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Cheap flights from Mexico City to Panama City from C$ 319

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/11. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — PTY
11 Oct — 18 Oct1
1 adult
1 adult, Economy

Cheapflights Tip: The best prices from Mexico City Benito Juarez to Panama City Tocumen Intl are usually found in July or June, booked 85 days in advance, depart on a Thursday or Monday and return on a Monday

Cheap flight deals from Mexico City to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 11 September 2025.

Round-trip from

C$ 377

One-way from

C$ 319

Popular in

December

Cheapest in

July

Average price

C$ 649

Good round-trip deal

C$ 457 or less

Good one-way deal

C$ 550 or less
Copa Airlines
  • Copa Airlines
  • 24/12-26/1
  • Nonstop
  • 7h 52m total
  • Mexico City to Panama City
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Avianca
  • Avianca
  • 2/11
  • 1 total stop
  • 8h 00m total
  • Mexico City to Panama City
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Highest demand for flights based on searches. 6% potential increase in price (C$ 56 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease (C$ 11 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Mexico City Benito Juarez to Panama City Tocumen Intl.
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Price to beat on a one-way flight from Mexico City Benito Juarez to Panama City Tocumen Intl.
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Find flight deals from Mexico City to Panama City

Cheapest flights from Mexico City to Panama City
Explore the most affordable flight options available from Mexico City to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 11 September 2025.

Wed 24/123:30 p.m.MEX - PTY
Nonstop3h 45mCopa Airlines
Mon 26/14:13 p.m.PTY - MEX
Nonstop4h 07mCopa Airlines
Deal found 11/9C$ 377
Thu 25/99:50 a.m.MEX - PTY
Nonstop3h 49mCopa Airlines
Tue 30/99:21 a.m.PTY - MEX
Nonstop3h 49mCopa Airlines
Deal found 11/9C$ 456
Fri 14/1112:55 p.m.MEX - PTY
1 stop5h 30mAvianca
Mon 17/117:50 p.m.PTY - MEX
1 stop6h 25mAvianca
Deal found 10/9C$ 468
Wed 1/101:40 a.m.MEX - PTY
Nonstop3h 40mCopa Airlines
Sun 5/1010:21 p.m.PTY - MEX
Nonstop3h 39mCopa Airlines
Deal found 10/9C$ 496
Tue 30/91:40 a.m.MEX - PTY
Nonstop3h 40mCopa Airlines
Wed 8/109:26 a.m.PTY - MEX
Nonstop3h 44mCopa Airlines
Deal found 11/9C$ 532
Thu 30/102:00 a.m.MEX - PTY
Nonstop3h 41mCopa Airlines
Sat 8/114:10 p.m.PTY - MEX
Nonstop4h 10mCopa Airlines
Deal found 11/9C$ 535
Tue 25/113:30 p.m.MEX - PTY
Nonstop3h 44mCopa Airlines
Fri 6/39:26 p.m.PTY - MEX
Nonstop3h 49mCopa Airlines
Deal found 11/9C$ 582
Tue 23/91:40 a.m.MEX - PTY
Nonstop3h 40mCopa Airlines
Fri 26/99:33 p.m.PTY - MEX
Nonstop3h 42mCopa Airlines
Deal found 11/9C$ 607
Sun 28/121:20 a.m.MEX - PTY
Nonstop3h 40mCopa Airlines
Tue 13/14:13 p.m.PTY - MEX
Nonstop4h 07mCopa Airlines
Deal found 11/9C$ 615
Fri 3/101:40 a.m.MEX - PTY
Nonstop3h 40mCopa Airlines
Sat 11/109:26 a.m.PTY - MEX
Nonstop3h 44mCopa Airlines
Deal found 11/9C$ 633
Sat 25/101:20 a.m.MEX - PTY
Nonstop3h 40mCopa Airlines
Sun 2/117:02 p.m.PTY - MEX
Nonstop4h 03mCopa Airlines
Deal found 11/9C$ 643

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 11 September 2025.
Use the filters below to find and compare flights from Mexico City to Panama City that are best for you.

Fly from

Mexico City

Fly to

Panama City

Route

Depart

Return

Price

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 24/12

3:30 p.m.-8:15 p.m.

Nonstop3h 45m

Panama City Tocumen Intl

Mon 26/1

4:13 p.m.-7:20 p.m.

Nonstop4h 07m

C$ 377

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 31/10

1:10 p.m.-5:55 p.m.

Nonstop3h 45m

Panama City Tocumen Intl

Wed 5/11

10:03 p.m.-1:00 a.m.

Nonstop3h 57m

C$ 456

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 25/9

9:50 a.m.-2:39 p.m.

Nonstop3h 49m

Panama City Tocumen Intl

Mon 29/9

11:46 a.m.-2:30 p.m.

Nonstop3h 44m

C$ 456

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 4/10

3:30 p.m.-8:13 p.m.

Nonstop3h 43m

Panama City Tocumen Intl

Sat 11/10

9:26 a.m.-12:10 p.m.

Nonstop3h 44m

C$ 456

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 10/10

9:50 a.m.-2:39 p.m.

Nonstop3h 49m

Panama City Tocumen Intl

Wed 15/10

9:26 a.m.-12:10 p.m.

Nonstop3h 44m

C$ 456

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 22/9

3:30 p.m.-8:14 p.m.

Nonstop3h 44m

Panama City Tocumen Intl

Tue 30/9

11:46 a.m.-2:30 p.m.

Nonstop3h 44m

C$ 456

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 17/10

3:30 p.m.-8:13 p.m.

Nonstop3h 43m

Panama City Tocumen Intl

Mon 20/10

10:21 p.m.-1:00 a.m.

Nonstop3h 39m

C$ 456

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 8/10

3:30 p.m.-8:13 p.m.

Nonstop3h 43m

Panama City Tocumen Intl

Wed 15/10

10:21 p.m.-1:00 a.m.

Nonstop3h 39m

C$ 456

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 27/9

9:50 a.m.-2:39 p.m.

Nonstop3h 49m

Panama City Tocumen Intl

Sat 4/10

10:21 p.m.-1:00 a.m.

Nonstop3h 39m

C$ 456

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 9/10

1:05 p.m.-5:50 p.m.

Nonstop3h 45m

Panama City Tocumen Intl

Mon 13/10

9:26 a.m.-12:10 p.m.

Nonstop3h 44m

C$ 456

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/9

Showing 1-10 of 16 results
1
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Best time to book a flight from Mexico City to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Panama City

How far ahead should I book a flight from Mexico City to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Mexico City to Panama City. Price data was last updated on 29 August 2025.

To ensure you get the cheapest price possible for a flight from Mexico City to Panama City, you should look to book at least 85 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Mexico City to Panama City?

Currently, January is the cheapest month in which you can book a flight from Mexico City to Panama City (average of C$ 542). Flying from Mexico City to Panama City in December is currently the most expensive (average of C$ 874). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to PTY?

Find hourly flight availability from Mexico City to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 11 September 2025.

It’s typically best to fly out from Mexico City to Panama City in the evening. Doing so could potentially save you 50% on the flight price compared to flying at noon, which is usually more expensive.

How much does it cost to fly round-trip from Mexico City to Panama City?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated 11 September 2025.
Get a feel of what it's like to fly with Copa Airlines from Mexico City to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews
Check prices

Food

6.8

Boarding

7.8

Overall

7.6

Entertainment

6.8

Crew

8.1

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews
Check prices

Food

6.8

Boarding

7.8

Overall

7.6

Entertainment

6.8

Crew

8.1

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Mexico City to Panama City?

    Booking a flight from Mexico City Benito Juarez (MEX) to Panama City Tocumen Intl (PTY) is your only option if you wish to fly from Mexico City to Panama City. On a typical day, there are 8 flights from Benito Juarez to Tocumen Intl, all of which are around 3h 39m for a nonstop flight. You can also purchase a plane ticket from 1 airline when you book a flight from Benito Juarez to Panama City.

  • How popular is this Mexico City to Panama City flight route?

    Flights from Mexico City Benito Juarez to Panama City Tocumen Intl have been viewed 8 times in the past calendar month.

  • How long is the flight from Mexico City to Panama City?

    There are many flights that can get you from Mexico City to Panama City in 3h 45m. Fly via Copa Airlines to get the fastest option. The distance between Mexico City and Panama City is about 2409 km. Most flights are nonstop.

  • What is the cheapest airline to fly from Mexico City to Panama City round-trip?

    Flying on Copa Airlines is currently your cheapest option to Panama City, with prices starting at C$ 213. Users have found that Copa Airlines is 63% cheaper than the other options available to this destination.

  • What are the most reliable airlines from Mexico City to Panama City?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mexico City to Panama City on time: AeroMexico Connect (100%), Emirates (95%), Copa Airlines (90%).

  • What are the cheapest flights from Mexico City to Panama City?

    The cheapest flight price from Mexico City to Panama City is C$ 213. On average you can expect to pay C$ 628. The most popular route, (Mexico City Benito Juarez - Panama City Tocumen Intl), can usually be booked for C$ 496.

  • Can I find deals for flights from Mexico City to Panama City that include hotel bookings?

    Yes. In addition to deals on Mexico City to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Panama City.

  • Can I find deals for business class flights from Mexico City to Panama City?

    Yes. Cheapflights offers flight deals from Mexico City to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Panama City?

    Currently, January is the cheapest month in which you can book a flight from Mexico City to Panama City (average of C$ 542). Flying from Mexico City to Panama City in December is currently the most expensive (average of C$ 874). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Mexico City to Panama City

Discover the top airline that operate flights from Mexico City to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 11 September 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapestC$ 213AverageC$ 603FlexibilityNo cancel feeOn-time70%
Search Copa Airlines flights

Fly with Cheapflights

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How does Cheapflights help users find flights from Mexico City to Panama City?

Cheapflights makes it easy to find Mexico City to Panama City flights by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.

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It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Mexico City to Panama City.

Can Cheapflights find flights from Mexico City to Panama City with no change fees?

Yes! Cheapflights helps users easily find flights from Mexico City to Panama City with no change fees.

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