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Cheap flights from Buffalo to St. Louis from C$ 172

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 22/3. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — STL
10 Mar — 17 Mar1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Buffalo to St. Louis

Enter your travel dates to find the best prices.

Cheapest flights from Buffalo to St. Louis
Explore the most affordable flight options available from Buffalo to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 8 February 2026.

Sun 1/312:26 p.m.
BUF
-
STL
1 stop5h 16m
Delta
Tue 3/36:35 a.m.
STL
-
BUF
1 stop4h 08m
Delta
Deal found 6/2C$ 440
Mon 16/35:59 p.m.
BUF
-
STL
1 stop6h 45m
American Airlines
Fri 20/36:00 a.m.
STL
-
BUF
1 stop4h 49m
American Airlines
Deal found 6/2C$ 459
Mon 16/37:38 p.m.
BUF
-
STL
1 stop5h 20m
Delta
Fri 20/35:59 p.m.
STL
-
BUF
1 stop3h 56m
Delta
Deal found 7/2C$ 461
Wed 11/36:02 a.m.
BUF
-
STL
1 stop7h 17m
Delta
Mon 16/35:59 p.m.
STL
-
BUF
1 stop3h 56m
Delta
Deal found 5/2C$ 467
Mon 2/34:05 p.m.
BUF
-
STL
1 stop7h 35m
Southwest
Tue 3/38:20 a.m.
STL
-
BUF
1 stop6h 55m
Southwest
Deal found 6/2C$ 481
Sun 1/36:07 a.m.
BUF
-
STL
2 stops7h 14m
United Airlines
Tue 3/39:55 a.m.
STL
-
BUF
2 stops8h 11m
United Airlines
Deal found 6/2C$ 488
Sat 6/66:00 a.m.
BUF
-
STL
2 stops7h 11m
United Airlines
Thu 11/69:23 a.m.
STL
-
BUF
1 stop6h 17m
United Airlines
Deal found 6/2C$ 508
Wed 11/310:45 a.m.
BUF
-
STL
2 stops10h 15m
Southwest
Mon 16/34:45 p.m.
STL
-
BUF
1 stop6h 25m
Southwest
Deal found 5/2C$ 510
Sat 22/87:50 a.m.
BUF
-
STL
2 stops8h 40m
Southwest
Sat 29/88:30 a.m.
STL
-
BUF
2 stops8h 05m
Southwest
Deal found 4/2C$ 515
Wed 25/31:20 p.m.
BUF
-
STL
2 stops7h 35m
Southwest
Sat 28/35:35 a.m.
STL
-
BUF
1 stop3h 40m
Southwest
Deal found 4/2C$ 521

Find flight deals from Buffalo to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 8 February 2026.

Round-trip from

C$ 440

One-way from

C$ 172

Popular in

February

Cheapest in

September

Average price

C$ 530
Delta
  • Delta
  • 1/3-3/3
  • 2 total stops
  • 9h 24m total
  • Buffalo to St. Louis
Search Deals
Frontier
  • Frontier
  • 22/3
  • 2 total stops
  • 37h 45m total
  • Buffalo to St. Louis
Search Deals
Highest demand for flights based on searches. 7% potential increase in price (C$ 51 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (C$ 8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 8 February 2026.
Use the filters below to find and compare flights from Buffalo to St. Louis that are best for you.

Fly from

Buffalo

Fly to

St. Louis

Route

Depart

Return

Price

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Sun 1/3

12:26 p.m.-4:42 p.m.

1 stop5h 16m

Lambert-St Louis

Tue 3/3

6:35 a.m.-11:43 a.m.

1 stop4h 08m

C$ 440

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Mon 16/3

5:59 p.m.-11:44 p.m.

1 stop6h 45m

Lambert-St Louis

Fri 20/3

6:00 a.m.-11:49 a.m.

1 stop4h 49m

C$ 459

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Mon 16/3

7:38 p.m.-11:58 p.m.

1 stop5h 20m

Lambert-St Louis

Fri 20/3

5:59 p.m.-10:55 p.m.

1 stop3h 56m

C$ 461

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Wed 25/3

5:29 p.m.-10:59 p.m.

1 stop6h 30m

Lambert-St Louis

Sat 28/3

8:17 a.m.-1:17 p.m.

1 stop4h 00m

C$ 467

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Wed 11/3

6:02 a.m.-12:19 p.m.

1 stop7h 17m

Lambert-St Louis

Mon 16/3

5:59 p.m.-10:55 p.m.

1 stop3h 56m

C$ 467

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Fri 10/7

7:03 p.m.-11:27 p.m.

1 stop5h 24m

Lambert-St Louis

Fri 17/7

1:13 p.m.-9:02 p.m.

1 stop6h 49m

C$ 502

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Fri 12/6

5:47 p.m.-9:11 p.m.

1 stop4h 24m

Lambert-St Louis

Sun 14/6

1:13 p.m.-9:02 p.m.

1 stop6h 49m

C$ 502

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Sat 6/6

6:00 a.m.-12:11 p.m.

2 stops7h 11m

Lambert-St Louis

Thu 11/6

9:23 a.m.-4:40 p.m.

1 stop6h 17m

C$ 508

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Wed 11/3

10:45 a.m.-8:00 p.m.

2 stops10h 15m

Lambert-St Louis

Mon 16/3

4:45 p.m.-12:10 a.m.

1 stop6h 25m

C$ 510

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Wed 25/3

1:20 p.m.-7:55 p.m.

2 stops7h 35m

Lambert-St Louis

Sat 28/3

5:35 a.m.-10:15 a.m.

1 stop3h 40m

C$ 521

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/2

Showing 1-10 of 18 results
1
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Best time to book a flight from Buffalo to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to St. Louis

What is the cheapest month to book a flight from Buffalo to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Buffalo to St. Louis (average of C$ 153). Flying from Buffalo to St. Louis in February is currently the most expensive (average of C$ 421). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated 8 February 2026.
Check out reviews from past customers who have flown with Southwest from Buffalo to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,280 reviews
Check prices

Overall

8.0

Comfort

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,280 reviews
Southwest
8.0
Very good
4,280 reviews
Check prices

Overall

8.0

Comfort

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Buffalo to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to St. Louis?

    For as low as C$ 440, Delta can have you in St. Louis from Buffalo in 5h 16m. The distance between Buffalo and St. Louis is about 1081 km. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Buffalo to St. Louis round-trip?

    Currently priced at C$ 350, Southwest will fly you from Buffalo to St. Louis and back. In addition to Southwest, many other airlines offer competitively priced options for your trip. You may be able to fly from Buffalo to St. Louis for 26% less than the average price by searching for this airline.

  • Can I find deals for flights from Buffalo to St. Louis that include hotel bookings?

    Yes. In addition to deals on Buffalo to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to St. Louis.

  • Can I find deals for business class flights from Buffalo to St. Louis?

    Yes. Cheapflights offers flight deals from Buffalo to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Buffalo to St. Louis (average of C$ 153). Flying from Buffalo to St. Louis in February is currently the most expensive (average of C$ 421). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Chesterfield

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Alternative routes for Buffalo to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
Buffalo to Kansas City flights

Top airline flying from Buffalo to St. Louis

Discover the top airline that operate flights from Buffalo to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 8 February 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapestC$ 350AverageC$ 610FlexibilityNo cancel feeOn-time63%
Search Southwest flights

Fly with Cheapflights

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How does Cheapflights help users find flights from Buffalo to St. Louis?

Cheapflights makes it easy to find Buffalo to St. Louis flights by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.

Why should you use Cheapflights to find cheap flight tickets from Buffalo to St. Louis?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Buffalo to St. Louis.

Can Cheapflights find flights from Buffalo to St. Louis with no change fees?

Cheapflights does show flights with no change fees to all users. To see these options for flights from Buffalo to St. Louis, users can toggle the no change fees filter when performing a flight search.

Can Cheapflights notify me if prices for flights from Buffalo to St. Louis become cheaper?

Yes! Start tracking prices for Buffalo to St. Louis flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.

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