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Cheap flights from Panama City to Madrid, Spain from C$ 706

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 15/10. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
15 Oct — 22 Oct1
1 adult
1 adult, Economy

Cheap flight deals from Panama City to Madrid

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Madrid (MAD). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 15 September 2025.

Round-trip from

C$ 954

One-way from

C$ 706

Popular in

July

Cheapest in

March

Average price

C$ 1,127
Air Europa
  • Air Europa
  • 14/11-17/11
  • Nonstop
  • 20h 10m total
  • Panama City to Madrid
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KLM
  • KLM
  • 15/10
  • 1 total stop
  • 31h 40m total
  • Panama City to Madrid
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Highest demand for flights based on searches. 7% potential increase in price (C$ 124 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease (C$ 19 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Panama City to Madrid

Cheapest flights from Panama City to Madrid
Explore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 15 September 2025.

Sun 2/119:30 p.m.PTY - MAD
Nonstop9h 35mAir Europa
Fri 14/113:10 p.m.MAD - PTY
Nonstop10h 35mAir Europa
Deal found 14/9C$ 954
Mon 3/119:30 p.m.PTY - MAD
Nonstop9h 35mAir Europa
Sun 23/113:10 p.m.MAD - PTY
Nonstop10h 35mAir Europa
Deal found 14/9C$ 955
Mon 27/102:55 a.m.PTY - MAD
1 stop23h 55mAvianca
Tue 4/114:20 p.m.MAD - PTY
1 stop14h 40mAvianca
Deal found 13/9C$ 956
Fri 5/129:30 p.m.PTY - MAD
Nonstop9h 35mAir Europa
Tue 13/13:10 p.m.MAD - PTY
Nonstop10h 35mAir Europa
Deal found 13/9C$ 961
Wed 22/106:50 p.m.PTY - MAD
1 stop14h 35mKLM
Wed 5/118:30 p.m.MAD - PTY
1 stop26h 00mKLM
Deal found 13/9C$ 992
Thu 30/109:30 p.m.PTY - MAD
Nonstop9h 35mAir Europa
Sun 16/113:10 p.m.MAD - PTY
Nonstop10h 35mAir Europa
Deal found 14/9C$ 998
Fri 24/108:25 p.m.PTY - MAD
Nonstop9h 50mAir Europa
Fri 14/113:10 p.m.MAD - PTY
Nonstop10h 35mAir Europa
Deal found 13/9C$ 999
Mon 6/105:10 p.m.PTY - MAD
Nonstop10h 05mIberia
Tue 14/1012:00 p.m.MAD - PTY
Nonstop10h 40mIberia
Deal found 14/9C$ 1,003
Sun 7/129:30 p.m.PTY - MAD
Nonstop9h 35mAir Europa
Tue 13/13:10 p.m.MAD - PTY
Nonstop10h 35mAir Europa
Deal found 13/9C$ 1,005
Sat 15/119:45 p.m.PTY - MAD
1 stop33h 35mTurkish Airlines
Sat 22/116:20 a.m.MAD - PTY
1 stop19h 30mTurkish Airlines
Deal found 14/9C$ 1,031
Mon 3/119:45 p.m.PTY - MAD
1 stop30h 40mTurkish Airlines
Sun 23/1111:55 a.m.MAD - PTY
1 stop37h 55mTurkish Airlines
Deal found 14/9C$ 1,034
Wed 22/106:50 p.m.PTY - MAD
1 stop31h 40mMultiple Airlines
Wed 5/1110:00 a.m.MAD - PTY
1 stop16h 10mMultiple Airlines
Deal found 14/9C$ 1,037

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 15 September 2025.
Use the filters below to find and compare flights from Panama City to Madrid that are best for you.

Fly from

Panama City

Fly to

Madrid

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 18/11

9:30 p.m.-1:05 p.m.

Nonstop9h 35m

Madrid Barajas

Sun 23/11

3:10 p.m.-7:45 p.m.

Nonstop10h 35m

C$ 954

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 15/11

9:45 p.m.-1:20 p.m.

1 stop33h 35m

Madrid Barajas

Sun 23/11

11:55 a.m.-7:50 p.m.

1 stop37h 55m

C$ 1,031

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 1/10

9:55 p.m.-4:50 p.m.

1 stop35h 55m

Madrid Barajas

Sat 18/10

6:20 p.m.-8:00 p.m.

1 stop32h 40m

C$ 1,056

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 5/10

9:55 p.m.-4:50 p.m.

1 stop35h 55m

Madrid Barajas

Tue 14/10

6:20 p.m.-8:00 p.m.

1 stop32h 40m

C$ 1,062

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 12/11

9:45 p.m.-10:25 a.m.

1 stop30h 40m

Madrid Barajas

Sun 23/11

2:25 p.m.-7:50 p.m.

1 stop35h 25m

C$ 1,062

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 16/11

9:30 p.m.-1:05 p.m.

Nonstop9h 35m

Madrid Barajas

Mon 24/11

3:10 p.m.-7:45 p.m.

Nonstop10h 35m

C$ 1,080

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 1/2

9:30 p.m.-1:05 p.m.

Nonstop9h 35m

Madrid Barajas

Sun 1/3

3:10 p.m.-7:45 p.m.

Nonstop10h 35m

C$ 1,080

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 4/2

9:45 p.m.-1:20 p.m.

1 stop33h 35m

Madrid Barajas

Wed 18/2

5:55 p.m.-5:05 p.m.

2 stops29h 10m

C$ 1,084

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 14/11

6:45 p.m.-10:25 a.m.

1 stop33h 40m

Madrid Barajas

Sat 22/11

6:20 a.m.-7:50 p.m.

1 stop19h 30m

C$ 1,091

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 3/10

9:55 p.m.-4:50 p.m.

1 stop35h 55m

Madrid Barajas

Thu 9/10

6:20 p.m.-8:00 p.m.

1 stop32h 40m

C$ 1,092

Flights are sorted by cheapest round-trip flights first.

Deals found on 13/9

Showing 1-10 of 18 results
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Best time to book a flight from Panama City to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Madrid

How far ahead should I book a flight from Panama City to Madrid?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Madrid. Price data was last updated on 12 September 2025.

The best time to book flights from Panama City to Madrid is 77 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Panama City to Madrid?

Currently, November is the cheapest month in which you can book a flight from Panama City to Madrid (average of C$ 658). Flying from Panama City to Madrid in December is currently the most expensive (average of C$ 951). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MAD?

Find hourly flight availability from Panama City to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 15 September 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Madrid as you normally would.

Reviews of airlines servicing Madrid

Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated 15 September 2025.
See what other customers who have flown with Air Europa from Panama City to Madrid have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Air Europa
7.0
Good
556 reviews
Check prices

Boarding

7.1

Overall

7.0

Crew

7.5

Comfort

7.0

Entertainment

6.6

Food

6.3

Reviews

1 / 10
8.0
Excellent

Christina,Jun 2025

ALC - MAD

It would be nice to have free messaging wifi on a trans Atlantic flight
Air Europa
7.0
Good
556 reviews
Air Europa
7.0
Good
556 reviews
Check prices

Boarding

7.1

Overall

7.0

Crew

7.5

Comfort

7.0

Entertainment

6.6

Food

6.3

Reviews

1 / 10
8.0
Excellent

Christina,Jun 2025

ALC - MAD

It would be nice to have free messaging wifi on a trans Atlantic flight

Related info for your journey

Find useful and relevant information for your journey from Panama City to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Madrid?

    To fly from Panama City to Madrid, you need to book a flight from Tocumen Intl (PTY) to Barajas (MAD). Nonstop flights to Madrid Barajas from Panama City Tocumen Intl take 9h 35m on average. When it comes time to book airfare, you have a few options: there are 7 outbound flights from Tocumen Intl to Barajas offered by 1 airline.

  • How popular is this Panama City to Madrid flight route?

    This flight path from Panama City Tocumen Intl to Madrid Barajas was viewed by 7 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Madrid?

    There are many flights that can get you from Panama City to Madrid in 33h 35m. Fly via Turkish Airlines to get the fastest option. The distance from Panama City to Madrid is about 8151 km.

  • What is the cheapest airline to fly from Panama City to Madrid round-trip?

    Cheapflights users have booked flights from Panama City to Madrid round-trip from C$ 1,453.

  • What are the most reliable airlines from Panama City to Madrid?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Panama City to Madrid on time: Qatar Airways (94%), Iberia (94%), EL AL (94%).

  • Can I find deals for flights from Panama City to Madrid that include hotel bookings?

    Yes. In addition to deals on Panama City to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Madrid?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Madrid.

  • Can I find deals for business class flights from Panama City to Madrid?

    Yes. Cheapflights offers flight deals from Panama City to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Madrid?

    Currently, November is the cheapest month in which you can book a flight from Panama City to Madrid (average of C$ 658). Flying from Panama City to Madrid in December is currently the most expensive (average of C$ 951). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Panama City to Madrid

Discover the top airline that operate flights from Panama City to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 15 September 2025.
AirlineCheapestAverageFlexibilityOn-time
Air EuropaCheapestC$ 1,453AverageC$ 2,663FlexibilityNo cancel feeOn-time83%
Search Air Europa flights

Fly with Cheapflights

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How does Cheapflights help users find flights from Panama City to Madrid?

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Why should you use Cheapflights to find cheap flight tickets from Panama City to Madrid?

Millions of users choose and trust Cheapflights to book the best flight deals from Panama City to Madrid for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

Can Cheapflights find flights from Panama City to Madrid with no change fees?

Need flexible booking options for your flight to Madrid from Panama City? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

Can Cheapflights notify me if prices for flights from Panama City to Madrid become cheaper?

Yes, Cheapflights offers price alerts on Panama City to Madrid flights so you can book your travel at the perfect time. Price Alerts can be enabled by clicking the bell icon next to the flight deals above and providing your email address where you want to receive the alerts.

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