It’s generally more expensive to depart on a Friday, if you have to leave on this day you can still search on Cheapflights to find great options that meet your needs.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Comox to San Diego as you normally would.
The Comox to San Diego flight path was viewed by 28 users in the past month. Keep an eye out for changes in search interest prior to high and low season.