Consider Kingston, Port Au Prince, and Santo Domingo if you prefer a quick journey with a short flight time. These locations are all within 248 km of Santiago de Cuba
If flights to distant destinations are more of your preference, check pricing for Kingston, Madrid, and Santo Domingo.
From Santiago de Cuba you can expect to find greater availability for the following destinations: Kingston (7 flights per day), Miami (7 flights per day) and Havana (3 flights per day).
For flights departing from Santiago de Cuba check dates and pricing for the following: American Airlines. This airline departs to the following popular destinations: Montevideo.