 a.m.

Nonstop3h 43m

Panama City Tocumen Intl

Sat 8/8

9:30 p.m.-12:15 a.m.

Nonstop3h 45m

C$ 505

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 6/4

3:30 p.m.-8:10 p.m.

Nonstop3h 40m

Panama City Tocumen Intl

Sat 11/4

10:11 p.m.-1:00 a.m.

Nonstop3h 49m

C$ 509

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 20/6

12:25 a.m.-5:08 a.m.

Nonstop3h 43m

Panama City Tocumen Intl

Sun 28/6

7:05 p.m.-10:05 p.m.

Nonstop4h 00m

C$ 519
Quickest round-trip

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 3/4

3:30 p.m.-8:10 p.m.

Nonstop3h 40m

Panama City Tocumen Intl

Mon 6/4

11:44 a.m.-2:30 p.m.

Nonstop3h 46m

C$ 538

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 16/4

1:10 p.m.-5:53 p.m.

Nonstop3h 43m

Panama City Tocumen Intl

Sun 26/4

9:19 a.m.-12:10 p.m.

Nonstop3h 51m

C$ 541

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 24/6

3:30 p.m.-8:16 p.m.

Nonstop3h 46m

Panama City Tocumen Intl

Sun 28/6

11:46 a.m.-2:30 p.m.

Nonstop3h 44m

C$ 576
Cheapest one-way

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Tue 7/4

1:10 p.m.-5:53 p.m.

Nonstop3h 43m

C$ 222

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/3

Showing 1-10 of 18 resultsSorted by cheapest first
1
2

Best time to book a flight from Mexico City to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Panama City

How far ahead should I book a flight from Mexico City to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Panama City. Price data was last updated on 13 March 2026.

To ensure you get the cheapest price possible for a flight from Mexico City to Panama City, you should look to book at least 72 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Mexico City to Panama City?

Currently, September is the cheapest month in which you can book a flight from Mexico City to Panama City (average of C$ 240). Flying from Mexico City to Panama City in May is currently the most expensive (average of C$ 401). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to PTY?

Find hourly flight availability from Mexico City to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 15 March 2026.

It’s typically best to fly out from Mexico City to Panama City in the evening. Doing so could potentially save you 17% on the flight price compared to flying in the afternoon, which is usually more expensive.

How much does it cost to fly round-trip from Mexico City to Panama City?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated 15 March 2026.
Get a feel of what it's like to fly with Copa Airlines from Mexico City to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,569 reviews
Check prices

Comfort

7.4

Food

6.8

Overall

7.5

Entertainment

6.8

Crew

8.1

Boarding

7.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Copa Airlines
7.5
Good
1,569 reviews
Copa Airlines
7.5
Good
1,569 reviews
Check prices

Comfort

7.4

Food

6.8

Overall

7.5

Entertainment

6.8

Crew

8.1

Boarding

7.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Mexico City to Panama City?

    Booking a flight from Mexico City Benito Juarez (MEX) to Panama City Tocumen Intl (PTY) is your only option if you wish to fly from Mexico City to Panama City. On a typical day, there are 7 flights from Benito Juarez to Tocumen Intl, all of which are around 3h 40m for a nonstop flight. You can also purchase a plane ticket from 1 airline when you book a flight from Benito Juarez to Panama City.

  • How popular is this Mexico City to Panama City flight route?

    Flights from Mexico City Benito Juarez to Panama City Tocumen Intl have been viewed 7 times in the past calendar month.

  • How long is the flight from Mexico City to Panama City?

    There are many flights that can get you from Mexico City to Panama City in 3h 46m. Fly via Copa Airlines to get the fastest option. The distance between Mexico City and Panama City is about 2409 km. Most flights are nonstop.

  • What is the cheapest airline to fly from Mexico City to Panama City round-trip?

    Flying on Copa Airlines is currently your cheapest option to Panama City, with prices starting at C$ 211. Users have found that Copa Airlines is 59% cheaper than the other options available to this destination.

  • What are the most reliable airlines from Mexico City to Panama City?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mexico City to Panama City on time: Copa Airlines (90%), Emirates (89%), AeroMexico Connect (82%).

  • What are the cheapest flights from Mexico City to Panama City?

    The cheapest flight price from Mexico City to Panama City is C$ 277. On average you can expect to pay C$ 618. The most popular route, (Mexico City Benito Juarez - Panama City Tocumen Intl), can usually be booked for C$ 494.

  • Can I find deals for flights from Mexico City to Panama City that include hotel bookings?

    Yes. In addition to deals on Mexico City to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Panama City.

  • Can I find deals for business class flights from Mexico City to Panama City?

    Yes. Cheapflights offers flight deals from Mexico City to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Panama City?

    Currently, September is the cheapest month in which you can book a flight from Mexico City to Panama City (average of C$ 240). Flying from Mexico City to Panama City in May is currently the most expensive (average of C$ 401). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Mexico City to Panama City

Discover the top airline that operate flights from Mexico City to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 15 March 2026.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapestC$ 211AverageC$ 554FlexibilityNo cancel feeOn-time70%
Search Copa Airlines flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travelers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Mexico City to Panama City?

Cheapflights makes it easy to find Mexico City to Panama City flights by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.

Why should you use Cheapflights to find cheap flight tickets from Mexico City to Panama City?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Mexico City to Panama City.

Can Cheapflights find flights from Mexico City to Panama City with no change fees?

Yes! Cheapflights helps users easily find flights from Mexico City to Panama City with no change fees.

Can Cheapflights notify me if prices for flights from Mexico City to Panama City become cheaper?

Of course! You can now track prices for flights from Mexico City to Panama City and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.

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