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Cheap flights from Cusco to Santiago from C$ 173

CUZ — SCL
12 Oct — 19 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Cuzco to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Cuzco to Santiago

Thu 19/113:10 p.m. -
1 stop12h 15m
Sun 22/111:33 p.m. -
1 stop9h 02m
Deal found 11/9C$ 407
Fri 11/99:10 p.m. -
1 stop15h 25m
Fri 18/96:00 a.m. -
1 stop7h 30m
Deal found 10/9C$ 482
Tue 15/99:10 p.m. -
1 stop15h 25m
Tue 22/91:35 a.m. -
2 stops17h 20m
Deal found 8/9C$ 621
Tue 8/95:35 p.m. -
2 stops16h 30m
Mon 14/91:55 a.m. -
2 stops19h 55m
Deal found 7/9C$ 691
Tue 15/123:35 p.m. -
2 stops30h 57m
Mon 1/39:15 a.m. -
2 stops28h 55m
Deal found 10/9C$ 758
Wed 9/95:35 p.m. -
2 stops16h 30m
Tue 15/91:35 a.m. -
2 stops11h 50m
Deal found 8/9C$ 932

Find flight deals from Cuzco to Santiago

Round-trip from

C$ 407

One-way from

C$ 173

Popular in

February

Cheapest in

October

Average price

C$ 442

Good one-way deal

C$ 349 or less
Sky Airline
  • Sky Airline
  • 19/11-22/11
  • 2 total stops
  • 21h 17m total
  • Cusco to Santiago
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Sky Airline
  • Sky Airline
  • 24/10-31/12
  • 1 total stop
  • 7h 26m total
  • Cusco to Santiago
Search Deals
Highest demand for flights based on searches. 14% potential increase in price (C$ 102 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease (C$ 17 potential savings vs. average RT price).
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Average for round-trip flights in September 2026
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Price to beat on a one-way flight from Cusco Velazco Astete to Santiago Arturo Merino Benitez.
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Cusco to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

CuscoSantiago

CUZ Cusco Velazco Astete - SCL Santiago Arturo Merino Benitez

CUZSCL

Cusco Velazco Astete

Sat 24/10

8:00 p.m.-5:26 a.m.

1 stop7h 26m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:00 p.m.

Nonstop0h 00m

C$ 173

CuscoSantiago

CUZ Cusco Velazco Astete - SCL Santiago Arturo Merino Benitez

CUZSCL

Cusco Velazco Astete

Fri 9/10

9:30 p.m.-12:41 p.m.

1 stop13h 11m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:00 p.m.

Nonstop0h 00m

C$ 173

CuscoSantiago

CUZ Cusco Velazco Astete - SCL Santiago Arturo Merino Benitez

CUZSCL

Cusco Velazco Astete

Tue 9/2

4:31 p.m.-7:58 p.m.

1 stop25h 27m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:00 p.m.

Nonstop0h 00m

C$ 202

CuscoSantiago

CUZ Cusco Velazco Astete - SCL Santiago Arturo Merino Benitez

CUZSCL

Cusco Velazco Astete

Sat 24/10

8:00 a.m.-5:00 a.m.

2 stops19h 00m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:00 p.m.

Nonstop0h 00m

C$ 240

CuscoSantiago

CUZ Cusco Velazco Astete - SCL Santiago Arturo Merino Benitez

CUZSCL

Cusco Velazco Astete

Thu 24/9

9:10 p.m.-2:35 p.m.

1 stop15h 25m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:00 p.m.

Nonstop0h 00m

C$ 240

CuscoSantiago

CUZ Cusco Velazco Astete - SCL Santiago Arturo Merino Benitez

CUZSCL

Cusco Velazco Astete

Thu 19/11

3:10 p.m.-5:25 a.m.

1 stop12h 15m

Santiago Arturo Merino Benitez

Sun 22/11

1:33 p.m.-8:35 p.m.

1 stop9h 02m

C$ 407

CuscoSantiago

CUZ Cusco Velazco Astete - SCL Santiago Arturo Merino Benitez

CUZSCL

Cusco Velazco Astete

Tue 13/10

10:15 p.m.-12:36 a.m.

2 stops48h 21m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:00 p.m.

Nonstop0h 00m

C$ 441

CuscoSantiago

CUZ Cusco Velazco Astete - SCL Santiago Arturo Merino Benitez

CUZSCL

Cusco Velazco Astete

Mon 21/9

9:10 p.m.-12:05 p.m.

2 stops12h 55m

Santiago Arturo Merino Benitez

Wed 31/12

12:00 a.m.-10:00 p.m.

Nonstop0h 00m

C$ 615

CuscoSantiago

CUZ Cusco Velazco Astete - SCL Santiago Arturo Merino Benitez

CUZSCL

Cusco Velazco Astete

Tue 15/12

3:35 p.m.-12:32 a.m.

2 stops30h 57m

Santiago Arturo Merino Benitez

Mon 1/3

9:15 a.m.-12:10 p.m.

2 stops28h 55m

C$ 758

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/9

Sorted by cheapest first

Best time to book a flight from Cuzco to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Cuzco with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Cusco to Santiago

How far ahead should I book a flight from Cusco to Santiago?

The best time to book flights from Cusco to Santiago is 47 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Cusco to Santiago?

Currently, October is the cheapest month in which you can book a flight from Cusco to Santiago (average of C$ 339). Flying from Cusco to Santiago in February is currently the most expensive (average of C$ 587). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CUZ to SCL?

When flying from Cusco to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Cusco to Santiago?

Airfare is typical for this route at the moment.

Cusco to Santiago flights typically cost between C$ 389 and C$ 526 in November.
The cheapest round-trip price found within the last 5 days was C$ 407 on Sky Airline (19 Nov-22 Nov).

Related info for your journey

  • How popular is this Cusco to Santiago flight route?

    This flight path from Cusco Velazco Astete to Santiago Arturo Merino Benitez was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Cusco to Santiago?

    Sky Airline and JetSMART can get you from Cusco to Santiago in just under 12h 15m. Your travel time can differ by up to 18h 42m. Airlines will cover a distance of 2210 km. When browsing for deals, the options you’ll see will be for both direct flights and flights with stops.

  • Can I find deals for flights from Cuzco to Santiago that include hotel bookings?

    Yes. In addition to deals on Cuzco to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Cuzco to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Cuzco to Santiago.

  • Can I find deals for business class flights from Cuzco to Santiago?

    Yes. Cheapflights offers flight deals from Cuzco to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Cusco to Santiago?

    Currently, October is the cheapest month in which you can book a flight from Cusco to Santiago (average of C$ 339). Flying from Cusco to Santiago in February is currently the most expensive (average of C$ 587). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Valparaíso
Viña del Mar

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Alternative routes for Cuzco to Santiago

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Need flexible booking options for your flight to Santiago from Cuzco? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

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