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Cheap flights from Buffalo to St. Louis from C$ 275

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 30/4. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — STL
18 May — 25 May1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Buffalo to St. Louis

Enter your travel dates to find the best prices.

Cheapest flights from Buffalo to St. Louis
Explore the most affordable flight options available from Buffalo to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 18 April 2026.

Mon 11/58:00 p.m.
BUF
-
STL
1 stop3h 45m
Southwest
Wed 13/56:35 a.m.
STL
-
BUF
1 stop7h 00m
Southwest
Deal found 16/4C$ 409
Tue 19/56:04 a.m.
BUF
-
STL
1 stop7h 19m
Delta
Sun 24/56:04 p.m.
STL
-
BUF
1 stop3h 50m
Delta
Deal found 14/4C$ 420
Thu 21/54:55 p.m.
BUF
-
STL
1 stop5h 43m
Delta
Sun 24/56:00 a.m.
STL
-
BUF
1 stop7h 07m
Delta
Deal found 14/4C$ 450
Tue 12/51:10 p.m.
BUF
-
STL
2 stops7h 50m
Southwest
Tue 19/57:35 a.m.
STL
-
BUF
2 stops6h 00m
Southwest
Deal found 17/4C$ 453
Wed 6/51:10 p.m.
BUF
-
STL
2 stops7h 50m
Southwest
Tue 12/57:35 a.m.
STL
-
BUF
2 stops6h 00m
Southwest
Deal found 15/4C$ 454
Mon 18/57:39 p.m.
BUF
-
STL
1 stop5h 20m
Delta
Thu 28/56:04 p.m.
STL
-
BUF
1 stop4h 55m
Delta
Deal found 14/4C$ 484
Mon 18/57:39 p.m.
BUF
-
STL
1 stop5h 20m
Delta
Sun 24/56:04 p.m.
STL
-
BUF
1 stop3h 50m
Delta
Deal found 14/4C$ 495
Sat 9/511:02 a.m.
BUF
-
STL
1 stop4h 30m
United Airlines
Tue 12/59:21 a.m.
STL
-
BUF
1 stop6h 33m
United Airlines
Deal found 16/4C$ 502
Wed 20/51:10 p.m.
BUF
-
STL
2 stops7h 50m
Southwest
Tue 26/510:25 a.m.
STL
-
BUF
2 stops6h 50m
Southwest
Deal found 14/4C$ 513
Mon 15/67:55 p.m.
BUF
-
STL
1 stop3h 55m
Southwest
Wed 17/63:15 p.m.
STL
-
BUF
2 stops6h 25m
Southwest
Deal found 15/4C$ 516

Find flight deals from Buffalo to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 18 April 2026.

Round-trip from

C$ 409

One-way from

C$ 275

Popular in

March

Cheapest in

December

Average price

C$ 538
Southwest
  • Southwest
  • 11/5-13/5
  • 2 total stops
  • 10h 45m total
  • Buffalo to St. Louis
Search Deals
Frontier
  • Frontier
  • 30/4
  • 1 total stop
  • 13h 00m total
  • Buffalo to St. Louis
Search Deals
Highest demand for flights based on searches. 25% potential increase in price (C$ 238 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease (C$ 46 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 629,999 searches. Data last updated 18 April 2026.
Use the filters below to find and compare flights from Buffalo to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Tue 19/5

6:04 a.m.-12:23 p.m.

1 stop7h 19m

Lambert-St Louis

Sun 24/5

6:04 p.m.-10:54 p.m.

1 stop3h 50m

C$ 420

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Thu 4/6

5:55 p.m.-12:35 a.m.

2 stops7h 40m

Lambert-St Louis

Mon 8/6

4:25 p.m.-12:10 a.m.

2 stops6h 45m

C$ 453

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Tue 12/5

1:10 p.m.-8:00 p.m.

2 stops7h 50m

Lambert-St Louis

Tue 19/5

7:35 a.m.-2:35 p.m.

2 stops6h 00m

C$ 453
Quickest round-trip

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Mon 18/5

7:39 p.m.-11:59 p.m.

1 stop5h 20m

Lambert-St Louis

Thu 28/5

6:04 p.m.-11:59 p.m.

1 stop4h 55m

C$ 484

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Sat 9/5

11:02 a.m.-2:32 p.m.

1 stop4h 30m

Lambert-St Louis

Tue 12/5

9:21 a.m.-4:54 p.m.

1 stop6h 33m

C$ 502

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Mon 15/6

5:55 p.m.-12:05 a.m.

2 stops7h 10m

Lambert-St Louis

Wed 17/6

3:15 p.m.-10:40 p.m.

2 stops6h 25m

C$ 523

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Tue 26/5

1:10 p.m.-8:00 p.m.

2 stops7h 50m

Lambert-St Louis

Mon 1/6

2:25 p.m.-11:20 p.m.

2 stops7h 55m

C$ 528

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Thu 28/5

6:00 a.m.-12:11 p.m.

2 stops7h 11m

Lambert-St Louis

Mon 1/6

9:23 a.m.-4:46 p.m.

1 stop6h 23m

C$ 555

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Thu 18/6

7:35 a.m.-1:50 p.m.

2 stops7h 15m

Lambert-St Louis

Mon 22/6

4:35 p.m.-12:10 a.m.

2 stops6h 35m

C$ 571

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

Sun 3/5

5:50 a.m.-12:05 p.m.

2 stops7h 15m

Lambert-St Louis

Thu 7/5

2:25 p.m.-11:20 p.m.

2 stops7h 55m

C$ 625

Flights are sorted by cheapest round-trip flights first.

Deals found on 16/4

Showing 1-10 of 14 resultsSorted by cheapest first
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Best time to book a flight from Buffalo to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to St. Louis

What is the cheapest month to book a flight from Buffalo to St. Louis?

Currently, December is the cheapest month in which you can book a flight from Buffalo to St. Louis (average of C$ 436). Flying from Buffalo to St. Louis in March is currently the most expensive (average of C$ 872). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Buffalo to St. Louis?

Related info for your journey

Find useful and relevant information for your journey from Buffalo to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to St. Louis?

    For as low as C$ 502, Southwest can have you in St. Louis from Buffalo in 5h 19m. The distance between Buffalo and St. Louis is about 1081 km. This flight may include one or multiple stops.

  • Can I find deals for flights from Buffalo to St. Louis that include hotel bookings?

    Yes. In addition to deals on Buffalo to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to St. Louis.

  • Can I find deals for business class flights from Buffalo to St. Louis?

    Yes. Cheapflights offers flight deals from Buffalo to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to St. Louis?

    Currently, December is the cheapest month in which you can book a flight from Buffalo to St. Louis (average of C$ 436). Flying from Buffalo to St. Louis in March is currently the most expensive (average of C$ 872). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
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How does Cheapflights help users find flights from Buffalo to St. Louis?

Cheapflights makes it easy to find Buffalo to St. Louis flights by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.

Why should you use Cheapflights to find cheap flight tickets from Buffalo to St. Louis?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Buffalo to St. Louis.

Can Cheapflights find flights from Buffalo to St. Louis with no change fees?

Cheapflights does show flights with no change fees to all users. To see these options for flights from Buffalo to St. Louis, users can toggle the no change fees filter when performing a flight search.

Can Cheapflights notify me if prices for flights from Buffalo to St. Louis become cheaper?

Yes! Start tracking prices for Buffalo to St. Louis flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.

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